Objective:To explore and validate the potential targets of Paeoniae Radix Alba(P.Radix,Bai Shao)in protecting against chemical liver injury through network pharmacology,molecular docking technology,and in vitro cell e...Objective:To explore and validate the potential targets of Paeoniae Radix Alba(P.Radix,Bai Shao)in protecting against chemical liver injury through network pharmacology,molecular docking technology,and in vitro cell experiments.Methods:Network pharmacology was used to identify the common potential targets of P.Radix and chemical liver injury.Molecular docking was used to fit the components,which were subsequently verified in vitro.A cell model of hepatic fibrosis was established by activating hepatic stellate cell(HSC)-LX2 cells with 10 ng/mL transforming growth factor-β1.The cells were exposed to different concentrations of total glucosides of paeony(TGP),the active substance of P.Radix,and then evaluated using the cell counting kit-8 assay,enzyme-linked immunosorbent assay,and western blot.Results:Analysis through network pharmacology revealed 13 key compounds of P.Radix,and the potential targets for preventing chemical liver injury were IL-6,AKT serine/threonine kinase 1,jun protooncogene,heat shock protein 90 alpha family class A member 1(HSP90AA1),peroxisome proliferator activated receptor gamma(PPARG),PTGS2,and CASP3.Gene Ontology(GO)enrichment analysis indicated the involvement of response to drugs,membrane rafts,and peptide binding.Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis revealed that the main pathways involved lipid and atherosclerosis and chemical carcinogenesis-receptor activation.Paeoniflorin and albiflorin exhibited strong affinity for HSP90AA1,PTGS2,PPARG,and CASP3.Different concentrations of TGP can inhibit the expression of COL-I,COL-III,IL-6,TNF-a,IL-1β,HSP-90a,and PTGS2 while increasing the expression of PPAR-γand CASP3 in activated HSC-LX2 cells.Conclusion:P.Radix primarily can regulate targets such as HSP90AA1,PTGS2,PPARG,CASP3.TGP,the main active compound of P.Radix,protects against chemical liver injury by reducing the inflammatory response,activating apoptotic proteins,and promoting the apoptosis of activated HSCs.展开更多
In recent years,herbicide sulfometuron-methyl(SM)has been used to kill the invasive plant Spartina alterniflora in some coastal areas of China,which may lead to the toxic effects on non-target marine organisms.The 96-...In recent years,herbicide sulfometuron-methyl(SM)has been used to kill the invasive plant Spartina alterniflora in some coastal areas of China,which may lead to the toxic effects on non-target marine organisms.The 96-h median effective concentrations(96-h EC50)of SM on six species of marine microalgae were measured in growth inhibition tests,and were then compared with other published toxicity data,based on which a method of species sensitivity distribution(SSD)was built to estimate the hazardous concentration of SM for 5%of species(HC5)and potentially affected fraction(PAF)for a certain concentration.Results indicate that SM exhibited a high toxicity to two species of green algae(Chlorella pacifica and Dunaliella salina)with a 96-h EC50 of 0.11 and 0.13 mg/L respectively,had a medium toxicity to two species of golden algae(Diacronema viridis and Isochrysis galbana)with a 96-h EC50 of 14.24 and 21.48 mg/L respectively,and showed a low toxicity to two species of diatoms(Skeletonema costatum and Phaeodactylum tricornutum)with a 96-h EC50 of 148.99 and>100 mg/L,respectively.The estimated values of HC5 and the predicted no-effect concentrations(PNEC)for SM were 0.077 and 0.015 mg/L,respectively.According to the current dosage for killing S.alterniflora in tidal flats in Fujian Province,China,SM entering the sea by spraying might cause the acute injury or death of 14%of marine species.This hazard could last for about a month for those sensitive species.Therefore,on the premise of inhibiting the growth of this invasive plant,the dosage of SM should be reduced as much as possible to avoid severe damage to the marine ecosystem.The results provide a valuable information for marine ecological risk assessment on SM and for marine environmental management.展开更多
Tribovoltaic nanogenerators(TVNGs)have the characteristics of high current density,low matched impedance and continuous output,which is expected to solve the problem of power supply for small electronic devices.Howeve...Tribovoltaic nanogenerators(TVNGs)have the characteristics of high current density,low matched impedance and continuous output,which is expected to solve the problem of power supply for small electronic devices.However,wear occurrence in friction interface will seriously reduce the performance of TVNGs as well as lifetime.Here,we employ MXene solution as lubricate to improve output current density and lifetime of TVNG simultaneously,where a high value of 754 mA m^(-2)accompanied with a record durability of 90,000 cycles were achieved.By comparing multiple liquid lubricates with different polarity,we show that conductive polar liquid with MXene as additive plays a crucial role in enhancing the electrical output performance and durability of TVNG.Moreover,the universality of MXene solution is well demonstrated in various TVNGs with Cu and P-type Si,and Cu and N-GaAs as material pairs.This work may guide and accelerates the practical application of TVNG in future.展开更多
Polarizing beam splitter has rather significant applications in polarization diversity circuits and polarization multiplexing systems.In this paper,we present an asymmetric polarizing beam splitter utilizing hybrid pl...Polarizing beam splitter has rather significant applications in polarization diversity circuits and polarization multiplexing systems.In this paper,we present an asymmetric polarizing beam splitter utilizing hybrid plasmonic waveguide.The special hybrid structure with a hybrid waveguide and a dielectric waveguide can limit the energy of TE and TM modes to a different layer.Therefore,we can achieve beam splitting by adjusting the corresponding parameters of the two waveguides.First,we studied the influences of different structure parameters on the real part of the effective mode refractive index of the two waveguides,and obtained a set of parameters that satisfy the condition of strong coupling of TM mode and weak coupling of TE mode.Then,the performance of our proposed polarizing beam splitter is evaluated numerically.The length of the coupling section is only 4.1μm,and the propagation loss of TM and TE modes is 0.0025 d B/μm and 0.0031 d B/μm respectively.Additionally,the extinction ratios of TM and TE modes are 10.62 d B and 12.55 d B,respectively.Particularly,the proposed device has excellent wavelength insensitivity.Over the entire C-band,the fluctuation of the whole normalized output power is less than 0.03.In short,our proposed asymmetric polarizing beam splitter features ultra-compactness,low propagation loss,and broad bandwidth,which would provide promising applications in polarization multiplexing system and polarization diversity circuits relevant to optical interconnection.展开更多
