Non-intrusive methods for eye tracking are important for many applications of vision-based human computer interaction.However,due to the high nonlinearity of eye motion,how to ensure the robustness of external interfe...Non-intrusive methods for eye tracking are important for many applications of vision-based human computer interaction.However,due to the high nonlinearity of eye motion,how to ensure the robustness of external interference and accuracy of eye tracking pose the primary obstacle to the integration of eye movements into today＇s interfaces.In this paper,we present a strong tracking unscented Kalman filter （ST-UKF） algorithm,aiming to overcome the difficulty in nonlinear eye tracking.In the proposed ST-UKF,the Suboptimal fading factor of strong tracking filtering is introduced to improve robustness and accuracy of eye tracking.Compared with the related Kalman filter for eye tracking,the proposed ST-UKF has potential advantages in robustness and tracking accuracy.The last experimental results show the validity of our method for eye tracking under realistic conditions.展开更多
Knowledge of the plasticity of language pathways neurosurgeons to achieve maximum resection wh n patients with low-grade glioma is important for e preserving neurological function. The current study sought to investig...Knowledge of the plasticity of language pathways neurosurgeons to achieve maximum resection wh n patients with low-grade glioma is important for e preserving neurological function. The current study sought to investigate changes in the ventral language pathways in patients with low-grade glioma located in regions likely to affect the dorsal language pathways. The results revealed no significant difference in fractional anisotropy values in the arcuate fasciculus between groups or between hemispheres. However, fractional anisotropy and lateralization index values in the left inferior longitudinal fasciculus and lateralization index values in the left inferior fronto-occpital fasciculus were higher in patients than in healthy subjects. These results indicate plasticity of language pathways in patients with low-grade glioma. The ventral language pathways may perform more functions in patients than in healthy subjects. As such, it is important to protect the ventral language pathways intraoperatively.展开更多
Insular lesions remain surgically challenging because of the need to balance aggressive resection and functional protection. Motor function deficits due to corticospinal tract injury are a common complication of surge...Insular lesions remain surgically challenging because of the need to balance aggressive resection and functional protection. Motor function deficits due to corticospinal tract injury are a common complication of surgery for lesions adjacent to the internal capsule and it is therefore essential to evaluate the corticospinal tract adjacent to the lesion. We used diffusion tensor imaging to evaluate the corticospinal tract in 89 patients with insular lobe lesions who underwent surgery in Chinese PLA General Hospital from February 2009 to May 2011. Postoperative motor function evaluation revealed that 57 patients had no changes in motor function, and 32 patients suffered motor dysfunction or aggravated motor dysfunction. Of the affected patients, 20 recovered motor function during the 6-12-month follow-up, and an additional 12 patients did not recover over more than 12 months of follow-up. Following reconstruction of the corticospinal tract, fractional anisotropy comparison demonstrated that preoperative, intraoperative and follow-up normalized fractional anisotropy in the stable group was higher than in the transient deficits group or the long-term deficits group. Compared with the transient deficits group, intraoperative normalized fractional anisotropy significantly decreased in the long-term deficits group. We conclude that intraoperative fractional anisotropy values of the corticospinal tracts can be used as a prognostic indicator of motor function outcome.展开更多
If a user wants to acquire different network services from various application servers in a traditional single server environment,the user must register these servers separately and remember different usernames and pa...If a user wants to acquire different network services from various application servers in a traditional single server environment,the user must register these servers separately and remember different usernames and passwords for different servers.To solve these problems,a lot of authentication schemes for multi-server environment have been proposed.Recently,Odelu and Das et al.proposed a secure multi-server authentication protocol based on smart card,biometric and elliptic curve cryptography(ECC) .We firstly analyze Odelu et al.'s scheme and find some flaws as follows:1) the scheme may suffer Denial of Service(Dos) attack and insider attack;2) The scheme doesn't have strong robustness because improper work of the register center(RC) may lead to the collapse of the whole system;3) There are some design flaws in this scheme.For example,the user cannot choose his/her identity randomly and the register center needs to maintain a data table.In order to solve these problems,this paper proposes a new secure three-factor authentication protocol for multi-server environment based on Chebyshev chaotic map and secure sketch algorithm.To verify the security of the proposed scheme,we simulate our scheme using BAN logic and Pro Verif tool.Through a thorough analysis,we can see that the proposed schemenot only has stronger security but also has less computation cost than Odelu et al.'s protocol.展开更多
