期刊文献+
共找到22篇文章
< 1 2 >
每页显示 20 50 100
Kidney disease models:tools to identify mechanisms and potential therapeutic targets 被引量:12
1
作者 Yin-Wu Bao Yuan Yuan +1 位作者 jiang-hua chen Wei-Qiang Lin 《Zoological Research》 SCIE CAS CSCD 2018年第2期72-86,共15页
Acute kidney injury (AKI) and chronic kidney disease (CKD) are worldwide public health problems affecting millions of people and have rapidly increased in prevalence in recent years. Due to the multiple causes of ... Acute kidney injury (AKI) and chronic kidney disease (CKD) are worldwide public health problems affecting millions of people and have rapidly increased in prevalence in recent years. Due to the multiple causes of renal failure, many animal models have been developed to advance our understanding of human nephropathy. Among these experimental models, rodents have been extensively used to enable mechanistic understanding of kidney disease induction and progression, as well as to identify potential targets for therapy. In this review, we discuss AKI models induced by surgical operation and drugs or toxins, as well as a variety of CKD models (mainly genetically modified mouse models). Results from recent and ongoing clinical trials and conceptual advances derived from animal models are also explored. 展开更多
关键词 Acute kidney injury Chronic kidneydisease Mouse models Transgenic mice
下载PDF
Thermal stability and precipitate microstructures of Al−Si−Mg−Er alloy 被引量:4
2
作者 Yi HE Hai-hui XI +5 位作者 Wen-quan MING Qin-qin SHAO Ruo-han SHEN Yu-xiang LAI Cui-lan WU jiang-hua chen 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2021年第1期1-10,共10页
The effect of Er on the microhardness and precipitation behavior of the heat-treated Al−Si−Mg alloy was investigated by microhardness tester and TEM.As a comparison,the influence of natural aging was also studied.It i... The effect of Er on the microhardness and precipitation behavior of the heat-treated Al−Si−Mg alloy was investigated by microhardness tester and TEM.As a comparison,the influence of natural aging was also studied.It is shown that the thermal stability of the over-aged Al−Si−Mg−Er alloy is highly related to the average size of the precipitates.The average size ofβ''precipitates in Al−Si−Mg−Er alloy is smaller than that in Al−Si−Mg alloy,and the distribution is more localized under condition of without introducing natural aging.However,when natural aging is introduced before artificial aging,the Al−Si−Mg−Er alloy has similar average size and distribution of precipitates with the Al−Si−Mg alloy,resulting in similar mechanical properties.The effect of Er on the precipitation kinetics in the alloy was also discussed in detail to explain these phenomena. 展开更多
关键词 Al−Si−Mg alloy ER natural aging PRECIPITATE thermal stability
下载PDF
Impact of replacement of Re by W on dislocation slip mediated creeps of γ'-Ni_(3)Al phases 被引量:2
3
作者 Zhou YI Yun-lei XU +1 位作者 Ping PENG jiang-hua chen 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2021年第7期2013-2023,共11页
The anomalous flow behavior of γ'-Ni_(3)Al phases at high temperature is closely related to the cross-slip of 1/2<110>{111}super-partial dislocations.Generalized stacking fault energy curves(i.e.,Γ-surface... The anomalous flow behavior of γ'-Ni_(3)Al phases at high temperature is closely related to the cross-slip of 1/2<110>{111}super-partial dislocations.Generalized stacking fault energy curves(i.e.,Γ-surfaces)along the lowest energy path can provide a great deal of information on the nucleation and movement of dislocations.With the first-principles calculation,the interplay between Re and W,Mo,Ta,Ti doped at preferential sites and their synergetic influence on Γ-surfaces and ideal shear strength(τ_(max))in γ'-Ni_(3)Al phases are investigated.Similar to single Re-addition,the Suzuki segregation of W at stacking faults is demonstrated to enable to impede the movement of 1/6<112>{111} Shockley partial dislocations and promote the cross-slip of 1/2<110>{111}super-partial dislocations.With the replacement of a part of Re by W,a decreased γ_(APB)^(111)/γ_(APB)^(001) indicates that the anomalous flow behavior of γ'phases at high temperature is not as excellent as the double Re-addition,but an increasedτmax means that the creep rupture strength of Ni-based single crystal superalloys can be benefited from this replacement to some extent,especially in the co-segregation of Re and W at Al−Al sites.As the interaction between X1_(Al) and X2_(Al) point defects is characterized by an correlation energy function ΔE^(X1_(Al)+X2_(Al))(d),it is found that both strong attraction and strong repulsion are unfavarable for the improvement of yield strengths of γ'phase. 展开更多
关键词 Ni-based single crystal superalloy γ'-Ni_(3)Al generalized stacking fault energy ideal shear strength dislocation CROSS-SLIP
下载PDF
Severe mental disorders following anti-retroviral treatment in a patient on peritoneal dialysis: A case report and literature review