Using meteorological data from 8 national basic meteorological observation stations in Qingyang City of Longdong region from 1972 to 2021,the causes and change characteristics of high-temperature weather were analyzed...Using meteorological data from 8 national basic meteorological observation stations in Qingyang City of Longdong region from 1972 to 2021,the causes and change characteristics of high-temperature weather were analyzed,and targeted countermeasures and suggestions were proposed for residents' production,life,and energy security supply affected by high-temperature weather.The results showed that①affected by global warming,the annual average temperature,annual average maximum temperature,annual extreme maximum temperature,days of daily maximum temperature≥30℃,and days of daily maximum temperature≥35℃in Longdong region were all showing an upward trend;②due to the different terrain and soil properties of the underlying surface,the increase in high temperature weather varied in different regions.Due to the influence of desert and hilly terrain,the frequency and days of high temperature occurrence were relatively high in the central and northern parts of Qingyang City.Due to the climate regulation of the Ziwuling Mountains,the days of high temperature in the central and southern parts was significantly less than that in the central and northern parts;③if the warm high pressure ridge on the Qinghai-Tibet Plateau developed strongly in summer,the temperature of the closed warm center reached 0-4℃on the 500 hPa of high-altitude weather map.If the warm air mass developed eastward,it often led to sustained high temperature weather in Longdong region;④when the El Nino phenomenon occurred,the subtropical high in the western Pacific developed strongly in summer,with a center located northward,which was stable,with little movement.It was dry,sunny,hot,and rainless in Longdong region,and the high temperature weather was more significant than that in normal years.展开更多
The structure of S Oilfield of Bohai sea area in China is located in the low uplift slope zone of the Dongwa Laibei area in the Huanghekou depression. The target interval of the oilfield belongs to the Paleogene layer...The structure of S Oilfield of Bohai sea area in China is located in the low uplift slope zone of the Dongwa Laibei area in the Huanghekou depression. The target interval of the oilfield belongs to the Paleogene layered structural oil reservoir under the influence of igneous rocks. Due to the widespread development of igneous rocks, and the diversity of igneous rock types, the structure is complex, and the lateral changes are intense. The differences in volcanic eruption intensity and volcanic materials made the igneous rock masses overlap each other, with rapid changes in lithofacies, and complex seismic reflection structures. Therefore, it was difficult to carry out fine characterization of igneous rocks. Based on the lithofacies model, lithofacies combination types, and seismic response characteristics of volcanic mechanisms, this paper summarized three types of development models of volcanic mechanisms in the study area. At the same time, through technical means such as stratigraphic slicing, seismic attribute extraction, and attribute optimization analysis, the spatial distribution characteristics of various facies zones of igneous rocks at different stages were described in detail, achieving precise prediction of igneous rocks in Bozhong S Oilfield. During the development process of the oilfield, the technical research results guided the optimization of well locations and provided technical support for the efficient development of the oilfield.展开更多
An in situ coupling strategy to prepare Co_9S_8/S and N dual?doped graphene composite(Co_9S_8/NSG) has been proposed. The key point of this strategy is the function?oriented design of organic compounds. Herein, cobalt...An in situ coupling strategy to prepare Co_9S_8/S and N dual?doped graphene composite(Co_9S_8/NSG) has been proposed. The key point of this strategy is the function?oriented design of organic compounds. Herein, cobalt porphyrin derivatives with sulfo groups are employed as not only the coupling agents to form and anchor Co_9S_8 on the graphene in situ, but also the heteroatom?doped agent to generate S and N dual?doped graphene. The tight coupling of multiple active sites endows the composite materials with fast electrochemical kinetics and excellent stability for both oxygen reduction reaction(ORR) and oxygen evolution reaction(OER). The obtained electrocatalyst exhibits better activity parameter(ΔE = 0.82 V) and smaller Tafel slope(47.7 mV dec^(-1) for ORR and 69.2 mV dec^(-1) for OER) than commercially available Pt/C and RuO_2. Most importantly, as electrocatalyst for rechargeable Zn–air battery, Co_9S_8/NSG displays low charge–discharge voltage gap and outstanding long?term cycle stability over 138 h compared to Pt/C–RuO_2. To further broaden its application scope, a homemade all?solid?state Zn–air battery is also prepared, which displays good charge–discharge performance and cycle performance. The function?oriented design of N_4?metallomacrocycle derivatives might open new avenues to strategic construction of high?performance and long?life multifunctional electrocatalysts for wider electro?chemical energy applications.展开更多
Samples of methane molecules grade diameter channel CHA-type molecular sieves(Chabazite-K, SAPO-34 and SSZ-13) were investigated using the adsorption separation of CH4/N2 mixtures. The isotherms recorded for CH4 and N...Samples of methane molecules grade diameter channel CHA-type molecular sieves(Chabazite-K, SAPO-34 and SSZ-13) were investigated using the adsorption separation of CH4/N2 mixtures. The isotherms recorded for CH4 and N2 follow a typical type-Ι behavior, which were fitted well with the Sips model(R2>0.999) and the selectivity was calculated using IAST theory. The results reveal that Chabazite-K has the highest selectivity(SCH4/N= 5.5).2 SSZ-13 has the largest capacity, which can adsorb up to a maximum of 30.957 cm3·g-1(STP) of CH4, due to it having the largest pore volume and surface area, but the lowest selectivity(SCH4/N2= 2.5). From the breakthrough test, we can conclude that SSZ-13 may be a suitable candidate for the recovery of CH4 from low concentration methane(CH4<20%) based on its larger pore volume and higher CH4 capacity. Chabazite-K is more suited to the separation of high concentration methane(CH4>50%) due to its higher selectivity.展开更多
With the aim of deep desulfurization, silica-supported polyoxometalate-based ionic liquids were successfully prepared by a one-pot hydrothermal process and employed in heterogeneous oxidative desulfurization of variou...With the aim of deep desulfurization, silica-supported polyoxometalate-based ionic liquids were successfully prepared by a one-pot hydrothermal process and employed in heterogeneous oxidative desulfurization of various sulfur compounds. The compositions and structures of the hybrid samples were characterized by various methods such as FT-IR, XPS, Raman,UV–Vis, wide-angle XRD and N_2 adsorption–desorption. The experimental results indicated that the hybrid materials presented a high dispersion of tungsten species and excellent catalytic activity for the removal of 4,6-dimethyldibenzothiophene without any organic solvent as extractant, and the sulfur removal could reach 100.0% under mild conditions.The catalytic performance on various substrates was also investigated in detail. After cycling seven cycles, the sulfur removal of the heterogeneous system still reached 93.0%. The GC-MS analysis results demonstrated that the sulfur compound was first adsorbed by the catalyst and subsequently oxidized to its corresponding sulfone.展开更多
