3D printing techniques offer an effective method in fabricating complex radially multi-material structures.However,it is challenging for complex and delicate radially multi-material model geometries without supporting...3D printing techniques offer an effective method in fabricating complex radially multi-material structures.However,it is challenging for complex and delicate radially multi-material model geometries without supporting structures,such as tissue vessels and tubular graft,among others.In this work,we tackle these challenges by developing a polar digital light processing technique which uses a rod as the printing platform.The 3D model fabrication is accomplished through line projection.The rotation and translation of the rod are synchronized to project and illuminate the photosensitive material volume.By controlling the distance between the rod and the printing window,we achieved the printing of tubular structures with a minimum wall thickness as thin as 50 micrometers.By controlling the width of fine slits at the printing window,we achieved the printing of structures with a minimum feature size of 10 micrometers.Our process accomplished the fabrication of thin-walled tubular graft structure with a thickness of only 100 micrometers and lengths of several centimeters within a timeframe of just 100 s.Additionally,it enables the printing of axial multi-material structures,thereby achieving adjustable mechanical strength.This method is conducive to rapid customization of tubular grafts and the manufacturing of tubular components in fields such as dentistry,aerospace,and more.展开更多
Invisible orthodontic treatment is an effective form of malocclusion treatment favored in recent years.The magnitude of its orthodontic force has a crucial impact on the outcome of the treatment and has gained a high ...Invisible orthodontic treatment is an effective form of malocclusion treatment favored in recent years.The magnitude of its orthodontic force has a crucial impact on the outcome of the treatment and has gained a high level of clinical interest.However,there are very few explorations of in vivo measurements of orthodontic force,and existing studies are limited to a large number of couplings,which are inconvenient for clinical use.In this work,we developed a wireless flexible measurement system that allows quantitative measurement of the orthodontic force of an invisible aligner on a dental model.The system is wireless,tiny,flexible,fast responding,and has a range suitable for the range of orthodontic forces.We show the difference in the orthodontic force applied to different tooth positions and the difference in the orthodontic force applied to different positions of the same tooth.In addition,the system can evaluate the mechanical differences between aligners of different brands and materials as well as the deviation of fabrication results.This system provides a test tool and evaluation method for future real-time assessment of clinical orthodontic forces.展开更多
Effective disease management based on real-time physiological changes presents a significant clinical challenge.A flexible electrode system integrating diagnosis and treatment can overcome the uncertainties associated...Effective disease management based on real-time physiological changes presents a significant clinical challenge.A flexible electrode system integrating diagnosis and treatment can overcome the uncertainties associated with treatment progress during localized interventions.In this study,we develop a system featuring a biomimetic feedback regulation mechanism for drug delivery and real-time monitoring.To prevent drug leakage,the system incorporates a magnesium(Mg)valve in the outer layer,ensuring zero leakage when drug release is not required.展开更多
With the development and rising of antimicrobial resistance,rapid and effective killings of bacteria are urgently needed,especially for antibiotic-resistant bacteria and bacterial biofilms that are usually hard to be ...With the development and rising of antimicrobial resistance,rapid and effective killings of bacteria are urgently needed,especially for antibiotic-resistant bacteria and bacterial biofilms that are usually hard to be treated with conventional antibiotics.Here,a rapid and broad-spectrum antibacterial strategy is demonstrated through photothermal ablation with MXene and light.Ti3C2 MXenes,when combined with 808 nm light,show significant antibacterial effects in just 20 min.The antibacterial strategy is effective to 15 bacterial species tested,including methicillin-resistant Staphylococcus aureus(MRSA)and vancomycin-resistant Enterococci(VRE).In addition,the rapid antibacterial strategy works for MRSA biofilms,by damaging the structures as well as killing bacteria in biofilms.Furthermore,the investigation of the antibacterial mechanisms shows that Ti3C2 with light kills bacteria mainly physically through inserting/contact and photothermal effect.This work broadens the potential applications of MXene and provides a way to eradicate bacteria and biofilms physically,without the likelihood of resistance development.展开更多
基金supported financially by the Fundamental Research Funds for the Central Universities (YWF-22-K-101,YWF-23-L-805 and YWF-23-YG-QB-006)the support from the National Natural Science Foundation of China (12372106)Fundamental Research Funds for the Central Universities
文摘3D printing techniques offer an effective method in fabricating complex radially multi-material structures.However,it is challenging for complex and delicate radially multi-material model geometries without supporting structures,such as tissue vessels and tubular graft,among others.In this work,we tackle these challenges by developing a polar digital light processing technique which uses a rod as the printing platform.The 3D model fabrication is accomplished through line projection.The rotation and translation of the rod are synchronized to project and illuminate the photosensitive material volume.By controlling the distance between the rod and the printing window,we achieved the printing of tubular structures with a minimum wall thickness as thin as 50 micrometers.By controlling the width of fine slits at the printing window,we achieved the printing of structures with a minimum feature size of 10 micrometers.Our process accomplished the fabrication of thin-walled tubular graft structure with a thickness of only 100 micrometers and lengths of several centimeters within a timeframe of just 100 s.Additionally,it enables the printing of axial multi-material structures,thereby achieving adjustable mechanical strength.This method is conducive to rapid customization of tubular grafts and the manufacturing of tubular components in fields such as dentistry,aerospace,and more.
