Background:Breast cancer and endometriosis are two significant diseases that threaten the health of female worldwide.The relationship between them is still in a state of controversy.In present study,we identified the ...Background:Breast cancer and endometriosis are two significant diseases that threaten the health of female worldwide.The relationship between them is still in a state of controversy.In present study,we identified the risk of breast cancer in patients with endometriosis through a meta-analysis.Methods:A systematic search of the PubMed,Embase and Cochrane Library,with the terms for endometriosis,breast and cancer,tumor,neoplasm,or carcinoma combined.Studies on related risk estimates of endometriosis and breast cancer were included in the meta-analysis.Furthermore,a series of analytical methods such as sensitivity analysis,the Cochran Q test,Begg’s and Egger’s test were used to analyze the information of collected studies.Results:Finally,a total of 8 studies were included.After statistical analysis based on STATA software,the combined odds ratio of the results was 1.13(95%CI:1.09–1.17).And the results of subgroup analysis showed that the odds ratio values of different outcome indexes were 1.06(95%CI:1.02–1.09,P<0.05),the effective effect estimates were presented in SIR(P=0.006,I^(2)=80.3%).Conclusion:In present study,we identified that patients with endometriosis have an increased risk of breast cancer.It is worth considering that our research was a summary analysis of epidemiological data.More in-depth studies are needed to determine the pathophysiology of this relationship.展开更多
Background:A cluster of pneumonia cases were reported by Wuhan Municipal Health Commission,China in December 2019.A novel coronavirus was eventually identified,and became the COVID-19 epidemic that affected public hea...Background:A cluster of pneumonia cases were reported by Wuhan Municipal Health Commission,China in December 2019.A novel coronavirus was eventually identified,and became the COVID-19 epidemic that affected public health and life.We investigated the psychological status and behavior changes of the general public in China from January 30 to February 3,2020.Methods:Respondents were recruited via social media(WeChat)and completed an online questionnaire.We used the State-Trait Anxiety Inventory,Self-rating Depression Scale,and Symptom Checklist-90 to evaluate psychological status.We also investigated respondents’behavior changes.Quantitative data were analyzed by t-tests or analysis of variance,and classified data were analyzed with chi-square tests.Results:In total,608 valid questionnaires were obtained.More respondents had state anxiety than trait anxiety(15.8%vs 4.0%).Depression was found among 27.1%of respondents and 7.7%had psychological abnormalities.About 10.1%of respondents suffered from phobia.Our analysis of the relationship between subgroup characteristics and psychological status showed that age,gender,knowledge about COVID-19,degree of worry about epidemiological infection,and confidence about overcoming the outbreak significantly influenced psychological status.Around 93.3%of respondents avoided going to public places and almost all respondents reduced Spring Festival-related activities.At least 70.9%of respondents chose to take three or more preventive measures to avoid infection.The three most commonly used prevention measures were making fewer trips outside and avoiding contact(98.0%),wearing a mask(83.7%),and hand hygiene(82.4%).Conclusions:We need to pay more attention to public psychological stress,especially among young people,as they are likely to experience anxiety,depression,and psychological abnormalities.Different psychological interventions could be formulated according to the psychological characteristics of different gender and age groups.The majority of respondents followed specific behaviors required by the authorities,but it will take time to observe the effects of these behaviors on the epidemic.展开更多
Background: There is an urgent need to better understand the novel coronavirus,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),for that the coronavirus disease 2019(COVID-19)continues to cause considerable...Background: There is an urgent need to better understand the novel coronavirus,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),for that the coronavirus disease 2019(COVID-19)continues to cause considerable morbidity and mortality worldwide.This paper was to differentiate COVID-19 from other respiratory infectious diseases such as avian-origin influenza A(H7N9)and influenza A(H1N1)virus infections.Methods:: We included patients who had been hospitalized with laboratory-confirmed infection by SARS-CoV-2(n=83),H7N9(n=36),H1N1(n=44)viruses.Clinical presentation,chest CT features,and progression of patients were compared.We used the Logistic regression model to explore the possible risk factors.Results: Both COVID-19 and H7N9 patients had a longer duration of hospitalization than H1N1 patients(P<0.01),a higher complication rate,and more severe cases than H1N1 patients.H7N9 patients had higher hospitalization-fatality ratio than COVID-19 patients(P=0.01).H7N9 patients had similar patterns of lymphopenia,neutrophilia,elevated alanine aminotransferase,C-reactive protein,lactate dehydrogenase,and those seen in H1N1 patients,which were all significantly different from patients with COVID-19(P<0.01).Either H7N9 or H1N1 patients had more obvious symptoms,like fever,fatigue,yellow sputum,and myalgia than COVID-19 patients(P<0.01).The mean duration of viral shedding was 9.5 days for SARS-CoV-2 vs 9.9 days for H7N9(P=0.78).For severe cases,the meantime from illness onset to severity was 8.0 days for COVID-19 vs 5.2 days for H7N9(P<0.01),the comorbidity of chronic heart disease was more common in the COVID-19 patients than H7N9(P=0.02).Multivariate analysis showed that chronic heart disease was a possible risk factor(OR>1)for COVID-19,compared with H1N1 and H7N9.Conclusions: The proportion of severe cases were higher for H7N9 and SARS-CoV-2 infections,compared with H1N1.The meantime from illness onset to severity was shorter for H7N9.Chronic heart disease was a possible risk factor for COVID-19.The comparison may provide the rationale for strategies of isolation and treatment of infected patients in the future.展开更多
文摘Background:Breast cancer and endometriosis are two significant diseases that threaten the health of female worldwide.The relationship between them is still in a state of controversy.In present study,we identified the risk of breast cancer in patients with endometriosis through a meta-analysis.Methods:A systematic search of the PubMed,Embase and Cochrane Library,with the terms for endometriosis,breast and cancer,tumor,neoplasm,or carcinoma combined.Studies on related risk estimates of endometriosis and breast cancer were included in the meta-analysis.Furthermore,a series of analytical methods such as sensitivity analysis,the Cochran Q test,Begg’s and Egger’s test were used to analyze the information of collected studies.Results:Finally,a total of 8 studies were included.After statistical analysis based on STATA software,the combined odds ratio of the results was 1.13(95%CI:1.09–1.17).And the results of subgroup analysis showed that the odds ratio values of different outcome indexes were 1.06(95%CI:1.02–1.09,P<0.05),the effective effect estimates were presented in SIR(P=0.006,I^(2)=80.3%).Conclusion:In present study,we identified that patients with endometriosis have an increased risk of breast cancer.It is worth considering that our research was a summary analysis of epidemiological data.More in-depth studies are needed to determine the pathophysiology of this relationship.
