Hepatocellular carcinoma (HCC) is one of the most common tumor types and remains a major clinical challenge. Increasing evidence has revealed that mitophagy inhibitors can enhance the effect of chemotherapy on HCC. Ho...Hepatocellular carcinoma (HCC) is one of the most common tumor types and remains a major clinical challenge. Increasing evidence has revealed that mitophagy inhibitors can enhance the effect of chemotherapy on HCC. However, few mitophagy inhibitors have been approved for clinical use in humans. Pyrimethamine (Pyr) is used to treat infections caused by protozoan parasites. Recent studies have reported that Pyr may be beneficial in the treatment of various tumors. However, its mechanism of action is still not clearly defined. Here, we found that blocking mitophagy sensitized cells to Pyr-induced apoptosis. Mechanistically, Pyr potently induced the accumulation of autophagosomes by inhibiting autophagosome-lysosome fusion in human HCC cells. In vitro and in vivo studies revealed that Pyr blocked autophagosome-lysosome fusion by upregulating BNIP3 to inhibit synaptosomal-associated protein 29 (SNAP29)-vesicle-associated membrane protein 8 (VAMP8) interaction. Moreover, Pyr acted synergistically with sorafenib (Sora) to induce apoptosis and inhibit HCC proliferation in vitro and in vivo. Pyr enhances the sensitivity of HCC cells to Sora, a common chemotherapeutic, by inhibiting mitophagy. Thus, these results provide new insights into the mechanism of action of Pyr and imply that Pyr could potentially be further developed as a novel mitophagy inhibitor. Notably, Pyr and Sora combination therapy could be a promising treatment for malignant HCC.展开更多
Profile shift is a highly effective technique for optimizing the performance of spur gear transmission systems.However,tooth surface wear is inevitable during gear meshing due to inadequate lubrication and long-term o...Profile shift is a highly effective technique for optimizing the performance of spur gear transmission systems.However,tooth surface wear is inevitable during gear meshing due to inadequate lubrication and long-term operation.Both profile shift and tooth surface wear(TSW)can impact the meshing characteristics by altering the involute tooth profile.In this study,a tooth stiffness model of spur gears that incorporates profile shift,TSW,tooth deformation,tooth contact deformation,fillet-foundation deformation,and gear body structure coupling is established.This model efficiently and accurately determines the time-varying mesh stiffness(TVMS).Additionally,an improved wear depth prediction method for spur gears is developed,which takes into consideration the mutually prime teeth numbers and more accurately reflects actual gear meshing conditions.Results show that consideration of the mutual prime of teeth numbers will have a certain impact on the TSW process.Furthermore,the finite element method(FEM)is employed to accurately verify the values of TVMS and load sharing ratio(LSR)of profile-shifted gears and worn gears.This study quantitatively analyzes the effect of profile shift on the surface wear process,which suggests that gear profile shift can partially alleviate the negative effects of TSW.The contribution of this study provides valuable insights into the design and maintenance of spur gear systems.展开更多
Excessive consumption of refined grains harms human health and ecosystem viability.Whole grains,as a healthy and sustainable alternative to refined grains,can benefit individual health by providing dietary fiber,B vit...Excessive consumption of refined grains harms human health and ecosystem viability.Whole grains,as a healthy and sustainable alternative to refined grains,can benefit individual health by providing dietary fiber,B vitamins,and bioactive substances.Additionally,they aid in improving the environment due to their higher extraction rate and lower carbon emission during the processing stage.However,few studies have attempted to evaluate the economic and social benefits of increasing the amount of whole grain in grain intake.This paper estimates the potential savings in healthcare costs and reduced food carbon footprints(CFs)that could result from a shift toward whole grain consumption following the Chinese Dietary Guidelines(CDG).We investigate hypothetical scenarios where a certain proportion(5–100%)of Chinese adults could increase their whole grain intakes as proposed by CDG to meet the average shortfall of 30.2 g.In that case,the healthcare costs for associated diseases(e.g.,type2 diabetes mellitus(T2DM),cardiovascular disease(CVD),and colorectal cancer(CRC))are expected to reduce by a substantial amount,from USD 2.82 to 56.37 billion;the carbon emission levels are also projected to decrease by0.24–5.72 million tons.This study provides compelling evidence that advocating for the transition towards greater consumption of whole grain products could benefit individual health,the environment,and society,by reducing both healthcare costs and carbon emissions.展开更多
