Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-c...Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS.展开更多
It is a challenging issue to detect bearing fault under nonstationary conditions and gear noise interferences. Meanwhile, the application of the traditional methods is limited by their deficiencies in the aspect of co...It is a challenging issue to detect bearing fault under nonstationary conditions and gear noise interferences. Meanwhile, the application of the traditional methods is limited by their deficiencies in the aspect of computational accuracy and e ciency, or dependence on the tachometer. Hence, a new fault diagnosis strategy is proposed to remove gear interferences and spectrum smearing phenomenon without the tachometer and angular resampling technique. In this method, the instantaneous dominant meshing multiple(IDMM) is firstly extracted from the time-frequency representation(TFR) of the raw signal, which can be used to calculate the phase functions(PF) and the frequency points(FP). Next, the resonance frequency band excited by the faulty bearing is obtained by the band-pass filter. Furthermore, based on the PFs, the generalized demodulation transform(GDT) is applied to the envelope of the filtered signal. Finally, the target bearing is diagnosed by matching the peaks in the spectra of demodulated signals with the theoretical FPs. The analysis results of simulated and experimental signal demonstrate that the proposed method is an e ective and reliable tool for bearing fault diagnosis without the tachometer and the angular resampling.展开更多
This study sought to analyze the clinical features and prognosis of multiple myeloma with isolated extramedullary relapse and with the absence of systemic progression.The clinical features and outcome were retrospecti...This study sought to analyze the clinical features and prognosis of multiple myeloma with isolated extramedullary relapse and with the absence of systemic progression.The clinical features and outcome were retrospectively analyzed in six multiple myeloma patients.These patients had secretory multiple myeloma at diagnosis.When relapsed,the dissociation between medullary and extramedullary response was detected.The serum or urine monoclonal component was extremely low or absent.The plasma cells in bone marrow were 〈5%.All patients received new targeted therapies（thalidomide or bortezomib） before extramedullary relapse.It is difficult to achieve second remission for them.Even in those showing response,the duration of response was extremely short.The median of overall survival from diagnosis and from extramedullary relapse was 19 months and 6 months,respectively.The overall survival was significantly shorter compared to the patients without extramedullary involvement（84 months,P= 0.001）.These patients exhibited a special and rare relapse pattern.Patients with this relapse pattern were resistant to current therapies,including novel targeted agents and associated with poor prognosis.展开更多
[Objectives] To determine the optimal preparation process of compound Ban Huang oral liquid. [Methods] Orthogonal test and other methods were used to optimize the preparation conditions of compound Ban Huang oral liqu...[Objectives] To determine the optimal preparation process of compound Ban Huang oral liquid. [Methods] Orthogonal test and other methods were used to optimize the preparation conditions of compound Ban Huang oral liquid. [Results] The optimal conditions determined were as follows: soaking for 12 h,decocting twice with 2 h per time,concentrating filtrate to 1. 18-1. 25 g/m L at 80 ℃,ethanol precipitating twice with ethanol contents of 600 and 750 ml/L,standing for 24 h. [Conclusions] The optimized preparation process is simple,feasible and stable,and can be used for preparing compound Ban Huang oral liquid.展开更多
With the development of the PK-PD model,its application in veterinary antimicrobials has also received great attention.This paper expounded the theory of PK-PD model,and made a brief analysis of the dosing regimens of...With the development of the PK-PD model,its application in veterinary antimicrobials has also received great attention.This paper expounded the theory of PK-PD model,and made a brief analysis of the dosing regimens of various antibiotics according to the parameters of antimicrobial drugs,in order to optimize the clinical drug delivery plan and promote the rational use of clinical antibiotics.展开更多
On the basis of consulting related information and data,costs for flue-cured tobacco production were surveyed and analyzed with Liuyang tobacco growing areas as an example.Results showed that there is rise and fall in...On the basis of consulting related information and data,costs for flue-cured tobacco production were surveyed and analyzed with Liuyang tobacco growing areas as an example.Results showed that there is rise and fall in fertilizer cost for flue-cured tobacco production;change in pesticide and agricultural plastic film is little;other costs for flue-cured tobacco production rise rapidly in recent years.Besides,there is certain reduction in labor units per mu for flue-cured tobacco production;labor price has an annual growth rate of 15%-25%.The proportion of labor cost to total cost for flue-cured tobacco production is increasing,thus rise of labor cost is the major factor promoting rise of costs for flue-cured tobacco production.Through adjustment of purchasing price and various subsidies,the change of per mu yield is a decisive factor influencing benefits of flue-cured tobacco production.展开更多
