Aiming to increase the efficiency of gem design and manufacturing, a new method in computer-aided-design (CAD) of convex faceted gem cuts (CFGC) based on Half-edge data structure (HDS), including the algorithms for th...Aiming to increase the efficiency of gem design and manufacturing, a new method in computer-aided-design (CAD) of convex faceted gem cuts (CFGC) based on Half-edge data structure (HDS), including the algorithms for the implementation is presented in this work. By using object-oriented methods, geometrical elements of CFGC are classified and responding geometrical feature classes are established. Each class is implemented and embedded based on the gem process. Matrix arithmetic and analytical geometry are used to derive the affine transformation and the cutting algorithm. Based on the demand for a diversity of gem cuts, CAD functions both for free-style faceted cuts and parametric designs of typical cuts and visualization and human-computer interactions of the CAD system including two-dimensional and three-dimensional interactions have been realized which enhances the flexibility and universality of the CAD system. Furthermore, data in this CAD system can also be used directly by the gem CAM module, which will promote the gem CAD/CAM integration.展开更多
Our previous studies have documented the unique enrichment of activated CD4 T cells in the liver.Blocking de novo T cell activation did not interfere with their function in ischemia reperfusion injury(IRI).1 We also d...Our previous studies have documented the unique enrichment of activated CD4 T cells in the liver.Blocking de novo T cell activation did not interfere with their function in ischemia reperfusion injury(IRI).1 We also demonstrated that the CD154-CD40 pathway,but not IFN-γ,was critical for IRI in the liver.Interestingly,alloimmune-primed hosts had significantly more severe IRI in their own livers,which was mediated mainly by CD4 T cells.2 These data prompted us to propose that pre-existing activated CD4 T cells in a host participate in the liver innate immune response against IRI.However,whether these activated/memory T cells require Ag stimulation to function in liver IRI remains unclear.In this report,we addressed this question by utilizing OT II(RAG−/−)T cell receptor transgenic CD4 T cells in a murine liver IRI model.展开更多
基金Supported by the National Natural Science Foundation of China(21576240)Experimental Technology Research Program of China University of Geosciences(Key Program)(SJ-201422)
文摘Aiming to increase the efficiency of gem design and manufacturing, a new method in computer-aided-design (CAD) of convex faceted gem cuts (CFGC) based on Half-edge data structure (HDS), including the algorithms for the implementation is presented in this work. By using object-oriented methods, geometrical elements of CFGC are classified and responding geometrical feature classes are established. Each class is implemented and embedded based on the gem process. Matrix arithmetic and analytical geometry are used to derive the affine transformation and the cutting algorithm. Based on the demand for a diversity of gem cuts, CAD functions both for free-style faceted cuts and parametric designs of typical cuts and visualization and human-computer interactions of the CAD system including two-dimensional and three-dimensional interactions have been realized which enhances the flexibility and universality of the CAD system. Furthermore, data in this CAD system can also be used directly by the gem CAM module, which will promote the gem CAD/CAM integration.
基金the Foundation of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials,Six talent peaks project in Jiangsu Province(WSW-019)the Foundation of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials,Six talent peaks project in Jiangsu Province(WSW-019).
文摘Our previous studies have documented the unique enrichment of activated CD4 T cells in the liver.Blocking de novo T cell activation did not interfere with their function in ischemia reperfusion injury(IRI).1 We also demonstrated that the CD154-CD40 pathway,but not IFN-γ,was critical for IRI in the liver.Interestingly,alloimmune-primed hosts had significantly more severe IRI in their own livers,which was mediated mainly by CD4 T cells.2 These data prompted us to propose that pre-existing activated CD4 T cells in a host participate in the liver innate immune response against IRI.However,whether these activated/memory T cells require Ag stimulation to function in liver IRI remains unclear.In this report,we addressed this question by utilizing OT II(RAG−/−)T cell receptor transgenic CD4 T cells in a murine liver IRI model.