Controlling the content of athermal martensite and retained austenite is important to improving the mechanical properties of high-strength steels,but a mechanism for the accurate description of martensitic transformat...Controlling the content of athermal martensite and retained austenite is important to improving the mechanical properties of high-strength steels,but a mechanism for the accurate description of martensitic transformation during the cooling process must be addressed.At present,frequently used semi-empirical kinetics models suffer from huge errors at the beginning of transformation,and most of them fail to exhibit the sigmoidal shape characteristic of transformation curves.To describe the martensitic transformation process accurately,based on the Magee model,we introduced the changes in the nucleation activation energy of martensite with temperature,which led to the varying nucleation rates of this model during martensitic transformation.According to the calculation results,the relative error of the modified model for the martensitic transformation kinetics curves of Fe-C-X(X = Ni,Cr,Mn,Si) alloys reached 9.5% compared with those measured via the thermal expansion method.The relative error was approximately reduced by two-thirds compared with that of the Magee model.The incorporation of nucleation activation energy into the kinetics model contributes to the improvement of its precision.展开更多
Using scanner data on the consumption of packaged liquid beverages by Chinese urban households,we estimated the price elasticity of various beverages and compared the effects of volume-based versus sugar-content-based...Using scanner data on the consumption of packaged liquid beverages by Chinese urban households,we estimated the price elasticity of various beverages and compared the effects of volume-based versus sugar-content-based taxation strategies on consumer welfare.Compared to the volume-based tax,the sugar-content-based beverage tax was predicted to cost less in compensating variation under the same amount of sugar reduced,indicating that taxation based on sugar content may be more efficient in preserving consumer welfare.Further comparison across different socioeconomic groups reveals that,given current beverage consumption status in China,the efficiency advantage of the sugar-content-based taxation strategy is more pronounced than that of the volume-based taxation.Our conclusions can provide insights for the food industry and the government to reduce the sugar content in beverages.展开更多
Recent experimental advancements reported a chemical reaction between antimony and nitrogen under high temperature and high pressure,yielding crystalline antimony nitride(Sb_(3)N_(5))with an orthorhombic structure.Mot...Recent experimental advancements reported a chemical reaction between antimony and nitrogen under high temperature and high pressure,yielding crystalline antimony nitride(Sb_(3)N_(5))with an orthorhombic structure.Motivated by this statement,we calculate the stability,elastic properties,electronic properties and energy density of the Cmc2_(1) structure for pnictogen nitrides X_(3)N_(5)(X=P,As,Sb,and Bi)using first-principles calculations combined with particle swarm optimization algorithms.Calculations of formation enthalpies,elastic constants and phonon spectra show that P_(3)N_(5),As_(3)N_(5) and Sb_(3)N_(5) are thermodynamically,mechanically and kinetically stable at 35 GPa,whereas Bi_(3)N_(5) is mechanically and kinetically stable but thermodynamically unstable.The computed electronic density of states shows strong covalent bonding between the N atoms and the phosphorus group atoms in the four compounds,confirmed by the calculated electronic localization function.We also calculate the energy densities for Sb_(3)N_(5) and find it to be a potentially high-energy-density material.展开更多
Recovering high-quality inscription images from unknown and complex inscription noisy images is a challenging research issue.Different fromnatural images,character images pay more attention to stroke information.Howev...Recovering high-quality inscription images from unknown and complex inscription noisy images is a challenging research issue.Different fromnatural images,character images pay more attention to stroke information.However,existingmodelsmainly consider pixel-level informationwhile ignoring structural information of the character,such as its edge and glyph,resulting in reconstructed images with mottled local structure and character damage.To solve these problems,we propose a novel generative adversarial network(GAN)framework based on an edge-guided generator and a discriminator constructed by a dual-domain U-Net framework,i.e.,EDU-GAN.Unlike existing frameworks,the generator introduces the edge extractionmodule,guiding it into the denoising process through the attention mechanism,which maintains the edge detail of the restored inscription image.Moreover,a dual-domain U-Net-based discriminator is proposed to learn the global and local discrepancy between the denoised and the label images in both image and morphological domains,which is helpful to blind denoising tasks.The proposed dual-domain discriminator and generator for adversarial training can reduce local artifacts and keep the denoised character structure intact.Due to the lack of a real-inscription image,we built the real-inscription dataset to provide an effective benchmark for studying inscription image denoising.The experimental results show the superiority of our method both in the synthetic and real-inscription datasets.展开更多