Background:Meat quality is largely driven by fat deposition,which is regulated by several genes and signaling pathways.The cyclic adenosine monophosphate(cAMP)-regulated transcriptional coactivator 3(CRTC3)is a coacti...Background:Meat quality is largely driven by fat deposition,which is regulated by several genes and signaling pathways.The cyclic adenosine monophosphate(cAMP)-regulated transcriptional coactivator 3(CRTC3)is a coactivator of cAMP response element binding protein(CREB)that mediates the function of protein kinase A(PKA)signaling pathway and is involved in various biological processes including lipid and energy metabolism.However,the effects of CRTC3 on the metabolome and transcriptome of porcine subcutaneous adipocytes have not been studied yet.Here,we tested whether porcine CRTC3 expression would be related to fat deposition in Heigai pigs(a local fatty breed in China)and Duroc×Landrace×Yorkshire(DLY,a lean breed)pigs in vivo.The effects of adenovirus-induced CRTC3 overexpression on the metabolomic and transcriptomic profiles of subcutaneous adipocytes were also determined in vitro by performing mass spectrometry-based metabolomics combined with RNA sequencing(RNA-seq).Results:Porcine CRTC3 expression is associated with fat deposition in vivo.In addition,CRTC3 overexpression increased lipid accumulation and the expression of mature adipocyte-related genes in cultured porcine subcutaneous adipocytes.According to the metabolomic analysis,CRTC3 overexpression induced significant changes in adipocyte lipid,amino acid and nucleotide metabolites in vitro.The RNA-seq analysis suggested that CRTC3 overexpression alters the expression of genes and pathways involved in adipogenesis,fatty acid metabolism and glycerophospholipid metabolism in vitro.Conclusions:We identified significant alterations in the metabolite composition and the expression of genes and pathways involved in lipid metabolism in CRTC3-overexpressing adipocytes.Our results suggest that CRTC3 might play an important regulatory role in lipid metabolism and thus affects lipid accumulation in porcine subcutaneous adipocytes.展开更多
Turbine blisks are assembled using blades,disks and casings.They can endure complex loads at a high temperature,high pressure and high speed.The safe operation of assembled structures depends on the reliability of eac...Turbine blisks are assembled using blades,disks and casings.They can endure complex loads at a high temperature,high pressure and high speed.The safe operation of assembled structures depends on the reliability of each component.Monte Carlo(MC)simulation is commonly used to analyze structural reliability,but this method needs to run thousands of computations.In order to assess the clearance reliability of assembled structures in an efficient and precise manner,the novel Kriging-based decomposed-coordinated(DC)(DCNK)approach is proposed by integrating the DC strategy,the Kriging model and the importance sampling-based Markov chain(MCIS)technique.In this method,the DC strategy is used to decompose a multi-objective problem into many single-objective problems.The relationships between these many single-objectives and the overall objective are then coordinated.The Kriging model is applied to establish the limit state functions of the single-objectives and multi-objective problems,while the MCIS method is used to assess the structural assembled clearance reliability.Moreover,a highly nonlinear complex compound function is first utilized to verify the DCNK model from a mathematical perspective.Then,the reliability of an aeroengine high-pressure turbine(HPT)blade-tip radial running clearance(BTRRC)is analyzed to validate the DCNK approach by considering thermo-structural interaction.The analytical results show that the reliability is 0.9976 when the allowance value of the BTTRC is 1.7650×10^(−3)m.Compared with different methodologies(including direct simulation,the classical Kriging model,and the weighted response surface method(WRSM)),the proposed method holds obvious advantages in computing time and precision,as well as simulation efficiency and precision.The efforts of this paper provide a useful approach to analyzing assembled clearance reliability and contribute to the development of structural reliability theory.展开更多
An automatic detection method is employed to identify and track eddies in the Gulf of Mexico. The physical parameters of the eddies, such as lifespan, radius, and distribution position are first examined and used to d...An automatic detection method is employed to identify and track eddies in the Gulf of Mexico. The physical parameters of the eddies, such as lifespan, radius, and distribution position are first examined and used to determine the spatio–temporal evolution of a strong warm eddy separated from the Mexico current. Then, the influence of this strong warm eddy on sound propagation during its lifespan are comprehensively analyzed with the parabolic equation and explained by using the normal mode and ray theories. Additionally, the influence of mesoscale eddies on the redistribution of total depth-integrated energy among the normal modes in the deep water is also discussed. The variation of arrival angle is investigated to explain the spreading acoustic energy caused by eddies. Overall, the results show that warm eddies can change the propagation paths and cause the convergence zone to broaden and approach the sound source. Moreover,the warm eddy can disperse sound energy and cause the total depth-integrated energy to incline to a lower normal mode.Throughout the whole of these three periods(eddy generating, eddy maturing, and eddy terminating), the fluctuation in the transmission loss is up to 30 dB(depending on the relative location of eddy center to the source).展开更多
Alkali metal DC arc discharge has the characteristics of easy ionization,low power consumption,high plasma temperature and ionization degree,etc,which can be applied in aerospace vehicles in various ways.In this paper...Alkali metal DC arc discharge has the characteristics of easy ionization,low power consumption,high plasma temperature and ionization degree,etc,which can be applied in aerospace vehicles in various ways.In this paper,we calculate the physical property parameters of lithium vapor,one of the major alkali metals,and analyze the discharge characteristics of lithium plasma with the magnetohydrodynamic(MHD)model.The discharge effects between constant current and voltage sources are also compared.It is shown that the lithium plasma of DC arc discharge has relatively high temperature and current density.The peak temperature can reach tens of thousands of K,and the current density reaches 6 x 107 A m 2.Under the same rated power,the plasma parameters of the constant voltage source discharge are much higher than those of the constant current source discharge,which can be used as the preferred discharge mode for aerospace applications.展开更多
The flux-modulated compound-structure permanent magnet synchronous machine (CS-PMSM), composed of a brushless double rotor machine (DRM) and a conventional permanent magnet synchronous machine (PMSM), is a power split...The flux-modulated compound-structure permanent magnet synchronous machine (CS-PMSM), composed of a brushless double rotor machine (DRM) and a conventional permanent magnet synchronous machine (PMSM), is a power split device for plug-in hybrid electric vehicles. In this paper, its operating principle and mathematical model are introduced. A modified current controller with decoupled state feedback is proposed and verified. The system control strategy is simulated in Matlab, and the feasibility of the control system is proven. To improve fuel economy, an energy management strategy based on fuzzy logic controller is proposed and evaluated by the Urban Dynamometer Driving Schedule (UDDS) drive cycle. The results show that the total energy consumption is similar to that of Prius 2012.展开更多
