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聚乙烯醇基凝胶聚合物电解质的制备及在锌离子混合电容器中的应用
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作者 左丹英 王静静 +2 位作者 杨赫 许静 张宏伟 《高分子材料科学与工程》 EI CAS CSCD 北大核心 2024年第2期157-163,共7页
锌离子混合电容器(ZIHC)兼有电池高能量密度和电容器高功率密度的特点,是下一代能源存储设备的有力竞争者,但电池型阴极-电容型阳极ZIHC的研究中使用的多为电解质溶液,容易泄漏而导致安全风险。针对这一问题,文中以纤维素、羟乙基纤维... 锌离子混合电容器(ZIHC)兼有电池高能量密度和电容器高功率密度的特点,是下一代能源存储设备的有力竞争者,但电池型阴极-电容型阳极ZIHC的研究中使用的多为电解质溶液,容易泄漏而导致安全风险。针对这一问题,文中以纤维素、羟乙基纤维素和聚乙烯醇为原料,通过冷冻-解冻和电解液吸收的方法,快速制备了具有蜂巢状的三维网络形貌的凝胶聚合物电解质(GPE)。优化的GPE不仅具有良好力学性能(拉伸强度0.24 MPa、断裂伸长率289%),而且表现出较高的离子电导率(58.5 mS/cm)。使用GPE、二氧化锰阴极和活性炭阳极组成的ZIHC,其比电容和能量密度分别为31.5 F/g和15.0 Wh/kg,2 A/g充放电循环1.5×104次后比电容保持率约80%,展示出GPE在ZIHC领域中潜在的应用价值。原料环保和方便快捷的制备方法为能量存储和柔性可穿戴电子领域应用的GPE研究提供了新的思路。 展开更多
关键词 聚乙烯醇 凝胶聚合物电解质 锌离子混合电容器
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Transforming agri-food systems for multiple wins in nutrition,inclusion and environment
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作者 Shenggen Fan Qiran Zhao jingjing wang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第2期355-358,共4页
The call for agri-food system transformation is urgent in many global development agendas(UN 2023).Food systems have contributed to economic prosperity and feeding the world,but they are also associated with numerous ... The call for agri-food system transformation is urgent in many global development agendas(UN 2023).Food systems have contributed to economic prosperity and feeding the world,but they are also associated with numerous challenges,including climate change,continued hunger,poor diets and malnutrition,and increasing disparities(Webb et al.2020;Fanzo et al.2021). 展开更多
关键词 continued NUTRITION URGENT
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金属单原子催化剂增强硫正极动力学的研究进展 被引量:3
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作者 王晶晶 曹贵强 +2 位作者 段瑞贤 李向阳 李喜飞 《物理化学学报》 SCIE CAS CSCD 北大核心 2023年第5期43-60,共18页
单质硫具有理论能量密度高(2600 Wh·kg^(−1))、放电比容量高(1672 mAh·g^(−1))、成本低等优势,是锂硫电池的理想正极材料。然而,在充放电过程中硫正极迟缓的反应动力学显著地限制了锂硫电池的性能。金属单原子催化剂(SMACs)... 单质硫具有理论能量密度高(2600 Wh·kg^(−1))、放电比容量高(1672 mAh·g^(−1))、成本低等优势,是锂硫电池的理想正极材料。然而,在充放电过程中硫正极迟缓的反应动力学显著地限制了锂硫电池的性能。金属单原子催化剂(SMACs)具有独特的电子结构、金属含量低、理论上100%的原子利用率、催化活性高等优势,其不仅有效地促进了不同中间相的转化反应,而且可为含硫物质提供丰富的锚定位点,从而显著优化硫正极氧化还原反应动力学、多硫化物的穿梭行为和锂硫电池电化学性能。本文以剖析金属单原子催化剂与硫正极间的相互作用为出发点,结合其催化效应表征技术,重点解析了不同类型单原子催化剂的构筑策略、活性调控及其优化硫正极氧化还原行为的机制,展望了金属单原子催化剂在锂硫电池领域面临的挑战和未来发展方向。 展开更多
关键词 硫正极 反应动力学 金属单原子催化剂 多硫化物转化 锂硫电池
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骨科植入物无机抗菌涂层的研究现状
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作者 张卓 马迅 +3 位作者 刘平 王静静 章浩 李伟 《材料工程》 EI CAS CSCD 北大核心 2023年第9期13-27,共15页
植入物感染是骨科最常见和最严重的并发症之一,也是导致植入手术失败的重要原因。当细菌在植入物表面形成生物膜后会极难消除,并吸附更多的细菌和真菌。大量研究表明,通过采用表面改性技术可有效减少致病菌的黏附和聚积,进而预防植入物... 植入物感染是骨科最常见和最严重的并发症之一,也是导致植入手术失败的重要原因。当细菌在植入物表面形成生物膜后会极难消除,并吸附更多的细菌和真菌。大量研究表明,通过采用表面改性技术可有效减少致病菌的黏附和聚积,进而预防植入物周围感染。本文首先分析了细菌生物膜在骨科植入物表面的形成过程以及金属抗菌剂的抗菌机制。然后综述了目前国内外使用最广泛的一些金属基无机抗菌涂层及其相关的制备工艺,讨论了这些涂层在应用中存在的问题和改善方法,并展望了未来无机抗菌涂层的发展方向,包括协同抗菌型涂层和促成骨型抗菌涂层等。 展开更多
关键词 骨科植入体 无机抗菌涂层 制备工艺 组织结构 生物相容性 银纳米颗粒
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Regulating solid electrolyte interphases on phosphorus/carbon anodes via localized high-concentration electrolytes for potassium-ion batteries 被引量:1
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作者 Wei Xiao Peiyi Shi +7 位作者 Zhengkui Li Chong Xie Jian Qin Huijuan Yang jingjing wang Wenbin Li Jiujun Zhang Xifei Li 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第3期589-605,I0016,共18页