The call for agri-food system transformation is urgent in many global development agendas(UN 2023).Food systems have contributed to economic prosperity and feeding the world,but they are also associated with numerous ...The call for agri-food system transformation is urgent in many global development agendas(UN 2023).Food systems have contributed to economic prosperity and feeding the world,but they are also associated with numerous challenges,including climate change,continued hunger,poor diets and malnutrition,and increasing disparities(Webb et al.2020;Fanzo et al.2021).展开更多
Aqueous zinc-ion batteries(AZIBs)are regarded as promising electrochemical energy storage devices owing to its low cost,intrinsic safety,abundant zinc reserves,and ideal specific capacity.Compared with other cathode m...Aqueous zinc-ion batteries(AZIBs)are regarded as promising electrochemical energy storage devices owing to its low cost,intrinsic safety,abundant zinc reserves,and ideal specific capacity.Compared with other cathode materials,manganese dioxide with high voltage,environmental protection,and high theoretical specific capacity receives considerable attention.However,the problems of structural instability,manganese dissolution,and poor electrical conductivity make the exploration of high-performance manganese dioxide still a great challenge and impede its practical applications.Besides,zinc storage mechanisms involved are complex and somewhat controversial.To address these issues,tremendous efforts,such as surface engineering,heteroatoms doping,defect engineering,electrolyte modification,and some advanced characterization technologies,have been devoted to improving its electrochemical performance and illustrating zinc storage mechanism.In this review,we particularly focus on the classification of manganese dioxide based on crystal structures,zinc ions storage mechanisms,the existing challenges,and corresponding optimization strategies as well as structure-performance relationship.In the final section,the application perspectives of manganese oxide cathode materials in AZIBs are prospected.展开更多
The resourceful and inexpensive red phosphorus has emerged as a promising anode material of potassium-ion batteries(PIBs) for its large theoretical capacities and low redox potentials in the multielectron alloying/dea...The resourceful and inexpensive red phosphorus has emerged as a promising anode material of potassium-ion batteries(PIBs) for its large theoretical capacities and low redox potentials in the multielectron alloying/dealloying reactions,yet chronically suffering from the huge volume expansion/shrinkage with a sluggish reaction kinetics and an unsatisfactory interfacial stability against volatile electrolytes.Herein,we systematically developed a series of localized high-concentration electrolytes(LHCE) through diluting high-concentration ether electrolytes with a non-solvating fluorinated ether to regulate the formation/evolution of solid electrolyte interphases(SEI) on phosphorus/carbon(P/C) anodes for PIBs.Benefitting from the improved mechanical strength and structural stability of a robust/uniform SEI thin layer derived from a composition-optimized LHCE featured with a unique solvation structure and a superior K+migration capability,the P/C anode with noticeable pseudocapacitive behaviors could achieve a large reversible capacity of 760 mA h g^(-1)at 100 mA g^(-1),a remarkable capacity retention rate of 92.6% over 200 cycles at 800 mA g^(-1),and an exceptional rate capability of 334 mA h g^(-1)at8000 mA g^(-1).Critically,a suppressed reduction of ether solvents with a preferential decomposition of potassium salts in anion-derived interfacial reactions on P/C anode for LHCE could enable a rational construction of an outer organic-rich and inner inorganic-dominant SEI thin film with remarkable mechanical strength/flexibility to buffer huge volume variations and abundant K+diffusion channels to accelerate reaction kinetics.Additionally,the highly reversible/durable full PIBs coupling P/C anodes with annealed organic cathodes further verified an excellent practical applicability of LHCE.This encouraging work on electrolytes regulating SEI formation/evolution would advance the development of P/C anodes for high-performance PIBs.展开更多
Unmanned aerial vehicles(UAVs) enable flexible networking functions in emergency scenarios.However,due to the movement characteristic of ground users(GUs),it is challenging to capture the interactions among GUs.Thus,w...Unmanned aerial vehicles(UAVs) enable flexible networking functions in emergency scenarios.However,due to the movement characteristic of ground users(GUs),it is challenging to capture the interactions among GUs.Thus,we propose a learningbased dynamic connectivity maintenance architecture to reduce the delay for the UAV-assisted device-todevice(D2D) multicast communication.In this paper,each UAV transmits information to a selected GU,and then other GUs receive the information in a multi-hop manner.To minimize the total delay while ensuring that all GUs receive the information,we decouple it into three subproblems according to the time division on the topology:For the cluster-head selection,we adopt the Whale Optimization Algorithm(WOA) to imitate the hunting behavior of whales by abstracting the UAVs and cluster-heads into whales and preys,respectively;For the D2D multi-hop link establishment,we make the best of social relationships between GUs,and propose a node mapping algorithm based on the balanced spanning tree(BST) with reconfiguration to minimize the number of hops;For the dynamic connectivity maintenance,Restricted Q-learning(RQL) is utilized to learn the optimal multicast timeslot.Finally,the simulation results show that our proposed algorithms perfor better than other benchmark algorithms in the dynamic scenario.展开更多
