The aquaporin-4(AQP4)is a highly selective membrane protein.It is important for the body to maintain the water balance between internal and external environment of cells,the studies have found that the abnormal expres...The aquaporin-4(AQP4)is a highly selective membrane protein.It is important for the body to maintain the water balance between internal and external environment of cells,the studies have found that the abnormal expression of AQP4 is related to the occurrence of many diseases.The cerebral edema is the most common and serious complication of brain trauma,and its pathogenesis is closely related to AQP4.The development of multimodal magnetic resonance imaging(M-MRI)could been provided imaging basis for accurate diagnosis of traumatic brain edema.In recent years,the correlation between AQP4 and M-MRI has become a hotspot of research.This paper reviews the research progress on the correlation between AQP4 expression in traumatic cerebral edema and M-MRI.展开更多
Objective:To investigate the correlation of cardiac magnetic resonance imaging(MRI)in the assessment of myocardial activity in patients with myocardial infarction and the outcome of cardiac function after PCI.Methods:...Objective:To investigate the correlation of cardiac magnetic resonance imaging(MRI)in the assessment of myocardial activity in patients with myocardial infarction and the outcome of cardiac function after PCI.Methods:30 patients with myocardial infarction(MI)who had complete clinical and imaging data from July 2016 to December 2018 after PCI were analyzed retrospectively.MR and echocardiogram were performed before and 6 months after PCI,and the parameters related to left ventricular function were measured by post-processing software of MRI workstation.The left ventricular transmural degree of CMR late gadolinium enhancement was compared with the left ventricular wall motion degree of 6-month echocardiography as a standard to judge the viable myocardium.Result:There were 193 left ventricular segmental abnormalities in 30 cases,including 121 viable myocardium and 72 non viable myocardium in CMR-LGE before operation.Six months after PCI,echocardiography showed that 125 of 193 abnormal segments of left ventricle detected by CMR-LGE before PCI were viable myocardium and 68 were non viable myocaridium.The sensitivity and specificity of CMR-LGE to determinate of viable myocardium were 92.0%and 91.1%respectively.The larger the non-viable myocardial area of the left ventricular wall,the worse the recovery of wall motion ability,and there was a negative correlation between them(r=0.416,P<0.05).The first-pass perfusion time in CMR-LEG region was significantly longer than that in normal myocardial region(4.85(+)1.51)s and(3.79(+)1.73)s,respectively.The difference was statistically significant(t=5.191,P<0.05).Conclusion:MRI can evaluate the myocardial activity of myocardial infarction,reflect the range of viable myocardium,and provide imaging basis for clinical treatment and prognosis.展开更多
Objective:To explore the value of four-dimensional spatiotemporal image correlation and tomographic ultrasound imaging in screening fetal congenital heart disease.Methods: A total of 671 pregnant women at 22-24 gestat...Objective:To explore the value of four-dimensional spatiotemporal image correlation and tomographic ultrasound imaging in screening fetal congenital heart disease.Methods: A total of 671 pregnant women at 22-24 gestational weeks from January 2018 to December 2018 were examined by two-dimensional ultrasound and four-dimensional spatiotemporal image correlation and tomographic ultrasound imaging to observe the development of fetal cardiovascular structure and to compare the two methods in terms of diagnostic accuracy, examination time, image quality and new physician training cycle.Results: Cardiac malformations were found in 12 of the 671 fetuses, among which 11 cases were detected by four-dimensional spatiotemporal image correlation and tomographic ultrasound imaging and 1 case was missed. Postnatal echocardiographic reexamination and autopsy confirmed 12 cases of children with cardiac malformation, including 1 case of atrial septal defect (missed diagnosis by four-dimensional spatiotemporal image correlation and tomographic ultrasound imaging), 4 cases of tetralogy of Fallot's disease, 1 case of right ventricular double outlet, 3 cases of left ventricular dysplasia, 2 cases of complete transposition of the great artery and 1 case of tricuspid valve descending malformation. There was no statistically significant difference between four-dimensional spatiotemporal image correlation and tomographic ultrasound imaging and conventional two-dimensional color echocardiography or/and autopsy (P>0.05). In terms of examination time and new physician training, the four-dimensional spatiotemporal image correlation and tomographic ultrasound imaging technique was superior to conventional color ultrasound screening. No statistically significant difference in image quality.Conclusions:The four-dimensional spatiotemporal image correlation and tomographic ultrasound imaging can rapidly and accurately display fetal heart development, and can be used as the main screening method for fetal congenital heart disease in clinical practice.展开更多
基金General program of Chongqing Natural Science Foundation(No.cstc2019jcyj-msxmx0353)Science and technology program of Banan District of Chongqing(No.018-25)
文摘The aquaporin-4(AQP4)is a highly selective membrane protein.It is important for the body to maintain the water balance between internal and external environment of cells,the studies have found that the abnormal expression of AQP4 is related to the occurrence of many diseases.The cerebral edema is the most common and serious complication of brain trauma,and its pathogenesis is closely related to AQP4.The development of multimodal magnetic resonance imaging(M-MRI)could been provided imaging basis for accurate diagnosis of traumatic brain edema.In recent years,the correlation between AQP4 and M-MRI has become a hotspot of research.This paper reviews the research progress on the correlation between AQP4 expression in traumatic cerebral edema and M-MRI.