Employing magnetic resonance diffusion tensor imaging, three-dimensional white-matter imaging and conventional magnetic resonance imaging can demonstrate the tumor parenchyma, peritumoral edema and compression on surr...Employing magnetic resonance diffusion tensor imaging, three-dimensional white-matter imaging and conventional magnetic resonance imaging can demonstrate the tumor parenchyma, peritumoral edema and compression on surrounding brain tissue. A color-coded tensor map and three-dimensional tracer diagram were applied to clearly display the optic-radiation location, course and damage. Results showed that the altered anisotropy values of meningioma patients corresponded with optic-radiation shape, size and position on both sides. Experimental findings indicate that the magnetic resonance diffusion tensor imaging technique is a means of tracing and clearly visualizing the optic radiation.展开更多
The spatiotemporal relationships in high-resolution during odontogenesis remain poorly understood.We report a cell lineage and atlas of developing mouse teeth.We performed a large-scale(92,688 cells)single cell RNA se...The spatiotemporal relationships in high-resolution during odontogenesis remain poorly understood.We report a cell lineage and atlas of developing mouse teeth.We performed a large-scale(92,688 cells)single cell RNA sequencing,tracing the cell trajectories during odontogenesis from embryonic days 10.5 to 16.5.Combined with an assay for transposase-accessible chromatin with high-throughput sequencing,our results suggest that mesenchymal cells show the specific transcriptome profiles to distinguish the tooth types.Subsequently,we identified key gene regulatory networks in teeth and bone formation and uncovered spatiotemporal patterns of odontogenic mesenchymal cells.CD24^(+)and Plac8^(+)cells from the mesenchyme at the bell stage were distributed in the upper half and preodontoblast layer of the dental papilla,respectively,which could individually induce nonodontogenic epithelia to form tooth-like structures.Specifically,the Plac8^(+)tissue we discovered is the smallest piece with the most homogenous cells that could induce tooth regeneration to date.Our work reveals previously unknown heterogeneity and spatiotemporal patterns of tooth germs that may lead to tooth regeneration for regenerative dentistry.展开更多
基金supported by the National Natural Science Foundation of China(No.60971104)the Program for New Century Excellent Talents in University of China(No.NCET-05-0794)the Young Teacher Scientific Research Foundation of Southwest Jiaotong University(No.2009Q032)
文摘Non-intrusive methods for eye tracking are important for many applications of vision-based human computer interaction.However,due to the high nonlinearity of eye motion,how to ensure the robustness of external interference and accuracy of eye tracking pose the primary obstacle to the integration of eye movements into today＇s interfaces.In this paper,we present a strong tracking unscented Kalman filter （ST-UKF） algorithm,aiming to overcome the difficulty in nonlinear eye tracking.In the proposed ST-UKF,the Suboptimal fading factor of strong tracking filtering is introduced to improve robustness and accuracy of eye tracking.Compared with the related Kalman filter for eye tracking,the proposed ST-UKF has potential advantages in robustness and tracking accuracy.The last experimental results show the validity of our method for eye tracking under realistic conditions.
基金supported by the National Natural Science Foundation of China, No. 31040039the Natural Science Foundation of Beijing, No. 7102145the Military Clinical High-Tech Foundation, No. 2010gxjso94
文摘Knowledge of the plasticity of language pathways neurosurgeons to achieve maximum resection wh n patients with low-grade glioma is important for e preserving neurological function. The current study sought to investigate changes in the ventral language pathways in patients with low-grade glioma located in regions likely to affect the dorsal language pathways. The results revealed no significant difference in fractional anisotropy values in the arcuate fasciculus between groups or between hemispheres. However, fractional anisotropy and lateralization index values in the left inferior longitudinal fasciculus and lateralization index values in the left inferior fronto-occpital fasciculus were higher in patients than in healthy subjects. These results indicate plasticity of language pathways in patients with low-grade glioma. The ventral language pathways may perform more functions in patients than in healthy subjects. As such, it is important to protect the ventral language pathways intraoperatively.