4
作者 Qi-En He Min Xia +3 位作者 Guang-Hui Ying Xue-Lin He jiang-hua chen Yi Yang 《World Journal of Clinical Cases》 SCIE 2019年第20期3329-3334,共6页
BACKGROUND Antiviral drugs are widely used in populations with viral infection caused by immunologic inadequacy.Because these drugs are mainly metabolized by the kidneys,patients with renal failure undergoing renal re... BACKGROUND Antiviral drugs are widely used in populations with viral infection caused by immunologic inadequacy.Because these drugs are mainly metabolized by the kidneys,patients with renal failure undergoing renal replacement therapy are prone to drug adverse effects and poisoning.Severe neurotoxicity caused by antiviral drugs is a rare but life-threatening complication.CASE SUMMARY This study reported one male patient on peritoneal dialysis who suffered from severe mental disorders after receiving an overdose of acyclovir and valacyclovir for the treatment of herpes zoster.The literature review suggested that hemodialysis is better than peritoneal dialysis to clear acyclovir from the circulation.The patient died after his consciousness deteriorated despite peritoneal dialysis and continuous blood purification.CONCLUSION This case emphasizes cautiousness when using anti-retroviral drugs in patients with uremia.Hemodialysis is optimal method to remove the drugs. 展开更多
关键词 Chronic renal failure PERITONEAL dialysis ACYCLOVIR VALACYCLOVIR NEUROTOXICITY HERPES ZOSTER Case report
下载PDF
Can sacubitril/valsartan become the promising drug to delay the progression of chronic kidney disease?
5
作者 Yang chen Lu-Ying GUO +4 位作者 Ling-Fei ZHAO Yan-Hong MA Xue-Ling ZHU Ying XU jiang-hua chen 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2020年第12期782-786,共5页
1 Introduction Chronic kidney disease(CKD)often coexists with or is a complication of cardiovascular disease.Previous studies have shown that CKD increases the risk of cardiovascular death and all-cause death and was ... 1 Introduction Chronic kidney disease(CKD)often coexists with or is a complication of cardiovascular disease.Previous studies have shown that CKD increases the risk of cardiovascular death and all-cause death and was considered to be a risk equivalent of coronary heart disease.[1,2]Adjusted for confounders,decreased glomerular filtration rate(GFR)and increased albuminuria are both independent risk factors for cardiovascular events.[3,4]The risk for cardiovascular death linearly increases with the decline of GFR in a certain range(<70 mL/min per 1.73 m^2)and the increase of albuminuria without a threshold effect[3]. 展开更多
关键词 Cardiovascular disease Chronic kidney disease Kidney function Sacubitril/valsartan
下载PDF
Influence of Peritoneal Transport Characteristics on Nutritional Status and Clinical Outcome in Chinese Diabetic Nephropathy Patients on Peritoneal Dialysis 被引量:31
6
作者 Ji-Chao Guan Wei Bian +2 位作者 Xiao-Hui Zhang Zhang-Fei Shou jiang-hua chen 《Chinese Medical Journal》 SCIE CAS CSCD 2015年第7期859-864,共6页
Background: High peritoneal transport status was previously thought to be a poor prognostic factor in peritoneal dialysis (PD) patients. However, its effect on diabetic nephropathy PD patients is unclear in conside... Background: High peritoneal transport status was previously thought to be a poor prognostic factor in peritoneal dialysis (PD) patients. However, its effect on diabetic nephropathy PD patients is unclear in consideration of the adverse impact of diabetes itself. The purpose of this study was to investigate the influence of peritoneal transport characteristics on nutritional status and clinical outcome in diabetic nephropathy patients on PD. Methods: One hundred and two diabetic nephropathy patients on PD were enrolled in this observational cohort study. According to the initial peritoneal equilibration test result, patients were divided into two groups: Higher transport group (HT, including high and high average transport) and lower transport group (LT, including low and low-average transport). Demographic characteristics, biochemical data, dialysis adequacy, and nutritional status were evaluated. Clinical outcomes were compared. Risk factors for death-censored technique failure and mortality were analyzed. Results: Compared with LT group (n = 37), serum albumin was significantly lower and the incidence of malnutrition by subjective global assessment was significantly higher in HT group (n = 65) (P 〈 0.05). Kaplan-Meier analyses showed that death-censored technique failure and mortality were significantly increased in HT group compared with that in LT group. On multivariate Cox analyses, higher peritoneal transport status and lower residual renal function (RRF) were independent predictors of death-censored technique failure when adjusted for serum albumin and total weekly urea clearance (Kt/V). Independent predictors of mortality were advanced age, anemia, hypoalbuminemia, and lower RRF, but not higher peritoneal transport status. Conclusions: Higher peritoneal transport status has an adverse influence on nutrition for diabetic nephropathy patients on PD. Higher peritoneal transport status is a significant independent risk factor for death-censored technique failure, but not for mortality in diabetic nephropathy patients on PD. 展开更多
