Nitrogen(N)fertilization affects grain quality in common buckwheat(Fagopyrum esculentum Moench).But the effects of N fertilizer on various buckwheat protein parameters are not fully understood.This study aimed to inve...Nitrogen(N)fertilization affects grain quality in common buckwheat(Fagopyrum esculentum Moench).But the effects of N fertilizer on various buckwheat protein parameters are not fully understood.This study aimed to investigate the synthesis,accumulation,and quality of buckwheat protein under four N application rates in the Loess Plateau,China.Optimal N application(180 kg N ha-1)improved yield,agronomic traits,and N transport and increased protein yield and protein component accumulation.Prolamin and glutelin accumulation first increased and then decreased with increasing N application.The relationships between the contents of protein components and the amount of applied N generally followed quadratic functions.Nitrate reductase and glutamine synthetase activities first increased and then decreased with increasing N levels.Optimal N fertilizer increased the waterholding capacity and thermal stability of buckwheat protein and reduced its emulsification capacity,but negligibly changed its oil-absorption capacity.Hydrophobic amino acids and glutelin content were the main factors affecting protein quality.展开更多
In this paper, we study transmission of packets with time constraints in cooperative 5G wireless networks. As we know, the packets which are transmitted with large delay become useless and have to be dropped. In order...In this paper, we study transmission of packets with time constraints in cooperative 5G wireless networks. As we know, the packets which are transmitted with large delay become useless and have to be dropped. In order to minimize packet dropping probability, we consider multiple transmission methods and integrate packet scheduling with adaptive network coding method selection. Firstly we introduce queue length to obtain the gain of network. Based on this, we present the dynamic coding-aware routing metric, which can increase potential coding opportunities. Moreover, we propose a distributed packet-aware transmission routing scheme based on the above routing metric, which can discover the available paths timely and efficiently. Simulation results show that the proposed method can reduce average packet dropping probability with lower computational complexity.展开更多
This paper is concerned with the problem of robust stability analysis for networked control systems （NCSs）. A new NCS model is proposed under consideration of both the network-induced delay and parameter uncertainti...This paper is concerned with the problem of robust stability analysis for networked control systems （NCSs）. A new NCS model is proposed under consideration of both the network-induced delay and parameter uncertainties. The parameter uncertainties appearing in NCSs are norm-bounded, and possibly time-varying. The conventional method and the descriptor system method are used to obtain maximum allowable delay bound （MADB） guaranteeing robust stability and stability of the NCSs, respectively, where the stability criteria are formulated in terms of linear matrix inequalities （LMIs）. And the MADB can be derived by solving the feasibility problem of the corresponding LMI. Some numerical examples are provided to illustrate the effectiveness of the proposed method.展开更多
The problem of robust stabilization for a class of uncertain networked control systems （NCSs） with nonlinearities satisfying a given sector condition is investigated in this paper. By introducing a new model of NCSs...The problem of robust stabilization for a class of uncertain networked control systems （NCSs） with nonlinearities satisfying a given sector condition is investigated in this paper. By introducing a new model of NCSs with parameter uncertainty, network-induced delay, nonlinearity and data packet dropout in the transmission, a strict linear matrix inequality （LMI） criterion is proposed for robust stabilization of the uncertain nonlinear NCSs based on the Lyapunov stability theory. The maximum allowable transfer interval （MATI） can be derived by solving the feasibility problem of the corresponding LMI. Some numerical examples are provided to demonstrate the applicability of the proposed algorithm.展开更多
The robust D stabilization problem is considered for singular systems with polytopic uncertainties in this paper.Both the derivative matrix E and the state matrix A are with uncertainties,which were not considered bef...The robust D stabilization problem is considered for singular systems with polytopic uncertainties in this paper.Both the derivative matrix E and the state matrix A are with uncertainties,which were not considered before.First,with the introduction of some free matrices,a necessary and sufficient condition for the singular system to be D stable is proposed,based on which,the robust D stable problem is solved,and a sufficient condition for the closed system to be robust D stabilizable is obtained.The desired state feedback controller is given in an explicit expression.Numerical examples show the efficiency of the proposed approach.展开更多