Microcantilever is one of the most popular miniaturized structures in micro-electromechanical systems(MEMS).Sensors based on microcantilever are ideal for biochemical detection,since they have high sensitivity,high th...Microcantilever is one of the most popular miniaturized structures in micro-electromechanical systems(MEMS).Sensors based on microcantilever are ideal for biochemical detection,since they have high sensitivity,high throughput,good specification,fast response,thus have attracted extensive attentions.A number of devices that are based on static deflections or shifts of resonant frequency of the cantilevers responding to analyte attachment have been demonstrated.This review comprehensively presents state of art of microcantilever sensors working in gaseous and aqueous environments and highlights the challenges and opportunities of microcantilever biochemical sensors.展开更多
Burning coal briquettes or biomass pellets in household decoupling stoves is of significance to the reduction of residential pollutant emissions such as NO and CO. In order to make full use of the superiority of decou...Burning coal briquettes or biomass pellets in household decoupling stoves is of significance to the reduction of residential pollutant emissions such as NO and CO. In order to make full use of the superiority of decoupling combustion technology, the household stoves should be specially designed and optimized to adapt to fuel types and combustion characteristics. Using numerical simulation and experimental validation, this study quantitatively clarified that the reducibility of devolatilization char plays an important role in the suppression of NO emission in the decoupling combustion of coal, while the reducibility of pyrolysis gases has a dominant effect on the reduction of NO in the decoupling combustion of biomass. An optimal parameter combination of throat height and grate angle was obtained for the simultaneous suppression of NO and CO emissions in the household decoupling stove burning coal briquettes. Two types of decoupling stoves were developed to enable the clean combustion of biomass pellets. The A-type biomass stove with a multi-pass smoke tunnel shows a better comprehensive NO and CO reduction effectiveness than the B-type biomass stove consisting of a two-stage grate structure and an S-shaped pyrolysis chamber. The optimal structural parameters provided references for the design and manufacture of commercial decoupling coal and biomass stoves.展开更多
The space constellation of the BeiDou navigation satellite system(BDS) is a hybrid constellation containing medium earth orbit(MEO) satellites, geostationary earth orbit(GEO) satellites, and inclined geosynchronous or...The space constellation of the BeiDou navigation satellite system(BDS) is a hybrid constellation containing medium earth orbit(MEO) satellites, geostationary earth orbit(GEO) satellites, and inclined geosynchronous orbit(IGSO) satellites. Due to the geosynchronous characteristics of GEO and IGSO, GEO satellites and IGSO satellites often need to perform orbital maneuvers, which can affect the signal-inspace(SIS) availability performance of BeiDou satellites. A two-step detection method for BeiDou satellite orbital maneuvers has been proposed in this paper. The first step is to identify orbital maneuvers based on time series analysis of broadcast ephemeris, and the second step is to verify orbital maneuvers based on bidirectional orbit prediction. The two-step detection method was used to detect the orbital maneuvers of BeiDou satellites in 2019. Through the double guarantees of identification and verification,the detection accuracy of BeiDou satellite orbital maneuvers has been effectively improved. And the orbital maneuver detection results are continued to be used to assess the SIS availability of BeiDou satellites. The results show that the availability loss of GEO satellite orbital maneuvers is about 0.45%-1.07%, and the availability loss of IGSO satellite orbital maneuvers is about 0.12%-0.19%.展开更多
基金supported by the National Natural Science Foundation of China(Grant No:81903643)the“Young Talent Support Plan”of Xi'an Jiaotong University,the Shaanxi Province Science and Technology Development Plan Project(Grant No.:2022ZDLSF05-05)+1 种基金the Project of Shaanxi Provincial Administration of Traditional Chinese Medicine(Project No.:2021-03-ZZ-002)the Shaanxi Province Science Fund for Distinguished Young Scholars(Grant No:2023-JC-JQ-59).