The resourceful and inexpensive red phosphorus has emerged as a promising anode material of potassium-ion batteries(PIBs) for its large theoretical capacities and low redox potentials in the multielectron alloying/dea... The resourceful and inexpensive red phosphorus has emerged as a promising anode material of potassium-ion batteries(PIBs) for its large theoretical capacities and low redox potentials in the multielectron alloying/dealloying reactions,yet chronically suffering from the huge volume expansion/shrinkage with a sluggish reaction kinetics and an unsatisfactory interfacial stability against volatile electrolytes.Herein,we systematically developed a series of localized high-concentration electrolytes(LHCE) through diluting high-concentration ether electrolytes with a non-solvating fluorinated ether to regulate the formation/evolution of solid electrolyte interphases(SEI) on phosphorus/carbon(P/C) anodes for PIBs.Benefitting from the improved mechanical strength and structural stability of a robust/uniform SEI thin layer derived from a composition-optimized LHCE featured with a unique solvation structure and a superior K+migration capability,the P/C anode with noticeable pseudocapacitive behaviors could achieve a large reversible capacity of 760 mA h g^(-1)at 100 mA g^(-1),a remarkable capacity retention rate of 92.6% over 200 cycles at 800 mA g^(-1),and an exceptional rate capability of 334 mA h g^(-1)at8000 mA g^(-1).Critically,a suppressed reduction of ether solvents with a preferential decomposition of potassium salts in anion-derived interfacial reactions on P/C anode for LHCE could enable a rational construction of an outer organic-rich and inner inorganic-dominant SEI thin film with remarkable mechanical strength/flexibility to buffer huge volume variations and abundant K+diffusion channels to accelerate reaction kinetics.Additionally,the highly reversible/durable full PIBs coupling P/C anodes with annealed organic cathodes further verified an excellent practical applicability of LHCE.This encouraging work on electrolytes regulating SEI formation/evolution would advance the development of P/C anodes for high-performance PIBs. 展开更多
关键词 Potassium-ion batteries Phosphorus/carbon anodes Localized high-concentration electrolytes Solid electrolyte interphases Interfacial stability
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物理化学理论课与实验课的融合教学模式探索 被引量:3
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作者 贾娜尔·吐尔逊 王晶晶 杜光明 《大学化学》 CAS 2023年第1期22-28,共7页
开展物理化学理论课与实验课相融合的教学。理论课教学过程中找准切入点融入实验原理,加深学生对知识的理解,调动学生的学习兴趣和求知欲,课堂气氛活跃,学生融入课堂并互动。实验课上引导学生学习实验设计思路与方法,提出严格的数据记... 开展物理化学理论课与实验课相融合的教学。理论课教学过程中找准切入点融入实验原理,加深学生对知识的理解,调动学生的学习兴趣和求知欲,课堂气氛活跃,学生融入课堂并互动。实验课上引导学生学习实验设计思路与方法,提出严格的数据记录与处理要求,学生实验报告的逻辑性增强,可独立对实验结果进行讨论,能够正确分析实验误差可能的原因,对实验方案、方法和仪器可提出改进的意见和建议。通过理论课与实验课融合的教学模式可培养学生的逻辑思维能力和实践能力。该教学模式的实施需要学校和系部强有力的政策保障。 展开更多
关键词 物理化学 理论课 实验课 融合教学模式
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绿色建筑评价标准在北京老城平房院落更新改造中的适应性分析与建议
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作者 王晶晶 宋修教 +2 位作者 张悦 苗基芸 余旺仔 《城市设计》 2023年第6期44-53,共10页
在国家“双碳”战略目标下,针对北京老城平房院落更新改造难以达到绿色建筑高等级评价、难以有力支撑首都功能核心区落实双碳目标的工作任务等问题,从老城街巷肌理尺度、平房院落空间格局、社区运维绿色转型等方面出发,逐条分析现有绿... 在国家“双碳”战略目标下,针对北京老城平房院落更新改造难以达到绿色建筑高等级评价、难以有力支撑首都功能核心区落实双碳目标的工作任务等问题,从老城街巷肌理尺度、平房院落空间格局、社区运维绿色转型等方面出发,逐条分析现有绿色建筑评价标准的安全耐久、健康舒适、生活便利、资源节约和环境宜居5个类别、100个评价条目在北京老城的适应性并提出删改建议。对探索构建匹配北京老城平房院落的绿色评价新体系具有参照意义,对全国各地老城区的绿色低碳更新具有普适借鉴意义。经分析,有17项条目建议剔除,11项条目建议调整,另建议新增“砖木结构延寿利用、院落空间格局传承、功能适宜性提升、立面风貌协调”4个评分项条目。 展开更多