Information encoding plays a crucial role in neuroscience. One of the fundamental questions in cognitive neuroscience is how the brain encodes external stimuli in the sensory cortex. We use a network model based on th...Information encoding plays a crucial role in neuroscience. One of the fundamental questions in cognitive neuroscience is how the brain encodes external stimuli in the sensory cortex. We use a network model based on the Hodgkin–Huxley type to study the information transmitting including its storage and recall. The model is inspired by psychological and neurobiological evidence on sequential memories. The model contains excitatory and inhibitory neurons with all-to-all connections whose architecture has two layers. A lower layer represents consecutive events during the information encoding process, and the upper layer is used to tag sequences of events represented in the lower layer. The spike-timing-dependent plasticity learning rule is used for sequential storage of excitatory connections between the modules. Computer simulations demonstrate that the synchronization status of multiple neurons is dependent on the network connectivity patterns, and also this model has good performance for different sequences of storage and recall.展开更多
Populations and metropolitan centers are accumulated in coastal areas around the world.In view of the fact that they are geographically adjacent to coasts and intense anthropogenic activities,increasing global offshor...Populations and metropolitan centers are accumulated in coastal areas around the world.In view of the fact that they are geographically adjacent to coasts and intense anthropogenic activities,increasing global offshore pollution has been an important worldwide concern over the past several decades and has become a very serious problem that needs to be addressed urgently.Due to offshore pollution,various geological disasters occur in high frequency,including intensified erosion and salinization of coastal soils,frequent geological collapses and landslides and increasing seismic activities.Moreover,offshore pollution shows increasingly serious impacts on the topography and geomorphology of offshore and coastal areas,including coastal degradation,retreating coastlines and estuary delta erosion.Offshore sedimentation processes are strongly influenced by the pH changes of terrestrial discharges,and sedimentary dynamics have become extremely acute and complex due to offshore pollution.The seabed topography and hydrodynamic environment determine the fate and transport of pollutants entering offshore regions.Coastal estuaries,port basins and lagoons that have relatively moderate ocean currents and winds are more likely to accumulate pollutants.Offshore regions and undersea canyons can be used as conduits for transporting pollutants from the continent to the seabed.It is particularly noteworthy that the spatial/temporal distribution of species,community structures,and ecological functions in offshore areas have undergone unprecedented changes in recent decades.Due to increasing offshore pollution,the stable succession and development trend of marine ecosystems has been broken.It is thus important to identify and regulate the quantity,composition and transportation of pollutants in offshore regions and their behavior in marine ecosystems.In particular,crucial actions for stabilizing marine ecosystems,including increasing species and biodiversity,should be implemented to enhance their anti-interference capabilities.This review provides an overview of the current situation of offshore pollution,as well as major trends of pollutant fate and transportation from continent to marine ecosystems,transformation of pollutants in sediments,and their bioaccumulation and diffusion.This study retrospectively reviews the long-term geological evolution of offshore pollution from the perspective of marine geology,and analyses their long-term potential impacts on marine ecosystems.Due to ecological risks associated with pollutants released from offshore sediments,more research on the influence of global offshore pollution based on marine geology is undoubtedly needed.展开更多
Rural areas are multifunctional and often have production,living,and ecological functions.The high-quality and balanced development of these three functions is key to sustainable rural development(SRD).Thus,the evalua...Rural areas are multifunctional and often have production,living,and ecological functions.The high-quality and balanced development of these three functions is key to sustainable rural development(SRD).Thus,the evaluation of SRD based on rural multifunctionality is of immense significance.This study clarifies the rela‐tionship between multifunctionality and sustainable rural development.An evaluation index system with six sub-components was established for calculating the SRD.In addition,we included 129 counties from the Sich‐uan Province in our case study,and used this index system to analyze the characteristics of rural multifunc‐tionality for evaluating the SRD.The results showed indisputable evidence of multifunctional development.At the county level,rural multifunctionality faces the challenge of insufficient and uneven development,particu‐larly in production functions.Significant spatial differences existed in rural multifunctional development,and the suburban counties generally performed better.Moreover,a mutually reinforcing relationship between pro‐duction,living,and ecological functions was established;however,there was still a significant gap in realizing SRD.Our results emphasize the necessity of a differentiated SRD strategy that should be formulated and imple‐mented based on rural multifunctionality differentiation rules.Our study offers useful guidance for realizing rural multifunctional and sustainable development.展开更多
Background:Reversibility of pulmonary hypertension(PH)is closely related to the treatment options for and prognosis of children with congenital heart disease.Objective:We combined patient-specific clinical features in...Background:Reversibility of pulmonary hypertension(PH)is closely related to the treatment options for and prognosis of children with congenital heart disease.Objective:We combined patient-specific clinical features including diagnosis,age and echocardiographic results,and biomarkers of pulmonary vascular dysfunction to explore the noninvasive methods that can be used to accurately evaluate the reversibility of pulmonary hypertension in congenital heart disease(PH-CHD).Methods:Based on the preoperative systolic pulmonary arterial pressure(sPAP),70 CHD patients were divided into normal,PH-CHD suspected,and confirmed groups.Additionally,biomarkers of circulating endothelial cells(CECs),endothelin-1(ET-1),and endothelial nitric oxide synthase(eNOS)were detected.Patients were categorized into reversible(RPH)and irreversible(IRPH)groups according to the sPAP 6 months after surgery.Risk stratification was performed according to the clinical features and biomarkers.Results:CECs and ET-1 levels in the confirmed group were significantly higher.eNOS was higher in the confirmed and suspected groups than that in the normal group.CECs in the IRPH group were significantly higher compared to the RPH group.No such intergroup differences were observed with respect to ET-1 and eNOS levels.The ROC curve showed that the risk stratification was of high diagnostic value to evaluate reversibility.Conclusion:The CECs,eNOS,and ET-1 were closely related with PH-CHD.CECs and risk stratification have high practical value in assessing the reversibility of PH-CHD.展开更多
基金supported by the National Natural Science Foundation of China(82074036).
