Background:Prolonged sitting and reduced physical activity lead to low energy expenditures.However,little is known about the joint impact of daily sitting time and physical activity on body fat distribution.We investi...Background:Prolonged sitting and reduced physical activity lead to low energy expenditures.However,little is known about the joint impact of daily sitting time and physical activity on body fat distribution.We investigated the independent and joint associations of daily sitting time and physical activity with body fat among adults.Methods:This was a cross-sectional analysis of U.S.nationally representative data from the National Health and Nutrition Examination Survey2011-2018 among adults aged 20 years or older.Daily sitting time and leisure-time physical activity(LTPA)were self-reported using the Global Physical Activity Questionnaire.Body fat(total and trunk fat percentage)was determined via dual X-ray absorptiometry.Results:Among 10,808 adults,about 54.6%spent 6 h/day or more sitting;more than one-half reported no LTPA(inactive)or less than 150 min/week LTPA(insufficiently active)with only 43.3%reported 150 min/week or more LTPA(active)in the past week.After fully adjusting for sociodemographic data,lifestyle behaviors,and chronic conditions,prolonged sitting time and low levels of LTPA were associated with higher total and trunk fat percentages in both sexes.When stratifying by LTPA,the association between daily sitting time and body fat appeared to be stronger in those who were inactive/insuufficiently active.In the joint analyses,inactive/insuufficiently active adults who reported sitting more than 8 h/day had the highest total(female:3.99%(95%confidence interval(95%CI):3.09%-4.88%);male:3.79%(95%CI:2.75%-4.82%))and trunk body fat percentages(female:4.21%(95%CI:3.09%-5.32%);male:4.07%(95%CI:2.95%-5.19%))when compared with those who were active and sitting less than 4 h/day.Conclusion:Prolonged daily sitting time was associated with increased body fat among U.S.adults.The higher body fat associated with 6 h/day sitting may not be offset by achieving recommended levels of physical activity.展开更多
The transformation of aldose to ketose or common sugars into rare saccharides,including rare ketoses and aldoses,is of great value and interest to the food industry and for saccharidic biomass utilization,medicine,and...The transformation of aldose to ketose or common sugars into rare saccharides,including rare ketoses and aldoses,is of great value and interest to the food industry and for saccharidic biomass utilization,medicine,and the synthesis of drugs.Nowadays,high-fructose corn syrup(HFCS)is industrially produced in more than 10 million tons annually using immobilized glucose isomerase.Some low-calorie saccharides such as tagatose and psicose,which are becoming popular sweeteners,have also been produced on a pilot scale in order to replace sucrose and HFCS.However,current catalysts and catalytic processes are still difficult to utilize in biomass conversion and also have strong substrate dependence in producing high-value,rare sugars.Considering the specific reaction properties of saccharides and catalysts,since the pioneering discovery by Fischer,various catalysts and catalytic systems have been discovered or developed in attempts to extend the reaction pathways,improve the reaction efficiency,and to potentially produce commercial products.In this review,we trace the history of sugar isomerization/epimerization reactions and summarize the important breakthroughs for each reaction as well as the difficulties that remain unresolved to date.展开更多
This article uses NCEP 1° × 1° grid point reanalysis data, conventional meteorological observation data, FY2G satellite TBB data, radar combined reflectivity data, ground-encrypted automatic station obs...This article uses NCEP 1° × 1° grid point reanalysis data, conventional meteorological observation data, FY2G satellite TBB data, radar combined reflectivity data, ground-encrypted automatic station observation data, etc., through the synoptic diagnostic analysis method for a comprehensive analysis of a large-scale underreporting of a strong convective weather process under weak water vapor conditions on the 13th April 2017. The results show that the severe convective weather process is affected by the short-wave disturbance in the northwesterly airflow, triggered by the uplift of the westerly trough, the mid-low shear line and the mesoscale front of the boundary layer in the dry northwest. The jet stream is also an important system for the development of this strong convective weather. In the case of weak water vapor and energy conditions, if there is strong dynamic uplift, vertical wind shear and large temperature differences, strong convection can still occur;the convection occurrence area corresponds to the high potential vorticity abnormal area. The movement speed and direction of the cloud cluster are