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A cohort study of adolescents with depression in China:tracking multidimensional outcomes and early biomarkers for intervention 被引量:3
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作者 Xiaofei Zhang Yanling Zhou +8 位作者 Jiaqi Sun Ruilan Yang jianshan chen Xiaofang cheng Zezhi Li Xinlei chen Chanjuan Yang Xinhong Zhu Liping Cao 《General Psychiatry》 CAS CSCD 2022年第4期257-265,共9页
Background Depression in adolescents is recognised as a global public health concern,but little is known about the trajectory of its clinical symptoms and pathogenesis.Understanding the nature of adolescents with depr... Background Depression in adolescents is recognised as a global public health concern,but little is known about the trajectory of its clinical symptoms and pathogenesis.Understanding the nature of adolescents with depression and identifying earlybiomarkers can facilitatepersonalised intervention andreducediseaseburden.Aims To track multidimensional outcomes of adolescents with depression and develop objective biomarkers for diagnosis,as well as response to treatment,prognosis and guidance for early identification and intervention.Methods This is a multidimensional cohort study on the Symptomatic trajectory and Biomarkers of Early Adolescent Depression(sBEAD).We planned to recruit more than 1000 adolescents with depression and 300 healthy controls within 5 years.Multidimensional clinical presentations and objective indicators are collected at baseline,weeks 4,8,12 and 24,and years 1,2,3,4 and 5.Conclusions To the best of our knowledge,this is the first longitudinal cohort study that examines multidimensional clinical manifestations and multilevel objective markers in Chinese adolescents with depression.This study aims at providing early individualised interventions for young,depressed patients to reduce the burden of disease. 展开更多
关键词 ADOLESCENT diagnosis INTERVENTION
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