AIM:To evaluate the clinical efficacy of small-diameter acellular porcine corneal stroma(SAPS)for the treatment of peripheral corneal ulceration(PCU).METHODS:This retrospective clinical study included 18 patients(18 e...AIM:To evaluate the clinical efficacy of small-diameter acellular porcine corneal stroma(SAPS)for the treatment of peripheral corneal ulceration(PCU).METHODS:This retrospective clinical study included 18 patients(18 eyes)with PCU between April 2018 and December 2020.All patients had PCU and underwent lamellar keratoplasty with SAPS.Observation indicators included preoperative and postoperative best-corrected visual acuity(BCVA)and transparency of SAPS.The infection control rate in the surgical eye-lesion area was also calculated.RESULTS:Eighteen patients underwent lamellar keratoplasty with SAPS to treat PCU.None of the patients experienced rejection after 6mo(18/18)and 12mo(16/16)of follow-up.The BCVA(0.47±0.30)at the 6mo followup after operation was significantly improved compared with the baseline(0.99±0.80),and the difference was statistically significant(Z=-3.415,P<0.05).The BCVA at the 12mo follow-up after operation was not statistically significant compared to the 6mo(Z=0,P=1).With time,the SAPS graft gradually became transparent.At the 6mo(18/18)and 12mo(16/16)follow-up,none of the patients had recurrent corneal infection.CONCLUSION:SAPS is clinically effective in the treatment of PCU,improving the patient’s BCVA and reducing the incidence of rejection after keratoplasty.展开更多
The picking efficiency of seismic first breaks(FBs)has been greatly accelerated by deep learning(DL)technology.However,the picking accuracy and efficiency of DL methods still face huge challenges in low signal-to-nois...The picking efficiency of seismic first breaks(FBs)has been greatly accelerated by deep learning(DL)technology.However,the picking accuracy and efficiency of DL methods still face huge challenges in low signal-to-noise ratio(SNR)situations.To address this issue,we propose a regression approach to pick FBs based on bidirectional long short-term memory(Bi LSTM)neural network by learning the implicit Eikonal equation of 3D inhomogeneous media with rugged topography in the target region.We employ a regressive model that represents the relationships among the elevation of shots,offset and the elevation of receivers with their seismic traveltime to predict the unknown FBs,from common-shot gathers with sparsely distributed traces.Different from image segmentation methods which automatically extract image features and classify FBs from seismic data,the proposed method can learn the inner relationship between field geometry and FBs.In addition,the predicted results by the regressive model are continuous values of FBs rather than the discrete ones of the binary distribution.The picking results of synthetic data shows that the proposed method has low dependence on label data,and can obtain reliable and similar predicted results using two types of label data with large differences.The picking results of9380 shots for 3D seismic data generated by vibroseis indicate that the proposed method can still accurately predict FBs in low SNR data.The subsequent stacked profiles further illustrate the reliability and effectiveness of the proposed method.The results of model data and field seismic data demonstrate that the proposed regression method is a robust first-break picker with high potential for field application.展开更多
Neurotrophic keratopathy is a persistent defect of the corneal epithelium,with or without stromal ulceration,due to corneal nerve deficiency caused by a variety of etiologies.The treatment options for neurotrophic ker...Neurotrophic keratopathy is a persistent defect of the corneal epithelium,with or without stromal ulceration,due to corneal nerve deficiency caused by a variety of etiologies.The treatment options for neurotrophic keratopathy are limited.In this study,an ophthalmic solution was constructed from a chitosan-based thermosensitive hydrogel with long-term release of murine nerve growth factor(CTH-mNGF).Its effectiveness was evaluated in corneal denervation(CD)mice and patients with neurotrophic keratopathy.In the preclinical setting,CTH-mNGF was assessed in a murine corneal denervation model.CTH-mNGF was transparent,thermosensitive,and ensured sustained release of mNGF for over 20 hours on the ocular surface,maintaining the local mNGF concentration around 1300 pg/mL in vivo.Corneal denervation mice treated with CTH-mNGF for 10 days showed a significant increase in corneal nerve area and total corneal nerve length compared with non-treated and CTH treated mice.A subsequent clinical trial of CTH-mNGF was conducted in patients with stage 2 or 3 neurotrophic keratopathy.Patients received topical CTH-mNGF twice daily for 8 weeks.Fluorescein sodium images,Schirmer’s test,intraocular pressure,Cochet-Bonnet corneal perception test,and best corrected visual acuity were evaluated.In total,six patients(total of seven eyes)diagnosed with neurotrophic keratopathy were enrolled.After 8 weeks of CTH-mNGF treatment,all participants showed a decreased area of corneal epithelial defect,as stained by fluorescence.Overall,six out of seven eyes had fluorescence staining scores<5.Moreover,best corrected visual acuity,intraocular pressure,Schirmer’s test and Cochet-Bonnet corneal perception test results showed no significant improvement.An increase in corneal nerve density was observed by in vivo confocal microscopy after 8 weeks of CTH-mNGF treatment in three out of seven eyes.This study demonstrates that CTH-mNGF is transparent,thermosensitive,and has sustained-release properties.Its effectiveness in healing corneal epithelial defects in all eyes with neurotrophic keratopathy suggests CTH-mNGF has promising application prospects in the treatment of neurotrophic keratopathy,being convenient and cost effective.展开更多
Background The establishment of a robust gut microbiota in piglets during their early developmental stage holds the potential for long-term advantageous effects.However,the optimal timeframe for introducing probiotics...Background The establishment of a robust gut microbiota in piglets during their early developmental stage holds the potential for long-term advantageous effects.However,the optimal timeframe for introducing probiotics to achieve this outcome remains uncertain.Results In the context of this investigation,we conducted a longitudinal assessment of the fecal microbiota of 63 piglets at three distinct pre-weaning time points.Simultaneously,we gathered vaginal and fecal samples from 23 sows.Employing 16S rRNA gene and metagenomic sequencing methodologies,we conducted a comprehensive analysis of the fluctuation patterns in microbial composition,functional capacity,interaction networks,and colonization resistance within the gut microbiota of piglets.As the piglets progressed in age,discernible modifications in intestinal microbial diversity,composition,and function were observed.A source-tracking analysis unveiled the pivotal role of fecal and vaginal microbiota derived from sows in populating the gut microbiota of neonatal piglets.By D21,the microbial interaction network displayed a more concise and efficient configuration,accompanied by enhanced colonization resistance relative to the other two time points.Moreover,we identified three strains of Ruminococcus sp.at D10 as potential candidates for improving piglets’weight gain during the weaning phase.Conclusions The findings of this study propose that D10 represents the most opportune juncture for the introduction of external probiotic interventions during the early stages of piglet development.This investigation augments our comprehension of the microbiota dynamics in early-life of piglets and offers valuable insights for guiding forthcoming probiotic interventions.展开更多