This paper has numerically studied the dynamical behaviors of a fractional-order single-machine infinite-bus (FOSMIB) power system. Periodic motions, period- doubling bifurcations and chaotic attractors are observed i...This paper has numerically studied the dynamical behaviors of a fractional-order single-machine infinite-bus (FOSMIB) power system. Periodic motions, period- doubling bifurcations and chaotic attractors are observed in the FOSMIB power system. The existence of chaotic behavior is affirmed by the positive largest Lyapunov exponent (LLE). Based on the fractional-order backstepping method, an adaptive controller is proposed to suppress chaos in the FOSMIB power system. Numerical simulation results demonstrate the validity of the proposed controller.展开更多
Activation of the local renin-angiotensin system(RAS)promotes cardiomyocyte apoptosis and cardiac remodeling after acute myocardial infarction(AMI).As an anti-RAS drug,the effect of Valsartan in the early stage of acu...Activation of the local renin-angiotensin system(RAS)promotes cardiomyocyte apoptosis and cardiac remodeling after acute myocardial infarction(AMI).As an anti-RAS drug,the effect of Valsartan in the early stage of acute MI is limited by its low drug concentration in the heart and low dosage.Here,by exploiting the inherent nature of neutrophils migrating to the injured myocardium and the local low-pH microenvironment caused by ischemia and hypoxia after myocardial infarction,we designed nanocarrier(NSLP)-hybridized neutrophil membranes and pH-sensitive liposomes(SLPs)for the delivery of Valsartan(NSLPVal).These functional nanocarriers could mimic neutrophils and are homed to the injured heart;they were also found to respond to a low-pH microenvironment.In the mouse model of MI,we found that NSLP-Val could target the infarct marginal zone and release Valsartan locally in the low-pH microenvironment without affecting hemodynamic stability.Further,locally released angiotensin receptor inhibitors reduced the infarct size and inflammatory response by inhibiting cardiomyocytes.Ultimately,NSLP-Val improved cardiac function and inhibited cardiac hypertrophy and fibrosis.展开更多
Myocardial ischemia-reperfusion (MI/R) injury is common in patients who undergo revascularization therapy for myocardial infarction, often leading to cardiac dysfunction. Carbon monoxide (CO) has emerged as a therapeu...Myocardial ischemia-reperfusion (MI/R) injury is common in patients who undergo revascularization therapy for myocardial infarction, often leading to cardiac dysfunction. Carbon monoxide (CO) has emerged as a therapeutic molecule due to its beneficial properties such as anti-inflammatory, anti-apoptotic, and mitochondrial biogenesis-promoting properties. However, its clinical application is limited due to uncontrolled release, potential toxicity, and poor targeting efficiency. To address these limitations, a peroxynitrite (ONOO )-triggered CO donor (PCOD585) is utilized to generate a poly (lactic-co-glycolic acid) (PLGA)-based, biomimetic CO nanogenerator (M/PCOD@PLGA) that is coated with the macrophage membrane, which could target to the ischemic area and neutralize proinflammatory cytokines. In the ischemic area, local produced ONOO triggers the continuous release of CO from M/PCOD@PLGA, which efficiently ameliorates MI/R injury by clearing harmful ONOO , attenuating the inflammatory response, inhibiting cardiomyocyte apoptosis, and promoting mitochondrial biogenesis. This study provides a novel insight into the safe therapeutic use of CO for MI/R injury by utilizing a novel CO donor combined with biomimetic technology. The M/PCOD@PLGA nanogenerator offers targeted delivery of CO to the ischemic area, minimizing potential toxicity and enhancing therapeutic efficacy.展开更多
The promise of regeneration therapy for restoration of damaged myocardium after cardiac ischemic injury relies on targeted delivery of proliferative molecules into cardiomyocytes whose healing benefits are still limit...The promise of regeneration therapy for restoration of damaged myocardium after cardiac ischemic injury relies on targeted delivery of proliferative molecules into cardiomyocytes whose healing benefits are still limited owing to severe immune microenvironment due to local high concentration of proinflammatory cytokines.Optimal therapeutic strategies are therefore in urgent need to both modulate local immunity and deliver proliferative molecules.Here,we addressed this unmet need by developing neutrophil-mimic nanoparticles NM@miR,fabricated by coating hybrid neutrophil membranes with artificial lipids onto mesoporous silica nanoparticles(MSNs)loaded with microRNA-10b.The hybrid membrane could endow nanoparticles with strong capacity to migrate into infammatory sites and neutralize proinfammatory cytokines and increase the delivery efficiency of microRNA-1Ob into adult mammalian cardiomyocytes(CMs)by fusing with cell membranes and leading to the release of MSNs-miR into cytosol.Upon NM@miR administration,this nanoparticle could home to the injured myocardium,restore the local immunity,and efficiently deliver microRNA-1Ob to cardiomyocytes,which could reduce the activation of Hippo-YAP pathway mediated by excessive cytokines and exert the best proliferative effect of miR-1Ob.This combination therapy could finally improve cardiac function and mitigate ventricular remodeling.Consequently,this work offers a combination strategy of immunity modulation and proliferative molecule delivery to boost cardiac regeneration after injury.展开更多