关键词 绿色建筑评价标准 北京老城 平房院落 更新改造 适应性分析
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Optimization of decoupling combustion characteristics of coal briquettes and biomass pellets in household stoves
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作者 Jian Han Xinhua Liu +3 位作者 Shanwei Hu Nan Zhang jingjing wang Bin Liang 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2023年第7期182-192,共11页
Burning coal briquettes or biomass pellets in household decoupling stoves is of significance to the reduction of residential pollutant emissions such as NO and CO. In order to make full use of the superiority of decou... Burning coal briquettes or biomass pellets in household decoupling stoves is of significance to the reduction of residential pollutant emissions such as NO and CO. In order to make full use of the superiority of decoupling combustion technology, the household stoves should be specially designed and optimized to adapt to fuel types and combustion characteristics. Using numerical simulation and experimental validation, this study quantitatively clarified that the reducibility of devolatilization char plays an important role in the suppression of NO emission in the decoupling combustion of coal, while the reducibility of pyrolysis gases has a dominant effect on the reduction of NO in the decoupling combustion of biomass. An optimal parameter combination of throat height and grate angle was obtained for the simultaneous suppression of NO and CO emissions in the household decoupling stove burning coal briquettes. Two types of decoupling stoves were developed to enable the clean combustion of biomass pellets. The A-type biomass stove with a multi-pass smoke tunnel shows a better comprehensive NO and CO reduction effectiveness than the B-type biomass stove consisting of a two-stage grate structure and an S-shaped pyrolysis chamber. The optimal structural parameters provided references for the design and manufacture of commercial decoupling coal and biomass stoves. 展开更多
关键词 Decoupling combustion COAL BIOMASS Numerical simulation Nitrogen oxide Carbon monoxide
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A two-step method to detect broadcast ephemeris unavailable periods caused by BeiDou satellite orbital maneuvers
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作者 jingjing wang Chao Zhou Zhixuan Sun 《Geodesy and Geodynamics》 EI CSCD 2023年第5期456-466,共11页
The space constellation of the BeiDou navigation satellite system(BDS) is a hybrid constellation containing medium earth orbit(MEO) satellites, geostationary earth orbit(GEO) satellites, and inclined geosynchronous or... The space constellation of the BeiDou navigation satellite system(BDS) is a hybrid constellation containing medium earth orbit(MEO) satellites, geostationary earth orbit(GEO) satellites, and inclined geosynchronous orbit(IGSO) satellites. Due to the geosynchronous characteristics of GEO and IGSO, GEO satellites and IGSO satellites often need to perform orbital maneuvers, which can affect the signal-inspace(SIS) availability performance of BeiDou satellites. A two-step detection method for BeiDou satellite orbital maneuvers has been proposed in this paper. The first step is to identify orbital maneuvers based on time series analysis of broadcast ephemeris, and the second step is to verify orbital maneuvers based on bidirectional orbit prediction. The two-step detection