基金Hainan key research and development plan science and technology project funding(No.ZDYF2018166)Hainan key science and technology project Sanya supporting fund project support(No.2019PT107)Sanya medical science and technology innovation project(No.2019YW01)
文摘Objective:To investigate the correlation of cardiac magnetic resonance imaging(MRI)in the assessment of myocardial activity in patients with myocardial infarction and the outcome of cardiac function after PCI.Methods:30 patients with myocardial infarction(MI)who had complete clinical and imaging data from July 2016 to December 2018 after PCI were analyzed retrospectively.MR and echocardiogram were performed before and 6 months after PCI,and the parameters related to left ventricular function were measured by post-processing software of MRI workstation.The left ventricular transmural degree of CMR late gadolinium enhancement was compared with the left ventricular wall motion degree of 6-month echocardiography as a standard to judge the viable myocardium.Result:There were 193 left ventricular segmental abnormalities in 30 cases,including 121 viable myocardium and 72 non viable myocardium in CMR-LGE before operation.Six months after PCI,echocardiography showed that 125 of 193 abnormal segments of left ventricle detected by CMR-LGE before PCI were viable myocardium and 68 were non viable myocaridium.The sensitivity and specificity of CMR-LGE to determinate of viable myocardium were 92.0%and 91.1%respectively.The larger the non-viable myocardial area of the left ventricular wall,the worse the recovery of wall motion ability,and there was a negative correlation between them(r=0.416,P<0.05).The first-pass perfusion time in CMR-LEG region was significantly longer than that in normal myocardial region(4.85(+)1.51)s and(3.79(+)1.73)s,respectively.The difference was statistically significant(t=5.191,P<0.05).Conclusion:MRI can evaluate the myocardial activity of myocardial infarction,reflect the range of viable myocardium,and provide imaging basis for clinical treatment and prognosis.
文摘Objective:To explore the value of four-dimensional spatiotemporal image correlation and tomographic ultrasound imaging in screening fetal congenital heart disease.Methods: A total of 671 pregnant women at 22-24 gestational weeks from January 2018 to December 2018 were examined by two-dimensional ultrasound and four-dimensional spatiotemporal image correlation and tomographic ultrasound imaging to observe the development of fetal cardiovascular structure and to compare the two methods in terms of diagnostic accuracy, examination time, image quality and new physician training cycle.Results: Cardiac malformations were found in 12 of the 671 fetuses, among which 11 cases were detected by four-dimensional spatiotemporal image correlation and tomographic ultrasound imaging and 1 case was missed. Postnatal echocardiographic reexamination and autopsy confirmed 12 cases of children with cardiac malformation, including 1 case of atrial septal defect (missed diagnosis by four-dimensional spatiotemporal image correlation and tomographic ultrasound imaging), 4 cases of tetralogy of Fallot's disease, 1 case of right ventricular double outlet, 3 cases of left ventricular dysplasia, 2 cases of complete transposition of the great artery and 1 case of tricuspid valve descending malformation. There was no statistically significant difference between four-dimensional spatiotemporal image correlation and tomographic ultrasound imaging and conventional two-dimensional color echocardiography or/and autopsy (P>0.05). In terms of examination time and new physician training, the four-dimensional spatiotemporal image correlation and tomographic ultrasound imaging technique was superior to conventional color ultrasound screening. No statistically significant difference in image quality.Conclusions:The four-dimensional spatiotemporal image correlation and tomographic ultrasound imaging can rapidly and accurately display fetal heart development, and can be used as the main screening method for fetal congenital heart disease in clinical practice.