关键词 Diabetic Nephropathy NUTRITION OUTCOME Peritoneal Dialysis Peritoneal Equilibration Test
原文传递
Effects of rapamycin against paraquat-induced pulmonary fibrosis in mice 被引量:8
7
作者 Xue SHAO Meng LI +11 位作者 Chong LUO Ying-ying WANG Ying-ying LU Shi FENG Heng LI Xia-bing LANG Yu-cheng WANG Chuan LIN Xiu-jin SHEN Qin ZHOU Hong JIANG jiang-hua chen 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2015年第1期52-61,共10页
Background and aims: Ingestion of paraquat (PQ), a widely used herbicide, can cause severe toxicity in humans, leading to a poor survival rate and prognosis. One of the main causes of death by PQ is PQ-induced pul-... Background and aims: Ingestion of paraquat (PQ), a widely used herbicide, can cause severe toxicity in humans, leading to a poor survival rate and prognosis. One of the main causes of death by PQ is PQ-induced pul- monary fibrosis, for which there are no effective therapies. The aim of this study was to evaluate the effects of ra- pamycin (PAPA) on inhibiting PQ-induced pulmonary fibrosis in mice and to explore its possible mechanisms. Methods: Male C57BL/6J mice were exposed to either saline (control group) or PQ (10 mg/kg body weight, intraper- itoneally; test group). The test group was divided into four subgroups: a PQ group (PQ-exposed, non-treated), a PQ+RAPA group (PQ-exposed, treated with RAPA at I mg/kg intragastrically), a PQ+MP group (PQ-exposed, treated with methylprednisolone (MP) at 30 mg/kg intraperitoneally), and a PQ+MP+RAPA group (PQ-exposed, treated with MP at 30 mg/kg intraperitoneally and with PAPA at 1 mg/kg intragastrically). The survival rate and body weight of all the mice were recorded every day. Three mice in each group were sacrificed at 14 d and the rest at 28 d after intox- ication. Lung tissues were excised and stained with hematoxylin-eosin (H&E) and Masson's trichrome stain for his- topathological analysis. The hydroxyproline (HYP) content in lung tissues was detected using an enzyme-linked im- munosorbent assay (ELISA) kit. The expression of transforming growth factor-β1 (TGF-β1) and α-smooth muscle actin (α-SMA) in lung tissues was detected by immunohistochemical staining and Western blotting. Results: A mice model of PQ-induced pulmonary fibrosis was established. Histological examination of lung tissues showed that PAPA treatment moderated the pathological changes of pulmonary fibrosis, including alveolar collapse and interstitial collagen depo- sition. HYP content in lung tissues increased soon after PQ intoxication but had decreased significantly by the 28th day after PAPA treatment. Immunohistochemical staining and Western blotting showed that PAPA treatment significantly down-regulated the enhanced levels of TGF-β1 and e-SMA in lung tissues caused by PQ exposure. However, PAPA treatment alone could not significantly ameliorate the lower survival rate and weight loss of treated mice. MP treatment enhanced the survival rate, but had no significant effects on attenuating PQ-induced pulmonary fibrosis or reducing the expression of TGF-β1 and a-SMA. Conclusions: This study demonstrates that PAPA treatment effectively suppresses PQ-induced alveolar collapse and collagen deposition in lung tissues through reducing the expression of TGF-β1 and a-SMA. Thus, RAPA has potential value in the treatment of PQ-induced pulmonary fibrosis. 展开更多
关键词 PARAQUAT Pulmonary fibrosis RAPAMYCIN Transforming growth factor-β1 a-Smooth muscle actin METHYLPREDNISOLONE
原文传递
Mycophenolate mofetil plus prednisone for inducing remission of Henoch-Sch?nlein purpura nephritis: a retrospective study 被引量:7
8
作者 Fei HAN Liang-liang chen +5 位作者 Ping-ping REN Jing-yun LE Pei-jing CHOONG Hong-ju WANG Ying XU jiang-hua chen 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2015年第9期772-780,共9页