OBJECTIVE Though doxorubicin is highly active in the treatment of multiple myeloma, its toxicity profile limits its therapeutic index. We performed this study to evaluate the efficacy and liposomal doxorubicin （PLD, ...OBJECTIVE Though doxorubicin is highly active in the treatment of multiple myeloma, its toxicity profile limits its therapeutic index. We performed this study to evaluate the efficacy and liposomal doxorubicin （PLD, Ca of pegylated , vincristine, and reduced-dose dexamethasone combination therapy in newly diagnosed multiple myeloma （MM） patients in a Chinese population. METHODS This was an open-label, single-arm study in which newly diagnosed patients with MM received PLD 40 mg/m2 intravenously on Day 1, vincristine 1.4 mg/m2 intravenously （maximum 2 rag） on Day 1, and 40 mg of dexamethasone （intravenously or orally） from Day 1 to Day 4. Treatment was repeated every 28 days for at least 4 cycles. RESULTS In the intent-to-treat （ITT） analysis, the overall response rate was 68.29%, and the complete remission rate was 10.98%. The incidence of all adverse events was 46.34%. The most common non-hematologic toxicities were palmar-plantar erythrodysesthesia （13.4%） and stomatitis （6.1%）. CONCLUSION PLD, vincristine, and a reduceddose dexamethasone combination （DVd） is an effective and safe regimen in newly diagnosed MM patients in a Chinese population.展开更多
Background:Although the treatment of peripheral T-cell lymphoma(PTCL)has undergone advancements during the past several years,the response rate and long-term effects with respect to patients with PTCL remain unsatisfa...Background:Although the treatment of peripheral T-cell lymphoma(PTCL)has undergone advancements during the past several years,the response rate and long-term effects with respect to patients with PTCL remain unsatisfactory—particularly for relapsed or refractory(R/R)patients.This phase II trial was designed to explore the efficacy and safety of an all-oral regimen of chidamide plus prednisone,cyclophosphamide,and thalidomide(CPCT)for R/R PTCL patients who could not tolerate the standard chemotherapy for a variety of reasons.Methods:We conducted a multicenter phase II clinical trial in which we combined chidamide(30 mg twice weekly)with prednisone(20 mg daily after breakfast),cyclophosphamide(50 mg daily after lunch),and thalidomide(100 mg daily at bedtime)(the CPCT regimen)for a total of fewer than 12 cycles as an induction-combined treatment period,and then applied chidamide as single-drug maintenance.Forty-five patients were ultimately enrolled from August 2016 to April 2021 with respect to Chinese patients at nine centers.Our primary objective was to assess the overall response rate(ORR)after the treatment with CPCT.Results:Of the 45 enrolled patients,the optimal ORR and complete response(CR)/CR unconfirmed(CRu)were 71.1%(32/45)and 28.9%(13/45),respectively,and after a median follow-up period of 56 months,the median progression-free survival(PFS)and overall survival(OS)were 8.5 months and 17.2 months,respectively.The five-year PFS and OS rates were 21.2%(95%confidence interval[CI],7.9-34.5%)and 43.8%(95%CI,28.3-59.3%),respectively.The most common adverse event was neutropenia(20/45,44.4%),but we observed no treatment-related death.Conclusion:The all-oral CPCT regimen was an effective and safe regimen for R/R PTCL patients who could not tolerate standard chemotherapy for various reasons.Trial Registration:ClinicalTrials.gov,NCT02879526.展开更多
PR/SET domain 1(PRDM1)gene is located on chromosome 6q21,encoding the B lymphocyte-induced maturation protein 1(BLIMP1).1 It is reported that loss of PRDM1 function is exacerbated in activated B-cell-like(ABC)-diffuse...PR/SET domain 1(PRDM1)gene is located on chromosome 6q21,encoding the B lymphocyte-induced maturation protein 1(BLIMP1).1 It is reported that loss of PRDM1 function is exacerbated in activated B-cell-like(ABC)-diffuse large B cell lymphoma(DLBCL)and associated with inferior survival.However,it remains unclear what leads to PRDM1 inactivation and the drug resistance mechanism caused by abnormal inactivation of PRDM1.We investigated the contribution of PRDM1 gene as a prognosis and potential therapeutic target for ABC-DLBCL patients and further clarified the possible mechanism of PRDM1 abnormal inactivation.We first proposed that TP53 could regulate PRDM1 by histone ubiquitination modification at the post-transcriptional level.展开更多
Ionospheric TEC （total electron content） time series are derived from GPS measurements at 13 stations around the epicenter of the 2008 Wenchuan earthquake. Defining anomaly bounds for a sliding window by quartile an...Ionospheric TEC （total electron content） time series are derived from GPS measurements at 13 stations around the epicenter of the 2008 Wenchuan earthquake. Defining anomaly bounds for a sliding window by quartile and 2-standard deviation of TEC values, this paper analyzed the characteristics of ionospheric changes before and after the destructive event. The Neyman-Pearson signal detection method is employed to compute the probabilities of TEC abnormalities. Result shows that one week before the Wenchuan earthquake, ionospheric TEC over the epicenter and its vicinities displays obvious abnormal disturbances, most of which are positive anomalies. The largest TEC abnormal changes appeared on May 9, three days prior to the seismic event. Signal detection shows that the largest possibility ofTEC abnormity on May 9 is 50.74%, indicating that ionospheric abnormities three days before the main shock are likely related to the preparation process of the Ms8.0 Wenchuan earthquake.展开更多