The trajectory of the compact torus(CT)within a tokamak discharge is crucial to fueling.In this study,we developed a penetration model with a vacuum magnetic field region to accurately determine CT trajectories in tok...The trajectory of the compact torus(CT)within a tokamak discharge is crucial to fueling.In this study,we developed a penetration model with a vacuum magnetic field region to accurately determine CT trajectories in tokamak discharges.This model was used to calculate the trajectory and penetration parameters of CT injections by applying both perpendicular and tangential injection schemes in both HL-2A and ITER tokamaks.For perpendicular injection along the tokamak's major radius direction from the outboard,CTs with the same injection parameters exhibited a 0.08 reduction in relative penetration depth when injected into HL-2A and a 0.13reduction when injected into ITER geometry when considering the vacuum magnetic field region compared with cases where this region was not considered.In addition,we proposed an optimization method for determining the CT's initial injection velocity to accurately calculate the initial injection velocity of CTs for central fueling in tokamaks.Furthermore,this paper discusses schemes for the tangential injection of CT into tokamak discharges.The optimal injection angle and CT magnetic moment direction for injection into both HL-2A and ITER were determined through numerical simulations.Finally,the kinetic energy loss occurring when the CT penetrated the vacuum magnetic field region in ITER was reduced byΔEk=975.08 J by optimizing the injection angle for the CT injected into ITER.These results provide valuable insights for optimizing injection angles in fusion experiments.Our model closely represents actual experimental scenarios and can assist the design of CT parameters.展开更多
Intelligent diagnosis driven by big data for mechanical fault is an important means to ensure the safe operation ofequipment. In these methods, deep learning-based machinery fault diagnosis approaches have received in...Intelligent diagnosis driven by big data for mechanical fault is an important means to ensure the safe operation ofequipment. In these methods, deep learning-based machinery fault diagnosis approaches have received increasingattention and achieved some results. It might lead to insufficient performance for using transfer learning alone andcause misclassification of target samples for domain bias when building deep models to learn domain-invariantfeatures. To address the above problems, a deep discriminative adversarial domain adaptation neural networkfor the bearing fault diagnosis model is proposed (DDADAN). In this method, the raw vibration data are firstlyconverted into frequency domain data by Fast Fourier Transform, and an improved deep convolutional neuralnetwork with wide first-layer kernels is used as a feature extractor to extract deep fault features. Then, domaininvariant features are learned from the fault data with correlation alignment-based domain adversarial training.Furthermore, to enhance the discriminative property of features, discriminative feature learning is embeddedinto this network to make the features compact, as well as separable between classes within the class. Finally, theperformance and anti-noise capability of the proposedmethod are evaluated using two sets of bearing fault datasets.The results demonstrate that the proposed method is capable of handling domain offset caused by differentworkingconditions and maintaining more than 97.53% accuracy on various transfer tasks. Furthermore, the proposedmethod can achieve high diagnostic accuracy under varying noise levels.展开更多
BACKGROUND Gastric cancer is a common malignant tumor of the digestive tract,and endosco-pic submucosal dissection(ESD)is the preferred treatment for early-stage gastric cancer.The analysis of the epidemiological char...BACKGROUND Gastric cancer is a common malignant tumor of the digestive tract,and endosco-pic submucosal dissection(ESD)is the preferred treatment for early-stage gastric cancer.The analysis of the epidemiological characteristics of gastric mucosal tumors with different differentiation degrees and the influencing factors of long-term ESD efficacy may have certain significance for revealing the development of gastric cancer and ESD.AIM To analyze the features of gastric mucosal tumors at different differentiation levels,and to explore the prognostic factors of ESD.METHODS We retrospectively studied 301 lesions in 285 patients at The Second Affiliated Hospital of Xi'an Jiaotong University from 2014 to 2021,according to the latest Japanese guidelines(sixth edition),and divided them into low-grade intrae-pithelial neoplasia(LGIN),high-grade intraepithelial neoplasia(HGIN),and computed tomography at 3,6 and 12 months after ESD.We compared clinicopathologic characteristics,ESD efficacy,and complications with different degrees of differentiation,and analyzed the related factors associated with ESD.RESULTS HGIN and differentiated carcinoma patients were significantly older compared with LGIN patients(P<0.001)and accounted for more 0-IIc(P<0.001),atrophic gastritis was common(P<0.001),and irregular microvascular patterns(IMVPs)and demarcation lines(DLs)were more obvious(P<0.001).There was more infiltration in the undifferentiated carcinoma tissue(P<0.001),more abnormal folds and poorer mucosal peristalsis(P<0.001),and more obvious IMVPs,irregular microsurface patterns and DLs(P<0.05)than in the LGIN and HGIN tissues.The disease-free survival rates at 2,5,and 8 years after ESD were 95.0%,90.1%,and 86.9%,respectively.Undifferen-tiated lesions(HR 5.066),white moss(HR 7.187),incomplete resection(HR 3.658),and multiple primary cancers(HR 2.462)were significantly associated with poor prognosis.CONCLUSION Differentiations of gastric mucosal tumors have different epidemiological and endoscopic characteristics,which are closely related to the safety and efficacy of ESD.展开更多
A multi-channel polarimeter-interferometer has been developed on the Keda Torus eXperiment(KTX)for the study of equilibrium dynamics and internal magnetic fluctuations.A three-wave technique based on terahertz solid-s...A multi-channel polarimeter-interferometer has been developed on the Keda Torus eXperiment(KTX)for the study of equilibrium dynamics and internal magnetic fluctuations.A three-wave technique based on terahertz solid-state sources(-650 GHz)is applied for simultaneous measurements of electron density and Faraday rotation angle.The output power of the microwave source is 2 mW.Faraday rotation effect using a rotating wave plate is tested with phase noise less than 0.8°,and the density phase noise is less than 0.9°.Measurement of Faraday rotation angle and density for discharges on KTX have demonstrated high sensitivity to internal MHD activities.展开更多
The booming live-streaming commerce has significantly changed the traditional e-commerce model,thus attracting much attention from both industry and academia.In recent years,an increasing number of scholars have appli...The booming live-streaming commerce has significantly changed the traditional e-commerce model,thus attracting much attention from both industry and academia.In recent years,an increasing number of scholars have applied analytical models to explore live-streaming strategies for firms in different scenarios.However,the previous literature mainly considers monopolists,while in the real world,competition is not rare.To fill this gap between the literature and practical observations,this paper applies a game theoretical model to study live-streaming adoption and pricing strategy for firms under competitive environments.The results show that,for competitive firms,the equilibrium strategy depends on the relation between the commission rate and the intensity of the market expansion effect.Additionally,compared to the case in which no firm adopts live-streaming,competitive firms do not always benefit from the adoption of live-streaming selling.The paper also shows that competition plays a negative role in inducing a firm to adopt live-streaming.展开更多