method was used to detect the orbital maneuvers of BeiDou satellites in 2019. Through the double guarantees of identification and verification,the detection accuracy of BeiDou satellite orbital maneuvers has been effectively improved. And the orbital maneuver detection results are continued to be used to assess the SIS availability of BeiDou satellites. The results show that the availability loss of GEO satellite orbital maneuvers is about 0.45%-1.07%, and the availability loss of IGSO satellite orbital maneuvers is about 0.12%-0.19%. 展开更多
关键词 BDS Orbital maneuver Signal-in-space AVAILABILITY Time series analysis
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Learning-Based Dynamic Connectivity Maintenance for UAV-Assisted D2D Multicast Communication
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作者 jingjing wang Yanjing Sun +3 位作者 Bowen wang Shenshen Qian Zhijian Tian Xiaolin wang 《China Communications》 SCIE CSCD 2023年第10期305-322,共18页
Unmanned aerial vehicles(UAVs) enable flexible networking functions in emergency scenarios.However,due to the movement characteristic of ground users(GUs),it is challenging to capture the interactions among GUs.Thus,w... Unmanned aerial vehicles(UAVs) enable flexible networking functions in emergency scenarios.However,due to the movement characteristic of ground users(GUs),it is challenging to capture the interactions among GUs.Thus,we propose a learningbased dynamic connectivity maintenance architecture to reduce the delay for the UAV-assisted device-todevice(D2D) multicast communication.In this paper,each UAV transmits information to a selected GU,and then other GUs receive the information in a multi-hop manner.To minimize the total delay while ensuring that all GUs receive the information,we decouple it into three subproblems according to the time division on the topology:For the cluster-head selection,we adopt the Whale Optimization Algorithm(WOA) to imitate the hunting behavior of whales by abstracting the UAVs and cluster-heads into whales and preys,respectively;For the D2D multi-hop link establishment,we make the best of social relationships between GUs,and propose a node mapping algorithm based on the balanced spanning tree(BST) with reconfiguration to minimize the number of hops;For the dynamic connectivity maintenance,Restricted Q-learning(RQL) is utilized to learn the optimal multicast timeslot.Finally,the simulation results show that our proposed algorithms perfor better than other benchmark algorithms in the dynamic scenario. 展开更多
关键词 cluster-head selection whale optimization algorithm(WOA) balanced spanning tree(BST) multi-hop link establishment dynamic connectivity maintenance
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Microcantilever sensors for biochemical detection
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作者 jingjing wang Baozheng Xu +1 位作者 Yinfang Zhu Junyuan Zhao 《Journal of Semiconductors》 EI CAS CSCD 2023年第2期66-76,共11页
Microcantilever is one of the most popular miniaturized structures in micro-electromechanical systems(MEMS).Sensors based on microcantilever are ideal for biochemical detection,since they have high sensitivity,high th... Microcantilever is one of the most popular miniaturized structures in micro-electromechanical systems(MEMS).Sensors based on microcantilever are ideal for biochemical detection,since they have high sensitivity,high throughput,good specification,fast response,thus have attracted extensive attentions.A number of devices that are based on static deflections or shifts of resonant frequency of the cantilevers responding to analyte attachment have been demonstrated.This review comprehensively presents state of art of microcantilever sensors working in gaseous and aqueous environments and highlights the challenges and opportunities of microcantilever biochemical sensors. 展开更多