We retrospectively investigated the prognostic factors of acute myeloid leukemia（AML） in 152 Chinese patients with de novo AML who were older than 60 years of age and who received treatment at our hospital.Log-rank ...We retrospectively investigated the prognostic factors of acute myeloid leukemia（AML） in 152 Chinese patients with de novo AML who were older than 60 years of age and who received treatment at our hospital.Log-rank test showed that 6 parameters including older age,higher white blood cell（WBC） counts,lactate dehydrogenase（LDH）and bone marrow（BM） blasts at diagnosis,unfavorable risk cytogenetics,and non-mutated CEBPα were significant adverse prognostic factors of overall survival（OS） for elderly AML patients（P = 0.0013,0.0358,0.0132,0.0242,0.0236 and 0.0130,respectively）.Moreover,older age and higher LDH were significant adverse predictors for relapse-free survival（RFS）（P = 0.0447 and 0.0470,respectively）.Univariate analysis revealed similar results for OS to those of the log-rank test and only higher LDH at diagnosis was a significant adverse predictor for RFS（P = 0.028,HR：1.979,95%CI：1.075-3.644）.In multivariate analysis,we identified 2 trends towards independent prognostic factors for OS,including BM blasts at diagnosis（P = 0.057,HR：1.676,95%CI：0.984-2.854）and mutation status of CEBPα（P = 0.064,HR：4.173,95%CI：0.918-18.966）.Our data indicated that older age,gender and a previous history of hematologic diseases resulted in lower complete remission rate（P = 0.012,0.051 and 0.086,respectively）.We further developed an easy scoring system for predicting prognosis and response to induction therapy in older AML patients.Patients who had lower scores showed significantly longer OS and RFS（P = 0.0006 and 0.1001,respectively） and higher CR rate（P = 0.014）.Our research is limited by its retrospective nature and the results from our study need to be further validated by prospective randomized clinical trials.展开更多
The growth laws of leaves of flue-cured tobacco in different positions in various periods were summarized. The results showed that the growth speed of new leaves of flue-cured tobacco increased constantly until their ...The growth laws of leaves of flue-cured tobacco in different positions in various periods were summarized. The results showed that the growth speed of new leaves of flue-cured tobacco increased constantly until their growth was the fastest, and then it reduced irreversibly. The length and width of leaves in each position increased fastest when they grew depending on photosynthates instead of or- ganic compounds from functional leaves. Therefore, it is concluded that the increases of leaf length, width and area, and dry matter, and the peak of photosynthetic rate appear successively during the process of leaves of flue-cured tobacco, and the leaf area correction coefficient of leaves of flue-cured tobacco is related to the shape of leaves, which are affected by leaf position and the variety of flue-cured tobacco. The study can provide scientific reference for further research on the growth laws of leaves of flue-cured tobacco.展开更多
To the Editor:Non-Hodgkin lymphoma(NHL)is a common type of hematological malignancy.Although the development of targeted therapies has improved the survival of patients with aggressive NHL,autologous hematopoietic ste...To the Editor:Non-Hodgkin lymphoma(NHL)is a common type of hematological malignancy.Although the development of targeted therapies has improved the survival of patients with aggressive NHL,autologous hematopoietic stem cell transplantation(HSCT)remains indispensable.There is no standard conditioning regimen for autologous stem cell transplantation(ASCT).展开更多
Phase folding algorithms are conventionally used in periodicity analyses using X-ray astronomy pulsar. These allow for accurate identification of the cycle and phase characteristics of the physical parameters of the p...Phase folding algorithms are conventionally used in periodicity analyses using X-ray astronomy pulsar. These allow for accurate identification of the cycle and phase characteristics of the physical parameters of the periodic variation. Although periodic variations in earth- quake activity have long been studied, this paper is the first to apply the phase folding algorithm to the analysis of shallow （〈70 km） seismic data for the period 1973-2010. The goal is to study the phase distribution characteristics of earthquake frequencies and we see a connection between earthquake occurrence and solar and lunar cycles. First, the rotation of the Sun may play a significant role in impacting on the occurrence time of earthquakes with magnitudes of less than 6.0. This may be especially pertinent for earth- quakes with magnitudes between 5.0 and 6.0, when the modulation ratio reaches 12 %. The Moon＇s gravity, which is generally thought to have the greatest influence on the global environment, may actually play less of a role on earthquake timing than the rotation of the Sun. Second, when we consider the world to be divided into 72 local regions based on latitude and longitude, we can see that there are more than a dozen regions with significant non- uniform distributions of earthquake occurrence time. In these regions, the ratio of χ2 to the number of degrees of freedom far exceeds five. As a result, we posit that some factors associated with the Sun-Earth-Moon relationship may trigger earthquake activity under certain temporal and spatial conditions.展开更多