Immunotherapy and associated immune regulation strategies gained huge attraction in order to be utilized for treatment and prevention of respiratory diseases.Engineering specifically nanomedicines can be used to regul...Immunotherapy and associated immune regulation strategies gained huge attraction in order to be utilized for treatment and prevention of respiratory diseases.Engineering specifically nanomedicines can be used to regulate host immunity in lungs in the case of respiratory diseases including coronavirus disease 2019(COVID-19)infection.COVID-19 causes pulmonary embolisms,thus new therapeutic options are required to target thrombosis,as conventional treatment options are either not effective due to the complexity of the immunethrombosis pathophysiology.In this review,we discuss regulation of immune response in respiratory diseases especially COVID-19.We further discuss thrombosis and provide an overview of some antithrombotic nanoparticles,which can be used to develop nanomedicine against thrombo-inflammation induced by COVID-19 and other respiratory infectious diseases.We also elaborate the importance of immunomodulatory nanomedicines that can block pro-inflammatory signalling pathways,and thus can be recommended to treat respiratory infectious diseases.展开更多
The discourse on developing high-quality productivity marks a significant theoretical innovation,which is conducive to the modernization and sinicization of Marxism.It refines our understanding of“new quality product...The discourse on developing high-quality productivity marks a significant theoretical innovation,which is conducive to the modernization and sinicization of Marxism.It refines our understanding of“new quality productivity,”defining it as an advanced form driven by innovation,embodying“high technology,efficiency,and quality,”with the aim of comprehensively enhancing productivity.It elucidates the necessity of cultivating such forces,asserting that they are crucial for achieving high-quality development,securing a leading position in global technology,and fulfilling the aspirations for a better life.Moreover,it outlines a new implementation route,emphasizing strategies such as fostering technological autonomy,nurturing emerging industries,integrating education and talent in technology,adopting a“build through challenges”approach,adjusting solutions locally,and providing categorized guidance,all of which are based on the ongoing comprehensive reforms.展开更多
Advanced lead-free energy storage ceramics play an indispensable role in next-generation pulse power capacitors market.Here,an ultrahigh energy storage density of~13.8 J cm^(-3)and a large efficiency of~82.4%are achie...Advanced lead-free energy storage ceramics play an indispensable role in next-generation pulse power capacitors market.Here,an ultrahigh energy storage density of~13.8 J cm^(-3)and a large efficiency of~82.4%are achieved in high-entropy lead-free relaxor ferroelectrics by increasing configuration entropy,named high-entropy strategy,realizing nearly ten times growth of energy storage density compared with low-entropy material.Evolution of energy storage performance and domain structure with increasing configuration entropy is systematically revealed for the first time.The achievement of excellent energy storage properties should be attributed to the enhanced random field,decreased nanodomain size,strong multiple local distortions,and improved breakdown field.Furthermore,the excellent frequency and fatigue stability as well as charge/discharge properties with superior thermal stability are also realized.The significantly enhanced comprehensive energy storage performance by increasing configuration entropy demonstrates that high entropy is an effective but convenient strategy to design new high-performance dielectrics,promoting the development of advanced capacitors.展开更多
To ensure safe and economical backfill mining,the mechanical response of the backfill–rock interaction system needs to be understood.The numerical investigation of the mechanical behavior of backfill–rock composite ...To ensure safe and economical backfill mining,the mechanical response of the backfill–rock interaction system needs to be understood.The numerical investigation of the mechanical behavior of backfill–rock composite structure(BRCS)under triaxial compression,which includes deformation,failure patterns,strength characteristics,and acoustic emission(AE)evolution,was proposed.The models used in the tests have one rough interface,two cement–iron tailings ratios(CTRs),four interface angles(IAs),and three confining pressures(CPs).Results showed that the deformation,strength characteristics,and failure patterns of BRCS under triaxial compression depend on IA,CP,and CTR.The stress–strain curves of BRCS under triaxial compression could be divided into five stages,namely,compaction,elasticity,yield,strain softening,and residual stress.The relevant AE counts have corresponding relationships with different stages.The triaxial compressive strengths of composites increase linearly with the increase of the CP.Furthermore,the CP stress strengthening effect occurs.When the IAs are45°and 60°,the failure areas of composites appear in the interface and backfill.When the IAs are 75°and 90°,the failure areas of composites appear in the backfill,interface,and rock.Moreover,the corresponding failure modes yield the combined shear failure.The research results provide the basis for further understanding of the stability of the BRCS.展开更多
Northeast Asian cut-off lows are crucial cyclonic systems that can bring temperature and precipitation extremes over large areas.Skillful subseasonal forecasting of Northeast Asian cut-off lows is of great importance....Northeast Asian cut-off lows are crucial cyclonic systems that can bring temperature and precipitation extremes over large areas.Skillful subseasonal forecasting of Northeast Asian cut-off lows is of great importance.Using two dynamical forecasting systems,one from the Beijing Climate Center(BCC-CSM2-HR)and the other from the Met Office(GloSea5),this study assesses simulation ability and subseasonal prediction skill for early-summer Northeast Asian cut-off lows.Both models are shown to have good ability in representing the spatial structure of cut-off lows,but they underestimate the intensity.The skillful prediction time scales for cut-off low intensity are about 10.2 days for BCC-CSM2-HR and 11.4 days for GloSea5 in advance.Further examination shows that both models can essentially capture the initial Rossby wave train,rapid growth and decay processes responsible for the evolution of cut-off lows,but the models show weaker amplitudes for the three-stage processes.The underestimated simulated strength of both the Eurasian midlatitude and East Asian subtropical jets may lead to the weaker local eddy-mean flow interaction responsible for the cut-off low evolution.展开更多