also consistent with the movement of the high potential vorticity anomaly area;the potential vorticity anomaly will cause the cyclonic circulation to increase, and the upward movement will also increase, which is conducive to the development of strong convective weather. According to the position of the dew point front in the β mesoscale, the ground cold pool corresponds to the small value area of the convective cloud cluster TBB. The front of the cold pool is accompanied by a mesoscale ground convergence line, and the uplift is strengthened, which is conducive to the development and forward movement of thunderstorms;the outflow of the cold pool is guided by 700 hPa. When the wind direction is the same, the movement speed will increase, and the stronger the outflow, the faster the movement speed.展开更多
Based on the theories and methods of ecology,landscape architecture and water conservancy,combined with the current status of the ecological environment of Zhuxi River in Chongqing,ecological environment protection,la...Based on the theories and methods of ecology,landscape architecture and water conservancy,combined with the current status of the ecological environment of Zhuxi River in Chongqing,ecological environment protection,landscape space shaping and river culture creation are determined as the core of the design.Based on the design concept of ecological landscape restoration,river ecological protection,waterfront landscape layout,cultural shaping,wetland construction,sponge city construction,etc.are proposed.The design and construction of the Zhuxi River ecological landscape will effectively improve its ecological environment and help to shape a good social and economic environment.This is a useful exploration in the practical application of domestic river ecological landscape design research.展开更多
AIM:To report the clinical characteristics,treatment and outcomes of active syphilitic uveitis in human immunodeficiency virus(HIV)positive patients and compare them with the previously published data.METHODS:Retrospe...AIM:To report the clinical characteristics,treatment and outcomes of active syphilitic uveitis in human immunodeficiency virus(HIV)positive patients and compare them with the previously published data.METHODS:Retrospective analysis of the case series from an infectious disease center in southern China was conducted.Comprehensive review of previously published cases of HIV positive syphilitic uveitis was conducted using the PubMed and Web of Science databases and the references listed in the identified articles.RESULTS:Twelve HIV positive patients with active syphilitic uveitis were collected.All were male,with age of 36.3y(range 27 to 53y).Five(41.7%)had a history of syphilis,and three of them had received anti-syphilis treatment.Ocular manifestations included corneal epithelial defect(13%),complicated cataract(17.4%),vitreous opacity(82.6%),optic disc edema(26.1%),macular edema(30.4%),neuro-retinitis(43.5%),and retinal hemorrhage(26.1%).After standardized syphilitic treatment,intraocular inflammation was reduced and vision improved in all cases.The literature review summarizes 105 previously reported cases of HIV positive syphilitic uveitis.High serum rapid plasma regain(RPR)titers may be associated with severe uveitis and poor vision.Treatment with penicillin,ceftriaxone sodium,or penicillin plus benzylpenicillin instead of using benzylpenicillin alone can significantly improve bestcorrected visual acuity(BCVA)in HIV positive ocular syphilis patients.CONCLUSION:For HIV positive syphilitic uveitis patients,prompt diagnosis and appropriate treatment and follow-up are paramount.In our series,the clinical manifestations are diverse.Syphilis patients treated by penicillin G or long-acting penicillin before may still develop syphilitic uveitis.Patients who relapse after long-term penicillin treatment can still benefit from penicillin G.展开更多
In order to satisfy the growing global demand for lithium, selective extraction of lithium from brine has attracted extensive attention. LiMn_(2)O_(4)-based electrochemical lithium recovery system is one of the best c...In order to satisfy the growing global demand for lithium, selective extraction of lithium from brine has attracted extensive attention. LiMn_(2)O_(4)-based electrochemical lithium recovery system is one of the best choices for commercial applications because of its high selectivity and low energy consumption.However, the low ion diffusion coefficient of lithium manganate limits the further development of electrochemical lithium recovery system. In this work, a novel porous disc-like LiMn_(2)O_(4) was successfully synthesized for the first time via two-step annealing manganese(Ⅱ) precursors. The as-prepared LiMn_(2)O_(4) exhibits porous disc-like morphology, excellent crystallinity, high Li^(+)diffusion coefficient(average 7.6×10^(-9)cm^(2)·s^(-1)), high cycle stability(after 30 uninterrupted extraction