Objective: To study the relationship between the expression of multidrug resistance-associated protein (MRP) gene in nasopharyngeal carcinoma (NPC) and the radiosensitivity of primary lesions of NPC. Methods: Total 51...Objective: To study the relationship between the expression of multidrug resistance-associated protein (MRP) gene in nasopharyngeal carcinoma (NPC) and the radiosensitivity of primary lesions of NPC. Methods: Total 51 cases of NPC were analyzed retrospectively, who were treated by radiotherapy between January 1, 1999 and December 31, 2000 in our department, including the cases of pure radiotherapy and chemotherapy after radiotherapy. Using immunohistochemiscal S-P method, the expression of MRP in NPC was detected, and the relationship with the radiosensitivity of primary lesions of NPC was analyzed. Results: The rate of positive expression was 68.63% (35/51) in NPC, and there were significant difference between T stages (P<0.05), but no significant difference with radiosensitivity of primary lesions of NPC (P>0.05). Conclusion: There is a higher expression of MRP in NPC, but it has no relationship with radiosensitivity of primary lesions of NPC. So MRP can not be regarded as the predictive marker of radiosensitivity of primary lesions of NPC.展开更多
Dynamic manipulation of electromagnetic(EM)waves with multiple degrees of freedom plays an essential role in enhancing information processing.Currently,an enormous challenge is to realize directional terahertz(THz)hol...Dynamic manipulation of electromagnetic(EM)waves with multiple degrees of freedom plays an essential role in enhancing information processing.Currently,an enormous challenge is to realize directional terahertz(THz)holography.Recently,it was demonstrated that Janus metasurfaces could produce distinct responses to EM waves from two opposite incident directions,making multiplexed dynamic manipulation of THz waves possible.Herein,we show that thermally activated THz Janus metasurfaces integrating with phase change materials on the meta-atoms can produce asymmetric transmission with the designed phase delays.Such reconfigurable Janus metasurfaces can achieve asymmetric focusing of THz wave and directional THz holography with free-space image projections,and particularly the information can be manipulated via temperature and incident THz wave direction.This work not only offers a common strategy for realizing the reconfigurability of Janus metasurfaces,but also shows possible applications in THz optical information encryption,data storage,and smart windows.展开更多
Spatial light modulators(SLM),capable of dynamically and spatially manipulating electromagnetic waves,have reshaped modern life in projection display and remote sensing.The progress of SLM will expedite next-generatio...Spatial light modulators(SLM),capable of dynamically and spatially manipulating electromagnetic waves,have reshaped modern life in projection display and remote sensing.The progress of SLM will expedite next-generation communication and biomedical imaging in the terahertz(THz)range.However,most current THz SLMs are adapted from optical alternatives that still need improvement in terms of uniformity,speed,and bandwidth.Here,we designed,fabricated,and characterized an 8×8THz SLM based on tunable liquid crystal metamaterial absorbers for THz single-pixel compressive imaging.We demonstrated dual-color compressive sensing(CS)imaging for dispersive objects utilizing the large frequency shift controlled by an external electric field.We developed auto-calibrated compressive sensing(ACS)algorithm to mitigate the impact of the spatially nonuniform THz incident beam and pixel modulation,which significantly improves the fidelity of reconstructed images.Furthermore,the complementary modulation at two absorption frequencies enables Hadamard masks with negative element values to be realized by frequency-switching,thereby halving the imaging time.The demonstrated imaging system paves a new route for THz single-pixel multispectral imaging with high reliability and low cost.展开更多
文摘Objective: To study the relationship between the expression of multidrug resistance-associated protein (MRP) gene in nasopharyngeal carcinoma (NPC) and the radiosensitivity of primary lesions of NPC. Methods: Total 51 cases of NPC were analyzed retrospectively, who were treated by radiotherapy between January 1, 1999 and December 31, 2000 in our department, including the cases of pure radiotherapy and chemotherapy after radiotherapy. Using immunohistochemiscal S-P method, the expression of MRP in NPC was detected, and the relationship with the radiosensitivity of primary lesions of NPC was analyzed. Results: The rate of positive expression was 68.63% (35/51) in NPC, and there were significant difference between T stages (P<0.05), but no significant difference with radiosensitivity of primary lesions of NPC (P>0.05). Conclusion: There is a higher expression of MRP in NPC, but it has no relationship with radiosensitivity of primary lesions of NPC. So MRP can not be regarded as the predictive marker of radiosensitivity of primary lesions of NPC.
基金This study was supported by the National Key Research and Development Program of China(2017YFA0700202,2021YFB2800701)National Nature Science Foundation of China(62288101,91963128,62071215,62071217,62027807,62035014)Fundamental Research Funds for the Central Universities,and Research Fund for Jiangsu Key Laboratory of Advanced Techniques for Manipulating Electromagnetic Waves.J.W.acknowledges the support from Xiaomi Young Scholar Program.
文摘Dynamic manipulation of electromagnetic(EM)waves with multiple degrees of freedom plays an essential role in enhancing information processing.Currently,an enormous challenge is to realize directional terahertz(THz)holography.Recently,it was demonstrated that Janus metasurfaces could produce distinct responses to EM waves from two opposite incident directions,making multiplexed dynamic manipulation of THz waves possible.Herein,we show that thermally activated THz Janus metasurfaces integrating with phase change materials on the meta-atoms can produce asymmetric transmission with the designed phase delays.Such reconfigurable Janus metasurfaces can achieve asymmetric focusing of THz wave and directional THz holography with free-space image projections,and particularly the information can be manipulated via temperature and incident THz wave direction.This work not only offers a common strategy for realizing the reconfigurability of Janus metasurfaces,but also shows possible applications in THz optical information encryption,data storage,and smart windows.
基金financially supported by the National Natural Science Foundation of China (22005002)the Natural Science Foundation of Anhui Province (2208085Y03)+1 种基金Anhui University Scientific Research Start-up Fundsupported by the advanced computing resources provided by the Supercomputing Center of the University of Science and Technology of China。
基金supported by the National Key Research and Development Program of China(2017YFA0700202,2021YFB2800701)National Nature Science Foundation of China(61731010,62071217,61971465,62027807,61871212,62025108,62035014)Fundamental Research Funds for the Central Universities,and Research Fund for Jiangsu Key Laboratory of Advanced Techniques for Manipulatinp Electromagnetic Waves.
文摘Spatial light modulators(SLM),capable of dynamically and spatially manipulating electromagnetic waves,have reshaped modern life in projection display and remote sensing.The progress of SLM will expedite next-generation communication and biomedical imaging in the terahertz(THz)range.However,most current THz SLMs are adapted from optical alternatives that still need improvement in terms of uniformity,speed,and bandwidth.Here,we designed,fabricated,and characterized an 8×8THz SLM based on tunable liquid crystal metamaterial absorbers for THz single-pixel compressive imaging.We demonstrated dual-color compressive sensing(CS)imaging for dispersive objects utilizing the large frequency shift controlled by an external electric field.We developed auto-calibrated compressive sensing(ACS)algorithm to mitigate the impact of the spatially nonuniform THz incident beam and pixel modulation,which significantly improves the fidelity of reconstructed images.Furthermore,the complementary modulation at two absorption frequencies enables Hadamard masks with negative element values to be realized by frequency-switching,thereby halving the imaging time.The demonstrated imaging system paves a new route for THz single-pixel multispectral imaging with high reliability and low cost.