文摘Hepatocellular carcinoma (HCC) is one of the most common tumor types and remains a major clinical challenge. Increasing evidence has revealed that mitophagy inhibitors can enhance the effect of chemotherapy on HCC. However, few mitophagy inhibitors have been approved for clinical use in humans. Pyrimethamine (Pyr) is used to treat infections caused by protozoan parasites. Recent studies have reported that Pyr may be beneficial in the treatment of various tumors. However, its mechanism of action is still not clearly defined. Here, we found that blocking mitophagy sensitized cells to Pyr-induced apoptosis. Mechanistically, Pyr potently induced the accumulation of autophagosomes by inhibiting autophagosome-lysosome fusion in human HCC cells. In vitro and in vivo studies revealed that Pyr blocked autophagosome-lysosome fusion by upregulating BNIP3 to inhibit synaptosomal-associated protein 29 (SNAP29)-vesicle-associated membrane protein 8 (VAMP8) interaction. Moreover, Pyr acted synergistically with sorafenib (Sora) to induce apoptosis and inhibit HCC proliferation in vitro and in vivo. Pyr enhances the sensitivity of HCC cells to Sora, a common chemotherapeutic, by inhibiting mitophagy. Thus, these results provide new insights into the mechanism of action of Pyr and imply that Pyr could potentially be further developed as a novel mitophagy inhibitor. Notably, Pyr and Sora combination therapy could be a promising treatment for malignant HCC.
基金Supported by National Natural Science Foundation of China (Grant No.52275061)。
文摘Profile shift is a highly effective technique for optimizing the performance of spur gear transmission systems.However,tooth surface wear is inevitable during gear meshing due to inadequate lubrication and long-term operation.Both profile shift and tooth surface wear(TSW)can impact the meshing characteristics by altering the involute tooth profile.In this study,a tooth stiffness model of spur gears that incorporates profile shift,TSW,tooth deformation,tooth contact deformation,fillet-foundation deformation,and gear body structure coupling is established.This model efficiently and accurately determines the time-varying mesh stiffness(TVMS).Additionally,an improved wear depth prediction method for spur gears is developed,which takes into consideration the mutually prime teeth numbers and more accurately reflects actual gear meshing conditions.Results show that consideration of the mutual prime of teeth numbers will have a certain impact on the TSW process.Furthermore,the finite element method(FEM)is employed to accurately verify the values of TVMS and load sharing ratio(LSR)of profile-shifted gears and worn gears.This study quantitatively analyzes the effect of profile shift on the surface wear process,which suggests that gear profile shift can partially alleviate the negative effects of TSW.The contribution of this study provides valuable insights into the design and maintenance of spur gear systems.
基金the National Natural Science Foundation of China(72203214 and 72061147002)China Scholarship Council(CSC)(201913043)。
文摘Excessive consumption of refined grains harms human health and ecosystem viability.Whole grains,as a healthy and sustainable alternative to refined grains,can benefit individual health by providing dietary fiber,B vitamins,and bioactive substances.Additionally,they aid in improving the environment due to their higher extraction rate and lower carbon emission during the processing stage.However,few studies have attempted to evaluate the economic and social benefits of increasing the amount of whole grain in grain intake.This paper estimates the potential savings in healthcare costs and reduced food carbon footprints(CFs)that could result from a shift toward whole grain consumption following the Chinese Dietary Guidelines(CDG).We investigate hypothetical scenarios where a certain proportion(5–100%)of Chinese adults could increase their whole grain intakes as proposed by CDG to meet the average shortfall of 30.2 g.In that case,the healthcare costs for associated diseases(e.g.,type2 diabetes mellitus(T2DM),cardiovascular disease(CVD),and colorectal cancer(CRC))are expected to reduce by a substantial amount,from USD 2.82 to 56.37 billion;the carbon emission levels are also projected to decrease by0.24–5.72 million tons.This study provides compelling evidence that advocating for the transition towards greater consumption of whole grain products could benefit individual health,the environment,and society,by reducing both healthcare costs and carbon emissions.