and release cycles, the crystal structure hardly changed) and superior rate capacity(93.5% retention from 10-120 mA·g^(-1)). The porous structure and disc-like morphology further promote the contact between lithium ions and electrode materials. Therefore, the assembled electrochemical lithium extraction device with LiMn_(2)O_(4) as positive electrode and silver as negative electrode can realize the rapid and selective extraction of lithium in simulated brine(adsorption capacity of lithium can reach 4.85 mg·g^(-1) in 1 h). The mechanism of disc-like LiMn_(2)O_(4) in electrochemical lithium extraction was proposed based on the analysis of electrochemical characterization and quasi in situ XRD. This novel structure may further promote the practical application of electrochemical lithium extraction from brine.展开更多
Interactions between deoxyribonucleic acid(DNA) and metal ions are vital for maintaining life functions, however,there are still unsolved questions about its mechanisms. It is of great practical significance to study ...Interactions between deoxyribonucleic acid(DNA) and metal ions are vital for maintaining life functions, however,there are still unsolved questions about its mechanisms. It is of great practical significance to study these issues for medical chip design, drug development, health care, etc. In this investigation, the conductivity properties of λ-DNA solutions with mono-/divalent metal ions(Na+, K^(+), Mg^(2+), and Ca^(2+)) are experimentally studied as they are electrically driven through a 5 μm microfluidic channel. Experimental data indicate that the conductivities of λ-DNA solutions with metal ions(M+/M2+) basically tend to reduce firstly and then increase as the voltage increases, of which the turning points varied with the metal ions. When the voltage surpasses turning points, the conductivity of λ-DNA-M+solutions increases with the concentration of metal ions, while that of λ-DNA-M^(2+)solutions decrease. Moreover, the conductivity of λ-DNA-M^(2+)solutions is always smaller than that of λ-DNA-M+solutions, and with high-concentration M^(2+), it is even smaller than that of the λ-DNA solution. The main reasons for the above findings could be attributed to the polarization of electrodes and different mechanisms of interactions between metal ions and λ-DNA molecules. This investigation is helpful for the precise manipulation of single DNA molecules in micro-/nanofluidic space and the design of new biomedical micro-/nanofluidic sensors.展开更多
The degradation of titin could make the myofibrillar fragmentation to improve meat tenderization during postmortem.This study aimed to investigate effect of phosphorylation on titin degradation.Protein kinase A(PKA)an...The degradation of titin could make the myofibrillar fragmentation to improve meat tenderization during postmortem.This study aimed to investigate effect of phosphorylation on titin degradation.Protein kinase A(PKA)and alkaline phosphatase(AP)were added to crude titin extracted from ovine longissimus lumborum(LL)muscles.Phosphorylated/dephosphorylated titin were incubated withμ-calpain at 4℃ for 2 days.Results showed titin in AP group started degradation earlier than that in PKA and control groups.There were 20,16 and 12 phosphorylated sites identified by iTRAQ in the PKA,control and AP group,respectively.3D structure of dephosphorylated titin fragment was simulated and its molecular dynamics trajectory analysis was performed using Discovery StudioTM.The dihedral angle in AP group was less and the dephosphorylated fragment had a higher kinetic energy and total energy.We suggested that changes caused by AP treatment might make titin unstable,which easily degraded byμ-calpain.展开更多
Timbre,as one of the essential elements of sound,plays an important role in determining sound properties,whereas its manipulation has been remaining challenging for passive mechanical systems due to the intrinsic disp...Timbre,as one of the essential elements of sound,plays an important role in determining sound properties,whereas its manipulation has been remaining challenging for passive mechanical systems due to the intrinsic dispersion nature of resonances.Here,we present a meta-silencer supporting intensive mode density as well as highly tunable intrinsic loss and offering a fresh pathway for designable timbre in broadband.Strong global coupling is induced by intensive mode density and delicately modulated with the guidance of the theoretical model,which efficiently suppresses the resonance dispersion and provides desirable frequency-selective wave-manipulation capacity for timbre tuning.As proof-of-concept demonstrations for our design concepts,we propose three meta-silencers with the designing targets of high-efficiency broadband sound attenuation,efficiency-controlled sound attenuation and designable timbre,respectively.The proposed meta-silencers all operate in a broadband frequency range from 500 to 3200 Hz and feature deep-subwavelength sizes around 50 mm.Our work opens up a fundamental avenue to manipulate the timbre with passive resonances-controlled acoustic metamaterials and may inspire the development of novel multifunctional devices in noise-control engineering,impedance engineering,and architectural acoustics.展开更多
