目的:分析阿帕替尼治疗复发性和进展性韧带样纤维瘤(desmoid fibromatosis,DF)的疗效和安全性。方法:收集2017年10月至2020年9月就诊于四川大学华西医院的复发性或进展性韧带样纤维瘤患者37例,接受靶向药物阿帕替尼治疗,起始剂量250 mg...目的:分析阿帕替尼治疗复发性和进展性韧带样纤维瘤(desmoid fibromatosis,DF)的疗效和安全性。方法:收集2017年10月至2020年9月就诊于四川大学华西医院的复发性或进展性韧带样纤维瘤患者37例,接受靶向药物阿帕替尼治疗,起始剂量250 mg/d,根据药物不良反应调整剂量。结果:无完全缓解病例,17例(45.9%)为部分缓解,18例(48.6%)为疾病稳定,2例(5.4%)为疾病进展,客观有效率为45.9%,疾病控制率为94.6%。患者的关节活动度(rang of motion,ROM)、视觉模拟评分(visual analog scale,VAS)、上肢功能评定表(disabilities of the arm,shoulder and hand,DASH)评分、髋关节Harris评分及美国特种外科医院(HSS)评分均较治疗前有明显改善,且差异具有统计学意义(P<0.05)。常见的不良反应为手足综合征(37.8%)、胃肠反应(29.7%)和月经紊乱(21.6%)。结论:靶向药物阿帕替尼对复发性和进展性DF有一定的疗效,且不良反应可耐受,可作为复发性和进展性韧带样纤维瘤治疗的新途径。展开更多
In order to implement 3D scanning of those complicated parts such as blades in the aviation field,a non-contact optical measuring system is established in the paper,which integrates a laser displacement sensor,a probe...In order to implement 3D scanning of those complicated parts such as blades in the aviation field,a non-contact optical measuring system is established in the paper,which integrates a laser displacement sensor,a probe head,the frame of a coordinate measuring machine（CMM）,etc.As the output of the laser sensor directly obtained possesses the 1D length of the laser beam,it needs to determine the unit direction vector of the laser beam denoted as（l,m,n）by calibration so as to convert the 1D values into 3D coordinates of target points.Therefore,an extrinsic calibration method based on a standard sphere is proposed to accomplish this task in the paper.During the calibration procedure,the laser sensor moves along with the motion of the CMM and gathers the required data on the spherical surface.Then,both the output of the laser sensor and the grating readings of the CMM are substituted into the constraint equation of the spherical surface,in which an over-determined nonlinear equation group containing unknown parameters is established.For the purpose of solving the equation group,a method based on non-linear least squares optimization is put forward.Finally,the system after calibration is utilized to measure the diameter of a metallic sphere 10 times from different orientations to verify the calibration accuracy.In the experiment,the errors between the measured results and the true values are all smaller than 0.03 mm,which manifests the validity and practicality of the extrinsic calibration method presented in the paper.展开更多
The vicinal dithiol motif is widely present in proteins, and is critical for proteins’ structures and functions.In recent years, a variety of fluorescent probes with high specificity and outstanding optical propertie...The vicinal dithiol motif is widely present in proteins, and is critical for proteins’ structures and functions.In recent years, a variety of fluorescent probes with high specificity and outstanding optical properties for sensing protein vicinal dithiols have been developed. In this review, we summarized the fluorescent probes of protein vicinal dithiols in literature. These probes are classified into four types based on their acceptor sites, i.e., biarsenical probes, monoarsenical probes, dimaleimide probes and diacrylate probes.Through analyzing the properties of different probes, we expect that this review would help readers further understand the structural factors of these probes and provide the design strategy for novel fluorescent probes with improved properties.展开更多
文摘目的:分析阿帕替尼治疗复发性和进展性韧带样纤维瘤(desmoid fibromatosis,DF)的疗效和安全性。方法:收集2017年10月至2020年9月就诊于四川大学华西医院的复发性或进展性韧带样纤维瘤患者37例,接受靶向药物阿帕替尼治疗,起始剂量250 mg/d,根据药物不良反应调整剂量。结果:无完全缓解病例,17例(45.9%)为部分缓解,18例(48.6%)为疾病稳定,2例(5.4%)为疾病进展,客观有效率为45.9%,疾病控制率为94.6%。患者的关节活动度(rang of motion,ROM)、视觉模拟评分(visual analog scale,VAS)、上肢功能评定表(disabilities of the arm,shoulder and hand,DASH)评分、髋关节Harris评分及美国特种外科医院(HSS)评分均较治疗前有明显改善,且差异具有统计学意义(P<0.05)。常见的不良反应为手足综合征(37.8%)、胃肠反应(29.7%)和月经紊乱(21.6%)。结论:靶向药物阿帕替尼对复发性和进展性DF有一定的疗效,且不良反应可耐受,可作为复发性和进展性韧带样纤维瘤治疗的新途径。
基金supported by the National Science and Technology Major Project for ‘‘High-grade Numerical Control Machine Tools and Basic Manufacturing Equipment” of China (No. 2013ZX04001071)
文摘In order to implement 3D scanning of those complicated parts such as blades in the aviation field,a non-contact optical measuring system is established in the paper,which integrates a laser displacement sensor,a probe head,the frame of a coordinate measuring machine（CMM）,etc.As the output of the laser sensor directly obtained possesses the 1D length of the laser beam,it needs to determine the unit direction vector of the laser beam denoted as（l,m,n）by calibration so as to convert the 1D values into 3D coordinates of target points.Therefore,an extrinsic calibration method based on a standard sphere is proposed to accomplish this task in the paper.During the calibration procedure,the laser sensor moves along with the motion of the CMM and gathers the required data on the spherical surface.Then,both the output of the laser sensor and the grating readings of the CMM are substituted into the constraint equation of the spherical surface,in which an over-determined nonlinear equation group containing unknown parameters is established.For the purpose of solving the equation group,a method based on non-linear least squares optimization is put forward.Finally,the system after calibration is utilized to measure the diameter of a metallic sphere 10 times from different orientations to verify the calibration accuracy.In the experiment,the errors between the measured results and the true values are all smaller than 0.03 mm,which manifests the validity and practicality of the extrinsic calibration method presented in the paper.
基金financial supports from the National Natural Science Foundation of China (Nos. 21572093 & 21778028)the 111 Project
文摘The vicinal dithiol motif is widely present in proteins, and is critical for proteins’ structures and functions.In recent years, a variety of fluorescent probes with high specificity and outstanding optical properties for sensing protein vicinal dithiols have been developed. In this review, we summarized the fluorescent probes of protein vicinal dithiols in literature. These probes are classified into four types based on their acceptor sites, i.e., biarsenical probes, monoarsenical probes, dimaleimide probes and diacrylate probes.Through analyzing the properties of different probes, we expect that this review would help readers further understand the structural factors of these probes and provide the design strategy for novel fluorescent probes with improved properties.