关键词 MICROCANTILEVER SENSOR biochemical detection MEMS
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Depolarization of Li-rich Mn-based oxide via electrochemically active Prussian blue interface providing superior rate capability
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作者 Youchen Hao Xifei Li +7 位作者 Wen Liu jingjing wang Hui Shan Wenbin Li Xingjiang Liu Liangxu Lin Xianyou wang Xueliang Sun 《Carbon Energy》 SCIE CSCD 2023年第5期48-56,共9页
The high-rate cyclability of Li-rich Mn-based oxide(LMO)is highly limited by the electrochemical polarization resulting from the slow kinetic of the Li2MnO3 phase.Herein,the Prussian blue(PB)coating layer with specifi... The high-rate cyclability of Li-rich Mn-based oxide(LMO)is highly limited by the electrochemical polarization resulting from the slow kinetic of the Li2MnO3 phase.Herein,the Prussian blue(PB)coating layer with specific redox potential is introduced as a functionalized interface to overcome the side effect and the escaping of O on the surface of LMO,especially its poor rate capability.In detail,the PB layer can restrict the large polarization of LMO by sharing overloaded current at a high rate due to the synchronous redox of PB and LMO.Consequently,an enhanced high rate performance with capacity retention of 87.8%over 300 cycles is obtained,which is superior to 50.5%of the pristine electrode.Such strategies on the high-rate cyclability of Li-rich Mn-based oxide compatible with good low-rate performances may attract great attention for pursuing durable performances. 展开更多
关键词 Li-rich Mn-based oxide Prussian blue coating layer synchronous redox high-rate cyclability
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The Effect of Self-Investment on Hoarding Tendency of Chinese College Students:Role of Psychological Connections
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作者 Xiangli Guan Yue Zhang +6 位作者 Yang Li Yaqi Zhang jingjing wang Xuejiao Li Mary C.Jobe Md Zahir Ahmed Oli Ahmed 《International Journal of Mental Health Promotion》 2023年第6期755-766,共12页
Because of factors such as energy and time one invests in an object,the stronger the connection,value,and reluc-tance to lose said object individual will have.Hoarding behavior arises when individuals incorporate a st... Because of factors such as energy and time one invests in an object,the stronger the connection,value,and reluc-tance to lose said object individual will have.Hoarding behavior arises when individuals incorporate a strong attachment with themselves to an object.The purpose of this study is to examine the effect of self-investment on hoarding tendency and the roles of possession-self link and liking level in this connection.A hypothetical model of the relationship between self-investment,possession-self link,liking level,and hoarding tendency was tested.A convenience sampling method was used to survey 450 college students in Yunnan Province on either a paper-based or online self-report scale.The data were collected using self-investment,possession-self link,and liking