文摘Objective:To explore and validate the potential targets of Paeoniae Radix Alba(P.Radix,Bai Shao)in protecting against chemical liver injury through network pharmacology,molecular docking technology,and in vitro cell experiments.Methods:Network pharmacology was used to identify the common potential targets of P.Radix and chemical liver injury.Molecular docking was used to fit the components,which were subsequently verified in vitro.A cell model of hepatic fibrosis was established by activating hepatic stellate cell(HSC)-LX2 cells with 10 ng/mL transforming growth factor-β1.The cells were exposed to different concentrations of total glucosides of paeony(TGP),the active substance of P.Radix,and then evaluated using the cell counting kit-8 assay,enzyme-linked immunosorbent assay,and western blot.Results:Analysis through network pharmacology revealed 13 key compounds of P.Radix,and the potential targets for preventing chemical liver injury were IL-6,AKT serine/threonine kinase 1,jun protooncogene,heat shock protein 90 alpha family class A member 1(HSP90AA1),peroxisome proliferator activated receptor gamma(PPARG),PTGS2,and CASP3.Gene Ontology(GO)enrichment analysis indicated the involvement of response to drugs,membrane rafts,and peptide binding.Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis revealed that the main pathways involved lipid and atherosclerosis and chemical carcinogenesis-receptor activation.Paeoniflorin and albiflorin exhibited strong affinity for HSP90AA1,PTGS2,PPARG,and CASP3.Different concentrations of TGP can inhibit the expression of COL-I,COL-III,IL-6,TNF-a,IL-1β,HSP-90a,and PTGS2 while increasing the expression of PPAR-γand CASP3 in activated HSC-LX2 cells.Conclusion:P.Radix primarily can regulate targets such as HSP90AA1,PTGS2,PPARG,CASP3.TGP,the main active compound of P.Radix,protects against chemical liver injury by reducing the inflammatory response,activating apoptotic proteins,and promoting the apoptosis of activated HSCs.
基金Supported by the National Natural Science Foundation of China(No.42077335)。
文摘In recent years,herbicide sulfometuron-methyl(SM)has been used to kill the invasive plant Spartina alterniflora in some coastal areas of China,which may lead to the toxic effects on non-target marine organisms.The 96-h median effective concentrations(96-h EC50)of SM on six species of marine microalgae were measured in growth inhibition tests,and were then compared with other published toxicity data,based on which a method of species sensitivity distribution(SSD)was built to estimate the hazardous concentration of SM for 5%of species(HC5)and potentially affected fraction(PAF)for a certain concentration.Results indicate that SM exhibited a high toxicity to two species of green algae(Chlorella pacifica and Dunaliella salina)with a 96-h EC50 of 0.11 and 0.13 mg/L respectively,had a medium toxicity to two species of golden algae(Diacronema viridis and Isochrysis galbana)with a 96-h EC50 of 14.24 and 21.48 mg/L respectively,and showed a low toxicity to two species of diatoms(Skeletonema costatum and Phaeodactylum tricornutum)with a 96-h EC50 of 148.99 and>100 mg/L,respectively.The estimated values of HC5 and the predicted no-effect concentrations(PNEC)for SM were 0.077 and 0.015 mg/L,respectively.According to the current dosage for killing S.alterniflora in tidal flats in Fujian Province,China,SM entering the sea by spraying might cause the acute injury or death of 14%of marine species.This hazard could last for about a month for those sensitive species.Therefore,on the premise of inhibiting the growth of this invasive plant,the dosage of SM should be reduced as much as possible to avoid severe damage to the marine ecosystem.The results provide a valuable information for marine ecological risk assessment on SM and for marine environmental management.
基金Research was supported by the National Key R&D Project from Minister of Science and Technology(2021YFA1201602)National Natural Science Foundation of China(Grant no.61774016,22109013,62204017)+1 种基金Fundamental Research Funds for the Central Universities(E1E46802)China Postdoctoral Science Foundation(2021M703172,2021M703171).
文摘Tribovoltaic nanogenerators(TVNGs)have the characteristics of high current density,low matched impedance and continuous output,which is expected to solve the problem of power supply for small electronic devices.However,wear occurrence in friction interface will seriously reduce the performance of TVNGs as well as lifetime.Here,we employ MXene solution as lubricate to improve output current density and lifetime of TVNG simultaneously,where a high value of 754 mA m^(-2)accompanied with a record durability of 90,000 cycles were achieved.By comparing multiple liquid lubricates with different polarity,we show that conductive polar liquid with MXene as additive plays a crucial role in enhancing the electrical output performance and durability of TVNG.Moreover,the universality of MXene solution is well demonstrated in various TVNGs with Cu and P-type Si,and Cu and N-GaAs as material pairs.This work may guide and accelerates the practical application of TVNG in future.
基金supported by the Shenzhen Science and Technology Program(JCYJ20210324093806017)the ShenzhenHong Kong Joint Innovation Foundation(SGDX20190919094401725)。
文摘Polarizing beam splitter has rather significant applications in polarization diversity circuits and polarization multiplexing systems.In this paper,we present an asymmetric polarizing beam splitter utilizing hybrid plasmonic waveguide.The special hybrid structure with a hybrid waveguide and a dielectric waveguide can limit the energy of TE and TM modes to a different layer.Therefore,we can achieve beam splitting by adjusting the corresponding parameters of the two waveguides.First,we studied the influences of different structure parameters on the real part of the effective mode refractive index of the two waveguides,and obtained a set of parameters that satisfy the condition of strong coupling of TM mode and weak coupling of TE mode.Then,the performance of our proposed polarizing beam splitter is evaluated numerically.The length of the coupling section is only 4.1μm,and the propagation loss of TM and TE modes is 0.0025 d B/μm and 0.0031 d B/μm respectively.Additionally,the extinction ratios of TM and TE modes are 10.62 d B and 12.55 d B,respectively.Particularly,the proposed device has excellent wavelength insensitivity.Over the entire C-band,the fluctuation of the whole normalized output power is less than 0.03.In short,our proposed asymmetric polarizing beam splitter features ultra-compactness,low propagation loss,and broad bandwidth,which would provide promising applications in polarization multiplexing system and polarization diversity circuits relevant to optical interconnection.