基金supported by the National Natural Science Foundation of China, No. 30800349the Natural Science Foundation of Beijing, No. 7102145
文摘Insular lesions remain surgically challenging because of the need to balance aggressive resection and functional protection. Motor function deficits due to corticospinal tract injury are a common complication of surgery for lesions adjacent to the internal capsule and it is therefore essential to evaluate the corticospinal tract adjacent to the lesion. We used diffusion tensor imaging to evaluate the corticospinal tract in 89 patients with insular lobe lesions who underwent surgery in Chinese PLA General Hospital from February 2009 to May 2011. Postoperative motor function evaluation revealed that 57 patients had no changes in motor function, and 32 patients suffered motor dysfunction or aggravated motor dysfunction. Of the affected patients, 20 recovered motor function during the 6-12-month follow-up, and an additional 12 patients did not recover over more than 12 months of follow-up. Following reconstruction of the corticospinal tract, fractional anisotropy comparison demonstrated that preoperative, intraoperative and follow-up normalized fractional anisotropy in the stable group was higher than in the transient deficits group or the long-term deficits group. Compared with the transient deficits group, intraoperative normalized fractional anisotropy significantly decreased in the long-term deficits group. We conclude that intraoperative fractional anisotropy values of the corticospinal tracts can be used as a prognostic indicator of motor function outcome.
基金supported by Southwest University for Nationalities Foundation(No.2016NZYQN41)Key Technology Support Program of Sichuan Province(No.2014GZ0006)+1 种基金the Education Department of Sichuan Province(No.15ZB0489)Science and Technology Department in Sichuan province(No.2017JY0230)
文摘If a user wants to acquire different network services from various application servers in a traditional single server environment,the user must register these servers separately and remember different usernames and passwords for different servers.To solve these problems,a lot of authentication schemes for multi-server environment have been proposed.Recently,Odelu and Das et al.proposed a secure multi-server authentication protocol based on smart card,biometric and elliptic curve cryptography(ECC) .We firstly analyze Odelu et al.'s scheme and find some flaws as follows:1) the scheme may suffer Denial of Service(Dos) attack and insider attack;2) The scheme doesn't have strong robustness because improper work of the register center(RC) may lead to the collapse of the whole system;3) There are some design flaws in this scheme.For example,the user cannot choose his/her identity randomly and the register center needs to maintain a data table.In order to solve these problems,this paper proposes a new secure three-factor authentication protocol for multi-server environment based on Chebyshev chaotic map and secure sketch algorithm.To verify the security of the proposed scheme,we simulate our scheme using BAN logic and Pro Verif tool.Through a thorough analysis,we can see that the proposed schemenot only has stronger security but also has less computation cost than Odelu et al.'s protocol.
基金supported by the National Natural Science Foundation of China,No.30800349the Natural Science Foundation of Beijing,No.7102145
文摘Employing magnetic resonance diffusion tensor imaging, three-dimensional white-matter imaging and conventional magnetic resonance imaging can demonstrate the tumor parenchyma, peritumoral edema and compression on surrounding brain tissue. A color-coded tensor map and three-dimensional tracer diagram were applied to clearly display the optic-radiation location, course and damage. Results showed that the altered anisotropy values of meningioma patients corresponded with optic-radiation shape, size and position on both sides. Experimental findings indicate that the magnetic resonance diffusion tensor imaging technique is a means of tracing and clearly visualizing the optic radiation.
基金supported by the National Key Research and Development Program of China Stem Cell and Translational Research,China(2017YFA0104800)the Research Funds from Health@InnoHK Program launched by Innovation Technology Commission of the Hong Kong SAR,China+4 种基金National Natural Science Foundation of China(81570944 and 92068201)Science and Technology Planning Project of Guangdong Province,China(2020B1212060052)High-level Hospital Construction Project(DFJHBF202110)Youth Innovation Promotion of the Chinese Academy of Sciences(2019348)Guangzhou Key Medical Disciplines(2021–2023)。
文摘The spatiotemporal relationships in high-resolution during odontogenesis remain poorly understood.We report a cell lineage and atlas of developing mouse teeth.We performed a large-scale(92,688 cells)single cell RNA sequencing,tracing the cell trajectories during odontogenesis from embryonic days 10.5 to 16.5.Combined with an assay for transposase-accessible chromatin with high-throughput sequencing,our results suggest that mesenchymal cells show the specific transcriptome profiles to distinguish the tooth types.Subsequently,we identified key gene regulatory networks in teeth and bone formation and uncovered spatiotemporal patterns of odontogenic mesenchymal cells.CD24^(+)and Plac8^(+)cells from the mesenchyme at the bell stage were distributed in the upper half and preodontoblast layer of the dental papilla,respectively,which could individually induce nonodontogenic epithelia to form tooth-like structures.Specifically,the Plac8^(+)tissue we discovered is the smallest piece with the most homogenous cells that could induce tooth regeneration to date.Our work reveals previously unknown heterogeneity and spatiotemporal patterns of tooth germs that may lead to tooth regeneration for regenerative dentistry.