基金financially supported by the National Natural Science Foundation of China(No.U2102212)the Shanghai Rising-Star Program(No.21QA1403200)。
文摘Controlling the content of athermal martensite and retained austenite is important to improving the mechanical properties of high-strength steels,but a mechanism for the accurate description of martensitic transformation during the cooling process must be addressed.At present,frequently used semi-empirical kinetics models suffer from huge errors at the beginning of transformation,and most of them fail to exhibit the sigmoidal shape characteristic of transformation curves.To describe the martensitic transformation process accurately,based on the Magee model,we introduced the changes in the nucleation activation energy of martensite with temperature,which led to the varying nucleation rates of this model during martensitic transformation.According to the calculation results,the relative error of the modified model for the martensitic transformation kinetics curves of Fe-C-X(X = Ni,Cr,Mn,Si) alloys reached 9.5% compared with those measured via the thermal expansion method.The relative error was approximately reduced by two-thirds compared with that of the Magee model.The incorporation of nucleation activation energy into the kinetics model contributes to the improvement of its precision.
基金supported by the National Natural Science Foundation of China(71773122,42177463,and 72203214)the Youth Development Program(YDP)of Chinese Academy of Social Sciences(2024QQJH112)。
文摘Using scanner data on the consumption of packaged liquid beverages by Chinese urban households,we estimated the price elasticity of various beverages and compared the effects of volume-based versus sugar-content-based taxation strategies on consumer welfare.Compared to the volume-based tax,the sugar-content-based beverage tax was predicted to cost less in compensating variation under the same amount of sugar reduced,indicating that taxation based on sugar content may be more efficient in preserving consumer welfare.Further comparison across different socioeconomic groups reveals that,given current beverage consumption status in China,the efficiency advantage of the sugar-content-based taxation strategy is more pronounced than that of the volume-based taxation.Our conclusions can provide insights for the food industry and the government to reduce the sugar content in beverages.
基金the Young Talent Project of the Scientific Research Plan by the Hubei Provincial Department of Education(Grant No.Q20234301)the Guiding Project of the Scientific Research Plan by the Hubei Provincial Department of Education(Grant No.B2023222)+2 种基金the Natural Science Foundation of Hubei Province(Grant No.2022CFB527)the Scientific Research Project of Jingchu University of Technology(Grant Nos.YY202401,096201-5 Chin.Phys.B 33,096201(2024)YY202409,YY202207,and YB202212)the Open Research Projects of Jingchu University of Technology(Grant No.HX20240009).
文摘Recent experimental advancements reported a chemical reaction between antimony and nitrogen under high temperature and high pressure,yielding crystalline antimony nitride(Sb_(3)N_(5))with an orthorhombic structure.Motivated by this statement,we calculate the stability,elastic properties,electronic properties and energy density of the Cmc2_(1) structure for pnictogen nitrides X_(3)N_(5)(X=P,As,Sb,and Bi)using first-principles calculations combined with particle swarm optimization algorithms.Calculations of formation enthalpies,elastic constants and phonon spectra show that P_(3)N_(5),As_(3)N_(5) and Sb_(3)N_(5) are thermodynamically,mechanically and kinetically stable at 35 GPa,whereas Bi_(3)N_(5) is mechanically and kinetically stable but thermodynamically unstable.The computed electronic density of states shows strong covalent bonding between the N atoms and the phosphorus group atoms in the four compounds,confirmed by the calculated electronic localization function.We also calculate the energy densities for Sb_(3)N_(5) and find it to be a potentially high-energy-density material.
基金supported by the Key R&D Program of Shaanxi Province,China(Grant Nos.2022GY-274,2023-YBSF-505)the National Natural Science Foundation of China(Grant No.62273273).
文摘Recovering high-quality inscription images from unknown and complex inscription noisy images is a challenging research issue.Different fromnatural images,character images pay more attention to stroke information.However,existingmodelsmainly consider pixel-level informationwhile ignoring structural information of the character,such as its edge and glyph,resulting in reconstructed images with mottled local structure and character damage.To solve these problems,we propose a novel generative adversarial network(GAN)framework based on an edge-guided generator and a discriminator constructed by a dual-domain U-Net framework,i.e.,EDU-GAN.Unlike existing frameworks,the generator introduces the edge extractionmodule,guiding it into the denoising process through the attention mechanism,which maintains the edge detail of the restored inscription image.Moreover,a dual-domain U-Net-based discriminator is proposed to learn the global and local discrepancy between the denoised and the label images in both image and morphological domains,which is helpful to blind denoising tasks.The proposed dual-domain discriminator and generator for adversarial training can reduce local artifacts and keep the denoised character structure intact.Due to the lack of a real-inscription image,we built the real-inscription dataset to provide an effective benchmark for studying inscription image denoising.The experimental results show the superiority of our method both in the synthetic and real-inscription datasets.