This paper concerns the stability analysis problem of discrete linear systems with state saturation using a saturation-dependent Lyapunov functional. We introduce a free matrix characterized by the sum of the absolute...This paper concerns the stability analysis problem of discrete linear systems with state saturation using a saturation-dependent Lyapunov functional. We introduce a free matrix characterized by the sum of the absolute value of each elements for each row less than 1, which makes the state with saturation constraint reside in a convex polyhedron. A saturation-dependent Lyapunov functional is then designed to obtain a sufficient condition for such systems to be globally asymptotically stable. Based on this stability criterion, the state feedback control law synthesis problem is also studied. The obtained results are formulated in terms of bilinear matrix inequalities that can be solved by the presented iterative linear matrix ineoualitv algorithm. Two numerical examoles are used to demonstrate the effectiveness of the nronosed method_展开更多
基金supported by the National Key Research and Development Program of China(2020YFD1000805-03)National Natural Science Foundation of China(31671631)。
文摘Nitrogen(N)fertilization affects grain quality in common buckwheat(Fagopyrum esculentum Moench).But the effects of N fertilizer on various buckwheat protein parameters are not fully understood.This study aimed to investigate the synthesis,accumulation,and quality of buckwheat protein under four N application rates in the Loess Plateau,China.Optimal N application(180 kg N ha-1)improved yield,agronomic traits,and N transport and increased protein yield and protein component accumulation.Prolamin and glutelin accumulation first increased and then decreased with increasing N application.The relationships between the contents of protein components and the amount of applied N generally followed quadratic functions.Nitrate reductase and glutamine synthetase activities first increased and then decreased with increasing N levels.Optimal N fertilizer increased the waterholding capacity and thermal stability of buckwheat protein and reduced its emulsification capacity,but negligibly changed its oil-absorption capacity.Hydrophobic amino acids and glutelin content were the main factors affecting protein quality.
基金supported by National Nature Science Foundation of China (61302071, 61501105, 91438110)the Fundamental Research Funds for the Central Universities (N150404015, N150404018)
文摘In this paper, we study transmission of packets with time constraints in cooperative 5G wireless networks. As we know, the packets which are transmitted with large delay become useless and have to be dropped. In order to minimize packet dropping probability, we consider multiple transmission methods and integrate packet scheduling with adaptive network coding method selection. Firstly we introduce queue length to obtain the gain of network. Based on this, we present the dynamic coding-aware routing metric, which can increase potential coding opportunities. Moreover, we propose a distributed packet-aware transmission routing scheme based on the above routing metric, which can discover the available paths timely and efficiently. Simulation results show that the proposed method can reduce average packet dropping probability with lower computational complexity.
基金supported by the National Natural Science Foundation of China (No.60721062)863 Program of China (No.2006AA04Z182)+1 种基金Department of Science and Technology Project of Zhejiang Province (No.2006C31016)Science Foundation of Zhejiang SciTech University(No.0803817-Y)
文摘This paper is concerned with the problem of robust stability analysis for networked control systems （NCSs）. A new NCS model is proposed under consideration of both the network-induced delay and parameter uncertainties. The parameter uncertainties appearing in NCSs are norm-bounded, and possibly time-varying. The conventional method and the descriptor system method are used to obtain maximum allowable delay bound （MADB） guaranteeing robust stability and stability of the NCSs, respectively, where the stability criteria are formulated in terms of linear matrix inequalities （LMIs）. And the MADB can be derived by solving the feasibility problem of the corresponding LMI. Some numerical examples are provided to illustrate the effectiveness of the proposed method.