Monolithic carbon electrodes with robust mechanical integrity and porous architecture are highly desired for capacitive deionization but remain challenging.Owing to the excellent mechanical strength and electroconduct...Monolithic carbon electrodes with robust mechanical integrity and porous architecture are highly desired for capacitive deionization but remain challenging.Owing to the excellent mechanical strength and electroconductivity,commercial carbon fibers cloth demonstrates great potential as high-performance electrodes for ions storage.Despite this,its direct application on capacitive deionization is rarely reported in terms of limited pore structure and natural hydrophobicity.Herein,a powerful metal-organic framework-engaged structural regulation strategy is developed to boost the desalination properties of carbon fibers.The obtained porous carbon fibers features hierarchical porous structure and hydrophilic surface providing abundant ions-accessible sites,and continuous graphitized carbon core ensuring rapid electrons transport.The catalytic-etching mechanism involving oxidation of Co and subsequent carbonthermal reduction is proposed and highly relies on annealing temperature and holding time.When directly evaluated as a current collector-free capacitive deionization electrode,the porous carbon fibers demonstrates much superior desalination capability than pristine carbon fibers,and remarkable cyclic stability up to 20 h with negligible degeneration.Particularly,the PCF-1000 showcases the highest areal salt adsorption capacity of 0.037 mg cm^(−2) among carbon microfibers.Moreover,monolithic porous carbon fibers-carbon nanotubes with increased active sites and good structural integrity by in-situ growth of carbon nanotubes are further fabricated to enhance the desalination performance(0.051 mg cm^(−2)).This work demonstrates the great potential of carbon fibers in constructing high-efficient and robust monolithic electrode for capacitive deionization.展开更多
Based on the updates of the Climate Prediction Center and International Research Institute for Climate and Society(CPC/IRI)and the China Multi-Model Ensemble(CMME)El Niño-Southern Oscillation(ENSO)Outlook issued ...Based on the updates of the Climate Prediction Center and International Research Institute for Climate and Society(CPC/IRI)and the China Multi-Model Ensemble(CMME)El Niño-Southern Oscillation(ENSO)Outlook issued in April 2022,La Niña is favored to continue through the boreal summer and fall,indicating a high possibility of a three-year La Niña(2020-23).It would be the first three-year La Niña since the 1998-2001 event,which is the only observed three-year La Niña event since 1980.By examining the status of air-sea fields over the tropical Pacific in March 2022,it can be seen that while the thermocline depths were near average,the southeasterly wind stress was at its strongest since 1980.Here,based on a quaternary linear regression model that includes various relevant air-sea variables over the equatorial Pacific in March,we argue that the historic southeasterly winds over the equatorial Pacific are favorable for the emergence of the third-year La Niña,and both the anomalous easterly and southerly wind stress components are important and contribute~50%of the third-year La Niña growth,respectively.Additionally,the possible global climate impacts of this event are discussed.展开更多
Sustainable production of H2 through electrochemical water splitting is of great importance in the foreseeable future.Transition-metal metaphosphates(TMMPs)have a three-dimensional(3D)open-framework structure and a hi...Sustainable production of H2 through electrochemical water splitting is of great importance in the foreseeable future.Transition-metal metaphosphates(TMMPs)have a three-dimensional(3D)open-framework structure and a high content of P(which exists as PO3-),and therefore have been recognized as highly efficient catalysts for oxygen evolution reaction(OER)and the bottleneck of electrochemical water splitting.Furthermore,TMMPs can also contribute to hydrogen evolution reaction(HER)in alkaline and neutral media by facilitating water dissociation,and thus,overall water splitting can be achieved using this kind of material.In this timely review,we summarize the recent advances in the synthesis of TMMPs and their applications in OER and HER.We present a brief introduction of the structure and synthetic strategies of TMMPs in the first two parts.Then,we review the latest progress made in research on TMMPs as OER,HER,and overall water-splitting electrocatalysts.In this part,the intrinsic activity of TMMPs as well as the current strategy for improving the catalytic activity will be discussed systematically.Finally,we present the future opportunities and the remaining challenges for the application of TMMPs in the electrocatalysis field.展开更多
Compact torus(CT)injection is a highly promising technique for the central fueling of future reactor-grade fusion devices since it features extremely high injection velocity and relatively high plasma mass.Recently,a ...Compact torus(CT)injection is a highly promising technique for the central fueling of future reactor-grade fusion devices since it features extremely high injection velocity and relatively high plasma mass.Recently,a CT injector for the EAST tokamak,EAST-CTI,was developed and platform-tested.In the first round of experiments conducted with low parameter settings,the maximum velocity and mass of the CT plasma were 150 km·s^(-1)and 90μg,respectively.However,the parameters obtained by EAST-CTI were still very low and were far from the requirements of a device such as EAST that has a strong magnetic field.In future,we plan to solve the spark problem that EAST-CTI currently encounters(that mainly hinders the further development of experiments)through engineering methods,and use greater power to obtain a more stable and suitable CT plasma for EAST.展开更多
Seamless prediction is a weather-climate integrated prediction covering multiple time scales that include days,weeks,months,seasons,years,and decades.Seamless prediction can provide different industries with informati...Seamless prediction is a weather-climate integrated prediction covering multiple time scales that include days,weeks,months,seasons,years,and decades.Seamless prediction can provide different industries with information such as weather conditions and climate variations from the next few days to years,which have important impacts on economic and social development and important reference value for short-,medium-and long-term decision-making and planning of the country.Therefore,seamless prediction has received widespread attention from the international scientific community recently.As Chinese scientists have also carried out relevant research,this paper reviews the research in China on developments and applications of seamless prediction methods and prediction systems in recent years.Among them,the main progress of seamless prediction methods studies is reviewed from four aspects:short-and medium-range weather forecasting,subseasonal-to-seasonal,seasonal-to-interannual,and decadal climate prediction.In terms of development and application of seamless prediction systems,the main achievements made by meteorological operational departments,scientific institutes,and universities in China in recent years are reviewed.Finally,some of the issues in seamless prediction that need further study are discussed.展开更多
基金Key R&D Plan of Shaanxi Province(No.2021SF-331).
文摘AIM:To evaluate the clinical efficacy of small-diameter acellular porcine corneal stroma(SAPS)for the treatment of peripheral corneal ulceration(PCU).METHODS:This retrospective clinical study included 18 patients(18 eyes)with PCU between April 2018 and December 2020.All patients had PCU and underwent lamellar keratoplasty with SAPS.Observation indicators included preoperative and postoperative best-corrected visual acuity(BCVA)and transparency of SAPS.The infection control rate in the surgical eye-lesion area was also calculated.RESULTS:Eighteen patients underwent lamellar keratoplasty with SAPS to treat PCU.None of the patients experienced rejection after 6mo(18/18)and 12mo(16/16)of follow-up.The BCVA(0.47±0.30)at the 6mo followup after operation was significantly improved compared with the baseline(0.99±0.80),and the difference was statistically significant(Z=-3.415,P<0.05).The BCVA at the 12mo follow-up after operation was not statistically significant compared to the 6mo(Z=0,P=1).With time,the SAPS graft gradually became transparent.At the 6mo(18/18)and 12mo(16/16)follow-up,none of the patients had recurrent corneal infection.CONCLUSION:SAPS is clinically effective in the treatment of PCU,improving the patient’s BCVA and reducing the incidence of rejection after keratoplasty.
