Current treatments for advanced hepatocellular carcinoma(HCC)have limited success in improving patients’quality of life and prolonging life expectancy.The clinical need for more efficient and safe therapies has contr...Current treatments for advanced hepatocellular carcinoma(HCC)have limited success in improving patients’quality of life and prolonging life expectancy.The clinical need for more efficient and safe therapies has contributed to the exploration of emerging strategies.Recently,there has been increased interest in oncolytic viruses(OVs)as a therapeutic modality for HCC.OVs undergo selective replication in cancerous tissues and kill tumor cells.Strikingly,pexastimogene devacirepvec(Pexa-Vec)was granted an orphan drug status in HCC by the U.S.Food and Drug Administration(FDA)in 2013.Meanwhile,dozens of OVs are being tested in HCC-directed clinical and preclinical trials.In this review,the pathogenesis and current therapies of HCC are outlined.Next,we summarize multiple OVs as single therapeutic agents for the treatment of HCC,which have demonstrated certain efficacy and lowtoxicity.Emerging carrier cell-,bioengineered cell mimetic-or nonbiological vehicle-mediated OV intravenous delivery systems in HCC therapy are described.In addition,we highlight the combination treatments between oncolytic virotherapy and other modalities.Finally,the clinical challenges and prospects of OV-based biotherapy are discussed,with the aim of continuing to develop a fascinating approach in HCC patients.展开更多
围绕机动观测站和机动外辐射源的被动雷达(Passive Radar,PR)目标跟踪问题,提出了一种以到达时间差(Time Difference of Arrival,TDOA)为目标观测量的被动跟踪模型,通过在同一观测间隔内顺次纠正外辐射源和目标的状态,减小了外辐射源定...围绕机动观测站和机动外辐射源的被动雷达(Passive Radar,PR)目标跟踪问题,提出了一种以到达时间差(Time Difference of Arrival,TDOA)为目标观测量的被动跟踪模型,通过在同一观测间隔内顺次纠正外辐射源和目标的状态,减小了外辐射源定位误差对目标状态估计的影响。仿真分析了不同系统参数与目标跟踪精度之间的关系,证明了模型的有效性。展开更多
Most existing studies about passive radar systems are based on the already known illuminator of opportunity(IO)states.However,in practice,the receiver generally has little knowledge about the IO states.Little research...Most existing studies about passive radar systems are based on the already known illuminator of opportunity(IO)states.However,in practice,the receiver generally has little knowledge about the IO states.Little research has studied this problem.This paper analyzes the observability and estimability for passive radar systems with unknown IO states under three typical scenarios.Besides,the directions of high and low estimability with respect to various states are given.Moreover,two types of observations are taken into account.The effects of different observations on both observability and estimability are well analyzed.For the observability test,linear and nonlinear methods are considered,which proves that both tests are applicable to the system.Numerical simulations confirm the correctness of the theoretical analysis.展开更多
基金by the National Natural Science Foundation of China(No.81700453).
文摘Current treatments for advanced hepatocellular carcinoma(HCC)have limited success in improving patients’quality of life and prolonging life expectancy.The clinical need for more efficient and safe therapies has contributed to the exploration of emerging strategies.Recently,there has been increased interest in oncolytic viruses(OVs)as a therapeutic modality for HCC.OVs undergo selective replication in cancerous tissues and kill tumor cells.Strikingly,pexastimogene devacirepvec(Pexa-Vec)was granted an orphan drug status in HCC by the U.S.Food and Drug Administration(FDA)in 2013.Meanwhile,dozens of OVs are being tested in HCC-directed clinical and preclinical trials.In this review,the pathogenesis and current therapies of HCC are outlined.Next,we summarize multiple OVs as single therapeutic agents for the treatment of HCC,which have demonstrated certain efficacy and lowtoxicity.Emerging carrier cell-,bioengineered cell mimetic-or nonbiological vehicle-mediated OV intravenous delivery systems in HCC therapy are described.In addition,we highlight the combination treatments between oncolytic virotherapy and other modalities.Finally,the clinical challenges and prospects of OV-based biotherapy are discussed,with the aim of continuing to develop a fascinating approach in HCC patients.
文摘围绕机动观测站和机动外辐射源的被动雷达(Passive Radar,PR)目标跟踪问题,提出了一种以到达时间差(Time Difference of Arrival,TDOA)为目标观测量的被动跟踪模型,通过在同一观测间隔内顺次纠正外辐射源和目标的状态,减小了外辐射源定位误差对目标状态估计的影响。仿真分析了不同系统参数与目标跟踪精度之间的关系,证明了模型的有效性。
基金This work was supported by the National Natural Science Foundation of China(61803379)the China Postdoctoral Science Foundation(2017M613370,2018T111129).
文摘Most existing studies about passive radar systems are based on the already known illuminator of opportunity(IO)states.However,in practice,the receiver generally has little knowledge about the IO states.Little research has studied this problem.This paper analyzes the observability and estimability for passive radar systems with unknown IO states under three typical scenarios.Besides,the directions of high and low estimability with respect to various states are given.Moreover,two types of observations are taken into account.The effects of different observations on both observability and estimability are well analyzed.For the observability test,linear and nonlinear methods are considered,which proves that both tests are applicable to the system.Numerical simulations confirm the correctness of the theoretical analysis.