Objective：To investigate the association between the X-ray repair cross complementing（XRCC） group 5, XRCC6 and XRCC7 polymorphisms and risk of acute myeloid leukemia（AML）. Methods：This hospital-based case-contro...Objective：To investigate the association between the X-ray repair cross complementing（XRCC） group 5, XRCC6 and XRCC7 polymorphisms and risk of acute myeloid leukemia（AML）. Methods：This hospital-based case-control study included 120 AML patients and 210 cancer-free controls in a Chinese population. Three polymorphisms of XRCC5, XRCC6 and XRCC7 were genotyped using the polymerase chain reaction（PCR） or polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） method. Results： We found that there was a significant decrease in risk of AML associated with the XRCC6 -61 CG/GG genotype（adjusted odd ratio （OR） = 0.55; 95% confident interval（CI） = 0.34-0.89） compared with the -61CC genotype. For the novel tandem repeat polymorphism （VNTR） in the XRCC5 promoter, we found when the XRCC5 six genotypes were dichotomized（i.e., 2R/2R, 2R/1R versus 2R/0R, 1R/1R, 1R/0R and 0R/0R）, the latter group was associated with increased risk of AML（adjusted OR = 1.67; 95% CI = 1.00-2.79） compared to 2R/ 2R＋2R/1R genotype. However, the XRCC7 6721G〉T polymorphism had no effect on risk of AML. Conclusion：The XRCC6 -61C 〉 G and XRCC5 2R/1R/0R polymorphisms, but not XRCC7 6721G 〉 T polymorphism, could play an important role in the development of AML. Larger scale studies with more detailed data on environment exposure are needed to verify these findings.展开更多
Based on the investigation of the amount of labor used in each production link of flue-cured tobacco planting in Liuyang since 1989,and through the analysis of the changes of labor-related factors,it is concluded that...Based on the investigation of the amount of labor used in each production link of flue-cured tobacco planting in Liuyang since 1989,and through the analysis of the changes of labor-related factors,it is concluded that the amount of labor used in tobacco planting in Liuyang experienced a significant increase and relatively stable stage in the early 1990s,and it has been declining continuously since the beginning of the 21st century;the change of flue-cured tobacco planting technology mode,as well as mechanized,large-scale and specialized production are the main factors that affect the change of the amount of labor used in flue-cured tobacco planting in Liuyang.Based on the method of changing the technical model to reduce amount of labor used,the types of labor used for planting of flue-cured tobacco can be divided into the following types:reducing the amount of labor by technical methods;reducing the amount of labor by making use of weather;reducing the amount of labor by using drugs;reducing the amount of labor used at the cost of reducing the technical implementation standards of a certain production link.The change of labor used in flue-cured tobacco planting is not only related to the cost and price factors,but also related to the profound social and economic background.In the future,reducing labor and cost is the trend of flue-cured tobacco production,and mechanization,large-scale and specialized production are the main development direction of flue-cured tobacco production,but under the condition that flue-cured tobacco production is still dominated by manual operation,maintaining a certain amount of labor is still the basis for maintaining high quality of flue-cured tobacco planting at present.展开更多
This was a rare case, in which clinical manifestation was a thymus area tumor accompanied by proteinuria, kidney dysfunction and kidney enlargement. Tumor biopsy and bone marrow examination failed to clarify its diagn...This was a rare case, in which clinical manifestation was a thymus area tumor accompanied by proteinuria, kidney dysfunction and kidney enlargement. Tumor biopsy and bone marrow examination failed to clarify its diagnosis. Renal biopsy revealed diffuse infiltration by atypical lymphoid cells in renal interstitium. Immunoperoxidase studies demonstrated this case was non-Hodgkin ＇ s lymphoma （NHL） of the B cell type through the renal biopsy.展开更多
On the basis of full investigation and repeated trials,nutritional soil composed of cake fertilizer,mushroom residue,cow dung and calcium magnesium phosphate fertilizer was determined as an alternative for traditional...On the basis of full investigation and repeated trials,nutritional soil composed of cake fertilizer,mushroom residue,cow dung and calcium magnesium phosphate fertilizer was determined as an alternative for traditional flue-cured tobacco fired ash soil.In accordance with the feed grinding,mixing and processing integrated principle,processing machine for flue-cured tobacco nutritional soil was developed.The clogging problem of mixing box was solved by improving grinding and stirring method of mixing system.Mechanized and large-scale production and commercialized supply of flue-cured tobacco nutritional soil was piloted to simplify the production process and reduce the production cost of nutritional soil for flue-cured tobacco and meet the needs of green development of tobacco production,thereby creating good social and economic benefits.展开更多
For patients with chronic myeloid leukemia（CML） failing imatinib therapy,second-generation tyrosine kinase inhibitors（TKIs） are recommended.Here,we describe two patients with advanced CML who failed imatinib thera...For patients with chronic myeloid leukemia（CML） failing imatinib therapy,second-generation tyrosine kinase inhibitors（TKIs） are recommended.Here,we describe two patients with advanced CML who failed imatinib therapy and did not tolerate the recommended dose of dasatinib,but then achieved a major molecular response with the combination of imatinib and dasatinib with no significant extramedullar/ toxicity.Our observations suggest that combination of TKIs may provide an additive/synergistic antileukemic effect.展开更多
基金supported by funds from the National Natural Science Foundation of China(Grant Nos.81830002,81830004,82070168,and 32070951)the Translational Research grant of NCRCH(Grant No.2020ZKZC04)National Key R&D Program of China(Grant No.2021YFA1100800)。
文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS.
