Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form...Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly.展开更多
One of the important issues for geotechnical engineers is the characterization of soil properties such as cohesion and internal friction angle by means of soil testing. A new experimental method of soil characterizati...One of the important issues for geotechnical engineers is the characterization of soil properties such as cohesion and internal friction angle by means of soil testing. A new experimental method of soil characterization based on the surface displacement of strip loaded soils is proposed. The theory to relate the soil deformation/displacement to soil strength properties is presented and compared with a series of conventional soil characterization techniques with direct shear tests. The proposed/developed strip loading tests provide reasonably accurate results compared with traditional direct shear tests. The new strip loading physical simulation and testing devices are helpful for understanding soil strength concepts and also provide an effective bridge connecting with engineering mechanics and foundation engineering courses instructions wherein derivation of bearing capacity theory equations is based on the same MohrCoulomb soil strength parameters. The advantages, limitations, and use of the strip loading modeling/testing technique in engineering education and further more in depth researches are discussed in the concluding remarks part.展开更多
The analyses of PGE characteristics for the Kudi ophiolite, western Kunlun, are reported in this note. The Ir-depleted anomalous ancient upper mantle represented by the Kudi mantle peridotites had been percolated and ...The analyses of PGE characteristics for the Kudi ophiolite, western Kunlun, are reported in this note. The Ir-depleted anomalous ancient upper mantle represented by the Kudi mantle peridotites had been percolated and mixed by remelted oceanic crust material from a supra-subduction zone, leaving the rocks relatively enriched in Pd. The PGE contents in the Kudi cumulate pyroxenites and gabbros vary from 2.4 to 23.94 ng/g, and the highest values are in pyroxenites. The Pd/lr ratios increase from the pyroxenites to the gabbros. The PGE patterns for the Kudi cumulate rocks are steeply positively sloped. The Pd enrichment in these rocks is similar to that in pyroxenites from the Thetford ophiolite and the Troodos ophiolite. The Kudi diabase and basalts have low PGE contents and positively sloped PGE patterns, and are comparable with the upper pillow lava?from the Troodos ophiolite, indicative of the environment of back-arc spreading center in a supra-subduction zone.展开更多
As one of the largest Phanerozoic orogens in the world,the Central Asian Orogenic Belt(CAOB)is a natural laboratory for studies of continental dynamics and metallogenesis.This paper summarizes the research progresses ...As one of the largest Phanerozoic orogens in the world,the Central Asian Orogenic Belt(CAOB)is a natural laboratory for studies of continental dynamics and metallogenesis.This paper summarizes the research progresses of the accretionary processes and metallogenesis of the CAOB since the Peopled Republic of China was founded,and puts forward the prospect for future research.During the early period(1950s-1970s),several geological theories were applied to explain the geological evolution of Central Asia.In the early period of China's reform and opening-up,the plate tectonics theory was applied to explain the evolution of the northern Xinjiang and Xingmeng regions,and the opinion of subduction-collision between Siberian Kazakhstan and China-North Korea-Tarim plates was proposed.The idea of the Solonker-Yanbian suture zone was established.In the 1990s,the study of the CAOB entered a period of rapid development.One school of scholars including geologists from the former Soviet Union proposed a multi-block collision model for the assemblage of the CAOB.In contrast,another school of scholars,led by a Turkish geologist,Celal Sengor,proposed that the Altaids was formed through the growth and strike-slip duplicates of a single island arc,and pointed out that the Altaids is a special type of collisional orogen.During this period,Chinese geologists carried out a lot of pioneering researches on ophiolites and high-pressure metamorphic rocks in northern China,and confirmed the main suture zones accordingly.In 1999,the concept of"Central Asian metallogenic domain"was proposed,and it became one of the three major metallogenic domains in the world.Since the 21st century,given the importance for understanding continental accretion and metallogenic mechanism,the CAOB has become the international academic forefront.China has laid out a series of scientific research projects in Central Asia.A large number of important scientific research achievements have been spawned,including the tectonic attribution of micro-continents,timing and tectonic settings of ophiolites,magmatic arcs,identification and anatomy of accretionary wedges,regional metamorphism-deformation,(ultra)high-pressure metamorphism,ridge subduction plume-plate interaction archipelagic paleogeography and spatio-temporal framework of multiple accretionary orogeny,continental growth accretionary metallogenesis,structural superposition and transformation etc.These achievements have made important international influences.There still exist the following aspects that need further study:(1)Early evolution history and subduction initiation of the Paleo-Asian Ocean;(2)The accretionary mechanism of the extroversion Paleo-Asian Ocean;(3)The properties of the mantle of the Paleo-Asian Ocean and their spatiotemporal distribution;(4)The interaction between the Paleo-Asian Ocean and the Tethys Ocean;(5)Phanerozoic continental growth mechanism and its global comparison;(6)Accretionary metallogenic mechanism of the Central Asian metallogenic domain;and(7)Continental transformation mechanism.展开更多