文摘Using meteorological data from 8 national basic meteorological observation stations in Qingyang City of Longdong region from 1972 to 2021,the causes and change characteristics of high-temperature weather were analyzed,and targeted countermeasures and suggestions were proposed for residents' production,life,and energy security supply affected by high-temperature weather.The results showed that①affected by global warming,the annual average temperature,annual average maximum temperature,annual extreme maximum temperature,days of daily maximum temperature≥30℃,and days of daily maximum temperature≥35℃in Longdong region were all showing an upward trend;②due to the different terrain and soil properties of the underlying surface,the increase in high temperature weather varied in different regions.Due to the influence of desert and hilly terrain,the frequency and days of high temperature occurrence were relatively high in the central and northern parts of Qingyang City.Due to the climate regulation of the Ziwuling Mountains,the days of high temperature in the central and southern parts was significantly less than that in the central and northern parts;③if the warm high pressure ridge on the Qinghai-Tibet Plateau developed strongly in summer,the temperature of the closed warm center reached 0-4℃on the 500 hPa of high-altitude weather map.If the warm air mass developed eastward,it often led to sustained high temperature weather in Longdong region;④when the El Nino phenomenon occurred,the subtropical high in the western Pacific developed strongly in summer,with a center located northward,which was stable,with little movement.It was dry,sunny,hot,and rainless in Longdong region,and the high temperature weather was more significant than that in normal years.
文摘The structure of S Oilfield of Bohai sea area in China is located in the low uplift slope zone of the Dongwa Laibei area in the Huanghekou depression. The target interval of the oilfield belongs to the Paleogene layered structural oil reservoir under the influence of igneous rocks. Due to the widespread development of igneous rocks, and the diversity of igneous rock types, the structure is complex, and the lateral changes are intense. The differences in volcanic eruption intensity and volcanic materials made the igneous rock masses overlap each other, with rapid changes in lithofacies, and complex seismic reflection structures. Therefore, it was difficult to carry out fine characterization of igneous rocks. Based on the lithofacies model, lithofacies combination types, and seismic response characteristics of volcanic mechanisms, this paper summarized three types of development models of volcanic mechanisms in the study area. At the same time, through technical means such as stratigraphic slicing, seismic attribute extraction, and attribute optimization analysis, the spatial distribution characteristics of various facies zones of igneous rocks at different stages were described in detail, achieving precise prediction of igneous rocks in Bozhong S Oilfield. During the development process of the oilfield, the technical research results guided the optimization of well locations and provided technical support for the efficient development of the oilfield.
基金supported by the Natural Science Foundation of Liaoning Province(No.20170540086)the Open Fund of the State Key Laboratory of Molecular Reaction Dynamics in Dalian Institute of Chemical Physics,Chinese Academy of Sciences(SKLMRD-K202107,K202216)。
基金supported by the National Natural Science Foundation of China (Grant No. 21404014)the Science & Technology Department of Jilin Province (No. 20170101177JC)
文摘An in situ coupling strategy to prepare Co_9S_8/S and N dual?doped graphene composite(Co_9S_8/NSG) has been proposed. The key point of this strategy is the function?oriented design of organic compounds. Herein, cobalt porphyrin derivatives with sulfo groups are employed as not only the coupling agents to form and anchor Co_9S_8 on the graphene in situ, but also the heteroatom?doped agent to generate S and N dual?doped graphene. The tight coupling of multiple active sites endows the composite materials with fast electrochemical kinetics and excellent stability for both oxygen reduction reaction(ORR) and oxygen evolution reaction(OER). The obtained electrocatalyst exhibits better activity parameter(ΔE = 0.82 V) and smaller Tafel slope(47.7 mV dec^(-1) for ORR and 69.2 mV dec^(-1) for OER) than commercially available Pt/C and RuO_2. Most importantly, as electrocatalyst for rechargeable Zn–air battery, Co_9S_8/NSG displays low charge–discharge voltage gap and outstanding long?term cycle stability over 138 h compared to Pt/C–RuO_2. To further broaden its application scope, a homemade all?solid?state Zn–air battery is also prepared, which displays good charge–discharge performance and cycle performance. The function?oriented design of N_4?metallomacrocycle derivatives might open new avenues to strategic construction of high?performance and long?life multifunctional electrocatalysts for wider electro?chemical energy applications.
基金financial support from the National Natural Science Foundation of China (Nos. 51672186, 21676175)
文摘Samples of methane molecules grade diameter channel CHA-type molecular sieves(Chabazite-K, SAPO-34 and SSZ-13) were investigated using the adsorption separation of CH4/N2 mixtures. The isotherms recorded for CH4 and N2 follow a typical type-Ι behavior, which were fitted well with the Sips model(R2>0.999) and the selectivity was calculated using IAST theory. The results reveal that Chabazite-K has the highest selectivity(SCH4/N= 5.5).2 SSZ-13 has the largest capacity, which can adsorb up to a maximum of 30.957 cm3·g-1(STP) of CH4, due to it having the largest pore volume and surface area, but the lowest selectivity(SCH4/N2= 2.5). From the breakthrough test, we can conclude that SSZ-13 may be a suitable candidate for the recovery of CH4 from low concentration methane(CH4<20%) based on its larger pore volume and higher CH4 capacity. Chabazite-K is more suited to the separation of high concentration methane(CH4>50%) due to its higher selectivity.
基金financially supported by the National Nature Science Foundation of China (Nos. 21776116, 21576122, 21722604)Postdoctoral Foundation of China (No. 2017M621646)+1 种基金Postdoctoral Foundation of Jiangsu Province (No. 2018K083C)the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
文摘With the aim of deep desulfurization, silica-supported polyoxometalate-based ionic liquids were successfully prepared by a one-pot hydrothermal process and employed in heterogeneous oxidative desulfurization of various sulfur compounds. The compositions and structures of the hybrid samples were characterized by various methods such as FT-IR, XPS, Raman,UV–Vis, wide-angle XRD and N_2 adsorption–desorption. The experimental results indicated that the hybrid materials presented a high dispersion of tungsten species and excellent catalytic activity for the removal of 4,6-dimethyldibenzothiophene without any organic solvent as extractant, and the sulfur removal could reach 100.0% under mild conditions.The catalytic performance on various substrates was also investigated in detail. After cycling seven cycles, the sulfur removal of the heterogeneous system still reached 93.0%. The GC-MS analysis results demonstrated that the sulfur compound was first adsorbed by the catalyst and subsequently oxidized to its corresponding sulfone.