level questionnaires,as well as the Saving Inventory Revised.Results showed positive relationship between the study variables,ranging from 0.37 to 0.87.College students’self-investment had a direct positive pre-dictive effect on hoarding tendency;self-investment,in turn,indirectly predicted hoarding tendency through the mediating effect of possession-self link;and individual liking level of items had a moderating effect for self-invest-ment on the possession-self link.This study shows how self-investment affects the hoarding tendency of college students,and the results of this study also help demonstrate the value of self-investment and possession-self link in optimizing students’hoarding tendency and thus promoting good psychological status. 展开更多
关键词 Hoarding tendency self-investment psychological connections possession-self link liking level
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Effect of Family Cohesion on Depression of Chinese College Students in the COVID-19 Pandemic: Chain Mediation Effect of Perceived Social Support and Intentional Self-Regulation
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作者 jingjing wang Xiangli Guan +4 位作者 Yue Zhang Yang Li Md Zahir Ahmed Mary CJobe Oli Ahmed 《International Journal of Mental Health Promotion》 2023年第2期223-235,共13页
Individuals’perceptions,attitudes,and patterns of getting along with family members are important factors influencing Chinese people’s self-evaluation.The aim of this study was to investigate the effect of family co... Individuals’perceptions,attitudes,and patterns of getting along with family members are important factors influencing Chinese people’s self-evaluation.The aim of this study was to investigate the effect of family cohesion on depression and the role of perceived social support and intentional self-regulation in this association.A hypothesized model of the association of family cohesion,perceived social support,intentional self-regulation,and depression was examined.A convenience sampling method was used to survey 1,180 college students in Yunnan Province using self-report.Data were collected using the Family Cohesion Scale,the Perceived Social Support Scale,the Intentional Self-Regulation Scale,and the Center for Epidemiological Studies Depression Scale.The findings revealed low to moderate correlation between the variables studied.College students’family cohesion was a negative predictor of their depression.This association was also mediated by the knock-on effect of perceived social support and intentional self-regulation.These findings show how family cohesion affects college students’depressive status.Specifically,these results help demonstrate the importance of family cohesion,perceived social support,and intentional self-regulation in optimizing students’depression,which in turn can promote better psychological states. 展开更多
关键词 DEPRESSION family cohesion perceived social support intentional self-regulation
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Extreme gradient boosting algorithm based urban daily traffic index prediction model:a case study of Beijing,China
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作者 Jiancheng Weng Kai Feng +2 位作者 Yu Fu jingjing wang Lizeng Mao 《Digital Transportation and Safety》 2023年第3期220-228,共9页
