Luteolin （3＇,4＇,5,7-tetrahydroxyflavone） has powerful anti-apoptotic and antioxidant properties. This study aimed to investigate the effects of luteolin on hyperglycemia-mediated apoptosis in the hippocampi of rat...Luteolin （3＇,4＇,5,7-tetrahydroxyflavone） has powerful anti-apoptotic and antioxidant properties. This study aimed to investigate the effects of luteolin on hyperglycemia-mediated apoptosis in the hippocampi of rats with streptozotocin-induced diabetic encephalopathy after injection into the tail veins, and the molecular mechanisms involved. Biochemistry and terminal deoxynucleotidyl transferase mediated dUTP nick end labelling detection results showed that luteolin treatment （given twice daily for 15 days） significantly inhibited hyperglycemia-mediated apoptosis, decreased malondialdehyde levels and increased glutathione levels in the hippocampi of streptozotocin- induced diabetic rats. Western blot analysis revealed that luteolin also inhibited the expression of apoptosis-related factors and cytochrome c release from mitochondria. Luteolin also improved the learning and memory abiJities of rats with diabetic encephalopathy in a water maze test. Further western blot analysis revealed that luteolin treatment facilitated neuronal cell survival through activation of the phosphatidylinositol 3-kinase/Akt signaling pathway, an extracellular signal pathway involved in the suppression of cell apoptosis and promotion of cell survival. These experimental findings indicate that luteolin can inhibit apoptosis of hippocampal nerve cells in rats with diabetic encephalopathy, and that this effect is mediated by an indirect antioxidative effect, the inhibition of activation of apoptosis-related factors and the activation of phosphatidylinositol 3-kinase/Akt signal pathway.展开更多
The advancement of plant phenomics by using optical imaging-based phenotyping techniques has markedly improved breeding and crop management.However,there remains a challenge in increasing the spatial resolution and ac...The advancement of plant phenomics by using optical imaging-based phenotyping techniques has markedly improved breeding and crop management.However,there remains a challenge in increasing the spatial resolution and accuracy due to their noncontact measurement mode.Wearable sensors,an emerging data collection tool,present a promising solution to address these challenges.By using a contact measurement mode,wearable sensors enable in-situ monitoring of plant phenotypes and their surrounding environments.Although a few pioneering works have been reported in monitoring plant growth and microclimate,the utilization of wearable sensors in plant phenotyping has yet reach its full potential.This review aims to systematically examine the progress of wearable sensors in monitoring plant phenotypes and the environment from an interdisciplinary perspective,including materials science,signal communication,manufacturing technology,and plant physiology.Additionally,this review discusses the challenges and future directions of wearable sensors in the field of plant phenotyping.展开更多
文摘Luteolin （3＇,4＇,5,7-tetrahydroxyflavone） has powerful anti-apoptotic and antioxidant properties. This study aimed to investigate the effects of luteolin on hyperglycemia-mediated apoptosis in the hippocampi of rats with streptozotocin-induced diabetic encephalopathy after injection into the tail veins, and the molecular mechanisms involved. Biochemistry and terminal deoxynucleotidyl transferase mediated dUTP nick end labelling detection results showed that luteolin treatment （given twice daily for 15 days） significantly inhibited hyperglycemia-mediated apoptosis, decreased malondialdehyde levels and increased glutathione levels in the hippocampi of streptozotocin- induced diabetic rats. Western blot analysis revealed that luteolin also inhibited the expression of apoptosis-related factors and cytochrome c release from mitochondria. Luteolin also improved the learning and memory abiJities of rats with diabetic encephalopathy in a water maze test. Further western blot analysis revealed that luteolin treatment facilitated neuronal cell survival through activation of the phosphatidylinositol 3-kinase/Akt signaling pathway, an extracellular signal pathway involved in the suppression of cell apoptosis and promotion of cell survival. These experimental findings indicate that luteolin can inhibit apoptosis of hippocampal nerve cells in rats with diabetic encephalopathy, and that this effect is mediated by an indirect antioxidative effect, the inhibition of activation of apoptosis-related factors and the activation of phosphatidylinositol 3-kinase/Akt signal pathway.
基金supported by the National Natural Science Foundation of China(No.62101267)the Fundamental Research Funds for the Central Universities(No.KYCYXT2022015)+2 种基金Jiangsu Agricultural Science and Technology Innovation Funds(No.CX(22)3118 and No.CX(21)2004)Jiangsu Seed Industry Revitalization Project(No.JBGS(2021)020)China Postdoctoral Science Foundation(2022M721639).
文摘The advancement of plant phenomics by using optical imaging-based phenotyping techniques has markedly improved breeding and crop management.However,there remains a challenge in increasing the spatial resolution and accuracy due to their noncontact measurement mode.Wearable sensors,an emerging data collection tool,present a promising solution to address these challenges.By using a contact measurement mode,wearable sensors enable in-situ monitoring of plant phenotypes and their surrounding environments.Although a few pioneering works have been reported in monitoring plant growth and microclimate,the utilization of wearable sensors in plant phenotyping has yet reach its full potential.This review aims to systematically examine the progress of wearable sensors in monitoring plant phenotypes and the environment from an interdisciplinary perspective,including materials science,signal communication,manufacturing technology,and plant physiology.Additionally,this review discusses the challenges and future directions of wearable sensors in the field of plant phenotyping.