In order to improve the quality of undergraduate training and cultivate students innovation ability,more and more colleges and universities are implementing the research mentorship system among undergraduates.The stud...In order to improve the quality of undergraduate training and cultivate students innovation ability,more and more colleges and universities are implementing the research mentorship system among undergraduates.The study summarizes the main role of mentorship on the cultivation of innovation ability,analyzes the problems in the implementation of mentorship,and proposes corresponding solutions.展开更多
The cooperative education mode of academy system and undergraduate tutorial system is an important reform mode for cultivating top-notch innovative talents in colleges and universities.However,there is still room for ...The cooperative education mode of academy system and undergraduate tutorial system is an important reform mode for cultivating top-notch innovative talents in colleges and universities.However,there is still room for improvement in the operation of tutorial system.For example,the lack of synergy in the academy system leads to problems such as insufficient understanding between teachers and students and limited guidance effect.Therefore,this study analyzes the implementation status of tutorial system,and puts forward the corresponding strategies for the existing problems.展开更多
In the distribution center, the way of order picking personnel to pick goods has two kinds: single picking and batch picking. Based on the way of the single picking and assumed warehouse model, in order to reduce the ...In the distribution center, the way of order picking personnel to pick goods has two kinds: single picking and batch picking. Based on the way of the single picking and assumed warehouse model, in order to reduce the walking path of order picking, the order picking problem is transformed into the traveling salesman problem in this paper. Based on backtracking algorithm, the order picking path gets optimized. Finally verifing the optimization method under the environment of VC++6.0, order picking path in the warehouse model get optimized, and compared with the traditional order picking walking paths. The results show that in small and medium-sized warehouse, the optimization method proposed in this paper can reduce order picking walking path and improve the work efficiency as well as reduce the time cost.展开更多
文摘Background:Prolonged sitting and reduced physical activity lead to low energy expenditures.However,little is known about the joint impact of daily sitting time and physical activity on body fat distribution.We investigated the independent and joint associations of daily sitting time and physical activity with body fat among adults.Methods:This was a cross-sectional analysis of U.S.nationally representative data from the National Health and Nutrition Examination Survey2011-2018 among adults aged 20 years or older.Daily sitting time and leisure-time physical activity(LTPA)were self-reported using the Global Physical Activity Questionnaire.Body fat(total and trunk fat percentage)was determined via dual X-ray absorptiometry.Results:Among 10,808 adults,about 54.6%spent 6 h/day or more sitting;more than one-half reported no LTPA(inactive)or less than 150 min/week LTPA(insufficiently active)with only 43.3%reported 150 min/week or more LTPA(active)in the past week.After fully adjusting for sociodemographic data,lifestyle behaviors,and chronic conditions,prolonged sitting time and low levels of LTPA were associated with higher total and trunk fat percentages in both sexes.When stratifying by LTPA,the association between daily sitting time and body fat appeared to be stronger in those who were inactive/insuufficiently active.In the joint analyses,inactive/insuufficiently active adults who reported sitting more than 8 h/day had the highest total(female:3.99%(95%confidence interval(95%CI):3.09%-4.88%);male:3.79%(95%CI:2.75%-4.82%))and trunk body fat percentages(female:4.21%(95%CI:3.09%-5.32%);male:4.07%(95%CI:2.95%-5.19%))when compared with those who were active and sitting less than 4 h/day.Conclusion:Prolonged daily sitting time was associated with increased body fat among U.S.adults.The higher body fat associated with 6 h/day sitting may not be offset by achieving recommended levels of physical activity.
基金Financial support by Dual Initiative Project of Jiangsu Province and Changzhou University is gratefully acknowledgedSample analysis supported by Analysis and Testing Center,NERC Biomass of Changzhou University was also greatly acknowledged.