基金financially supported by the National Key R&D Program of China(2018YFA0702504)the National Natural Science Foundation of China(42174152)+1 种基金the Strategic Cooperation Technology Projects of China National Petroleum Corporation(CNPC)and China University of Petroleum-Beijing(CUPB)(ZLZX2020-03)the R&D Department of China National Petroleum Corporation(2022DQ0604-01)。
文摘The picking efficiency of seismic first breaks(FBs)has been greatly accelerated by deep learning(DL)technology.However,the picking accuracy and efficiency of DL methods still face huge challenges in low signal-to-noise ratio(SNR)situations.To address this issue,we propose a regression approach to pick FBs based on bidirectional long short-term memory(Bi LSTM)neural network by learning the implicit Eikonal equation of 3D inhomogeneous media with rugged topography in the target region.We employ a regressive model that represents the relationships among the elevation of shots,offset and the elevation of receivers with their seismic traveltime to predict the unknown FBs,from common-shot gathers with sparsely distributed traces.Different from image segmentation methods which automatically extract image features and classify FBs from seismic data,the proposed method can learn the inner relationship between field geometry and FBs.In addition,the predicted results by the regressive model are continuous values of FBs rather than the discrete ones of the binary distribution.The picking results of synthetic data shows that the proposed method has low dependence on label data,and can obtain reliable and similar predicted results using two types of label data with large differences.The picking results of9380 shots for 3D seismic data generated by vibroseis indicate that the proposed method can still accurately predict FBs in low SNR data.The subsequent stacked profiles further illustrate the reliability and effectiveness of the proposed method.The results of model data and field seismic data demonstrate that the proposed regression method is a robust first-break picker with high potential for field application.
基金supported by PLA General Hospital Program,No.LB20201A010024(to LW).
文摘Neurotrophic keratopathy is a persistent defect of the corneal epithelium,with or without stromal ulceration,due to corneal nerve deficiency caused by a variety of etiologies.The treatment options for neurotrophic keratopathy are limited.In this study,an ophthalmic solution was constructed from a chitosan-based thermosensitive hydrogel with long-term release of murine nerve growth factor(CTH-mNGF).Its effectiveness was evaluated in corneal denervation(CD)mice and patients with neurotrophic keratopathy.In the preclinical setting,CTH-mNGF was assessed in a murine corneal denervation model.CTH-mNGF was transparent,thermosensitive,and ensured sustained release of mNGF for over 20 hours on the ocular surface,maintaining the local mNGF concentration around 1300 pg/mL in vivo.Corneal denervation mice treated with CTH-mNGF for 10 days showed a significant increase in corneal nerve area and total corneal nerve length compared with non-treated and CTH treated mice.A subsequent clinical trial of CTH-mNGF was conducted in patients with stage 2 or 3 neurotrophic keratopathy.Patients received topical CTH-mNGF twice daily for 8 weeks.Fluorescein sodium images,Schirmer’s test,intraocular pressure,Cochet-Bonnet corneal perception test,and best corrected visual acuity were evaluated.In total,six patients(total of seven eyes)diagnosed with neurotrophic keratopathy were enrolled.After 8 weeks of CTH-mNGF treatment,all participants showed a decreased area of corneal epithelial defect,as stained by fluorescence.Overall,six out of seven eyes had fluorescence staining scores<5.Moreover,best corrected visual acuity,intraocular pressure,Schirmer’s test and Cochet-Bonnet corneal perception test results showed no significant improvement.An increase in corneal nerve density was observed by in vivo confocal microscopy after 8 weeks of CTH-mNGF treatment in three out of seven eyes.This study demonstrates that CTH-mNGF is transparent,thermosensitive,and has sustained-release properties.Its effectiveness in healing corneal epithelial defects in all eyes with neurotrophic keratopathy suggests CTH-mNGF has promising application prospects in the treatment of neurotrophic keratopathy,being convenient and cost effective.
基金supported by a Key Technologies R&D Program of Guangdong Province project(2022B0202090002)a China Postdoctoral Science Foundation(Grant No.2021M701263)+1 种基金a Local Innovative and Research Teams Project of Guangdong Province(2019BT02N630)a Project of Swine Innovation Team in the Guangdong Modern Agricultural Research System(2023KJ126).
文摘Background The establishment of a robust gut microbiota in piglets during their early developmental stage holds the potential for long-term advantageous effects.However,the optimal timeframe for introducing probiotics to achieve this outcome remains uncertain.Results In the context of this investigation,we conducted a longitudinal assessment of the fecal microbiota of 63 piglets at three distinct pre-weaning time points.Simultaneously,we gathered vaginal and fecal samples from 23 sows.Employing 16S rRNA gene and metagenomic sequencing methodologies,we conducted a comprehensive analysis of the fluctuation patterns in microbial composition,functional capacity,interaction networks,and colonization resistance within the gut microbiota of piglets.As the piglets progressed in age,discernible modifications in intestinal microbial diversity,composition,and function were observed.A source-tracking analysis unveiled the pivotal role of fecal and vaginal microbiota derived from sows in populating the gut microbiota of neonatal piglets.By D21,the microbial interaction network displayed a more concise and efficient configuration,accompanied by enhanced colonization resistance relative to the other two time points.Moreover,we identified three strains of Ruminococcus sp.at D10 as potential candidates for improving piglets’weight gain during the weaning phase.Conclusions The findings of this study propose that D10 represents the most opportune juncture for the introduction of external probiotic interventions during the early stages of piglet development.This investigation augments our comprehension of the microbiota dynamics in early-life of piglets and offers valuable insights for guiding forthcoming probiotic interventions.
基金supported by the National Magnetic Confinement Fusion Science Program of China(Nos.2022YFE03100004 and 2022YFE03060003)National Natural Science Foundation of China(Nos.12375226,12175227 and 11875255)the China Postdoctoral Science Foundation(No.2022M723066).
