Text event mining,as an indispensable method of text mining processing,has attracted the extensive attention of researchers.A modeling method for knowledge graph of events based on mutual information among neighbor do...Text event mining,as an indispensable method of text mining processing,has attracted the extensive attention of researchers.A modeling method for knowledge graph of events based on mutual information among neighbor domains and sparse representation is proposed in this paper,i.e.UKGE-MS.Specifically,UKGE-MS can improve the existing text mining technology's ability of understanding and discovering high-dimensional unmarked information,and solves the problems of traditional unsupervised feature selection methods,which only focus on selecting features from a global perspective and ignoring the impact of local connection of samples.Firstly,considering the influence of local information of samples in feature correlation evaluation,a feature clustering algorithm based on average neighborhood mutual information is proposed,and the feature clusters with certain event correlation are obtained;Secondly,an unsupervised feature selection method based on the high-order correlation of multi-dimensional statistical data is designed by combining the dimension reduction advantage of local linear embedding algorithm and the feature selection ability of sparse representation,so as to enhance the generalization ability of the selected feature items.Finally,the events knowledge graph is constructed by means of sparse representation and l1 norm.Extensive experiments are carried out on five real datasets and synthetic datasets,and the UKGE-MS are compared with five corresponding algorithms.The experimental results show that UKGE-MS is better than the traditional method in event clustering and feature selection,and has some advantages over other methods in text event recognition and discovery.展开更多
Objective:To explore the application value of spiral CT perfusion technology in the diagnosis of acute pancreatitis (AP).Methods:A total of 78 patients with AP who were admitted in our hospital from September, 2014 to...Objective:To explore the application value of spiral CT perfusion technology in the diagnosis of acute pancreatitis (AP).Methods:A total of 78 patients with AP who were admitted in our hospital from September, 2014 to September, 2016 were included in the study. The velocity method was used to detect S-Amy and U-Amy. The emulsion enhancement velocity scattering turbidimetry was used to detect CRP. ELISA was used to detect D-D. The patients in the control group were performed with abdomen CT, while AP patients were performed with 64 slice spiral CT. The most integrated layer of pancreas display was regarded as the perfusion weighted imaging scanning layer, and CT perfusion scanning was performed. BF, BV, MTT, and PS were calculated.Results: S-Amy, U-Amy, CRP, and D-D in AP patients were significantly higher than those in the control group. With the disease progression, S-Amy and U-Amy were significantly reduced, while CRP and D-D were significantly elevated. BF and BV in AP patients were significantly lower than those in the control group, and those in SAP patients were significantly lower than those in MAP patients. With the elevation of CT grading, BF and BV were significantly reduced, while the comparison of MTT and PS among the various grading was not statistically significant.Conclusions:The pancreas perfusion in AP patients is in a low perfusion state. BF and BV are negatively correlated with the severity degree of AP, which can predict the prognosis. BF and BV in combined with the serum S-Amy, U-Amy, CRP, and D-D can provide a forceful evidence for the diagnosis, treatment, and condition evaluation of AP.展开更多
Objective: To explore the role of MSCT and CRP detection in evaluating the severity of acute pancreatitis (AP). Methods: A total of 70 patients with AP who were admitted in our hospital from April, 2016 to April, 2017...Objective: To explore the role of MSCT and CRP detection in evaluating the severity of acute pancreatitis (AP). Methods: A total of 70 patients with AP who were admitted in our hospital from April, 2016 to April, 2017 were included in the study and divided into MAP group and SAP group with 35 cases in each group according to the clinical diagnosis and grading criteria of AP. Moreover, 35 healthy individuals who came for physical examination were served as the control group. The peripheral venous blood and urine were collected after admission. The enzyme dynamics method was used to detect AMY, UAMY, and CRP. The dynamic change of CRP was observed 1, 3, 5, and 7 d after admission. 16 spiral CT was used to study CRP change and CT grading. Results: AMY, UAMY, and CRP in MAP and SAP group were significantly higher than those in the control group. CRP level in SAP group was significantly higher than that in MAP group. CRP level was elevated with the increasing of clinical degree and CT grading. CRP level in D and E grades were significantly higher than those in grade A, B, and C grades. Conclusions: CT grading and CRP detection in patients with AP can accurately reflect the severity degree and prognosis, and the combined detection plays a vital role in the early diagnosis, condition evaluation and monitoring, and clinical treatment.展开更多