The exhaust emissions and frequent traffic incidents caused by traffic congestion have affected the operation and development of urban transport systems.Monitoring and accurately forecasting urban traffic operation is... The exhaust emissions and frequent traffic incidents caused by traffic congestion have affected the operation and development of urban transport systems.Monitoring and accurately forecasting urban traffic operation is a critical task to formulate pertinent strategies to alleviate traffic congestion.Compared with traditional short-time traffic prediction,this study proposes a machine learning algorithm-based traffic forecasting model for daily-level peak hour traffic operation status prediction by using abundant historical data of urban traffic performance index(TPI).The study also constructed a multi-dimensional influencing factor set to further investigate the relationship between different factors on the quality of road network operation,including day of week,time period,public holiday,car usage restriction policy,special events,etc.Based on long-term historical TPI data,this research proposed a daily dimensional road network TPI prediction model by using an extreme gradient boosting algorithm(XGBoost).The model validation results show that the model prediction accuracy can reach higher than 90%.Compared with other prediction models,including Bayesian Ridge,Linear Regression,ElatsicNet,SVR,the XGBoost model has a better performance,and proves its superiority in large high-dimensional data sets.The daily dimensional prediction model proposed in this paper has an important application value for predicting traffic status and improving the operation quality of urban road networks. 展开更多
关键词 Traffic prediction Traffic performance index(TPI) Influencing factor XGBOOST Machine learning model
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The Role of Structured Framework in Simulated Cardiac Emergency for Cardiothoracic Training
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作者 Yufeng Zhang Wenjing Lu +5 位作者 Junnan wang Hua Shen Jie Min Qing wang jingjing wang Zhinong wang 《Open Journal of Emergency Medicine》 2022年第2期100-110,共11页
Background: Both technical and nontechnical skills are important factors in cardiac emergency incident. The effects of structured framework on these skills have not been thoroughly studied. We hypothesized that struct... Background: Both technical and nontechnical skills are important factors in cardiac emergency incident. The effects of structured framework on these skills have not been thoroughly studied. We hypothesized that structured framework can improve the clinical performance and reduce errors to improve patients’ safety. Methodology: A total of 24 teams composed of cardiac residents, attending surgeons and ICU nurses performed simulated emergency incident tasks in cardiopulmonary resuscitation (CPR) and tracheal intubation (TI) scenarios. Framework education was introduced to the assigned groups in two separate semesters. All the scenarios were recorded by video for further evaluation by cardiologist and emergency medicine specialist. Clinical performance, time consumption in simulated scenarios, correlation between framework training and nontechnical skills performance were assessed. Results: The average percentages of CPR completed in the Group 1 (G1) with framework education and the Group 2 (G2) were 85% (SEM: 6.20%) and 53% (SEM: 5.77%) respectively (P < 0.001). And the average percentages of TI completed in G2 with framework education was 87% (SEM: 3.96%), higher than G1 (50%, SEM: 5.64%) (P < 