文摘The trajectory of the compact torus(CT)within a tokamak discharge is crucial to fueling.In this study,we developed a penetration model with a vacuum magnetic field region to accurately determine CT trajectories in tokamak discharges.This model was used to calculate the trajectory and penetration parameters of CT injections by applying both perpendicular and tangential injection schemes in both HL-2A and ITER tokamaks.For perpendicular injection along the tokamak's major radius direction from the outboard,CTs with the same injection parameters exhibited a 0.08 reduction in relative penetration depth when injected into HL-2A and a 0.13reduction when injected into ITER geometry when considering the vacuum magnetic field region compared with cases where this region was not considered.In addition,we proposed an optimization method for determining the CT's initial injection velocity to accurately calculate the initial injection velocity of CTs for central fueling in tokamaks.Furthermore,this paper discusses schemes for the tangential injection of CT into tokamak discharges.The optimal injection angle and CT magnetic moment direction for injection into both HL-2A and ITER were determined through numerical simulations.Finally,the kinetic energy loss occurring when the CT penetrated the vacuum magnetic field region in ITER was reduced byΔEk=975.08 J by optimizing the injection angle for the CT injected into ITER.These results provide valuable insights for optimizing injection angles in fusion experiments.Our model closely represents actual experimental scenarios and can assist the design of CT parameters.
基金the Natural Science Foundation of Henan Province(232300420094)the Science and TechnologyResearch Project of Henan Province(222102220092).
文摘Intelligent diagnosis driven by big data for mechanical fault is an important means to ensure the safe operation ofequipment. In these methods, deep learning-based machinery fault diagnosis approaches have received increasingattention and achieved some results. It might lead to insufficient performance for using transfer learning alone andcause misclassification of target samples for domain bias when building deep models to learn domain-invariantfeatures. To address the above problems, a deep discriminative adversarial domain adaptation neural networkfor the bearing fault diagnosis model is proposed (DDADAN). In this method, the raw vibration data are firstlyconverted into frequency domain data by Fast Fourier Transform, and an improved deep convolutional neuralnetwork with wide first-layer kernels is used as a feature extractor to extract deep fault features. Then, domaininvariant features are learned from the fault data with correlation alignment-based domain adversarial training.Furthermore, to enhance the discriminative property of features, discriminative feature learning is embeddedinto this network to make the features compact, as well as separable between classes within the class. Finally, theperformance and anti-noise capability of the proposedmethod are evaluated using two sets of bearing fault datasets.The results demonstrate that the proposed method is capable of handling domain offset caused by differentworkingconditions and maintaining more than 97.53% accuracy on various transfer tasks. Furthermore, the proposedmethod can achieve high diagnostic accuracy under varying noise levels.
基金Supported by Development Program of Shaanxi Province,No.2021SF-221.
文摘BACKGROUND Gastric cancer is a common malignant tumor of the digestive tract,and endosco-pic submucosal dissection(ESD)is the preferred treatment for early-stage gastric cancer.The analysis of the epidemiological characteristics of gastric mucosal tumors with different differentiation degrees and the influencing factors of long-term ESD efficacy may have certain significance for revealing the development of gastric cancer and ESD.AIM To analyze the features of gastric mucosal tumors at different differentiation levels,and to explore the prognostic factors of ESD.METHODS We retrospectively studied 301 lesions in 285 patients at The Second Affiliated Hospital of Xi'an Jiaotong University from 2014 to 2021,according to the latest Japanese guidelines(sixth edition),and divided them into low-grade intrae-pithelial neoplasia(LGIN),high-grade intraepithelial neoplasia(HGIN),and computed tomography at 3,6 and 12 months after ESD.We compared clinicopathologic characteristics,ESD efficacy,and complications with different degrees of differentiation,and analyzed the related factors associated with ESD.RESULTS HGIN and differentiated carcinoma patients were significantly older compared with LGIN patients(P<0.001)and accounted for more 0-IIc(P<0.001),atrophic gastritis was common(P<0.001),and irregular microvascular patterns(IMVPs)and demarcation lines(DLs)were more obvious(P<0.001).There was more infiltration in the undifferentiated carcinoma tissue(P<0.001),more abnormal folds and poorer mucosal peristalsis(P<0.001),and more obvious IMVPs,irregular microsurface patterns and DLs(P<0.05)than in the LGIN and HGIN tissues.The disease-free survival rates at 2,5,and 8 years after ESD were 95.0%,90.1%,and 86.9%,respectively.Undifferen-tiated lesions(HR 5.066),white moss(HR 7.187),incomplete resection(HR 3.658),and multiple primary cancers(HR 2.462)were significantly associated with poor prognosis.CONCLUSION Differentiations of gastric mucosal tumors have different epidemiological and endoscopic characteristics,which are closely related to the safety and efficacy of ESD.
基金supported by National Natural Science Foundation of China(No.12175227)the Fundamental Research Funds for the Central Universities(No.USTC 20210079)the Collaborative Innovation Program of Hefei Science Center,CAS(No.2022HSC-CIP022)。
文摘A multi-channel polarimeter-interferometer has been developed on the Keda Torus eXperiment(KTX)for the study of equilibrium dynamics and internal magnetic fluctuations.A three-wave technique based on terahertz solid-state sources(-650 GHz)is applied for simultaneous measurements of electron density and Faraday rotation angle.The output power of the microwave source is 2 mW.Faraday rotation effect using a rotating wave plate is tested with phase noise less than 0.8°,and the density phase noise is less than 0.9°.Measurement of Faraday rotation angle and density for discharges on KTX have demonstrated high sensitivity to internal MHD activities.
基金supported by the National Natural Science Foundation of China(72171219,72201264,71921001,71801206,71971203)the Fundamental Research Funds for the Central Universities(WK2040000027)+1 种基金the New Liberal Arts Fund of USTC(FSSF-A-230104)the Four Batch Talent Programs of China.
文摘The booming live-streaming commerce has significantly changed the traditional e-commerce model,thus attracting much attention from both industry and academia.In recent years,an increasing number of scholars have applied analytical models to explore live-streaming strategies for firms in different scenarios.However,the previous literature mainly considers monopolists,while in the real world,competition is not rare.To fill this gap between the literature and practical observations,this paper applies a game theoretical model to study live-streaming adoption and pricing strategy for firms under competitive environments.The results show that,for competitive firms,the equilibrium strategy depends on the relation between the commission rate and the intensity of the market expansion effect.Additionally,compared to the case in which no firm adopts live-streaming,competitive firms do not always benefit from the adoption of live-streaming selling.The paper also shows that competition plays a negative role in inducing a firm to adopt live-streaming.
