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Commentary: PROTACs make undruggable targets druggable: Challenge and opportunity 被引量:6
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作者 Bin Lu jianpin ye 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2021年第10期3335-3336,共2页
Proteostasis(protein homeostasis) ensures precise adjustment of cellular demand to proteins in the stress conditions, which is essential in the maintenance of health environment inside cells and is indispensable for t... Proteostasis(protein homeostasis) ensures precise adjustment of cellular demand to proteins in the stress conditions, which is essential in the maintenance of health environment inside cells and is indispensable for the life of organisms1. 展开更多
关键词 PROTEOSTASIS Protein degradation Drug discovery AUTOPHAGY E3 ligase UBIQUITINATION Drug resistance Off-target effect Tissue specificity
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