基金Supported by National Natural Science Foundation of China(Grant Nos.51335006 and 51605244)
文摘It is a challenging issue to detect bearing fault under nonstationary conditions and gear noise interferences. Meanwhile, the application of the traditional methods is limited by their deficiencies in the aspect of computational accuracy and e ciency, or dependence on the tachometer. Hence, a new fault diagnosis strategy is proposed to remove gear interferences and spectrum smearing phenomenon without the tachometer and angular resampling technique. In this method, the instantaneous dominant meshing multiple(IDMM) is firstly extracted from the time-frequency representation(TFR) of the raw signal, which can be used to calculate the phase functions(PF) and the frequency points(FP). Next, the resonance frequency band excited by the faulty bearing is obtained by the band-pass filter. Furthermore, based on the PFs, the generalized demodulation transform(GDT) is applied to the envelope of the filtered signal. Finally, the target bearing is diagnosed by matching the peaks in the spectra of demodulated signals with the theoretical FPs. The analysis results of simulated and experimental signal demonstrate that the proposed method is an e ective and reliable tool for bearing fault diagnosis without the tachometer and the angular resampling.
基金supported by Foundation of NationalNatural Science Foundation of China(81241074,81071946 and 81302040)Natural Science Foundation of Jiangsu Province(BK2012485)+4 种基金Jiangsu Province's Medical Elite Program(RC201148)a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutionsthe Program for Development of Innovative Research Team in the First Affiliated Hospital of NJMUClinical Research Program from Health Ministry of China(Key project 2010to 2012)Scientific Research Program for Public Interests from the Health Ministry of China(No.201202017)
文摘This study sought to analyze the clinical features and prognosis of multiple myeloma with isolated extramedullary relapse and with the absence of systemic progression.The clinical features and outcome were retrospectively analyzed in six multiple myeloma patients.These patients had secretory multiple myeloma at diagnosis.When relapsed,the dissociation between medullary and extramedullary response was detected.The serum or urine monoclonal component was extremely low or absent.The plasma cells in bone marrow were 〈5%.All patients received new targeted therapies（thalidomide or bortezomib） before extramedullary relapse.It is difficult to achieve second remission for them.Even in those showing response,the duration of response was extremely short.The median of overall survival from diagnosis and from extramedullary relapse was 19 months and 6 months,respectively.The overall survival was significantly shorter compared to the patients without extramedullary involvement（84 months,P= 0.001）.These patients exhibited a special and rare relapse pattern.Patients with this relapse pattern were resistant to current therapies,including novel targeted agents and associated with poor prognosis.
基金Supported by Earmarked Fund for China Agriculture Research System(CARS-38)Special Fund for Agro-scientific Research in the Public Interest of China(301303038-4)
文摘[Objectives] To determine the optimal preparation process of compound Ban Huang oral liquid. [Methods] Orthogonal test and other methods were used to optimize the preparation conditions of compound Ban Huang oral liquid. [Results] The optimal conditions determined were as follows: soaking for 12 h,decocting twice with 2 h per time,concentrating filtrate to 1. 18-1. 25 g/m L at 80 ℃,ethanol precipitating twice with ethanol contents of 600 and 750 ml/L,standing for 24 h. [Conclusions] The optimized preparation process is simple,feasible and stable,and can be used for preparing compound Ban Huang oral liquid.
基金Supported by China UK Technology and Innovation Project ICUK
文摘With the development of the PK-PD model,its application in veterinary antimicrobials has also received great attention.This paper expounded the theory of PK-PD model,and made a brief analysis of the dosing regimens of various antibiotics according to the parameters of antimicrobial drugs,in order to optimize the clinical drug delivery plan and promote the rational use of clinical antibiotics.
基金Supported by the GAP Project of Hunan Province"Study of Changsha Tobacco Monopoly Bureau on Sustainable Development Strategy for Tobacco Industry in Economically Developed Areas"
文摘On the basis of consulting related information and data,costs for flue-cured tobacco production were surveyed and analyzed with Liuyang tobacco growing areas as an example.Results showed that there is rise and fall in fertilizer cost for flue-cured tobacco production;change in pesticide and agricultural plastic film is little;other costs for flue-cured tobacco production rise rapidly in recent years.Besides,there is certain reduction in labor units per mu for flue-cured tobacco production;labor price has an annual growth rate of 15%-25%.The proportion of labor cost to total cost for flue-cured tobacco production is increasing,thus rise of labor cost is the major factor promoting rise of costs for flue-cured tobacco production.Through adjustment of purchasing price and various subsidies,the change of per mu yield is a decisive factor influencing benefits of flue-cured tobacco production.
文摘OBJECTIVE Though doxorubicin is highly active in the treatment of multiple myeloma, its toxicity profile limits its therapeutic index. We performed this study to evaluate the efficacy and liposomal doxorubicin （PLD, Ca of pegylated , vincristine, and reduced-dose dexamethasone combination therapy in newly diagnosed multiple myeloma （MM） patients in a Chinese population. METHODS This was an open-label, single-arm study in which newly diagnosed patients with MM received PLD 40 mg/m2 intravenously on Day 1, vincristine 1.4 mg/m2 intravenously （maximum 2 rag） on Day 1, and 40 mg of dexamethasone （intravenously or orally） from Day 1 to Day 4. Treatment was repeated every 28 days for at least 4 cycles. RESULTS In the intent-to-treat （ITT） analysis, the overall response rate was 68.29%, and the complete remission rate was 10.98%. The incidence of all adverse events was 46.34%. The most common non-hematologic toxicities were palmar-plantar erythrodysesthesia （13.4%） and stomatitis （6.1%）. CONCLUSION PLD, vincristine, and a reduceddose dexamethasone combination （DVd） is an effective and safe regimen in newly diagnosed MM patients in a Chinese population.