文摘Immunotherapy and associated immune regulation strategies gained huge attraction in order to be utilized for treatment and prevention of respiratory diseases.Engineering specifically nanomedicines can be used to regulate host immunity in lungs in the case of respiratory diseases including coronavirus disease 2019(COVID-19)infection.COVID-19 causes pulmonary embolisms,thus new therapeutic options are required to target thrombosis,as conventional treatment options are either not effective due to the complexity of the immunethrombosis pathophysiology.In this review,we discuss regulation of immune response in respiratory diseases especially COVID-19.We further discuss thrombosis and provide an overview of some antithrombotic nanoparticles,which can be used to develop nanomedicine against thrombo-inflammation induced by COVID-19 and other respiratory infectious diseases.We also elaborate the importance of immunomodulatory nanomedicines that can block pro-inflammatory signalling pathways,and thus can be recommended to treat respiratory infectious diseases.
基金The 2024 Chongqing Education Commission Humanities and Social Sciences Research Ideological and Political Education Special Project“Research on the Inner Logic and Practical Path of Empowering‘Digital Ideological and Political Education’with New Qualitative Productivity”(24SKSZ026)The 2024 Chongqing Education Commission Humanities and Social Sciences Research Ideological and Political Education Special Project“Research on the Value Connotation and Educational Path of‘Labor Innovation Collaboration’in Universities”(24SKSZ027)The 2023 Chongqing University of Posts and Telecommunications Education Reform Research Project“Innovation and Entrepreneurship Education Model Reform and Practice in New Engineering Talent Training:From the Perspective of the Second Classroom”(XJG23224)。
文摘The discourse on developing high-quality productivity marks a significant theoretical innovation,which is conducive to the modernization and sinicization of Marxism.It refines our understanding of“new quality productivity,”defining it as an advanced form driven by innovation,embodying“high technology,efficiency,and quality,”with the aim of comprehensively enhancing productivity.It elucidates the necessity of cultivating such forces,asserting that they are crucial for achieving high-quality development,securing a leading position in global technology,and fulfilling the aspirations for a better life.Moreover,it outlines a new implementation route,emphasizing strategies such as fostering technological autonomy,nurturing emerging industries,integrating education and talent in technology,adopting a“build through challenges”approach,adjusting solutions locally,and providing categorized guidance,all of which are based on the ongoing comprehensive reforms.
基金supported by the National Natural Science Foundation of China(Grant Nos.21825102,22235002,52172181,and 22105017)Key R&D Plan of the Ministry of Science and Technology of China(Grant No.2022YFB3204000)。
文摘Advanced lead-free energy storage ceramics play an indispensable role in next-generation pulse power capacitors market.Here,an ultrahigh energy storage density of~13.8 J cm^(-3)and a large efficiency of~82.4%are achieved in high-entropy lead-free relaxor ferroelectrics by increasing configuration entropy,named high-entropy strategy,realizing nearly ten times growth of energy storage density compared with low-entropy material.Evolution of energy storage performance and domain structure with increasing configuration entropy is systematically revealed for the first time.The achievement of excellent energy storage properties should be attributed to the enhanced random field,decreased nanodomain size,strong multiple local distortions,and improved breakdown field.Furthermore,the excellent frequency and fatigue stability as well as charge/discharge properties with superior thermal stability are also realized.The significantly enhanced comprehensive energy storage performance by increasing configuration entropy demonstrates that high entropy is an effective but convenient strategy to design new high-performance dielectrics,promoting the development of advanced capacitors.
基金financially supported by the National Natural Science Foundation of China(No.51774137)the Natural Science Foundation of Hebei Province,China(No.E2021209006)。
文摘To ensure safe and economical backfill mining,the mechanical response of the backfill–rock interaction system needs to be understood.The numerical investigation of the mechanical behavior of backfill–rock composite structure(BRCS)under triaxial compression,which includes deformation,failure patterns,strength characteristics,and acoustic emission(AE)evolution,was proposed.The models used in the tests have one rough interface,two cement–iron tailings ratios(CTRs),four interface angles(IAs),and three confining pressures(CPs).Results showed that the deformation,strength characteristics,and failure patterns of BRCS under triaxial compression depend on IA,CP,and CTR.The stress–strain curves of BRCS under triaxial compression could be divided into five stages,namely,compaction,elasticity,yield,strain softening,and residual stress.The relevant AE counts have corresponding relationships with different stages.The triaxial compressive strengths of composites increase linearly with the increase of the CP.Furthermore,the CP stress strengthening effect occurs.When the IAs are45°and 60°,the failure areas of composites appear in the interface and backfill.When the IAs are 75°and 90°,the failure areas of composites appear in the backfill,interface,and rock.Moreover,the corresponding failure modes yield the combined shear failure.The research results provide the basis for further understanding of the stability of the BRCS.
基金supported by the National Key Research and Development Program of China(2021YFA0718000)NSF of China under Grant No.42175075the UK-China Research&Innovation Partnership Fund through the Met Office Climate Science for Service Partnership(CSSP)China as part of the Newton Fund.
文摘Northeast Asian cut-off lows are crucial cyclonic systems that can bring temperature and precipitation extremes over large areas.Skillful subseasonal forecasting of Northeast Asian cut-off lows is of great importance.Using two dynamical forecasting systems,one from the Beijing Climate Center(BCC-CSM2-HR)and the other from the Met Office(GloSea5),this study assesses simulation ability and subseasonal prediction skill for early-summer Northeast Asian cut-off lows.Both models are shown to have good ability in representing the spatial structure of cut-off lows,but they underestimate the intensity.The skillful prediction time scales for cut-off low intensity are about 10.2 days for BCC-CSM2-HR and 11.4 days for GloSea5 in advance.Further examination shows that both models can essentially capture the initial Rossby wave train,rapid growth and decay processes responsible for the evolution of cut-off lows,but the models show weaker amplitudes for the three-stage processes.The underestimated simulated strength of both the Eurasian midlatitude and East Asian subtropical jets may lead to the weaker local eddy-mean flow interaction responsible for the cut-off low evolution.
基金We gratefully acknowledge financial supports from the Natural Science Founda-tion of Shandong Province (No.ZR2020QE066)Taishan Scholar Project (No.ts201511080)+1 种基金the fellowship of China Postdoctoral Science Foundation (No.2020M672081)Opening Project of State Key Laboratory of Advanced Tech-nology for Float Glass (No.2020KF08).