文摘The transformation of aldose to ketose or common sugars into rare saccharides,including rare ketoses and aldoses,is of great value and interest to the food industry and for saccharidic biomass utilization,medicine,and the synthesis of drugs.Nowadays,high-fructose corn syrup(HFCS)is industrially produced in more than 10 million tons annually using immobilized glucose isomerase.Some low-calorie saccharides such as tagatose and psicose,which are becoming popular sweeteners,have also been produced on a pilot scale in order to replace sucrose and HFCS.However,current catalysts and catalytic processes are still difficult to utilize in biomass conversion and also have strong substrate dependence in producing high-value,rare sugars.Considering the specific reaction properties of saccharides and catalysts,since the pioneering discovery by Fischer,various catalysts and catalytic systems have been discovered or developed in attempts to extend the reaction pathways,improve the reaction efficiency,and to potentially produce commercial products.In this review,we trace the history of sugar isomerization/epimerization reactions and summarize the important breakthroughs for each reaction as well as the difficulties that remain unresolved to date.
文摘This article uses NCEP 1° × 1° grid point reanalysis data, conventional meteorological observation data, FY2G satellite TBB data, radar combined reflectivity data, ground-encrypted automatic station observation data, etc., through the synoptic diagnostic analysis method for a comprehensive analysis of a large-scale underreporting of a strong convective weather process under weak water vapor conditions on the 13th April 2017. The results show that the severe convective weather process is affected by the short-wave disturbance in the northwesterly airflow, triggered by the uplift of the westerly trough, the mid-low shear line and the mesoscale front of the boundary layer in the dry northwest. The jet stream is also an important system for the development of this strong convective weather. In the case of weak water vapor and energy conditions, if there is strong dynamic uplift, vertical wind shear and large temperature differences, strong convection can still occur;the convection occurrence area corresponds to the high potential vorticity abnormal area. The movement speed and direction of the cloud cluster are also consistent with the movement of the high potential vorticity anomaly area;the potential vorticity anomaly will cause the cyclonic circulation to increase, and the upward movement will also increase, which is conducive to the development of strong convective weather. According to the position of the dew point front in the β mesoscale, the ground cold pool corresponds to the small value area of the convective cloud cluster TBB. The front of the cold pool is accompanied by a mesoscale ground convergence line, and the uplift is strengthened, which is conducive to the development and forward movement of thunderstorms;the outflow of the cold pool is guided by 700 hPa. When the wind direction is the same, the movement speed will increase, and the stronger the outflow, the faster the movement speed.
文摘Based on the theories and methods of ecology,landscape architecture and water conservancy,combined with the current status of the ecological environment of Zhuxi River in Chongqing,ecological environment protection,landscape space shaping and river culture creation are determined as the core of the design.Based on the design concept of ecological landscape restoration,river ecological protection,waterfront landscape layout,cultural shaping,wetland construction,sponge city construction,etc.are proposed.The design and construction of the Zhuxi River ecological landscape will effectively improve its ecological environment and help to shape a good social and economic environment.This is a useful exploration in the practical application of domestic river ecological landscape design research.
基金Supported by the“Zhujiang Talent Program”High Talent Project of Guangdong Province(No.2019QN01Y162)the Natural Science Foundation of Guangdong Province(No.2020A1515010072,No.2023A1515010167)。
文摘AIM:To report the clinical characteristics,treatment and outcomes of active syphilitic uveitis in human immunodeficiency virus(HIV)positive patients and compare them with the previously published data.METHODS:Retrospective analysis of the case series from an infectious disease center in southern China was conducted.Comprehensive review of previously published cases of HIV positive syphilitic uveitis was conducted using the PubMed and Web of Science databases and the references listed in the identified articles.RESULTS:Twelve HIV positive patients with active syphilitic uveitis were collected.All were male,with age of 36.3y(range 27 to 53y).Five(41.7%)had a history of syphilis,and three of them had received anti-syphilis treatment.Ocular manifestations included corneal epithelial defect(13%),complicated cataract(17.4%),vitreous opacity(82.6%),optic disc edema(26.1%),macular edema(30.4%),neuro-retinitis(43.5%),and retinal hemorrhage(26.1%).After standardized syphilitic treatment,intraocular inflammation was reduced and vision improved in all cases.The literature review summarizes 105 previously reported cases of HIV positive syphilitic uveitis.High serum rapid plasma regain(RPR)titers may be associated with severe uveitis and poor vision.Treatment with penicillin,ceftriaxone sodium,or penicillin plus benzylpenicillin instead of using benzylpenicillin alone can significantly improve bestcorrected visual acuity(BCVA)in HIV positive ocular syphilis patients.CONCLUSION:For HIV positive syphilitic uveitis patients,prompt diagnosis and appropriate treatment and follow-up are paramount.In our series,the clinical manifestations are diverse.Syphilis patients treated by penicillin G or long-acting penicillin before may still develop syphilitic uveitis.Patients who relapse after long-term penicillin treatment can still benefit from penicillin G.