基金The project was partially supported by the National Natural Science Foundation of China(31722053,31672427)the Natural Science Foundation of Zhejiang Province(LR17C170001)the“Hundred Talents Program”funding from Zhejiang University awarded to TZS.
文摘Background:Meat quality is largely driven by fat deposition,which is regulated by several genes and signaling pathways.The cyclic adenosine monophosphate(cAMP)-regulated transcriptional coactivator 3(CRTC3)is a coactivator of cAMP response element binding protein(CREB)that mediates the function of protein kinase A(PKA)signaling pathway and is involved in various biological processes including lipid and energy metabolism.However,the effects of CRTC3 on the metabolome and transcriptome of porcine subcutaneous adipocytes have not been studied yet.Here,we tested whether porcine CRTC3 expression would be related to fat deposition in Heigai pigs(a local fatty breed in China)and Duroc×Landrace×Yorkshire(DLY,a lean breed)pigs in vivo.The effects of adenovirus-induced CRTC3 overexpression on the metabolomic and transcriptomic profiles of subcutaneous adipocytes were also determined in vitro by performing mass spectrometry-based metabolomics combined with RNA sequencing(RNA-seq).Results:Porcine CRTC3 expression is associated with fat deposition in vivo.In addition,CRTC3 overexpression increased lipid accumulation and the expression of mature adipocyte-related genes in cultured porcine subcutaneous adipocytes.According to the metabolomic analysis,CRTC3 overexpression induced significant changes in adipocyte lipid,amino acid and nucleotide metabolites in vitro.The RNA-seq analysis suggested that CRTC3 overexpression alters the expression of genes and pathways involved in adipogenesis,fatty acid metabolism and glycerophospholipid metabolism in vitro.Conclusions:We identified significant alterations in the metabolite composition and the expression of genes and pathways involved in lipid metabolism in CRTC3-overexpressing adipocytes.Our results suggest that CRTC3 might play an important regulatory role in lipid metabolism and thus affects lipid accumulation in porcine subcutaneous adipocytes.
基金This paper is supported by the National Natural Science Foundation of China(51875465)the Civil Aircraft Scientific Research Project.The authors would like to thank their generous supports.
文摘Turbine blisks are assembled using blades,disks and casings.They can endure complex loads at a high temperature,high pressure and high speed.The safe operation of assembled structures depends on the reliability of each component.Monte Carlo(MC)simulation is commonly used to analyze structural reliability,but this method needs to run thousands of computations.In order to assess the clearance reliability of assembled structures in an efficient and precise manner,the novel Kriging-based decomposed-coordinated(DC)(DCNK)approach is proposed by integrating the DC strategy,the Kriging model and the importance sampling-based Markov chain(MCIS)technique.In this method,the DC strategy is used to decompose a multi-objective problem into many single-objective problems.The relationships between these many single-objectives and the overall objective are then coordinated.The Kriging model is applied to establish the limit state functions of the single-objectives and multi-objective problems,while the MCIS method is used to assess the structural assembled clearance reliability.Moreover,a highly nonlinear complex compound function is first utilized to verify the DCNK model from a mathematical perspective.Then,the reliability of an aeroengine high-pressure turbine(HPT)blade-tip radial running clearance(BTRRC)is analyzed to validate the DCNK approach by considering thermo-structural interaction.The analytical results show that the reliability is 0.9976 when the allowance value of the BTTRC is 1.7650×10^(−3)m.Compared with different methodologies(including direct simulation,the classical Kriging model,and the weighted response surface method(WRSM)),the proposed method holds obvious advantages in computing time and precision,as well as simulation efficiency and precision.The efforts of this paper provide a useful approach to analyzing assembled clearance reliability and contribute to the development of structural reliability theory.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11434012 and 41561144006)
文摘An automatic detection method is employed to identify and track eddies in the Gulf of Mexico. The physical parameters of the eddies, such as lifespan, radius, and distribution position are first examined and used to determine the spatio–temporal evolution of a strong warm eddy separated from the Mexico current. Then, the influence of this strong warm eddy on sound propagation during its lifespan are comprehensively analyzed with the parabolic equation and explained by using the normal mode and ray theories. Additionally, the influence of mesoscale eddies on the redistribution of total depth-integrated energy among the normal modes in the deep water is also discussed. The variation of arrival angle is investigated to explain the spreading acoustic energy caused by eddies. Overall, the results show that warm eddies can change the propagation paths and cause the convergence zone to broaden and approach the sound source. Moreover,the warm eddy can disperse sound energy and cause the total depth-integrated energy to incline to a lower normal mode.Throughout the whole of these three periods(eddy generating, eddy maturing, and eddy terminating), the fluctuation in the transmission loss is up to 30 dB(depending on the relative location of eddy center to the source).
文摘Alkali metal DC arc discharge has the characteristics of easy ionization,low power consumption,high plasma temperature and ionization degree,etc,which can be applied in aerospace vehicles in various ways.In this paper,we calculate the physical property parameters of lithium vapor,one of the major alkali metals,and analyze the discharge characteristics of lithium plasma with the magnetohydrodynamic(MHD)model.The discharge effects between constant current and voltage sources are also compared.It is shown that the lithium plasma of DC arc discharge has relatively high temperature and current density.The peak temperature can reach tens of thousands of K,and the current density reaches 6 x 107 A m 2.Under the same rated power,the plasma parameters of the constant voltage source discharge are much higher than those of the constant current source discharge,which can be used as the preferred discharge mode for aerospace applications.
基金This work was supported by National Natural Science Foundation of China under Project 51325701,51377030,and 51407042.