基金the National Natural Science Foundation of China (No.60421002)the National High Technology Research and Development Program of China under grant 863 Program (2006AA04 Z182).
文摘The problem of robust stabilization for a class of uncertain networked control systems （NCSs） with nonlinearities satisfying a given sector condition is investigated in this paper. By introducing a new model of NCSs with parameter uncertainty, network-induced delay, nonlinearity and data packet dropout in the transmission, a strict linear matrix inequality （LMI） criterion is proposed for robust stabilization of the uncertain nonlinear NCSs based on the Lyapunov stability theory. The maximum allowable transfer interval （MATI） can be derived by solving the feasibility problem of the corresponding LMI. Some numerical examples are provided to demonstrate the applicability of the proposed algorithm.
基金supported by the National Creative Research Groups Science Foundation of China(No.60721062)the National Natural Science Foundation of China(No.60736021)+1 种基金National Natural Science Foundation of China(No.60904011)the National High Technology Research and Development Program of China(863 Program)(No.2008AA042902)
文摘The robust D stabilization problem is considered for singular systems with polytopic uncertainties in this paper.Both the derivative matrix E and the state matrix A are with uncertainties,which were not considered before.First,with the introduction of some free matrices,a necessary and sufficient condition for the singular system to be D stable is proposed,based on which,the robust D stable problem is solved,and a sufficient condition for the closed system to be robust D stabilizable is obtained.The desired state feedback controller is given in an explicit expression.Numerical examples show the efficiency of the proposed approach.
文摘This paper has numerically studied the dynamical behaviors of a fractional-order single-machine infinite-bus (FOSMIB) power system. Periodic motions, period- doubling bifurcations and chaotic attractors are observed in the FOSMIB power system. The existence of chaotic behavior is affirmed by the positive largest Lyapunov exponent (LLE). Based on the fractional-order backstepping method, an adaptive controller is proposed to suppress chaos in the FOSMIB power system. Numerical simulation results demonstrate the validity of the proposed controller.
基金The authors thank the Shiyanjia Lab(www.shiyanjia.com)for TEM measurements.The authors are grateful to Ms.Xiao Guo at the Joint Live Small Animal Imaging Laboratory of Fudan University Shanghai Medical College-PerkinElmer Company,for her technical support with the use of the in vivo imaging system.This work was financially supported by the National Key Research and Development Program of China(No.2016YFC1301200)the National Natural Science Foundation of China(Nos.82070281,81870269,and 82170524)Shanghai Clinical Research Center for Interventional Medicine(No.19MC1910300).
文摘Activation of the local renin-angiotensin system(RAS)promotes cardiomyocyte apoptosis and cardiac remodeling after acute myocardial infarction(AMI).As an anti-RAS drug,the effect of Valsartan in the early stage of acute MI is limited by its low drug concentration in the heart and low dosage.Here,by exploiting the inherent nature of neutrophils migrating to the injured myocardium and the local low-pH microenvironment caused by ischemia and hypoxia after myocardial infarction,we designed nanocarrier(NSLP)-hybridized neutrophil membranes and pH-sensitive liposomes(SLPs)for the delivery of Valsartan(NSLPVal).These functional nanocarriers could mimic neutrophils and are homed to the injured heart;they were also found to respond to a low-pH microenvironment.In the mouse model of MI,we found that NSLP-Val could target the infarct marginal zone and release Valsartan locally in the low-pH microenvironment without affecting hemodynamic stability.Further,locally released angiotensin receptor inhibitors reduced the infarct size and inflammatory response by inhibiting cardiomyocytes.Ultimately,NSLP-Val improved cardiac function and inhibited cardiac hypertrophy and fibrosis.
