During radiotherapy to kill femoral hydatid tapeworms, the sciatic nerve surrounding the focus can be easily damaged by the treatment. Thus, it is very important to evaluate the effects of ra- diotherapy on the surrou...During radiotherapy to kill femoral hydatid tapeworms, the sciatic nerve surrounding the focus can be easily damaged by the treatment. Thus, it is very important to evaluate the effects of ra- diotherapy on the surrounding nervous tissue. In the present study, we used three-dimensional, conformal, intensity-modulated radiation therapy to treat bilateral femoral hydatid disease in Meriones meridiani. The focus of the hydatid disease on the left femur was subiected to radio- therapy （40 Gy） for 14 days, and the right femur received sham irradiation. Hematoxylin-eosin staining, electron microscopy, and terminal deoxynucleotidyl transferase-dUTP nick end labeling assays on the left femurs showed that the left sciatic nerve cell structure was normal, with no ob- vious apoptosis after radiation. Trypan blue staining demonstrated that the overall protoscolex structure in bone parasitized with Echinococcus granulosus disappeared in the left femur of the animals after treatment. The mortality of the protoscolex was higher in the left side than in the right side. The succinate dehydrogenase activity in the protoscolex in bone parasitized with Echi- nococcus granulosus was lower in the left femur than in the right femur. These results suggest that three-dimensional conformal intensity-modulated radiation therapy achieves good therapeutic effects on the secondary bone in hydatid disease in Meriones meridiani without damaging the morphology or function of the sciatic nerve.展开更多
A photoactive polyoxometalate-based metal-organic framework (POMOF),NiW-DPNDI,was synthesized by combination of Ni(Ⅱ) ions,[ZnW_(12)O_(40)]^(6–)anions,and N,N’-bis(4-pyridylmethyl)naphthalene diimide(DPNDI) molecul...A photoactive polyoxometalate-based metal-organic framework (POMOF),NiW-DPNDI,was synthesized by combination of Ni(Ⅱ) ions,[ZnW_(12)O_(40)]^(6–)anions,and N,N’-bis(4-pyridylmethyl)naphthalene diimide(DPNDI) molecules into one single framework.Ni W-DPNDI displays a three-dimensional structure by the strong anion···π interactions between the trapped[ZnW_(12)O_(40)]^(6–)anions and the electron-deficient naphthalenic ring centroids and theπ-πstacking interactions between DPNDI moieties.Ni W-DPNDI displayed a highly efficient hole-electron separation and ordered electron transfer under irradiation,thus ensuing its excellent photocatalysis in oxidation of styrene to produce benzaldehyde.In addition,it gave a high efficiency for styrene oxide under thermocatalytic conditions.Because the carbonic anhydrase (CA)-mimicking Ni sites and the negative electron-enriched[ZnW_(12)O_(40)]^(6–)anions are well aligned in the pores,it can promote the cycloaddition of CO_(2) with epoxides under mild conditions.展开更多
基金supported by the National Natural Science Foundation of China,No.81360276a grant from the Science and Technology Project of Xinjiang Uygur Autonomous Region in China,No.2013911129+2 种基金a grant from the Youth Science and Technology Innovation Talents Project of Xinjiang Uygur Autonomous Region-Young Doctor Talents Training Project,No.2013731013the Natural Science Foundation of Xinjiang Uygur Autonomous Region,No.2012211B34the China Postdoctoral Science Foundation,No.2014M552566XB
文摘During radiotherapy to kill femoral hydatid tapeworms, the sciatic nerve surrounding the focus can be easily damaged by the treatment. Thus, it is very important to evaluate the effects of ra- diotherapy on the surrounding nervous tissue. In the present study, we used three-dimensional, conformal, intensity-modulated radiation therapy to treat bilateral femoral hydatid disease in Meriones meridiani. The focus of the hydatid disease on the left femur was subiected to radio- therapy （40 Gy） for 14 days, and the right femur received sham irradiation. Hematoxylin-eosin staining, electron microscopy, and terminal deoxynucleotidyl transferase-dUTP nick end labeling assays on the left femurs showed that the left sciatic nerve cell structure was normal, with no ob- vious apoptosis after radiation. Trypan blue staining demonstrated that the overall protoscolex structure in bone parasitized with Echinococcus granulosus disappeared in the left femur of the animals after treatment. The mortality of the protoscolex was higher in the left side than in the right side. The succinate dehydrogenase activity in the protoscolex in bone parasitized with Echi- nococcus granulosus was lower in the left femur than in the right femur. These results suggest that three-dimensional conformal intensity-modulated radiation therapy achieves good therapeutic effects on the secondary bone in hydatid disease in Meriones meridiani without damaging the morphology or function of the sciatic nerve.
基金supported by the Natural Science Foundation of Henan (Nos. 202300410043 and 222102230091)the Key Scientific Research Project of Henan Higher Education Institutions (No. 20ZX006)the National Natural Science Foundation of China (No. 21601048)。
文摘A photoactive polyoxometalate-based metal-organic framework (POMOF),NiW-DPNDI,was synthesized by combination of Ni(Ⅱ) ions,[ZnW_(12)O_(40)]^(6–)anions,and N,N’-bis(4-pyridylmethyl)naphthalene diimide(DPNDI) molecules into one single framework.Ni W-DPNDI displays a three-dimensional structure by the strong anion···π interactions between the trapped[ZnW_(12)O_(40)]^(6–)anions and the electron-deficient naphthalenic ring centroids and theπ-πstacking interactions between DPNDI moieties.Ni W-DPNDI displayed a highly efficient hole-electron separation and ordered electron transfer under irradiation,thus ensuing its excellent photocatalysis in oxidation of styrene to produce benzaldehyde.In addition,it gave a high efficiency for styrene oxide under thermocatalytic conditions.Because the carbonic anhydrase (CA)-mimicking Ni sites and the negative electron-enriched[ZnW_(12)O_(40)]^(6–)anions are well aligned in the pores,it can promote the cycloaddition of CO_(2) with epoxides under mild conditions.
