Precision therapy has become the preferred choice attributed to the optimal drug concentration in target sites,increased therapeutic efficacy,and reduced adverse effects.Over the past few years,sprayable or injectable...Precision therapy has become the preferred choice attributed to the optimal drug concentration in target sites,increased therapeutic efficacy,and reduced adverse effects.Over the past few years,sprayable or injectable thermosensitive hydrogels have exhibited high therapeutic potential.These can be applied as cell-growing scaffolds or drug-releasing reservoirs by simply mixing in a free-flowing sol phase at room temperature.Inspired by their unique properties,thermosensitive hydrogels have been widely applied as drug delivery and treatment platforms for precision medicine.In this review,the state-of-theart developments in thermosensitive hydrogels for precision therapy are investigated,which covers from the thermo-gelling mechanisms and main components to biomedical applications,including wound healing,anti-tumor activity,osteogenesis,and periodontal,sinonasal and ophthalmic diseases.The most promising applications and trends of thermosensitive hydrogels for precision therapy are also discussed in light of their unique features.展开更多
Nucleate pool boiling process is widely used in heat exchangers because of its excellent heat transfer performance.With the gradual increase of applications,more and more equipments work in a non-static state,but ther...Nucleate pool boiling process is widely used in heat exchangers because of its excellent heat transfer performance.With the gradual increase of applications,more and more equipments work in a non-static state,but there is little research under rolling conditions.Therefore,it is necessary to investigate the influence of rolling motion on the nucleate pool boiling process.In this study,a numerical investigation of the nucleate pool boiling process under static and rolling conditions is performed based on the volume-of-fluid(VOF)method.Physical fields and phase distribution under static state and rolling motion are compared to investigate the effect of rolling motion on the nucleate pool boiling process.The results show that rolling motion greatly influences the bubble behavior and void fraction owing to the differences between flow fields.The void fraction decreased by 11.84%,48.82%,and 56.87%as the maximum rolling angle increased from 15°to 45°,and by 11.84%,22.27%,and 21.81%as the rolling period increased from 1 s to 3 s.The void fraction decreased by 11.84%,48.82%,and 56.87%as the maximum rolling angle increased from 15°to 45°.The heat transfer coefficients of different cases are compared,and it is found that the effects of rolling motion on heat transfer coefficients can be ignored.展开更多
基金financially supported by the National Natural Science Foundation of China(Grants 52172276)fund from Anhui Provincial Institute of Translational Medicine(2021zhyx-B15)。
文摘Precision therapy has become the preferred choice attributed to the optimal drug concentration in target sites,increased therapeutic efficacy,and reduced adverse effects.Over the past few years,sprayable or injectable thermosensitive hydrogels have exhibited high therapeutic potential.These can be applied as cell-growing scaffolds or drug-releasing reservoirs by simply mixing in a free-flowing sol phase at room temperature.Inspired by their unique properties,thermosensitive hydrogels have been widely applied as drug delivery and treatment platforms for precision medicine.In this review,the state-of-theart developments in thermosensitive hydrogels for precision therapy are investigated,which covers from the thermo-gelling mechanisms and main components to biomedical applications,including wound healing,anti-tumor activity,osteogenesis,and periodontal,sinonasal and ophthalmic diseases.The most promising applications and trends of thermosensitive hydrogels for precision therapy are also discussed in light of their unique features.
文摘Nucleate pool boiling process is widely used in heat exchangers because of its excellent heat transfer performance.With the gradual increase of applications,more and more equipments work in a non-static state,but there is little research under rolling conditions.Therefore,it is necessary to investigate the influence of rolling motion on the nucleate pool boiling process.In this study,a numerical investigation of the nucleate pool boiling process under static and rolling conditions is performed based on the volume-of-fluid(VOF)method.Physical fields and phase distribution under static state and rolling motion are compared to investigate the effect of rolling motion on the nucleate pool boiling process.The results show that rolling motion greatly influences the bubble behavior and void fraction owing to the differences between flow fields.The void fraction decreased by 11.84%,48.82%,and 56.87%as the maximum rolling angle increased from 15°to 45°,and by 11.84%,22.27%,and 21.81%as the rolling period increased from 1 s to 3 s.The void fraction decreased by 11.84%,48.82%,and 56.87%as the maximum rolling angle increased from 15°to 45°.The heat transfer coefficients of different cases are compared,and it is found that the effects of rolling motion on heat transfer coefficients can be ignored.