基金support by the National Natural Science Foundation of China(81900353,82270264,T2288101,82130010,21908065,22078098,22278138)the National Science Fund for Distinguished Young Scholars(817200010)+1 种基金the Basic research projects of Shanghai Science and Technology Commission(22JC1400500)the Innovation Program of Shanghai Municipal Education Commission.
文摘Myocardial ischemia-reperfusion (MI/R) injury is common in patients who undergo revascularization therapy for myocardial infarction, often leading to cardiac dysfunction. Carbon monoxide (CO) has emerged as a therapeutic molecule due to its beneficial properties such as anti-inflammatory, anti-apoptotic, and mitochondrial biogenesis-promoting properties. However, its clinical application is limited due to uncontrolled release, potential toxicity, and poor targeting efficiency. To address these limitations, a peroxynitrite (ONOO )-triggered CO donor (PCOD585) is utilized to generate a poly (lactic-co-glycolic acid) (PLGA)-based, biomimetic CO nanogenerator (M/PCOD@PLGA) that is coated with the macrophage membrane, which could target to the ischemic area and neutralize proinflammatory cytokines. In the ischemic area, local produced ONOO triggers the continuous release of CO from M/PCOD@PLGA, which efficiently ameliorates MI/R injury by clearing harmful ONOO , attenuating the inflammatory response, inhibiting cardiomyocyte apoptosis, and promoting mitochondrial biogenesis. This study provides a novel insight into the safe therapeutic use of CO for MI/R injury by utilizing a novel CO donor combined with biomimetic technology. The M/PCOD@PLGA nanogenerator offers targeted delivery of CO to the ischemic area, minimizing potential toxicity and enhancing therapeutic efficacy.
基金financially supported by State Key Clinical Specialty Construction Project(YW2021-002,China)the National Natural Science Foundation of China(Nos.82070281,81870269,and 81600199).
文摘The promise of regeneration therapy for restoration of damaged myocardium after cardiac ischemic injury relies on targeted delivery of proliferative molecules into cardiomyocytes whose healing benefits are still limited owing to severe immune microenvironment due to local high concentration of proinflammatory cytokines.Optimal therapeutic strategies are therefore in urgent need to both modulate local immunity and deliver proliferative molecules.Here,we addressed this unmet need by developing neutrophil-mimic nanoparticles NM@miR,fabricated by coating hybrid neutrophil membranes with artificial lipids onto mesoporous silica nanoparticles(MSNs)loaded with microRNA-10b.The hybrid membrane could endow nanoparticles with strong capacity to migrate into infammatory sites and neutralize proinfammatory cytokines and increase the delivery efficiency of microRNA-1Ob into adult mammalian cardiomyocytes(CMs)by fusing with cell membranes and leading to the release of MSNs-miR into cytosol.Upon NM@miR administration,this nanoparticle could home to the injured myocardium,restore the local immunity,and efficiently deliver microRNA-1Ob to cardiomyocytes,which could reduce the activation of Hippo-YAP pathway mediated by excessive cytokines and exert the best proliferative effect of miR-1Ob.This combination therapy could finally improve cardiac function and mitigate ventricular remodeling.Consequently,this work offers a combination strategy of immunity modulation and proliferative molecule delivery to boost cardiac regeneration after injury.
基金supported by the National Natural Science Foundation of China(Nos.60904011,61004034,61104016)the Doctoral Fund of Ministry of Education of China(No.20093227120010)+1 种基金the Natural Science Foundation of Jiangsu Province,China(No.BK2011465)the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(No.201106)
文摘This paper concerns the stability analysis problem of discrete linear systems with state saturation using a saturation-dependent Lyapunov functional. We introduce a free matrix characterized by the sum of the absolute value of each elements for each row less than 1, which makes the state with saturation constraint reside in a convex polyhedron. A saturation-dependent Lyapunov functional is then designed to obtain a sufficient condition for such systems to be globally asymptotically stable. Based on this stability criterion, the state feedback control law synthesis problem is also studied. The obtained results are formulated in terms of bilinear matrix inequalities that can be solved by the presented iterative linear matrix ineoualitv algorithm. Two numerical examoles are used to demonstrate the effectiveness of the nronosed method_
