AIM: To compare the safety and effectiveness of phacotrabeculectomy versus sequential surgery in chronic angle-closure glaucoma(CACG) with coexisting cataract.·METHODS: One hundred and sixty-two CACG patients(162...AIM: To compare the safety and effectiveness of phacotrabeculectomy versus sequential surgery in chronic angle-closure glaucoma(CACG) with coexisting cataract.·METHODS: One hundred and sixty-two CACG patients(162 eyes) were retrospectively analyzed. Of them, 87patients(87 eyes) in group A had underwent phacotrabeculectomy with intraocular lens(IOL)implantation, and 75 patients(75 eyes) in group B had underwent sequential surgery with IOL implanted. Best-corrected visual acuity(BCVA), intraocular pressure(IOP), complications and anterior chamber angle(ACA)were measured.· RESULTS: Demographic characteristics of the two groups were similar. A mean follow-up period was 15±6mo(range 13 to 24mo), a mean IOP of 12.14 ±5.32 mm Hg in group A and 11.38 ±4.06 mm Hg in group B(P =0.84) at the last follow up. The Kaplan-Meier analysis revealed that the cumulative probability of success in both groups was similar(P =0.61). Anterior uveitis and hypotony were the most common complications in group A, whereas group B experienced shallow anterior chamber with trabeculectomy. With the exception of anterior uveitis, no complications occurred to 11 trabeculectomized eyes. All postoperative measurements of anterior chamber showed statistically significant differences in each group according to the preoperative data(P <0.05). However,fewer changes occurred in group B than in group A.· CONCLUSION: Phacotrabeculectomy and sequential surgery exhibit similar IOP reduction, visual recovery,and complications when treating CACG patients with cataract. However, for a wider ACA, phacotrabeculectomy has demonstrated higher effectiveness than sequential surgery.展开更多
A novel biosensor based on a myoglobin/gold nanoparticles/carbon spheres(Mb AuNPs CNs)3-D architecture bioconjunction has been fabricated for the determination of hydrogen peroxide(H2O2).Cyclic voltammetry(CV),Fourier...A novel biosensor based on a myoglobin/gold nanoparticles/carbon spheres(Mb AuNPs CNs)3-D architecture bioconjunction has been fabricated for the determination of hydrogen peroxide(H2O2).Cyclic voltammetry(CV),Fourier transform infrared(FT-IR)spectroscopy and scanning electron microscopy(SEM)were used to characterize the bioconjunction of the AuNPs CNs with Mb.Experimental results demonstrate that the AuNPsCNs hybrid material is more effective in facilitating electron transfer of the immobilized enzyme than CNs alone,which can be attributed to the unique nanostructure and larger surface area of the bioconjunction.The biosensor displayed good performance for the detection of H_(2)O_(2)with a wide linear range from 0.28μmol/L to 116.5μmol/L and a detection limit of 0.12μmol/L.The Michaelis-Menten constant KMapp value was estimated to be 0.3 mmol/L.The resulting biosensor exhibited fast amperometric response,and good stability,reproducibility,and selectivity to H_(2)O_(2).展开更多
基金Supported by Projects of State Science and Technology Plans (No. 2009bai79b01-01-02)
文摘AIM: To compare the safety and effectiveness of phacotrabeculectomy versus sequential surgery in chronic angle-closure glaucoma(CACG) with coexisting cataract.·METHODS: One hundred and sixty-two CACG patients(162 eyes) were retrospectively analyzed. Of them, 87patients(87 eyes) in group A had underwent phacotrabeculectomy with intraocular lens(IOL)implantation, and 75 patients(75 eyes) in group B had underwent sequential surgery with IOL implanted. Best-corrected visual acuity(BCVA), intraocular pressure(IOP), complications and anterior chamber angle(ACA)were measured.· RESULTS: Demographic characteristics of the two groups were similar. A mean follow-up period was 15±6mo(range 13 to 24mo), a mean IOP of 12.14 ±5.32 mm Hg in group A and 11.38 ±4.06 mm Hg in group B(P =0.84) at the last follow up. The Kaplan-Meier analysis revealed that the cumulative probability of success in both groups was similar(P =0.61). Anterior uveitis and hypotony were the most common complications in group A, whereas group B experienced shallow anterior chamber with trabeculectomy. With the exception of anterior uveitis, no complications occurred to 11 trabeculectomized eyes. All postoperative measurements of anterior chamber showed statistically significant differences in each group according to the preoperative data(P <0.05). However,fewer changes occurred in group B than in group A.· CONCLUSION: Phacotrabeculectomy and sequential surgery exhibit similar IOP reduction, visual recovery,and complications when treating CACG patients with cataract. However, for a wider ACA, phacotrabeculectomy has demonstrated higher effectiveness than sequential surgery.
基金We greatly appreciate the support of the National Natural Science Foundation of China under the Key Program(20635020)Creative Research Group(20521503)+2 种基金General Program(90606016)This work is also supported by National Basic Research Program of China(2006CB933201)the European Community Sixth Framework Program through a STREP Grant to the SELECTNANO Consortium,Contract No.516922.
文摘A novel biosensor based on a myoglobin/gold nanoparticles/carbon spheres(Mb AuNPs CNs)3-D architecture bioconjunction has been fabricated for the determination of hydrogen peroxide(H2O2).Cyclic voltammetry(CV),Fourier transform infrared(FT-IR)spectroscopy and scanning electron microscopy(SEM)were used to characterize the bioconjunction of the AuNPs CNs with Mb.Experimental results demonstrate that the AuNPsCNs hybrid material is more effective in facilitating electron transfer of the immobilized enzyme than CNs alone,which can be attributed to the unique nanostructure and larger surface area of the bioconjunction.The biosensor displayed good performance for the detection of H_(2)O_(2)with a wide linear range from 0.28μmol/L to 116.5μmol/L and a detection limit of 0.12μmol/L.The Michaelis-Menten constant KMapp value was estimated to be 0.3 mmol/L.The resulting biosensor exhibited fast amperometric response,and good stability,reproducibility,and selectivity to H_(2)O_(2).