基金Beijing Natural Science Foundation(L232109)National Natural Science Foundation of China(No.12202274 and No.52171234)+1 种基金Fundamental Research Funds for the Central Universities(YWF-22-K-101)National Key Research and Development Project(Nos.2021YFC2400703 and 2019YFE0101100).
文摘Invisible orthodontic treatment is an effective form of malocclusion treatment favored in recent years.The magnitude of its orthodontic force has a crucial impact on the outcome of the treatment and has gained a high level of clinical interest.However,there are very few explorations of in vivo measurements of orthodontic force,and existing studies are limited to a large number of couplings,which are inconvenient for clinical use.In this work,we developed a wireless flexible measurement system that allows quantitative measurement of the orthodontic force of an invisible aligner on a dental model.The system is wireless,tiny,flexible,fast responding,and has a range suitable for the range of orthodontic forces.We show the difference in the orthodontic force applied to different tooth positions and the difference in the orthodontic force applied to different positions of the same tooth.In addition,the system can evaluate the mechanical differences between aligners of different brands and materials as well as the deviation of fabrication results.This system provides a test tool and evaluation method for future real-time assessment of clinical orthodontic forces.
基金support from the National Natural Science Foundation of China(nos.12272032,82222076,82074463,and 12332019)the Beijing Natural Science Foundation(no.L234020)the 111 Project(no.B13003).
文摘Effective disease management based on real-time physiological changes presents a significant clinical challenge.A flexible electrode system integrating diagnosis and treatment can overcome the uncertainties associated with treatment progress during localized interventions.In this study,we develop a system featuring a biomimetic feedback regulation mechanism for drug delivery and real-time monitoring.To prevent drug leakage,the system incorporates a magnesium(Mg)valve in the outer layer,ensuring zero leakage when drug release is not required.
基金the National Natural Science Foundation of China(81901790 and 21803006)the Natural Science Foundation of Beijing(7204274)+1 种基金the Fundamental Research Funds for the Central Universitiesthe Interdisciplinary Medicine Seed Fund of Peking University(BMU2017MX015)。
文摘With the development and rising of antimicrobial resistance,rapid and effective killings of bacteria are urgently needed,especially for antibiotic-resistant bacteria and bacterial biofilms that are usually hard to be treated with conventional antibiotics.Here,a rapid and broad-spectrum antibacterial strategy is demonstrated through photothermal ablation with MXene and light.Ti3C2 MXenes,when combined with 808 nm light,show significant antibacterial effects in just 20 min.The antibacterial strategy is effective to 15 bacterial species tested,including methicillin-resistant Staphylococcus aureus(MRSA)and vancomycin-resistant Enterococci(VRE).In addition,the rapid antibacterial strategy works for MRSA biofilms,by damaging the structures as well as killing bacteria in biofilms.Furthermore,the investigation of the antibacterial mechanisms shows that Ti3C2 with light kills bacteria mainly physically through inserting/contact and photothermal effect.This work broadens the potential applications of MXene and provides a way to eradicate bacteria and biofilms physically,without the likelihood of resistance development.