基金supported by the National Natural Science Foundation of China (21878133, 21908082, 22178154)the Natural Science Foundation of Jiangsu Province (BK20190854)+1 种基金the China Postdoctoral Science Foundation (2020 M671364, 2021 M701472)the Science & Technology Foundation of Zhenjiang (GY2020027)。
文摘In order to satisfy the growing global demand for lithium, selective extraction of lithium from brine has attracted extensive attention. LiMn_(2)O_(4)-based electrochemical lithium recovery system is one of the best choices for commercial applications because of its high selectivity and low energy consumption.However, the low ion diffusion coefficient of lithium manganate limits the further development of electrochemical lithium recovery system. In this work, a novel porous disc-like LiMn_(2)O_(4) was successfully synthesized for the first time via two-step annealing manganese(Ⅱ) precursors. The as-prepared LiMn_(2)O_(4) exhibits porous disc-like morphology, excellent crystallinity, high Li^(+)diffusion coefficient(average 7.6×10^(-9)cm^(2)·s^(-1)), high cycle stability(after 30 uninterrupted extraction and release cycles, the crystal structure hardly changed) and superior rate capacity(93.5% retention from 10-120 mA·g^(-1)). The porous structure and disc-like morphology further promote the contact between lithium ions and electrode materials. Therefore, the assembled electrochemical lithium extraction device with LiMn_(2)O_(4) as positive electrode and silver as negative electrode can realize the rapid and selective extraction of lithium in simulated brine(adsorption capacity of lithium can reach 4.85 mg·g^(-1) in 1 h). The mechanism of disc-like LiMn_(2)O_(4) in electrochemical lithium extraction was proposed based on the analysis of electrochemical characterization and quasi in situ XRD. This novel structure may further promote the practical application of electrochemical lithium extraction from brine.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 62275216 and 61775181)the Innovation Capability Support Program of Shaanxi Province of China (Grant Nos. S2018-ZC-TD-0061 and TZ0393)the National Key Scientific Instrument and Equipment Development Projects of China (Grant No. 51927804)。
文摘Interactions between deoxyribonucleic acid(DNA) and metal ions are vital for maintaining life functions, however,there are still unsolved questions about its mechanisms. It is of great practical significance to study these issues for medical chip design, drug development, health care, etc. In this investigation, the conductivity properties of λ-DNA solutions with mono-/divalent metal ions(Na+, K^(+), Mg^(2+), and Ca^(2+)) are experimentally studied as they are electrically driven through a 5 μm microfluidic channel. Experimental data indicate that the conductivities of λ-DNA solutions with metal ions(M+/M2+) basically tend to reduce firstly and then increase as the voltage increases, of which the turning points varied with the metal ions. When the voltage surpasses turning points, the conductivity of λ-DNA-M+solutions increases with the concentration of metal ions, while that of λ-DNA-M^(2+)solutions decrease. Moreover, the conductivity of λ-DNA-M^(2+)solutions is always smaller than that of λ-DNA-M+solutions, and with high-concentration M^(2+), it is even smaller than that of the λ-DNA solution. The main reasons for the above findings could be attributed to the polarization of electrodes and different mechanisms of interactions between metal ions and λ-DNA molecules. This investigation is helpful for the precise manipulation of single DNA molecules in micro-/nanofluidic space and the design of new biomedical micro-/nanofluidic sensors.
