Dioxane-NO2 was employed to oxidize oximes to corresponding aldehydes and ketones in high yield in nonaqueous condition at room temperature. Thr reaction proved to be mild and selective.
Meisoindigotin has been demonstrated as a new type of cancer chemotherapeutic agent.N-^（11）C-meisoindigotin was synthesized by N-^（11）C-methyIation of the isoindigotin precursor with ^（11）C-labelled methyl trifl...Meisoindigotin has been demonstrated as a new type of cancer chemotherapeutic agent.N-^（11）C-meisoindigotin was synthesized by N-^（11）C-methyIation of the isoindigotin precursor with ^（11）C-labelled methyl triflate.The decay corrected radiochemical yields were 15-25%,and the specific radioactivity was 1.0-1.2 Ci/μmol at the end of synthesis.The cellular uptake of[N-^（11）C]-meisoindigotin was evaluated in four different lung cancer cell lines.Our results showed that the A549,GLC-82,95D cell lines exhibited higher uptake than 95C cell line after incubation for 60 min.N-^（11）-meisoindigotin was a promising candidate for further development as a novel PET radiotracer for imaging of cyclin-dependent kinases（CDKs） and GSK-3β.展开更多
基金the National Natural Science Foundation of China and Henan Province Education Committee.
文摘Dioxane-NO2 was employed to oxidize oximes to corresponding aldehydes and ketones in high yield in nonaqueous condition at room temperature. Thr reaction proved to be mild and selective.
基金supported by grants from the National Natural Science Foundation of China(No81071170)
文摘Meisoindigotin has been demonstrated as a new type of cancer chemotherapeutic agent.N-^（11）C-meisoindigotin was synthesized by N-^（11）C-methyIation of the isoindigotin precursor with ^（11）C-labelled methyl triflate.The decay corrected radiochemical yields were 15-25%,and the specific radioactivity was 1.0-1.2 Ci/μmol at the end of synthesis.The cellular uptake of[N-^（11）C]-meisoindigotin was evaluated in four different lung cancer cell lines.Our results showed that the A549,GLC-82,95D cell lines exhibited higher uptake than 95C cell line after incubation for 60 min.N-^（11）-meisoindigotin was a promising candidate for further development as a novel PET radiotracer for imaging of cyclin-dependent kinases（CDKs） and GSK-3β.