Objective: The treatment of Henoch-Schonlein purpura (HSP) with moderate proteinuria remains con- troversial. We retrospectively analyzed the efficacy of immune suppressants, with a particular emphasis on myco- phe... Objective: The treatment of Henoch-Schonlein purpura (HSP) with moderate proteinuria remains con- troversial. We retrospectively analyzed the efficacy of immune suppressants, with a particular emphasis on myco- phenolate mofetil (MMF). Methods: Ninety-five HSP patients with moderate proteinuria (1.0-3.5 g/24 h) after at least three months of therapy with angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) were divided into three groups: an MMF group (n=33) that received MMF 1.0-1.5 g/d combined with prednisone (0.4-0.5 mg/(kg.d)), a corticosteroid (CS) group (n=31) that received full-dose prednisone (0.8-1.0 mg/(kg.d)), and a control group (n=31). Patients in the MMF and CS groups continued to take ACEI or ARB at the original dose. The patients in the control group continued to take ACEI or ARB but the dose was increased by (1.73±0.58)-fold. The patients were followed up for 6-78 months (median 28 months). Results: The baseline proteinuria was higher in the MMF group ((2.1±0.9) g/24 h) than in the control group ((1.6±0.8) g/24 h) (P=0.039). The proteinuria decreased sig- nificantly in all groups during follow-up, but only in the MMF group did it decrease significantly after the first month. At the end of follow-up, the proteinuria was (0.4±0.7) g/24 h in the MMF group and (0.4±0.4) g/24 h in the CS group, significantly lower than that in the control group ((0.9±1.1) g/24 h). The remission rates in the MMF group, CS group, and control group were respectively 72.7%, 71.0%, and 48.4% at six months and 72.7%, 64.5%, and 45.2% at the end of follow-up. The overall number of reported adverse events was 17 in the MMF group, 30 in the CS group, and 6 in the control group (P〈0.001). Conclusions: MMF with low-dose prednisone may be as effective as full-dose prednisone and tend to have fewer adverse events. Therefore, it is probably superior to conservative treatments of adult HSP patients with moderate proteinuria. 展开更多
关键词 Henoch-Schonlein purpura NEPHRITIS Mycophenolate mofetil REMISSION
原文传递
Toxicity comparison of different active fractions extracted from radix Sophorae tonkinensis in zebrafish 被引量:6
9
作者 Hong-cui LIU Xiao-yu ZHU +3 位作者 jiang-hua chen Sheng-ya GUO Chun-qi LI Zhong-ping DENG 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2017年第9期757-769,共13页
Radix Sophorae tonkinensis(RST) is a widely used herb in Traditional Chinese Medicine(TCM) for treating infectious and inflammatory diseases. However, the toxicity data for RST are limited. The aim of this work is to ... Radix Sophorae tonkinensis(RST) is a widely used herb in Traditional Chinese Medicine(TCM) for treating infectious and inflammatory diseases. However, the toxicity data for RST are limited. The aim of this work is to assess and compare the toxicity of the whole RST extract and its five active fractions using the zebrafish model. Five active fractions of RST were prepared using five different types of solvents, which included dealkalized water, ethanol, n-butyl ethanol, dichloromethane, and diethyl ether. The chemical profiles of the active fractions were determined by high-performance liquid chromatography(HPLC), and the toxicity observed in the zebrafish model was confirmed using mouse models. In the zebrafish model, cardiovascular toxicity was observed for the fraction extracted using diethyl ether, and hepatotoxicity was observed for the whole RST extract and the fractions extracted using water and ethanol, whereas both cardiovascular and hepatic toxicities were observed for the fractions extracted using n-butyl ethanol and dichloromethane. The hepatotoxicity of the fractions extracted using n-butyl ethanol and dichloromethane was also observed in mice. Our findings provide the toxicity data for RST and its five active fractions through modeling in a zebrafish, and indicate that the different fractions may each have a different toxicity, which is helpful for the optimal use of RST in clinical practice. 展开更多
关键词 Sophorae tonkinensis Gagnep Active fraction HEPATOTOXICITY Cardiovascular toxicity ZEBRAFISH
原文传递
Complex Precipitation Sequences of Al-Cu-Li-(Mg)Alloys Characterized in Relation to Thermal Ageing Processes 被引量:6
10
作者 Zhen Gao jiang-hua chen +2 位作者 Shi-Yun Duan Xiu-Bo Yang Cui-Lan Wu 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2016年第1期94-103,共10页
The A1-Cu-Li-(Mg) alloy is a high-performance lightweight material strengthened by complex coexisting precipitates that form in the alloy upon thermal ageing. Using high-resolution (scanning) transmission electron... The A1-Cu-Li-(Mg) alloy is a high-performance lightweight material strengthened by complex coexisting precipitates that form in the alloy upon thermal ageing. Using high-resolution (scanning) transmission electron microscopy in association with first-principles energy calculations, we systematically studied the complex coexisting precipitates in the alloys and correlated their precipitation sequences with thermal ageing processes applied. The principal results are the following: (1) eight types of precipitates can be observed in the alloy; (2) of these precipitates, the Tl-phase is most stable. The S-phase precipitates with segregated Li atoms at their interfacial edges are unexpectedly more stable than the a-phase; (3) the Tl-phase has a characteristic precursor that plays the key role in its nucleation and growth. 展开更多
关键词 AI-Cu-Li alloy Electron microscopy Ageing PRECIPITATION STRENGTH