基金This research was funded by the "Three Major"constructions emergency projects for the new coronavirus prevention and control in 2020 of Sun Yatsen University.
文摘Background:A cluster of pneumonia cases were reported by Wuhan Municipal Health Commission,China in December 2019.A novel coronavirus was eventually identified,and became the COVID-19 epidemic that affected public health and life.We investigated the psychological status and behavior changes of the general public in China from January 30 to February 3,2020.Methods:Respondents were recruited via social media(WeChat)and completed an online questionnaire.We used the State-Trait Anxiety Inventory,Self-rating Depression Scale,and Symptom Checklist-90 to evaluate psychological status.We also investigated respondents’behavior changes.Quantitative data were analyzed by t-tests or analysis of variance,and classified data were analyzed with chi-square tests.Results:In total,608 valid questionnaires were obtained.More respondents had state anxiety than trait anxiety(15.8%vs 4.0%).Depression was found among 27.1%of respondents and 7.7%had psychological abnormalities.About 10.1%of respondents suffered from phobia.Our analysis of the relationship between subgroup characteristics and psychological status showed that age,gender,knowledge about COVID-19,degree of worry about epidemiological infection,and confidence about overcoming the outbreak significantly influenced psychological status.Around 93.3%of respondents avoided going to public places and almost all respondents reduced Spring Festival-related activities.At least 70.9%of respondents chose to take three or more preventive measures to avoid infection.The three most commonly used prevention measures were making fewer trips outside and avoiding contact(98.0%),wearing a mask(83.7%),and hand hygiene(82.4%).Conclusions:We need to pay more attention to public psychological stress,especially among young people,as they are likely to experience anxiety,depression,and psychological abnormalities.Different psychological interventions could be formulated according to the psychological characteristics of different gender and age groups.The majority of respondents followed specific behaviors required by the authorities,but it will take time to observe the effects of these behaviors on the epidemic.
文摘Background: There is an urgent need to better understand the novel coronavirus,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),for that the coronavirus disease 2019(COVID-19)continues to cause considerable morbidity and mortality worldwide.This paper was to differentiate COVID-19 from other respiratory infectious diseases such as avian-origin influenza A(H7N9)and influenza A(H1N1)virus infections.Methods:: We included patients who had been hospitalized with laboratory-confirmed infection by SARS-CoV-2(n=83),H7N9(n=36),H1N1(n=44)viruses.Clinical presentation,chest CT features,and progression of patients were compared.We used the Logistic regression model to explore the possible risk factors.Results: Both COVID-19 and H7N9 patients had a longer duration of hospitalization than H1N1 patients(P<0.01),a higher complication rate,and more severe cases than H1N1 patients.H7N9 patients had higher hospitalization-fatality ratio than COVID-19 patients(P=0.01).H7N9 patients had similar patterns of lymphopenia,neutrophilia,elevated alanine aminotransferase,C-reactive protein,lactate dehydrogenase,and those seen in H1N1 patients,which were all significantly different from patients with COVID-19(P<0.01).Either H7N9 or H1N1 patients had more obvious symptoms,like fever,fatigue,yellow sputum,and myalgia than COVID-19 patients(P<0.01).The mean duration of viral shedding was 9.5 days for SARS-CoV-2 vs 9.9 days for H7N9(P=0.78).For severe cases,the meantime from illness onset to severity was 8.0 days for COVID-19 vs 5.2 days for H7N9(P<0.01),the comorbidity of chronic heart disease was more common in the COVID-19 patients than H7N9(P=0.02).Multivariate analysis showed that chronic heart disease was a possible risk factor(OR>1)for COVID-19,compared with H1N1 and H7N9.Conclusions: The proportion of severe cases were higher for H7N9 and SARS-CoV-2 infections,compared with H1N1.The meantime from illness onset to severity was shorter for H7N9.Chronic heart disease was a possible risk factor for COVID-19.The comparison may provide the rationale for strategies of isolation and treatment of infected patients in the future.