文摘The call for agri-food system transformation is urgent in many global development agendas(UN 2023).Food systems have contributed to economic prosperity and feeding the world,but they are also associated with numerous challenges,including climate change,continued hunger,poor diets and malnutrition,and increasing disparities(Webb et al.2020;Fanzo et al.2021).
基金supported by the National Natural Science Foundation of China(22279101,5210130199)the Natural Science Basic Research Plan in Shaanxi Province of China(2022JM-090)+2 种基金China Postdoctoral Science Foundation(2021 M693885)Science and Technology Planning Project of Beilin District(GX2111)and Young Talents Supporting Project of Xi'an Science Association(095920221359).
文摘Aqueous zinc-ion batteries(AZIBs)are regarded as promising electrochemical energy storage devices owing to its low cost,intrinsic safety,abundant zinc reserves,and ideal specific capacity.Compared with other cathode materials,manganese dioxide with high voltage,environmental protection,and high theoretical specific capacity receives considerable attention.However,the problems of structural instability,manganese dissolution,and poor electrical conductivity make the exploration of high-performance manganese dioxide still a great challenge and impede its practical applications.Besides,zinc storage mechanisms involved are complex and somewhat controversial.To address these issues,tremendous efforts,such as surface engineering,heteroatoms doping,defect engineering,electrolyte modification,and some advanced characterization technologies,have been devoted to improving its electrochemical performance and illustrating zinc storage mechanism.In this review,we particularly focus on the classification of manganese dioxide based on crystal structures,zinc ions storage mechanisms,the existing challenges,and corresponding optimization strategies as well as structure-performance relationship.In the final section,the application perspectives of manganese oxide cathode materials in AZIBs are prospected.
基金supported by the National Key Research and Development Program of China(2021YFB2400200)the National Natural Science Foundation of China(52104313,22172117,52072298)the Scientific Research Program of Shaanxi Provincial Education Department(21JK0808)。
文摘The resourceful and inexpensive red phosphorus has emerged as a promising anode material of potassium-ion batteries(PIBs) for its large theoretical capacities and low redox potentials in the multielectron alloying/dealloying reactions,yet chronically suffering from the huge volume expansion/shrinkage with a sluggish reaction kinetics and an unsatisfactory interfacial stability against volatile electrolytes.Herein,we systematically developed a series of localized high-concentration electrolytes(LHCE) through diluting high-concentration ether electrolytes with a non-solvating fluorinated ether to regulate the formation/evolution of solid electrolyte interphases(SEI) on phosphorus/carbon(P/C) anodes for PIBs.Benefitting from the improved mechanical strength and structural stability of a robust/uniform SEI thin layer derived from a composition-optimized LHCE featured with a unique solvation structure and a superior K+migration capability,the P/C anode with noticeable pseudocapacitive behaviors could achieve a large reversible capacity of 760 mA h g^(-1)at 100 mA g^(-1),a remarkable capacity retention rate of 92.6% over 200 cycles at 800 mA g^(-1),and an exceptional rate capability of 334 mA h g^(-1)at8000 mA g^(-1).Critically,a suppressed reduction of ether solvents with a preferential decomposition of potassium salts in anion-derived interfacial reactions on P/C anode for LHCE could enable a rational construction of an outer organic-rich and inner inorganic-dominant SEI thin film with remarkable mechanical strength/flexibility to buffer huge volume variations and abundant K+diffusion channels to accelerate reaction kinetics.Additionally,the highly reversible/durable full PIBs coupling P/C anodes with annealed organic cathodes further verified an excellent practical applicability of LHCE.This encouraging work on electrolytes regulating SEI formation/evolution would advance the development of P/C anodes for high-performance PIBs.
基金supported by the Future Scientists Program of China University of Mining and Technology(2020WLKXJ030)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX201993).