原文传递
Revisiting the Hierarchical Microstructures of an Al-Zn-Mg Alloy Fabricated by Pre-deformation and Aging 被引量:2
11
作者 Xiong-Wei Yu jiang-hua chen +5 位作者 Wen-Quan Ming Xiu-Bo Yang Tian-Tian Zhao Ruo-Han Shen Yu-Tao He Cui-Lan Wu 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2020年第11期1518-1526,共9页
Pre-deformation before aging has been demonstrated to have a positive effect on the mechanical strength of the 7N01 alloy in our previous study,which is rather different from the general negative effects of pre-deform... Pre-deformation before aging has been demonstrated to have a positive effect on the mechanical strength of the 7N01 alloy in our previous study,which is rather different from the general negative effects of pre-deformation on high-strength 7XXX aluminum alloys.In order to explain the strengthening mechanism relating to the positive effect,in the present study,the microstructure of the aged 7N01 alloy with different degrees of pre-deformation was investigated in detail using advanced electron microscopy techniques.Our results show that,without pre-deformation,the aged alloy is strengthened mainly by the η′type of hardening precipitates.In contrast,with pre-deformation,the aged alloy is strengthened by the hierarchical microstructure consisting of the GP-η′type of precipitates formed inside sub-grains,the ηp type of precipitates formed at small-angle boundaries,and the dislocation introduced by pre-deformation(residual work-hardening effect).By visualizing the distribution of theηp precipitates through three-dimensional electron tomography,the 3 D microstructures of dislocation cells are clearly revealed.Proper combinations of ηp precipitates,GP-η′precipitates and residual dislocations in the alloy are responsible for the positive effect of pre-deformation on its mechanical properties. 展开更多
关键词 Aluminum alloys PRECIPITATES PRE-DEFORMATION Three-dimensional electron tomography(3DET) Dislocation cell
原文传递
0.9% saline is neither normal nor physiological 被引量:1
12
作者 Heng LI Shi-ren SUN +2 位作者 John Q.YAP jiang-hua chen Qi QIAN 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2016年第3期181-187,共7页
The purpose of this review is to objectively evaluate the biochemical and pathophysiological properties of 0.9% saline (henceforth: saline) and to discuss the impact of saline infusion, specifically on systemic aci... The purpose of this review is to objectively evaluate the biochemical and pathophysiological properties of 0.9% saline (henceforth: saline) and to discuss the impact of saline infusion, specifically on systemic acid-base bal- ance and renal hemodynamics. Studies have shown that electrolyte balance, including effects of saline infusion on serum electrolytes, is often poorly understood among practicing physicians and inappropriate saline prescribing can cause increased morbidity and mortality. Large-volume (〉2 L) saline infusion in healthy adults induces hyperohloremia which is associated with metabolic acidosis, hyperkalemia, and negative protein balance. Saline overload (80 ml/kg) in rodents can cause intestinal edema and contractile dysfunction associated with activation of sodium-proton exchanger (NHE) and decrease in myosin light chain phosphorylation. Saline infusion can also adversely affect renal hemody- namics. Microperfusion experiments and real-time imaging studies have demonstrated a reduction in renal perfusion and an expansion in kidney volume, compromising 02 delivery to the renal perenchyma following saline infusion. Clinically, saline infusion for patients post abdominal and cardiovascular surgery is associated with a greater number of adverse effects including more frequent blood product transfusion and bicarbonate therapy, reduced gastric blood flow, delayed recovery of gut function, impaired cardiac contractility in response to inotropes, prolonged hospital stay, and possibly increased mortality. In critically ill patients, saline infusion, compared to balanced fluid infusions, in- creases the occurrence of acute kidney injury. In summary, saline is a highly acidic fluid. With the exception of saline infusion for patients with hypochloremic metabolic alkalosis and volume depletion due to vomiting or upper gastroin- testinal suction, indiscriminate use, especially for acutely ill patients, may cause unnecessary complications and should be avoided. More education regarding saline-related effects and adequate electrolyte management is needed. 展开更多
关键词 0.9% saline Hyperchloremia ACIDOSIS HYPERKALEMIA Balanced fluids Renal hemodynamics
原文传递
Synergistic Effect of Alloying Atoms on Intrinsic Stacking-Fault Energy in Austenitic Steels 被引量:1
13
作者 Ling-Hong Liu Tou-Wen Fan +3 位作者 Cui-Lan Wu Pan Xie Ding-Wang Yuan jiang-hua chen 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2017年第3期272-279,共8页