Geochronological and isotope studies have been carried out for two important plutons in the Central Western Kunlun Belt. U-Pb single grain zircon dating results show that the North Kudi Pluton (404 Ma) was produced ne...Geochronological and isotope studies have been carried out for two important plutons in the Central Western Kunlun Belt. U-Pb single grain zircon dating results show that the North Kudi Pluton (404 Ma) was produced near the end of Caledonian; whereas the previously labeled Hercynian Arkarz Mountain Pluton (215 Ma) is either an Indosinian pluton or a product展开更多
A set of metamorphic suites, previously known as the Precambrian metamorphic basement in Kuda, western Kunlun has been determined as a large nappe ductile shear zone which develops penetrative foliation, oriented stre...A set of metamorphic suites, previously known as the Precambrian metamorphic basement in Kuda, western Kunlun has been determined as a large nappe ductile shear zone which develops penetrative foliation, oriented stretching lineation, various but consistent kinematic indicators of thrusting from north to south. The microstructure and the展开更多
The objective of this study was to coat negatively charged polymer brushes by a covalent bond onto the surface of polyvinylchloride using a simple conventional surface free radical polymerisation technique.The coated ...The objective of this study was to coat negatively charged polymer brushes by a covalent bond onto the surface of polyvinylchloride using a simple conventional surface free radical polymerisation technique.The coated surfaces were assessed with contact angle,protein adsorption,cell adhesion,and bacterial adhesion.Bovine serum albumin and bovine fibrinogen were used for protein adsorption evaluation.Mouse fibroblast(NIH-3T3)cells and Pseudomonas aeruginosa were used to assess surface adhesion.Results show that the surface modified with all the attached polymers exhibited significantly reduced contact angle,protein adsorption,and cell as well as bacterial adhesion among which the negatively charged polymers showed extremely low values in all the tests.The negatively charged polymer shows its contact angle at 5°as compared to 70°for original polyvinylchloride.Its bovine serum albumin,bovine fibrinogen,3T3 adhesion,and P.aeruginosa adhesion were 93%,84%,92%,and 92%lower than the original PVC,respectively.Furthermore,the polyvinylchloride surface coated with negatively charged polymer brushes exhibited a hydrogel-like property.The results indicate that coating a polyvinylchloride surface with acrylic acids using a simple surface-initiated free radical polymerisation and then converting those to negatively charged salts can be an effective and efficient route for fouling-resistant applications.展开更多
基金Indiana University Collaborative Research GrantIndiana Clinical and Translational Sciences Institute,No.NIH UL1TR001108,No.NIH R01 AR069657,No.NIH R01AR060863 and No.NIH R01AG060621
文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly.
文摘One of the important issues for geotechnical engineers is the characterization of soil properties such as cohesion and internal friction angle by means of soil testing. A new experimental method of soil characterization based on the surface displacement of strip loaded soils is proposed. The theory to relate the soil deformation/displacement to soil strength properties is presented and compared with a series of conventional soil characterization techniques with direct shear tests. The proposed/developed strip loading tests provide reasonably accurate results compared with traditional direct shear tests. The new strip loading physical simulation and testing devices are helpful for understanding soil strength concepts and also provide an effective bridge connecting with engineering mechanics and foundation engineering courses instructions wherein derivation of bearing capacity theory equations is based on the same MohrCoulomb soil strength parameters. The advantages, limitations, and use of the strip loading modeling/testing technique in engineering education and further more in depth researches are discussed in the concluding remarks part.
文摘The analyses of PGE characteristics for the Kudi ophiolite, western Kunlun, are reported in this note. The Ir-depleted anomalous ancient upper mantle represented by the Kudi mantle peridotites had been percolated and mixed by remelted oceanic crust material from a supra-subduction zone, leaving the rocks relatively enriched in Pd. The PGE contents in the Kudi cumulate pyroxenites and gabbros vary from 2.4 to 23.94 ng/g, and the highest values are in pyroxenites. The Pd/lr ratios increase from the pyroxenites to the gabbros. The PGE patterns for the Kudi cumulate rocks are steeply positively sloped. The Pd enrichment in these rocks is similar to that in pyroxenites from the Thetford ophiolite and the Troodos ophiolite. The Kudi diabase and basalts have low PGE contents and positively sloped PGE patterns, and are comparable with the upper pillow lava?from the Troodos ophiolite, indicative of the environment of back-arc spreading center in a supra-subduction zone.