基金financially supported by National Natural Science Foundation(32102035)the Agricultural Science and Technology Innovation Program(CAAS-ASTIP-2020-IFST-03)Central Public-interest Scientific Institution Basal Research(S2019RCJC01,S2020JBKY-16).
文摘The degradation of titin could make the myofibrillar fragmentation to improve meat tenderization during postmortem.This study aimed to investigate effect of phosphorylation on titin degradation.Protein kinase A(PKA)and alkaline phosphatase(AP)were added to crude titin extracted from ovine longissimus lumborum(LL)muscles.Phosphorylated/dephosphorylated titin were incubated withμ-calpain at 4℃ for 2 days.Results showed titin in AP group started degradation earlier than that in PKA and control groups.There were 20,16 and 12 phosphorylated sites identified by iTRAQ in the PKA,control and AP group,respectively.3D structure of dephosphorylated titin fragment was simulated and its molecular dynamics trajectory analysis was performed using Discovery StudioTM.The dihedral angle in AP group was less and the dephosphorylated fragment had a higher kinetic energy and total energy.We suggested that changes caused by AP treatment might make titin unstable,which easily degraded byμ-calpain.
文摘Timbre,as one of the essential elements of sound,plays an important role in determining sound properties,whereas its manipulation has been remaining challenging for passive mechanical systems due to the intrinsic dispersion nature of resonances.Here,we present a meta-silencer supporting intensive mode density as well as highly tunable intrinsic loss and offering a fresh pathway for designable timbre in broadband.Strong global coupling is induced by intensive mode density and delicately modulated with the guidance of the theoretical model,which efficiently suppresses the resonance dispersion and provides desirable frequency-selective wave-manipulation capacity for timbre tuning.As proof-of-concept demonstrations for our design concepts,we propose three meta-silencers with the designing targets of high-efficiency broadband sound attenuation,efficiency-controlled sound attenuation and designable timbre,respectively.The proposed meta-silencers all operate in a broadband frequency range from 500 to 3200 Hz and feature deep-subwavelength sizes around 50 mm.Our work opens up a fundamental avenue to manipulate the timbre with passive resonances-controlled acoustic metamaterials and may inspire the development of novel multifunctional devices in noise-control engineering,impedance engineering,and architectural acoustics.
基金Supported by Hainan University Education Teaching Reform Research Program (hdjy2251)New Agricultural Science Research and Reform Practice Project of the Ministry of Education of China (Exploration and Practice of the Collaborative Cultivation Model of Science and Education Integration for High Quality Talents in Tropical Horticulture).
文摘In order to improve the quality of undergraduate training and cultivate students innovation ability,more and more colleges and universities are implementing the research mentorship system among undergraduates.The study summarizes the main role of mentorship on the cultivation of innovation ability,analyzes the problems in the implementation of mentorship,and proposes corresponding solutions.
基金Supported by Education and Teaching Reform Research Project of Hainan University(HDJY2251)New Agricultural Science Research and Reform Practice Project of the Ministry of Education of China(Exploration and Practice of the Collaborative Cultivation Model of Science and Education Integration for High Quality Talents in Tropical Horticulture).
文摘The cooperative education mode of academy system and undergraduate tutorial system is an important reform mode for cultivating top-notch innovative talents in colleges and universities.However,there is still room for improvement in the operation of tutorial system.For example,the lack of synergy in the academy system leads to problems such as insufficient understanding between teachers and students and limited guidance effect.Therefore,this study analyzes the implementation status of tutorial system,and puts forward the corresponding strategies for the existing problems.
基金Project(P2018-013)supported by the Open Foundation of State Key Laboratory of Materials Processing and Die&Mould Technology,Huazhong University of Science and Technology,China
文摘In the distribution center, the way of order picking personnel to pick goods has two kinds: single picking and batch picking. Based on the way of the single picking and assumed warehouse model, in order to reduce the walking path of order picking, the order picking problem is transformed into the traveling salesman problem in this paper. Based on backtracking algorithm, the order picking path gets optimized. Finally verifing the optimization method under the environment of VC++6.0, order picking path in the warehouse model get optimized, and compared with the traditional order picking walking paths. The results show that in small and medium-sized warehouse, the optimization method proposed in this paper can reduce order picking walking path and improve the work efficiency as well as reduce the time cost.