基金National Natural Science Foundation of China(Nos.81770166,81700193,82170186,and 81720108002)Jiangsu Province’s Medical Elite Programme(No.ZDRCA2016022)+3 种基金Project of the National Key Clinical Specialty,the Jiangsu Provincial Special Program of Medical Science(No.BE2017751)National Science and Technology Major Project(No.2018ZX09734007)China Postdoctoral Science Foundation(No.2021M691336)Jiangsu Postdoctoral Science Foundation(No.2021K083A)
文摘Background:Although the treatment of peripheral T-cell lymphoma(PTCL)has undergone advancements during the past several years,the response rate and long-term effects with respect to patients with PTCL remain unsatisfactory—particularly for relapsed or refractory(R/R)patients.This phase II trial was designed to explore the efficacy and safety of an all-oral regimen of chidamide plus prednisone,cyclophosphamide,and thalidomide(CPCT)for R/R PTCL patients who could not tolerate the standard chemotherapy for a variety of reasons.Methods:We conducted a multicenter phase II clinical trial in which we combined chidamide(30 mg twice weekly)with prednisone(20 mg daily after breakfast),cyclophosphamide(50 mg daily after lunch),and thalidomide(100 mg daily at bedtime)(the CPCT regimen)for a total of fewer than 12 cycles as an induction-combined treatment period,and then applied chidamide as single-drug maintenance.Forty-five patients were ultimately enrolled from August 2016 to April 2021 with respect to Chinese patients at nine centers.Our primary objective was to assess the overall response rate(ORR)after the treatment with CPCT.Results:Of the 45 enrolled patients,the optimal ORR and complete response(CR)/CR unconfirmed(CRu)were 71.1%(32/45)and 28.9%(13/45),respectively,and after a median follow-up period of 56 months,the median progression-free survival(PFS)and overall survival(OS)were 8.5 months and 17.2 months,respectively.The five-year PFS and OS rates were 21.2%(95%confidence interval[CI],7.9-34.5%)and 43.8%(95%CI,28.3-59.3%),respectively.The most common adverse event was neutropenia(20/45,44.4%),but we observed no treatment-related death.Conclusion:The all-oral CPCT regimen was an effective and safe regimen for R/R PTCL patients who could not tolerate standard chemotherapy for various reasons.Trial Registration:ClinicalTrials.gov,NCT02879526.
基金supported by the National Natural Science Foundation of China(No.81720108002,81700193,82170186)Jiangsu Province's Medical Elite Programme(China)(No.ZDRCA2016022)+4 种基金Project of National Key Clinical Specialty(China),Jiangsu Provincial Special Program of Medical Science(China)(No.BE2017751)National Science and Technology Major F Project(China)(No.2018ZX09734007)Nature Science Foundation for Youths of Jiangsu Province,China(No.BK20220719)China Postdoctoral Science Foundation(No.2021M691336)Jiangsu Post doctoral Science Foundation(China)(No.2021K083A).
文摘PR/SET domain 1(PRDM1)gene is located on chromosome 6q21,encoding the B lymphocyte-induced maturation protein 1(BLIMP1).1 It is reported that loss of PRDM1 function is exacerbated in activated B-cell-like(ABC)-diffuse large B cell lymphoma(DLBCL)and associated with inferior survival.However,it remains unclear what leads to PRDM1 inactivation and the drug resistance mechanism caused by abnormal inactivation of PRDM1.We investigated the contribution of PRDM1 gene as a prognosis and potential therapeutic target for ABC-DLBCL patients and further clarified the possible mechanism of PRDM1 abnormal inactivation.We first proposed that TP53 could regulate PRDM1 by histone ubiquitination modification at the post-transcriptional level.
基金supported by the Key Technology Research and Development Program of China (2008BAC35B02)
文摘Ionospheric TEC （total electron content） time series are derived from GPS measurements at 13 stations around the epicenter of the 2008 Wenchuan earthquake. Defining anomaly bounds for a sliding window by quartile and 2-standard deviation of TEC values, this paper analyzed the characteristics of ionospheric changes before and after the destructive event. The Neyman-Pearson signal detection method is employed to compute the probabilities of TEC abnormalities. Result shows that one week before the Wenchuan earthquake, ionospheric TEC over the epicenter and its vicinities displays obvious abnormal disturbances, most of which are positive anomalies. The largest TEC abnormal changes appeared on May 9, three days prior to the seismic event. Signal detection shows that the largest possibility ofTEC abnormity on May 9 is 50.74%, indicating that ionospheric abnormities three days before the main shock are likely related to the preparation process of the Ms8.0 Wenchuan earthquake.