Intrinsic stacking-fault energy is a critical parameter influencing the various mechanical performances of aus- tenitic steels with high Mn concentrations. However, quantitative calculations of the stacking-fault ener... Intrinsic stacking-fault energy is a critical parameter influencing the various mechanical performances of aus- tenitic steels with high Mn concentrations. However, quantitative calculations of the stacking-fault energy (SFE) of the face-centered cubic (fcc) Fe, including the changes in concentrations and geometrical distribution of alloying atoms, cannot be obtained by using previous computation models. On the basis of the interaction energy model, we evaluated the effects of a single alloying atom (i.e., Mn, A1, Si, C and N), as well as its aggregates, including the Mn-X dimer and Mn2-X trimer (X = A1, Si, C and N) on the SFE of the fcc Fe via first-principle calculations. Given low concentrations (〈10 wt%) of alloying atoms, dimers and trimers, theoretical calculations reveal the following: (1) Alloying atom Mn causes a decrease in the SFE, whereas A1, Si, C and N significantly increase the SFE; (2) combination with other alloying atoms to form the Mn-X dimer (X = A1, Si, C and N) exerts an effect on SFE that, to a certain extent, is close to that of the corresponding single X atom; (3) the interaction between Mnz-X and the stacking fault is stronger than that of the corresponding single X atom, inducing a significant increase in the SFE of fcc Fe. The theoretical results we obtained demonstrate that the increase in SFE in high-Mn steel originates from the synergistic effect of Mn and other trace alloy atoms. 展开更多
关键词 Stacking-fault energy Synergism First-principle calculation Austenitic steel Alloying effect
原文传递
Optimized Combinatorial Properties of an AlMgSi(Cu) Alloy Achieved by a Mechanical-Thermal Combinatorial Process 被引量:1
14
作者 Li-Mei Liu Yu-Xiang Lai +1 位作者 Chun-Hui Liu jiang-hua chen 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2020年第5期751-758,共8页
Enhancing combinatorial properties,such as excellent corrosion resistance,high strength and good ductility combined,is an important issue for manufacturing high-quality AlMgSi(Cu)alloys.Here,we show that this can be a... Enhancing combinatorial properties,such as excellent corrosion resistance,high strength and good ductility combined,is an important issue for manufacturing high-quality AlMgSi(Cu)alloys.Here,we show that this can be achieved by optimizing a combinatorial process consisting of pre-ageing,cold-rolling and post-ageing to tailor the hierarchical microstructures of the alloy.Transmission electron microscopy analysis reveals that the enhanced combinatorial properties of corrosion resistance,strength and ductility are owing to modification of grain boundary microstructure in good association with changes of precipitate microstructures and a more homogenous distribution of solute atoms,as compared with the microstructures of the alloy processed by thermal ageing only. 展开更多
关键词 Al alloy Corrosion resistance Mechanical property Ageing DEFORMATION
原文传递
Protective effect of indomethacin in renal ischemia-reperfusion injury in mice 被引量:1
15
作者 Sheng-hong ZHU Li-jia ZHOU +6 位作者 Hong JIANG Rong-jun chen Chuan LIN Shi FENG Juan JIN jiang-hua chen Jian-yong WU 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2014年第8期735-742,共8页
Objective: To evaluate the renoprotection effects of non-steroidal anti-inflammatory drugs (NSAIDs) in renal ischemia-reperfusion injury (IRI) and the cyclooxygenase (COX)-1/2 blockade association by indomethac... Objective: To evaluate the renoprotection effects of non-steroidal anti-inflammatory drugs (NSAIDs) in renal ischemia-reperfusion injury (IRI) and the cyclooxygenase (COX)-1/2 blockade association by indomethacin (IMT) in the mice model. Methods: After the left renal pedicle of mice was clamped, IMT was administrated by intraperitoneal injection with four doses: 1, 3, 5, and 7 mg/kg. Blood and kidney samples were collected 24 h after IRI. The renal functions were assayed by the cytokines and serum creatinine (SCr) using enzyme-linked immunosorbent assay (ELISA) kits. Kidney samples were analyzed by hematoxylin and eosin (H&E) and immunohistochemistry stainings. Results: The mice administered with 5 mg/kg IMT had a marked reduction in SCr and significantly less tubular damage The tumor necrosis factor a (TNF-α) activity in renal homogenates and interleukin 6 (IL-6) activity in serum had a marked reduction at doses of 5 and 7 mg/kg IMT. The administration of 3 and 5 mg/kg IMT had a marked reduction in the ratio of thromboxane B2 to 6-keto-prostaglandin F1α. COX-1 and COX-2 stainings were weaker in 5 mg/kg IMT groups than that in the other groups. Conclusions: There was a dose response in the IMT function of renal IRI in mice, and IMT had a protective effect in a certain dose range. The effect of IMT on mice IRI was related to COX-1/2 blockades. 展开更多