文摘Monolithic carbon electrodes with robust mechanical integrity and porous architecture are highly desired for capacitive deionization but remain challenging.Owing to the excellent mechanical strength and electroconductivity,commercial carbon fibers cloth demonstrates great potential as high-performance electrodes for ions storage.Despite this,its direct application on capacitive deionization is rarely reported in terms of limited pore structure and natural hydrophobicity.Herein,a powerful metal-organic framework-engaged structural regulation strategy is developed to boost the desalination properties of carbon fibers.The obtained porous carbon fibers features hierarchical porous structure and hydrophilic surface providing abundant ions-accessible sites,and continuous graphitized carbon core ensuring rapid electrons transport.The catalytic-etching mechanism involving oxidation of Co and subsequent carbonthermal reduction is proposed and highly relies on annealing temperature and holding time.When directly evaluated as a current collector-free capacitive deionization electrode,the porous carbon fibers demonstrates much superior desalination capability than pristine carbon fibers,and remarkable cyclic stability up to 20 h with negligible degeneration.Particularly,the PCF-1000 showcases the highest areal salt adsorption capacity of 0.037 mg cm^(−2) among carbon microfibers.Moreover,monolithic porous carbon fibers-carbon nanotubes with increased active sites and good structural integrity by in-situ growth of carbon nanotubes are further fabricated to enhance the desalination performance(0.051 mg cm^(−2)).This work demonstrates the great potential of carbon fibers in constructing high-efficient and robust monolithic electrode for capacitive deionization.
基金supported by the Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CASGrant No. ZDBS-LY-DQC010)+3 种基金the National Natural Science Foundation of China (Grant Nos. 4187601242175045)the Strategic Priority Research Program of CAS (Grant No. XDB42000000)Guangdong Major Project of Basic and Applied Basic Research (Grant No. 2020B0301030004)
文摘Based on the updates of the Climate Prediction Center and International Research Institute for Climate and Society(CPC/IRI)and the China Multi-Model Ensemble(CMME)El Niño-Southern Oscillation(ENSO)Outlook issued in April 2022,La Niña is favored to continue through the boreal summer and fall,indicating a high possibility of a three-year La Niña(2020-23).It would be the first three-year La Niña since the 1998-2001 event,which is the only observed three-year La Niña event since 1980.By examining the status of air-sea fields over the tropical Pacific in March 2022,it can be seen that while the thermocline depths were near average,the southeasterly wind stress was at its strongest since 1980.Here,based on a quaternary linear regression model that includes various relevant air-sea variables over the equatorial Pacific in March,we argue that the historic southeasterly winds over the equatorial Pacific are favorable for the emergence of the third-year La Niña,and both the anomalous easterly and southerly wind stress components are important and contribute~50%of the third-year La Niña growth,respectively.Additionally,the possible global climate impacts of this event are discussed.
基金the Natural Science Foundation of China(Grant Nos.21871065,22209129,and 22071038)the Heilongjiang Touyan Team(HITTY-20190033)+3 种基金High-Level Innovation and Entrepreneurship(QCYRCXM-2022-123)the Talent Project of Qinchuangyuan and Interdisciplinary Research Foundation of HIT(IR2021205)Professor Li acknowledges the financial support from the“Young Talent Support Plan”of Xi'an Jiaotong University(HG6J024)the“Young Talent Lift Plan”of Xi'an city(095920221352).
文摘Sustainable production of H2 through electrochemical water splitting is of great importance in the foreseeable future.Transition-metal metaphosphates(TMMPs)have a three-dimensional(3D)open-framework structure and a high content of P(which exists as PO3-),and therefore have been recognized as highly efficient catalysts for oxygen evolution reaction(OER)and the bottleneck of electrochemical water splitting.Furthermore,TMMPs can also contribute to hydrogen evolution reaction(HER)in alkaline and neutral media by facilitating water dissociation,and thus,overall water splitting can be achieved using this kind of material.In this timely review,we summarize the recent advances in the synthesis of TMMPs and their applications in OER and HER.We present a brief introduction of the structure and synthetic strategies of TMMPs in the first two parts.Then,we review the latest progress made in research on TMMPs as OER,HER,and overall water-splitting electrocatalysts.In this part,the intrinsic activity of TMMPs as well as the current strategy for improving the catalytic activity will be discussed systematically.Finally,we present the future opportunities and the remaining challenges for the application of TMMPs in the electrocatalysis field.
基金support of the National Key Research and Development Program of China(Nos.2017YFE0300501,2017YFE0300500)Institute of Energy,Hefei Comprehensive National Science Center(Nos.21KZS202,19KZS205)+3 种基金University Synergy Innovation Program of Anhui Province(Nos.GXXT-2021-014,GXXT-2021-029)National Natural Science Foundation of China(No.11905143)the Fundamental Research Funds for the Central Universities of China(No.JZ2022HGTB0302)supported in part by the Users with Excellence Program of Hefei Science Center CAS(No.2020HSC-UE008)。
文摘Compact torus(CT)injection is a highly promising technique for the central fueling of future reactor-grade fusion devices since it features extremely high injection velocity and relatively high plasma mass.Recently,a CT injector for the EAST tokamak,EAST-CTI,was developed and platform-tested.In the first round of experiments conducted with low parameter settings,the maximum velocity and mass of the CT plasma were 150 km·s^(-1)and 90μg,respectively.However,the parameters obtained by EAST-CTI were still very low and were far from the requirements of a device such as EAST that has a strong magnetic field.In future,we plan to solve the spark problem that EAST-CTI currently encounters(that mainly hinders the further development of experiments)through engineering methods,and use greater power to obtain a more stable and suitable CT plasma for EAST.
基金supported by the National Natural Science Foundation of China(Grant Nos.U2242206,42175015,and 41975094)the Basic Research and Operational Special Project of CAMS(Grant No.2021Z007).
文摘Seamless prediction is a weather-climate integrated prediction covering multiple time scales that include days,weeks,months,seasons,years,and decades.Seamless prediction can provide different industries with information such as weather conditions and climate variations from the next few days to years,which have important impacts on economic and social development and important reference value for short-,medium-and long-term decision-making and planning of the country.Therefore,seamless prediction has received widespread attention from the international scientific community recently.As Chinese scientists have also carried out relevant research,this paper reviews the research in China on developments and applications of seamless prediction methods and prediction systems in recent years.Among them,the main progress of seamless prediction methods studies is reviewed from four aspects:short-and medium-range weather forecasting,subseasonal-to-seasonal,seasonal-to-interannual,and decadal climate prediction.In terms of development and application of seamless prediction systems,the main achievements made by meteorological operational departments,scientific institutes,and universities in China in recent years are reviewed.Finally,some of the issues in seamless prediction that need further study are discussed.