基金supported by National Natural Science Foundation of China(No.81170486,81170485 and 81101498)Natural Science Fund for Distinguished Young Scholars of Jiangsu Province(BK20130049)+4 种基金Scientific Research Foundation from the Ministry of Education of China(43-NJYKDX-3)Jiangsu Province's Medical Elite Program(RC2011168)Key Project of Jiangsu Province Health Agency(K201107)"Liu Da Ren Cai Gao Feng"Project(2012-WS-017)A Project funded by the Priority Academic Program Development of Jiangsu Higher Education Institute(JX10231801)
文摘We retrospectively investigated the prognostic factors of acute myeloid leukemia（AML） in 152 Chinese patients with de novo AML who were older than 60 years of age and who received treatment at our hospital.Log-rank test showed that 6 parameters including older age,higher white blood cell（WBC） counts,lactate dehydrogenase（LDH）and bone marrow（BM） blasts at diagnosis,unfavorable risk cytogenetics,and non-mutated CEBPα were significant adverse prognostic factors of overall survival（OS） for elderly AML patients（P = 0.0013,0.0358,0.0132,0.0242,0.0236 and 0.0130,respectively）.Moreover,older age and higher LDH were significant adverse predictors for relapse-free survival（RFS）（P = 0.0447 and 0.0470,respectively）.Univariate analysis revealed similar results for OS to those of the log-rank test and only higher LDH at diagnosis was a significant adverse predictor for RFS（P = 0.028,HR：1.979,95%CI：1.075-3.644）.In multivariate analysis,we identified 2 trends towards independent prognostic factors for OS,including BM blasts at diagnosis（P = 0.057,HR：1.676,95%CI：0.984-2.854）and mutation status of CEBPα（P = 0.064,HR：4.173,95%CI：0.918-18.966）.Our data indicated that older age,gender and a previous history of hematologic diseases resulted in lower complete remission rate（P = 0.012,0.051 and 0.086,respectively）.We further developed an easy scoring system for predicting prognosis and response to induction therapy in older AML patients.Patients who had lower scores showed significantly longer OS and RFS（P = 0.0006 and 0.1001,respectively） and higher CR rate（P = 0.014）.Our research is limited by its retrospective nature and the results from our study need to be further validated by prospective randomized clinical trials.
文摘The growth laws of leaves of flue-cured tobacco in different positions in various periods were summarized. The results showed that the growth speed of new leaves of flue-cured tobacco increased constantly until their growth was the fastest, and then it reduced irreversibly. The length and width of leaves in each position increased fastest when they grew depending on photosynthates instead of or- ganic compounds from functional leaves. Therefore, it is concluded that the increases of leaf length, width and area, and dry matter, and the peak of photosynthetic rate appear successively during the process of leaves of flue-cured tobacco, and the leaf area correction coefficient of leaves of flue-cured tobacco is related to the shape of leaves, which are affected by leaf position and the variety of flue-cured tobacco. The study can provide scientific reference for further research on the growth laws of leaves of flue-cured tobacco.
基金National Natural Science Foundation of China(Nos.81770166,81700193,82170186 and 81720108002)Jiangsu Province’s Medical Elite Programme(No.ZDRCA2016022)+4 种基金Project of National Key Clinical Specialty,Jiangsu Provincial Special Program of Medical Science(No.BE2017751)National Science and Technology Major Project(No.2018 ZX09734007)China Postdoctoral Science Foundation(No.2021M691336)Jiangsu Postdoctoral Science Foundation(No.2021K083A)Translational Research Grant of NCRCH(No.2020ZKZB01)
文摘To the Editor:Non-Hodgkin lymphoma(NHL)is a common type of hematological malignancy.Although the development of targeted therapies has improved the survival of patients with aggressive NHL,autologous hematopoietic stem cell transplantation(HSCT)remains indispensable.There is no standard conditioning regimen for autologous stem cell transplantation(ASCT).
基金supported by special funds from the Welfare industry (201108004)Seismic Science and Technology Spark Plan of the China Earthquake Administration (XH12066)
文摘Phase folding algorithms are conventionally used in periodicity analyses using X-ray astronomy pulsar. These allow for accurate identification of the cycle and phase characteristics of the physical parameters of the periodic variation. Although periodic variations in earth- quake activity have long been studied, this paper is the first to apply the phase folding algorithm to the analysis of shallow （〈70 km） seismic data for the period 1973-2010. The goal is to study the phase distribution characteristics of earthquake frequencies and we see a connection between earthquake occurrence and solar and lunar cycles. First, the rotation of the Sun may play a significant role in impacting on the occurrence time of earthquakes with magnitudes of less than 6.0. This may be especially pertinent for earth- quakes with magnitudes between 5.0 and 6.0, when the modulation ratio reaches 12 %. The Moon＇s gravity, which is generally thought to have the greatest influence on the global environment, may actually play less of a role on earthquake timing than the rotation of the Sun. Second, when we consider the world to be divided into 72 local regions based on latitude and longitude, we can see that there are more than a dozen regions with significant non- uniform distributions of earthquake occurrence time. In these regions, the ratio of χ2 to the number of degrees of freedom far exceeds five. As a result, we posit that some factors associated with the Sun-Earth-Moon relationship may trigger earthquake activity under certain temporal and spatial conditions.