关键词 Non-steroidal anti-inflammatory drug (NSAID) Indomethacin (IMT) Ischemia-reperfusion injury (IRI) Dosage Protective effect
原文传递
Double-Shelled L1_(2) Nano-structures in Quaternary Al–Er–Sc–Zr Alloys: Origin and Critical Significance 被引量:1
16
作者 Chao-Min Zhang Pan Xie +5 位作者 Yong Jiang Sheng Zhan Wen-Quan Ming jiang-hua chen Ke-Xing Song Hao Zhang 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2021年第9期1277-1284,共8页
The formation of highly coherent double-shelled L1_(2) nano-precipitates in dilute Al–Er–Sc–Zr alloys was investigated with the combined use of Cs-corrected transmission electron microscopy characterization and fir... The formation of highly coherent double-shelled L1_(2) nano-precipitates in dilute Al–Er–Sc–Zr alloys was investigated with the combined use of Cs-corrected transmission electron microscopy characterization and first-principles energetics calculations. The double-shelled nano-precipitates are primarily featured with an Er-rich core surrounded by a Sc-rich inner shell and a Zr-rich outer shell. First-principles energetics analyses based on the classic homogenous nucleation theory suggested that once forms, this double-shell structure can be thermally stable. The predominant formation of this double-shell structure has thus both profound kinetic and thermodynamic origins. Its formation and stability preference to all other possible L1_(2) nano-structures would become more pronounced as its size increases, no matter what the solute ratio and aging temperature of interest. 展开更多
关键词 Al alloys Core–shell L12 nano-phase FIRST-PRINCIPLES
原文传递
Elastic Properties and Stacking Fault Energies of Borides, Carbides and Nitrides from First-Principles Calculations
17
作者 Yong Zhang Zi-Ran Liu +4 位作者 Ding-Wang Yuan Qin Shao jiang-hua chen Cui-Lan Wu Zao-Li Zhang 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2019年第9期1099-1110,共12页
Owing to the excellent elastic properties and chemical stability,binary metal or light element borides,carbides and nitrides have been extensively applied as hard and low-compressible materials.Researchers are searchi... Owing to the excellent elastic properties and chemical stability,binary metal or light element borides,carbides and nitrides have been extensively applied as hard and low-compressible materials.Researchers are searching for harder materials all the time.Recently,the successful fabrication of nano-twinned cubic BN(Tian et al.Nature 493:385–388,2013)and diamond(Huang et al.Nature 510:250–253,2014)exhibiting superior properties than their twin-free counterparts allows an efficient way to be harder.From this point of view,the borides,carbides and nitrides may be stronger by introducing twins,whose formation tendency can be measured using stacking fault energies(SFEs).The lower the SFEs,the easier the formation of twins.In the present study,by means of first-principles calculations,we first calculated the fundamental elastic constants of forty-two borides,seventeen carbides and thirty-one nitrides,and their moduli,elastic anisotropy factors and bonding characters were accordingly derived.Then,the SFEs of the{111}<112>glide system of twenty-seven compounds with the space group F43 m or Fm3m were calculated.Based on the obtained elastic properties and SFEs,we find that(1)light element compounds usually exhibit superior elastic properties over the metal borides,carbides or nitrides;(2)the 5 d transitionmetal compounds(ReB2,WB,OsC,RuC,WC,OsN2,TaN and WN)possess comparable bulk modulus(B)with that of cBN(B=363 GPa);(3)twins may form in ZrB,HfN,PtN,VN and ZrN,since their SFEs are lower or slightly higher than that of diamond(SFE=277 mJ/m^2).Our work can be used as a valuable database to compare these compounds. 展开更多
关键词 INORGANIC compounds Elastic properties STACKING FAULT ENERGIES FIRST-PRINCIPLES calculations
原文传递
Quantitative Electron Tomography for Accurate Measurement of Precipitates Microstructure Parameters in Al–Cu–Li Alloys
18
作者 Shi-Yong Li Ruo-Han Shen +2 位作者 Yu-Tao He Cui-Lan Wu jiang-hua chen 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2022年第11期1882-1894,共13页
Mechanical theories show that properties of alloys are strongly dependent on the morphological parameters oftheir strengthening precipitates.However,accurate measurement of precipitates microstructure parameters is st... Mechanical theories show that properties of alloys are strongly dependent on the morphological parameters oftheir strengthening precipitates.However,accurate measurement of precipitates microstructure parameters is still a challenging task.In this article,we develop a quantitative electron tomography method by combining computer vision technology to accurately characterize the three-dimensional microstructure parameters,such as volume fractions,sizes and distributions,of the T_(1) and δ’/θ’/δ’ precipitates in Al-Cu-Li(-Mg) alloys.Since they have extremely large aspect-ratios in shape and large numbers in density upon formation in the Al matrix,these thin plate-like precipitates are difficult to be characterized quantitatively without the assistance of computer vision technology.It is shown that the property difference between two peak-aged states of the alloy can be well explained with the quantitative precipitate parameters correctly measured.Using these correct precipitate data,we also tested the validity of current mechanical models for projecting the contribution of precipitates to the strengths of the alloy,demonstrating that quantitative relations between strength and micro structure parameters still need to be refined. 展开更多