文摘Unmanned aerial vehicles(UAVs) enable flexible networking functions in emergency scenarios.However,due to the movement characteristic of ground users(GUs),it is challenging to capture the interactions among GUs.Thus,we propose a learningbased dynamic connectivity maintenance architecture to reduce the delay for the UAV-assisted device-todevice(D2D) multicast communication.In this paper,each UAV transmits information to a selected GU,and then other GUs receive the information in a multi-hop manner.To minimize the total delay while ensuring that all GUs receive the information,we decouple it into three subproblems according to the time division on the topology:For the cluster-head selection,we adopt the Whale Optimization Algorithm(WOA) to imitate the hunting behavior of whales by abstracting the UAVs and cluster-heads into whales and preys,respectively;For the D2D multi-hop link establishment,we make the best of social relationships between GUs,and propose a node mapping algorithm based on the balanced spanning tree(BST) with reconfiguration to minimize the number of hops;For the dynamic connectivity maintenance,Restricted Q-learning(RQL) is utilized to learn the optimal multicast timeslot.Finally,the simulation results show that our proposed algorithms perfor better than other benchmark algorithms in the dynamic scenario.
基金supported by National Science Foundation of China(61804107,61804150)National Key Research and Development Program of China(2022YFF0706102)Tianjin Municipal Science and Technology Bureau(20JCQNJC00180).
文摘Microcantilever is one of the most popular miniaturized structures in micro-electromechanical systems(MEMS).Sensors based on microcantilever are ideal for biochemical detection,since they have high sensitivity,high throughput,good specification,fast response,thus have attracted extensive attentions.A number of devices that are based on static deflections or shifts of resonant frequency of the cantilevers responding to analyte attachment have been demonstrated.This review comprehensively presents state of art of microcantilever sensors working in gaseous and aqueous environments and highlights the challenges and opportunities of microcantilever biochemical sensors.
基金financial supports from the “Transformational Technologies for Clean Energy and Demonstration”, Strategic Priority Research Program of Chinese Academy of Sciences (XDA21040400)。
文摘Burning coal briquettes or biomass pellets in household decoupling stoves is of significance to the reduction of residential pollutant emissions such as NO and CO. In order to make full use of the superiority of decoupling combustion technology, the household stoves should be specially designed and optimized to adapt to fuel types and combustion characteristics. Using numerical simulation and experimental validation, this study quantitatively clarified that the reducibility of devolatilization char plays an important role in the suppression of NO emission in the decoupling combustion of coal, while the reducibility of pyrolysis gases has a dominant effect on the reduction of NO in the decoupling combustion of biomass. An optimal parameter combination of throat height and grate angle was obtained for the simultaneous suppression of NO and CO emissions in the household decoupling stove burning coal briquettes. Two types of decoupling stoves were developed to enable the clean combustion of biomass pellets. The A-type biomass stove with a multi-pass smoke tunnel shows a better comprehensive NO and CO reduction effectiveness than the B-type biomass stove consisting of a two-stage grate structure and an S-shaped pyrolysis chamber. The optimal structural parameters provided references for the design and manufacture of commercial decoupling coal and biomass stoves.
基金This research was funded by the Shandong Provincial Natural Science Foundation(ZR2022QD100,ZR2022QE221)the Weifang University of Science and Technology Doctoral Research Startup Fund(2021KJBS16).
文摘The space constellation of the BeiDou navigation satellite system(BDS) is a hybrid constellation containing medium earth orbit(MEO) satellites, geostationary earth orbit(GEO) satellites, and inclined geosynchronous orbit(IGSO) satellites. Due to the geosynchronous characteristics of GEO and IGSO, GEO satellites and IGSO satellites often need to perform orbital maneuvers, which can affect the signal-inspace(SIS) availability performance of BeiDou satellites. A two-step detection method for BeiDou satellite orbital maneuvers has been proposed in this paper. The first step is to identify orbital maneuvers based on time series analysis of broadcast ephemeris, and the second step is to verify orbital maneuvers based on bidirectional orbit prediction. The two-step detection method was used to detect the orbital maneuvers of BeiDou satellites in 2019. Through the double guarantees of identification and verification,the detection accuracy of BeiDou satellite orbital maneuvers has been effectively improved. And the orbital maneuver detection results are continued to be used to assess the SIS availability of BeiDou satellites. The results show that the availability loss of GEO satellite orbital maneuvers is about 0.45%-1.07%, and the availability loss of IGSO satellite orbital maneuvers is about 0.12%-0.19%.