The phytophagous miteTetranychus truncatusis a serious pest in East Asiabut has a relatively narrower host range than the pest miteTetranychus urticae,which canfeed on over 1200 plant species.Here,we generated a high-...The phytophagous miteTetranychus truncatusis a serious pest in East Asiabut has a relatively narrower host range than the pest miteTetranychus urticae,which canfeed on over 1200 plant species.Here,we generated a high-quality chromosomal levelgenome ofT.truncatusand compared it with that ofT.urticae,with an emphasis on thegenes related to detoxification and chemoreception,to explore the genomic basis under-lying the evolution of host range.We also conducted population genetics analyses(in 86females from 10 populations)and host transfer experiments(in 4 populations)to investi-gate transcription changes following transfer to a low-quality host(Solanum melongena,eggplant),and we established possible connections between fitness on eggplant and genesrelated to detoxification and chemoreception.We found thatT.truncatushas fewer genesrelated to detoxification,transport,and chemoreception thanT.urticae,with a particularlystrong reduction in gustatory receptor(GR)genes.We also found widespread transcrip-tional variation amongT.truncatuspopulations,which varied in fitness on eggplant.Wecharacterized selection on detoxification-related genes throughωvalues and found a nega-tive correlation between expression levels andωvalues.Based on the transcription results,as well as the fitness and genetic differences among populations,we identified genes po-tentially involved in adaptation to eggplant inT.truncatus.Our work provides a genomicresource for this pest mite and new insights into mechanisms underlying the adaptation ofherbivorous mites to host plants.展开更多
The two-spotted spider mite, Tetranychus urticae Koch has two forms： green form and red form. Understanding the molecular basis of how these two forms established without divergent genetic background is an intriguing...The two-spotted spider mite, Tetranychus urticae Koch has two forms： green form and red form. Understanding the molecular basis of how these two forms established without divergent genetic background is an intriguing area. As a well-known epigenetic process, DNA methylation has particularly important roles in gene regulation and developmental variation across diverse organisms that do not alter genetic background. Here, to investigate whether DNA methylation could be associated with different phenotypic conse- quences in the two forms of T. urticae, we surveyed the genome-wide cytosine methylation status and expression level of DNA methyltransferase 3 （Tudnmt3） throughout their entire life cycle. Methylation-sensitive amplification polymorphism （MSAP） analyses of 585 loci revealed variable methylation patterns in the different developmental stages. In particular, principal coordinates analysis （PCoA） indicates a significant epigenetic differentiation be- tween female adults of the two forms. The gene expression of Tudnmt3 was detected in all examined developmental stages, which was significantly different in the adult stage of the two forms. Together, our results reveal the epigenetic distance between the two forms of T. urticae, suggesting that DNA methylation might be implicated in different developmental demands, and contribute to different phenotypes in the adult stage of these two forms.展开更多
基金This study was funded by the International Science and Technology Cooperation Program of the Science and Technology Department of Shaanxi Province,China(No.2021KW-16)the Science and Technology Project in Xi’an(No.2019218114GXRC017CG018-GXYD17.11),Thesis work was supported by the special fund construction project of Key Disciplines in Ordinary Colleges and Universities in Shaanxi Province,the authors would like to thank the anonymous reviewers for their helpful comments and suggestions.
文摘Text event mining,as an indispensable method of text mining processing,has attracted the extensive attention of researchers.A modeling method for knowledge graph of events based on mutual information among neighbor domains and sparse representation is proposed in this paper,i.e.UKGE-MS.Specifically,UKGE-MS can improve the existing text mining technology's ability of understanding and discovering high-dimensional unmarked information,and solves the problems of traditional unsupervised feature selection methods,which only focus on selecting features from a global perspective and ignoring the impact of local connection of samples.Firstly,considering the influence of local information of samples in feature correlation evaluation,a feature clustering algorithm based on average neighborhood mutual information is proposed,and the feature clusters with certain event correlation are obtained;Secondly,an unsupervised feature selection method based on the high-order correlation of multi-dimensional statistical data is designed by combining the dimension reduction advantage of local linear embedding algorithm and the feature selection ability of sparse representation,so as to enhance the generalization ability of the selected feature items.Finally,the events knowledge graph is constructed by means of sparse representation and l1 norm.Extensive experiments are carried out on five real datasets and synthetic datasets,and the UKGE-MS are compared with five corresponding algorithms.The experimental results show that UKGE-MS is better than the traditional method in event clustering and feature selection,and has some advantages over other methods in text event recognition and discovery.
