Objective Vitamin D(VD)deficiency was reported to contribute to the progression of Crohn’s disease(CD)and affect the prognosis of CD patients.This study investigated the role of serum VD,body mass index(BMI),and tumo...Objective Vitamin D(VD)deficiency was reported to contribute to the progression of Crohn’s disease(CD)and affect the prognosis of CD patients.This study investigated the role of serum VD,body mass index(BMI),and tumor necrosis factor alpha(TNF-α)in the diagnosis of Crohn’s disease.Methods CD patients(n=76)and healthy subjects(n=76)were enrolled between May 2019 and December 2020.The serum 25-hydroxyvitamin D[25(OH)D]levels,BMI,and TNF-αlevels,together with other biochemical parameters,were assessed before treatment.The diagnostic efficacy of the single and joint detection of serum 25(OH)D,BMI,and TNF-αwas determined using receiver operating characteristic(ROC)curves.Results The levels of 25(OH)D,BMI,and nutritional indicators,including hemoglobin,total protein,albumin,and high-density lipoprotein cholesterol,were much lower,and the TNF-αlevels were much higher in the CD patients than in the healthy subjects(P<0.05 for all).The areas under the ROC curve for the single detection of 25(OH)D,BMI,and TNF-αwere 0.887,0.896,and 0.838,respectively,with the optimal cutoff values being 20.64 ng/mL,19.77 kg/m^(2),and 6.85 fmol/mL,respectively.The diagnostic efficacy of the joint detection of 25(OH)D,BMI,and TNF-αwas the highest,with an area under the ROC curve of 0.988(95%CI:0.968–1.000).Conclusion The joint detection of 25(OH)D,TNF-α,and BMI showed high sensitivity,specificity,and accuracy in CD diagnosis;thus,it would be effective for the diagnosis of CD in clinical practice.展开更多
Microbial electrolysis cells(MECs)present an attractive route for energy-saving hydrogen(H2)production along with treatment of various wastewaters,which can convert organic matter into H2 with the assistance of microb...Microbial electrolysis cells(MECs)present an attractive route for energy-saving hydrogen(H2)production along with treatment of various wastewaters,which can convert organic matter into H2 with the assistance of microbial electrocatalysis.However,the development of such renewable technologies for H2 production still faces considerable challenges regarding how to enhance the H2 production rate and to lower the energy and the system cost.In this review,we will focus on the recent research progress of MEC for H2 production.First,we present a brief introduction of MEC technology and the operating mechanism for H2 production.Then,the electrode materials including some typical electrocatalysts for hydrogen production are summarized and discussed.We also highlight how various substrates used in MEC affect the associated performance of hydrogen generation.Finally we presents several key scientific challenges and our perspectives on how to enhance the electrochemical performance.展开更多
Electrochemical water splitting requires efficient water oxidation catalysts to accelerate the sluggish kinetics of water oxidation reaction. Here, we designed an efficient Co304 electrocatalyst using a pyrolysis stra...Electrochemical water splitting requires efficient water oxidation catalysts to accelerate the sluggish kinetics of water oxidation reaction. Here, we designed an efficient Co304 electrocatalyst using a pyrolysis strategy for oxygen evolution reaction （OER）. Morphological characterization confirmed the ultra-thin structure of nanosheet. Further, the existence of oxygen vacancies was obviously evidenced by the X-ray photoelectron spectroscopy and elec- tron spin resonance spectroscopy. The increased surface area of Co3O4 ensures more exposed sites, whereas generated oxygen vacancies on Co3O4 surface create more active defects. The two scenarios were beneficial for accelerating the OER across the interface between the anode and electrolyte. As expected, the optimized Co3O4 nanosheets can catalyze the OER eftciently with a low overpotential of 310 mV at current density of 10 mA/cm2 and remarkable long-term stability in 1.0 mol/L KOH.展开更多
Since the discovery of C_(60)[1],considerable efforts have been made to explore the potential applications of fullerene-based materials in photoelectronic devices[2–9].Such materials show highly efficient charge carr...Since the discovery of C_(60)[1],considerable efforts have been made to explore the potential applications of fullerene-based materials in photoelectronic devices[2–9].Such materials show highly efficient charge carrier generation and separation upon light illumination due to their spherical polyene structure and high electron affinity[10].Many C_(60)-based composite materials,including C_(60)-embedded metal-organic frameworks(MOFs)[11,12],C60-doped polymers[2],organic C_(60)derivatives[7,13–15],and C_(60)-anchored perovskite films[16],show advantageous photoelectronic performances by virtue of highly efficient photogenerated donor-acceptor charge transfer[17–19].However,only a small number of these materials exhibit precise crystal structures,which hampers the evaluation of their structure-function relationships.展开更多