关键词 Al–Cu–Li–Mg alloy T1 precipitate δ′/θ′/δ′composite precipitate Morphological parameters Electron tomography Computer vision
原文传递
Application of the Peierls–Nabarro Model to Symmetric Tilt Low-Angle Grain Boundary with Full Dislocation in Pure Magnesium
19
作者 Tou-Wen Fan Xiu-Bo Yang +4 位作者 jiang-hua chen Ling-Hong Liu Ding-Wan Yuan Yong Zhang Cui-Lan Wu 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2016年第11期1053-1063,共11页
Three types of symmetric (1120) tilt low-angle grain boundaries (LAGBs) with array of basal, prismatic, and pyramidal edge full 〈a〉 dislocations in pure Mg have been studied by using the improved Peierls-Nabarro... Three types of symmetric (1120) tilt low-angle grain boundaries (LAGBs) with array of basal, prismatic, and pyramidal edge full 〈a〉 dislocations in pure Mg have been studied by using the improved Peierls-Nabarro model in combination with the generalized stacking fault energy curve. The results show that with decreasing distance between the dislocations in all the three types of tilt LAGBs, the stress and strain fields are gradually suppressed. The reduction extent of the stress and strain fields decreases from the prismatic to basal to pyramidal dislocations. The variation of dislocation line energy (DLE) for all tilt LAGBs is divided into three stages: DLE changes slightly and linearly when the distance is larger than 300 A, - 10%; DLE declines exponentially and quickly when the distance goes from 300 to 100 A, ,- 70%; and finally, the descent speed lowers when the distance is smaller than 100 A and the dislocation core energy is nearly half of the DLE. The grain boundary energy (GBE) decreases when the tilt angle of LAGB increases from1 ° to 2° for all cases. The tilt LAGB consists of pyramidal dislocations always has the largest GBE, while that with array of prismatic dislo- cations has the smallest one in the whole range. The Peierls stress of dislocation in tilt LAGB is nearly unchanged, the same as that of single dislocation. This work is useful for further study of dissociated dislocation, solute segregation, precipitate nucleation in tilt LAGB and its interaction with single dislocations. 展开更多
关键词 Tilt grain boundary Generalized stacking fault energy Magnesium alloy DISLOCATION Peierlsstress
原文传递
PI-3 kinase pathway can mediate the effect of TGF-β1 in inducing the expression of SHARP-2 in LLC-PK1 cells
20
作者 Zhang-fei SHOU Qin ZHOU +3 位作者 Jie-ru CAI jiang-hua chen Kazuya YAMADA Kaoru MIYAMOTO 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2009年第9期702-706,共5页
We aim to investigate the effect of transforming growth factor (TGF)-β1 on the expression of enhancer of split- and hairy-related protein-2 (SHARP-2) messenger RNA (mRNA) and its signaling pathway. In this stud... We aim to investigate the effect of transforming growth factor (TGF)-β1 on the expression of enhancer of split- and hairy-related protein-2 (SHARP-2) messenger RNA (mRNA) and its signaling pathway. In this study, several cell lines including LLC-PK1 (a porcine kidney tubular epithelial cell line), MDCK (Madin-Darby canine kidney) and CTLL-2 (cytotoxic T-lymphocyte line) were treated with recombinant human TGF-131, and a series of experiments were carried out, involving Northern blot analysis of total RNA from these cells. Further, several specific chemical inhibitors were applied before TGF-β1 treatment to probe the signaling pathway. The results showed that TGF-β1 can significadtly up-regulate SHARP-2 mRNA expression in the LLC-PK1 cell line. The peak level of induction was found 2 h after TGF-β1 stimulation. While one phospho- inositide 3-kinases (PI-3) kinase inhibitor, LY294002, completely blocked the effect of TGF-131 on SHARP-2 mRNA expression in LLC-PK1 cells at a low concentration, other inhibitors, including PD98059, staurosporine, AG490, wortmannin, okadaic acid and rapamycin, had no effect. The effect of LY294002 was dose-dependent. We conclude that, in LLC-PK1 cells at least, TGF-β1 can effectively induce the SHARP-2 mRNA expression and that the PI-3 kinase pathway can mediate this effect. 展开更多
关键词 Transforming growth factor (TGF)-β1 Split- and hairy-related protein-2 (SHARP-2) Phosphoinositide 3-kinases (PI-3)kinase pathway LY294002
原文传递
上一页 1 2 下一页 到第
使用帮助 返回顶部