文摘Objective:To explore the application value of spiral CT perfusion technology in the diagnosis of acute pancreatitis (AP).Methods:A total of 78 patients with AP who were admitted in our hospital from September, 2014 to September, 2016 were included in the study. The velocity method was used to detect S-Amy and U-Amy. The emulsion enhancement velocity scattering turbidimetry was used to detect CRP. ELISA was used to detect D-D. The patients in the control group were performed with abdomen CT, while AP patients were performed with 64 slice spiral CT. The most integrated layer of pancreas display was regarded as the perfusion weighted imaging scanning layer, and CT perfusion scanning was performed. BF, BV, MTT, and PS were calculated.Results: S-Amy, U-Amy, CRP, and D-D in AP patients were significantly higher than those in the control group. With the disease progression, S-Amy and U-Amy were significantly reduced, while CRP and D-D were significantly elevated. BF and BV in AP patients were significantly lower than those in the control group, and those in SAP patients were significantly lower than those in MAP patients. With the elevation of CT grading, BF and BV were significantly reduced, while the comparison of MTT and PS among the various grading was not statistically significant.Conclusions:The pancreas perfusion in AP patients is in a low perfusion state. BF and BV are negatively correlated with the severity degree of AP, which can predict the prognosis. BF and BV in combined with the serum S-Amy, U-Amy, CRP, and D-D can provide a forceful evidence for the diagnosis, treatment, and condition evaluation of AP.
文摘Objective: To explore the role of MSCT and CRP detection in evaluating the severity of acute pancreatitis (AP). Methods: A total of 70 patients with AP who were admitted in our hospital from April, 2016 to April, 2017 were included in the study and divided into MAP group and SAP group with 35 cases in each group according to the clinical diagnosis and grading criteria of AP. Moreover, 35 healthy individuals who came for physical examination were served as the control group. The peripheral venous blood and urine were collected after admission. The enzyme dynamics method was used to detect AMY, UAMY, and CRP. The dynamic change of CRP was observed 1, 3, 5, and 7 d after admission. 16 spiral CT was used to study CRP change and CT grading. Results: AMY, UAMY, and CRP in MAP and SAP group were significantly higher than those in the control group. CRP level in SAP group was significantly higher than that in MAP group. CRP level was elevated with the increasing of clinical degree and CT grading. CRP level in D and E grades were significantly higher than those in grade A, B, and C grades. Conclusions: CT grading and CRP detection in patients with AP can accurately reflect the severity degree and prognosis, and the combined detection plays a vital role in the early diagnosis, condition evaluation and monitoring, and clinical treatment.
基金supported by a grant-in-aid for Scientific Research(32020103011,U2003112,32202290,32161143014)from the National Natural Science Foun-dation of China.We thank Jia-Huan Guan and Qi-Qi Hufor their assistance in collecting biological materials.
文摘The phytophagous miteTetranychus truncatusis a serious pest in East Asiabut has a relatively narrower host range than the pest miteTetranychus urticae,which canfeed on over 1200 plant species.Here,we generated a high-quality chromosomal levelgenome ofT.truncatusand compared it with that ofT.urticae,with an emphasis on thegenes related to detoxification and chemoreception,to explore the genomic basis under-lying the evolution of host range.We also conducted population genetics analyses(in 86females from 10 populations)and host transfer experiments(in 4 populations)to investi-gate transcription changes following transfer to a low-quality host(Solanum melongena,eggplant),and we established possible connections between fitness on eggplant and genesrelated to detoxification and chemoreception.We found thatT.truncatushas fewer genesrelated to detoxification,transport,and chemoreception thanT.urticae,with a particularlystrong reduction in gustatory receptor(GR)genes.We also found widespread transcrip-tional variation amongT.truncatuspopulations,which varied in fitness on eggplant.Wecharacterized selection on detoxification-related genes throughωvalues and found a nega-tive correlation between expression levels andωvalues.Based on the transcription results,as well as the fitness and genetic differences among populations,we identified genes po-tentially involved in adaptation to eggplant inT.truncatus.Our work provides a genomicresource for this pest mite and new insights into mechanisms underlying the adaptation ofherbivorous mites to host plants.
文摘The two-spotted spider mite, Tetranychus urticae Koch has two forms： green form and red form. Understanding the molecular basis of how these two forms established without divergent genetic background is an intriguing area. As a well-known epigenetic process, DNA methylation has particularly important roles in gene regulation and developmental variation across diverse organisms that do not alter genetic background. Here, to investigate whether DNA methylation could be associated with different phenotypic conse- quences in the two forms of T. urticae, we surveyed the genome-wide cytosine methylation status and expression level of DNA methyltransferase 3 （Tudnmt3） throughout their entire life cycle. Methylation-sensitive amplification polymorphism （MSAP） analyses of 585 loci revealed variable methylation patterns in the different developmental stages. In particular, principal coordinates analysis （PCoA） indicates a significant epigenetic differentiation be- tween female adults of the two forms. The gene expression of Tudnmt3 was detected in all examined developmental stages, which was significantly different in the adult stage of the two forms. Together, our results reveal the epigenetic distance between the two forms of T. urticae, suggesting that DNA methylation might be implicated in different developmental demands, and contribute to different phenotypes in the adult stage of these two forms.