基金This research was funded by Guangzhou Science and Technology Plan Projects(No.202002020066)the Young Scientists to the NSFC Application of Guangdong Provincial People’s Hospital(No.8210120306)the Open Foundation of the State Key Laboratory of Bioactive Seaweed Substance(No.SKL-BMSG2022-03)。
文摘Objective Vitamin D(VD)deficiency was reported to contribute to the progression of Crohn’s disease(CD)and affect the prognosis of CD patients.This study investigated the role of serum VD,body mass index(BMI),and tumor necrosis factor alpha(TNF-α)in the diagnosis of Crohn’s disease.Methods CD patients(n=76)and healthy subjects(n=76)were enrolled between May 2019 and December 2020.The serum 25-hydroxyvitamin D[25(OH)D]levels,BMI,and TNF-αlevels,together with other biochemical parameters,were assessed before treatment.The diagnostic efficacy of the single and joint detection of serum 25(OH)D,BMI,and TNF-αwas determined using receiver operating characteristic(ROC)curves.Results The levels of 25(OH)D,BMI,and nutritional indicators,including hemoglobin,total protein,albumin,and high-density lipoprotein cholesterol,were much lower,and the TNF-αlevels were much higher in the CD patients than in the healthy subjects(P<0.05 for all).The areas under the ROC curve for the single detection of 25(OH)D,BMI,and TNF-αwere 0.887,0.896,and 0.838,respectively,with the optimal cutoff values being 20.64 ng/mL,19.77 kg/m^(2),and 6.85 fmol/mL,respectively.The diagnostic efficacy of the joint detection of 25(OH)D,BMI,and TNF-αwas the highest,with an area under the ROC curve of 0.988(95%CI:0.968–1.000).Conclusion The joint detection of 25(OH)D,TNF-α,and BMI showed high sensitivity,specificity,and accuracy in CD diagnosis;thus,it would be effective for the diagnosis of CD in clinical practice.
基金supported by the National Natural Science Foundation of China(No.21566025 and No.21875253)the Natural Science Foundation of Jiangxi Province(No.20152ACB21019 and No.20162BCB23044)。
文摘Microbial electrolysis cells(MECs)present an attractive route for energy-saving hydrogen(H2)production along with treatment of various wastewaters,which can convert organic matter into H2 with the assistance of microbial electrocatalysis.However,the development of such renewable technologies for H2 production still faces considerable challenges regarding how to enhance the H2 production rate and to lower the energy and the system cost.In this review,we will focus on the recent research progress of MEC for H2 production.First,we present a brief introduction of MEC technology and the operating mechanism for H2 production.Then,the electrode materials including some typical electrocatalysts for hydrogen production are summarized and discussed.We also highlight how various substrates used in MEC affect the associated performance of hydrogen generation.Finally we presents several key scientific challenges and our perspectives on how to enhance the electrochemical performance.
基金supported by the National Natural Science Foundation of China(No.21621003,No.21327806)National Key Research and Development Program of China(No.2016YFA0203101)Tsinghua University Initiative Scientific Research Program
文摘Electrochemical water splitting requires efficient water oxidation catalysts to accelerate the sluggish kinetics of water oxidation reaction. Here, we designed an efficient Co304 electrocatalyst using a pyrolysis strategy for oxygen evolution reaction （OER）. Morphological characterization confirmed the ultra-thin structure of nanosheet. Further, the existence of oxygen vacancies was obviously evidenced by the X-ray photoelectron spectroscopy and elec- tron spin resonance spectroscopy. The increased surface area of Co3O4 ensures more exposed sites, whereas generated oxygen vacancies on Co3O4 surface create more active defects. The two scenarios were beneficial for accelerating the OER across the interface between the anode and electrolyte. As expected, the optimized Co3O4 nanosheets can catalyze the OER eftciently with a low overpotential of 310 mV at current density of 10 mA/cm2 and remarkable long-term stability in 1.0 mol/L KOH.
基金financially supported by the National Natural Science Foundation of China (21731002, 21975104, 22071141 and 21471094)Guangdong Major Project of Basic and Applied Research (2019B030302009)Guangdong Basic and Applied Basic Research Foundation (2019A1515012162)
文摘Since the discovery of C_(60)[1],considerable efforts have been made to explore the potential applications of fullerene-based materials in photoelectronic devices[2–9].Such materials show highly efficient charge carrier generation and separation upon light illumination due to their spherical polyene structure and high electron affinity[10].Many C_(60)-based composite materials,including C_(60)-embedded metal-organic frameworks(MOFs)[11,12],C60-doped polymers[2],organic C_(60)derivatives[7,13–15],and C_(60)-anchored perovskite films[16],show advantageous photoelectronic performances by virtue of highly efficient photogenerated donor-acceptor charge transfer[17–19].However,only a small number of these materials exhibit precise crystal structures,which hampers the evaluation of their structure-function relationships.