基金supported by the National Key R & D Program of China (Grant No. 2017YFC0601201)the National Natural Science Foundation of China (Grant Nos. 41888101, 41730210, 41672219)the IGCP662 Project
文摘As one of the largest Phanerozoic orogens in the world,the Central Asian Orogenic Belt(CAOB)is a natural laboratory for studies of continental dynamics and metallogenesis.This paper summarizes the research progresses of the accretionary processes and metallogenesis of the CAOB since the Peopled Republic of China was founded,and puts forward the prospect for future research.During the early period(1950s-1970s),several geological theories were applied to explain the geological evolution of Central Asia.In the early period of China's reform and opening-up,the plate tectonics theory was applied to explain the evolution of the northern Xinjiang and Xingmeng regions,and the opinion of subduction-collision between Siberian Kazakhstan and China-North Korea-Tarim plates was proposed.The idea of the Solonker-Yanbian suture zone was established.In the 1990s,the study of the CAOB entered a period of rapid development.One school of scholars including geologists from the former Soviet Union proposed a multi-block collision model for the assemblage of the CAOB.In contrast,another school of scholars,led by a Turkish geologist,Celal Sengor,proposed that the Altaids was formed through the growth and strike-slip duplicates of a single island arc,and pointed out that the Altaids is a special type of collisional orogen.During this period,Chinese geologists carried out a lot of pioneering researches on ophiolites and high-pressure metamorphic rocks in northern China,and confirmed the main suture zones accordingly.In 1999,the concept of"Central Asian metallogenic domain"was proposed,and it became one of the three major metallogenic domains in the world.Since the 21st century,given the importance for understanding continental accretion and metallogenic mechanism,the CAOB has become the international academic forefront.China has laid out a series of scientific research projects in Central Asia.A large number of important scientific research achievements have been spawned,including the tectonic attribution of micro-continents,timing and tectonic settings of ophiolites,magmatic arcs,identification and anatomy of accretionary wedges,regional metamorphism-deformation,(ultra)high-pressure metamorphism,ridge subduction plume-plate interaction archipelagic paleogeography and spatio-temporal framework of multiple accretionary orogeny,continental growth accretionary metallogenesis,structural superposition and transformation etc.These achievements have made important international influences.There still exist the following aspects that need further study:(1)Early evolution history and subduction initiation of the Paleo-Asian Ocean;(2)The accretionary mechanism of the extroversion Paleo-Asian Ocean;(3)The properties of the mantle of the Paleo-Asian Ocean and their spatiotemporal distribution;(4)The interaction between the Paleo-Asian Ocean and the Tethys Ocean;(5)Phanerozoic continental growth mechanism and its global comparison;(6)Accretionary metallogenic mechanism of the Central Asian metallogenic domain;and(7)Continental transformation mechanism.
文摘Geochronological and isotope studies have been carried out for two important plutons in the Central Western Kunlun Belt. U-Pb single grain zircon dating results show that the North Kudi Pluton (404 Ma) was produced near the end of Caledonian; whereas the previously labeled Hercynian Arkarz Mountain Pluton (215 Ma) is either an Indosinian pluton or a product
文摘A set of metamorphic suites, previously known as the Precambrian metamorphic basement in Kuda, western Kunlun has been determined as a large nappe ductile shear zone which develops penetrative foliation, oriented stretching lineation, various but consistent kinematic indicators of thrusting from north to south. The microstructure and the
基金IUPUI BBRC Research Centre Support.Mr.Rashed Almousa would like to thank the Deanship of Scientific Research at Majmaah University for supporting this work under Project Number R-2023-788.
文摘The objective of this study was to coat negatively charged polymer brushes by a covalent bond onto the surface of polyvinylchloride using a simple conventional surface free radical polymerisation technique.The coated surfaces were assessed with contact angle,protein adsorption,cell adhesion,and bacterial adhesion.Bovine serum albumin and bovine fibrinogen were used for protein adsorption evaluation.Mouse fibroblast(NIH-3T3)cells and Pseudomonas aeruginosa were used to assess surface adhesion.Results show that the surface modified with all the attached polymers exhibited significantly reduced contact angle,protein adsorption,and cell as well as bacterial adhesion among which the negatively charged polymers showed extremely low values in all the tests.The negatively charged polymer shows its contact angle at 5°as compared to 70°for original polyvinylchloride.Its bovine serum albumin,bovine fibrinogen,3T3 adhesion,and P.aeruginosa adhesion were 93%,84%,92%,and 92%lower than the original PVC,respectively.Furthermore,the polyvinylchloride surface coated with negatively charged polymer brushes exhibited a hydrogel-like property.The results indicate that coating a polyvinylchloride surface with acrylic acids using a simple surface-initiated free radical polymerisation and then converting those to negatively charged salts can be an effective and efficient route for fouling-resistant applications.