基金supported in part by National Natural Science Foundation of China(30571541)Natural Science Foundation of Jiangsu Province(BK2006233,BK2005161)+1 种基金Medicine Foundation of Jiangsu Province(H200506)Creative Science Foundation of Nanjing Medical University(CX2004002)
文摘Objective：To investigate the association between the X-ray repair cross complementing（XRCC） group 5, XRCC6 and XRCC7 polymorphisms and risk of acute myeloid leukemia（AML）. Methods：This hospital-based case-control study included 120 AML patients and 210 cancer-free controls in a Chinese population. Three polymorphisms of XRCC5, XRCC6 and XRCC7 were genotyped using the polymerase chain reaction（PCR） or polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） method. Results： We found that there was a significant decrease in risk of AML associated with the XRCC6 -61 CG/GG genotype（adjusted odd ratio （OR） = 0.55; 95% confident interval（CI） = 0.34-0.89） compared with the -61CC genotype. For the novel tandem repeat polymorphism （VNTR） in the XRCC5 promoter, we found when the XRCC5 six genotypes were dichotomized（i.e., 2R/2R, 2R/1R versus 2R/0R, 1R/1R, 1R/0R and 0R/0R）, the latter group was associated with increased risk of AML（adjusted OR = 1.67; 95% CI = 1.00-2.79） compared to 2R/ 2R＋2R/1R genotype. However, the XRCC7 6721G〉T polymorphism had no effect on risk of AML. Conclusion：The XRCC6 -61C 〉 G and XRCC5 2R/1R/0R polymorphisms, but not XRCC7 6721G 〉 T polymorphism, could play an important role in the development of AML. Larger scale studies with more detailed data on environment exposure are needed to verify these findings.
文摘Based on the investigation of the amount of labor used in each production link of flue-cured tobacco planting in Liuyang since 1989,and through the analysis of the changes of labor-related factors,it is concluded that the amount of labor used in tobacco planting in Liuyang experienced a significant increase and relatively stable stage in the early 1990s,and it has been declining continuously since the beginning of the 21st century;the change of flue-cured tobacco planting technology mode,as well as mechanized,large-scale and specialized production are the main factors that affect the change of the amount of labor used in flue-cured tobacco planting in Liuyang.Based on the method of changing the technical model to reduce amount of labor used,the types of labor used for planting of flue-cured tobacco can be divided into the following types:reducing the amount of labor by technical methods;reducing the amount of labor by making use of weather;reducing the amount of labor by using drugs;reducing the amount of labor used at the cost of reducing the technical implementation standards of a certain production link.The change of labor used in flue-cured tobacco planting is not only related to the cost and price factors,but also related to the profound social and economic background.In the future,reducing labor and cost is the trend of flue-cured tobacco production,and mechanization,large-scale and specialized production are the main development direction of flue-cured tobacco production,but under the condition that flue-cured tobacco production is still dominated by manual operation,maintaining a certain amount of labor is still the basis for maintaining high quality of flue-cured tobacco planting at present.
文摘This was a rare case, in which clinical manifestation was a thymus area tumor accompanied by proteinuria, kidney dysfunction and kidney enlargement. Tumor biopsy and bone marrow examination failed to clarify its diagnosis. Renal biopsy revealed diffuse infiltration by atypical lymphoid cells in renal interstitium. Immunoperoxidase studies demonstrated this case was non-Hodgkin ＇ s lymphoma （NHL） of the B cell type through the renal biopsy.
基金Science and Technology Project of Changsha Tobacco Monopoly Bureau(Company)(20-21a06).
文摘On the basis of full investigation and repeated trials,nutritional soil composed of cake fertilizer,mushroom residue,cow dung and calcium magnesium phosphate fertilizer was determined as an alternative for traditional flue-cured tobacco fired ash soil.In accordance with the feed grinding,mixing and processing integrated principle,processing machine for flue-cured tobacco nutritional soil was developed.The clogging problem of mixing box was solved by improving grinding and stirring method of mixing system.Mechanized and large-scale production and commercialized supply of flue-cured tobacco nutritional soil was piloted to simplify the production process and reduce the production cost of nutritional soil for flue-cured tobacco and meet the needs of green development of tobacco production,thereby creating good social and economic benefits.
基金supported by the National Natural Science Foundation of the People's Republic of China(No.81070437,81270614 and 81300379)the National Science & Technology Pillar Program of China(No.2008BAI61B01)
文摘For patients with chronic myeloid leukemia（CML） failing imatinib therapy,second-generation tyrosine kinase inhibitors（TKIs） are recommended.Here,we describe two patients with advanced CML who failed imatinib therapy and did not tolerate the recommended dose of dasatinib,but then achieved a major molecular response with the combination of imatinib and dasatinib with no significant extramedullar/ toxicity.Our observations suggest that combination of TKIs may provide an additive/synergistic antileukemic effect.