文摘The flux-modulated compound-structure permanent magnet synchronous machine (CS-PMSM), composed of a brushless double rotor machine (DRM) and a conventional permanent magnet synchronous machine (PMSM), is a power split device for plug-in hybrid electric vehicles. In this paper, its operating principle and mathematical model are introduced. A modified current controller with decoupled state feedback is proposed and verified. The system control strategy is simulated in Matlab, and the feasibility of the control system is proven. To improve fuel economy, an energy management strategy based on fuzzy logic controller is proposed and evaluated by the Urban Dynamometer Driving Schedule (UDDS) drive cycle. The results show that the total energy consumption is similar to that of Prius 2012.
基金Supported by the National Natural Science Foundation of China under Grant Nos 11672107,11402294,11602224 and 11502062
文摘Information encoding plays a crucial role in neuroscience. One of the fundamental questions in cognitive neuroscience is how the brain encodes external stimuli in the sensory cortex. We use a network model based on the Hodgkin–Huxley type to study the information transmitting including its storage and recall. The model is inspired by psychological and neurobiological evidence on sequential memories. The model contains excitatory and inhibitory neurons with all-to-all connections whose architecture has two layers. A lower layer represents consecutive events during the information encoding process, and the upper layer is used to tag sequences of events represented in the lower layer. The spike-timing-dependent plasticity learning rule is used for sequential storage of excitatory connections between the modules. Computer simulations demonstrate that the synchronization status of multiple neurons is dependent on the network connectivity patterns, and also this model has good performance for different sequences of storage and recall.
基金financially supported by the National Natural Science Foundation of China as a Shandong joint key project(Grant No.U1906222)the Ministry of Environmental Science and Technology,People’s Republic of China as a key R&D project(Grant No.2019YFC1804104)the Ministry of Education,People’s Republic of China as a 111 program(Grant No.T2017002)。
文摘Populations and metropolitan centers are accumulated in coastal areas around the world.In view of the fact that they are geographically adjacent to coasts and intense anthropogenic activities,increasing global offshore pollution has been an important worldwide concern over the past several decades and has become a very serious problem that needs to be addressed urgently.Due to offshore pollution,various geological disasters occur in high frequency,including intensified erosion and salinization of coastal soils,frequent geological collapses and landslides and increasing seismic activities.Moreover,offshore pollution shows increasingly serious impacts on the topography and geomorphology of offshore and coastal areas,including coastal degradation,retreating coastlines and estuary delta erosion.Offshore sedimentation processes are strongly influenced by the pH changes of terrestrial discharges,and sedimentary dynamics have become extremely acute and complex due to offshore pollution.The seabed topography and hydrodynamic environment determine the fate and transport of pollutants entering offshore regions.Coastal estuaries,port basins and lagoons that have relatively moderate ocean currents and winds are more likely to accumulate pollutants.Offshore regions and undersea canyons can be used as conduits for transporting pollutants from the continent to the seabed.It is particularly noteworthy that the spatial/temporal distribution of species,community structures,and ecological functions in offshore areas have undergone unprecedented changes in recent decades.Due to increasing offshore pollution,the stable succession and development trend of marine ecosystems has been broken.It is thus important to identify and regulate the quantity,composition and transportation of pollutants in offshore regions and their behavior in marine ecosystems.In particular,crucial actions for stabilizing marine ecosystems,including increasing species and biodiversity,should be implemented to enhance their anti-interference capabilities.This review provides an overview of the current situation of offshore pollution,as well as major trends of pollutant fate and transportation from continent to marine ecosystems,transformation of pollutants in sediments,and their bioaccumulation and diffusion.This study retrospectively reviews the long-term geological evolution of offshore pollution from the perspective of marine geology,and analyses their long-term potential impacts on marine ecosystems.Due to ecological risks associated with pollutants released from offshore sediments,more research on the influence of global offshore pollution based on marine geology is undoubtedly needed.
文摘Rural areas are multifunctional and often have production,living,and ecological functions.The high-quality and balanced development of these three functions is key to sustainable rural development(SRD).Thus,the evaluation of SRD based on rural multifunctionality is of immense significance.This study clarifies the rela‐tionship between multifunctionality and sustainable rural development.An evaluation index system with six sub-components was established for calculating the SRD.In addition,we included 129 counties from the Sich‐uan Province in our case study,and used this index system to analyze the characteristics of rural multifunc‐tionality for evaluating the SRD.The results showed indisputable evidence of multifunctional development.At the county level,rural multifunctionality faces the challenge of insufficient and uneven development,particu‐larly in production functions.Significant spatial differences existed in rural multifunctional development,and the suburban counties generally performed better.Moreover,a mutually reinforcing relationship between pro‐duction,living,and ecological functions was established;however,there was still a significant gap in realizing SRD.Our results emphasize the necessity of a differentiated SRD strategy that should be formulated and imple‐mented based on rural multifunctionality differentiation rules.Our study offers useful guidance for realizing rural multifunctional and sustainable development.
基金We thank the support of National Nature Science Foundation of China(81771934)Shanghai Jiao Tong University Medical and Engineering Intersection Fund(YG2019ZDA03).
文摘Background:Reversibility of pulmonary hypertension(PH)is closely related to the treatment options for and prognosis of children with congenital heart disease.Objective:We combined patient-specific clinical features including diagnosis,age and echocardiographic results,and biomarkers of pulmonary vascular dysfunction to explore the noninvasive methods that can be used to accurately evaluate the reversibility of pulmonary hypertension in congenital heart disease(PH-CHD).Methods:Based on the preoperative systolic pulmonary arterial pressure(sPAP),70 CHD patients were divided into normal,PH-CHD suspected,and confirmed groups.Additionally,biomarkers of circulating endothelial cells(CECs),endothelin-1(ET-1),and endothelial nitric oxide synthase(eNOS)were detected.Patients were categorized into reversible(RPH)and irreversible(IRPH)groups according to the sPAP 6 months after surgery.Risk stratification was performed according to the clinical features and biomarkers.Results:CECs and ET-1 levels in the confirmed group were significantly higher.eNOS was higher in the confirmed and suspected groups than that in the normal group.CECs in the IRPH group were significantly higher compared to the RPH group.No such intergroup differences were observed with respect to ET-1 and eNOS levels.The ROC curve showed that the risk stratification was of high diagnostic value to evaluate reversibility.Conclusion:The CECs,eNOS,and ET-1 were closely related with PH-CHD.CECs and risk stratification have high practical value in assessing the reversibility of PH-CHD.