0.001). As for time consumption, the mean time to complete CPR in groups with framework education was shorter than in groups without framework education (P o complete TI in groups with framework education was shorter than in groups without framework education (P < 0.005). Further, there was a significant correlation between framework training and communication in simulated scenarios. Conclusion: The framework provides the whole procedure of the task to every participant. Structured framework education can improve nontechnical skills as well as technical skills of doctors and nurses. Further, researches should be conducted to evaluate the clinical performance and correlation between technical skills and nontechnical skills in cardiothoracic training. 展开更多
关键词 CPR Education FRAMEWORK Nontechnical Skills
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Amivantamab治疗EGFR/MET基因异常非小细胞肺癌的单中心经验 被引量:2
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作者 王静静 迟雨佳 +5 位作者 陈含笑 郏博 翟晓宇 马梦磊 李俭杰 卓明磊 《中国肺癌杂志》 CAS CSCD 北大核心 2022年第7期493-500,共8页
背景与目的表皮生长因子受体(epidermal growth factor receptor,EGFR)和细胞间质上皮转换因子(cellular-mesenchymal to epithelial transition factor,c-Met)是非小细胞肺癌(non-small cell lung cancer,NSCLC)中常见的变异基因,都是... 背景与目的表皮生长因子受体(epidermal growth factor receptor,EGFR)和细胞间质上皮转换因子(cellular-mesenchymal to epithelial transition factor,c-Met)是非小细胞肺癌(non-small cell lung cancer,NSCLC)中常见的变异基因,都是受体酪氨酸激酶,在下游信号转导方面具有协同作用。针对EGFR和c-Met通路的靶向药物联合应用后,能够阻断PI3K/AKT/mTOR途径和Ras/Raf/Mek途径,限制补偿通路激活,发挥抗肿瘤作用。以Amivantamab为代表的EGFR和c-Met双特异性抗体新型药物能同时阻断两条信号通路,在肺癌临床研究中展现出良好前景。然而目前国内应用较少,相关经验缺乏。本研究将介绍我中心Amivantamab疗效数据和不良反应处理经验,探讨此类药物对我国EGFR/MET基因异常NSCLC的应用价值。方法收集2020年8月-2021年12月于我院接受Amivantamab治疗的晚期NSCLC病例的临床数据,分析其治疗反应率、生存和不良反应。结果本研究共纳入15例患者,其中Amivantamab单药治疗6例,Amivantamab联合Lazertinib治疗9例。治疗后7例(46.7%)达部分缓解(partial response,PR),7例(46.7%)达疾病稳定(stable disease,SD),1例(6.7%)达疾病进展(progressive disease,PD),总体客观缓解率(objective response rate,ORR)为46.7%,总体疾病控制率(disease control rate,DCR)为93.3%。7例EGFR外显子20插入突变患者中,2例(28.6%)达PR,5例(71.4%)达SD,DCR为100.0%,中位缓解持续时间(duration of response,DOR)未成熟,2例PR者仍持续缓解。5例奥希替尼耐药的患者中,2例(40.0%)达PR,3例(60.0%)达SD,DCR为100.0%,中位DOR未成熟,1例PR者仍持续缓解。中位随访时间为8.7个月(0.9个月-18.6个月),截至最后一次随访,共有6例患者发生疾病进展,3例患者死亡,中位无进展生存期和中位总生存期未成熟。常见的不良事件为皮疹(86.7%),甲沟炎(80.0%)和输液反应(60.0%),多为1级-2级。3级及以上不良反应包括皮疹(33.3%),转氨酶升高(13.3%)、水肿(6.7%)、血栓栓塞(6.7%)、间质性肺炎(6.7%)和血小板减低(6.7%)。结论Amivantamab对EGFR外显子20插入突变和奥希替尼耐药的中国晚期NSCLC治疗有效,与国外疗效数据相仿。整体安全性可耐受,需重点关注皮疹、甲沟炎、输液反应等不良反应。 展开更多
关键词 肺肿瘤 EGFR MET 靶向治疗 Amivantamab
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CdS压电和应变敏感度调控工程用于压电催化产氢 被引量:1
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作者 王晶晶 胡程 +1 位作者 张以河 黄洪伟 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2022年第5期1277-1285,共9页
压电催化产氢成为当前实现机械能的采集和利用以及全天候可持续能源高效产出的极具潜力的研究方向.CdS半导体催化剂已被广泛用于光催化水裂解制氢研究.六方相CdS为空间群P63mc和点群6 mm的非中心对称晶体结构,这赋予其具有压电效应特征... 压电催化产氢成为当前实现机械能的采集和利用以及全天候可持续能源高效产出的极具潜力的研究方向.CdS半导体催化剂已被广泛用于光催化水裂解制氢研究.六方相CdS为空间群P63mc和点群6 mm的非中心对称晶体结构,这赋予其具有压电效应特征,在压电极化场下有望实现高效的载流子分离和催化效率的提升.目前,关于CdS的压电特性及结构与压电性和压电催化活性间的内在联系和相互影响尚不清楚.本文设计、构建CdS球和不同长度的CdS纳米棒两种拓扑结构,并进行深入研究.球状CdS采用水热法制得,不同长度的一维CdS纳米棒通过调控溶剂热反应时间得到.超声辅助催化产氢性能测试发现,在优化超声功率150 W的超声振动刺激下,CdS纳米棒的压电催化产氢性能达到157μmol g^(−1)h^(−1),较球状CdS催化剂的压电催化活性提高近2.8倍.整个超声辅助产氢体系无共催化剂的添加.然而,对于棒状CdS催化剂压电催化性能增强的原因并不清楚.扫描电子显微镜结果表明,CdS纳米棒和CdS球在微观形貌和晶粒尺寸表现出显著差异;X射线光电子能谱表明,二者表面组成和化学态没有明显区别.在此基础上,采用压电响应力显微镜(PFM)、有限元分析方法和压电化学测试等表征进一步研究了CdS纳米棒和CdS球在压电催化分解水产氢反应中性能差异的原因.PFM结果表明,在压力作用下棒状CdS表现出较强的压电电势和大的相位翻转角度.COMSOL模拟计算进一步验证了棒状CdS和球状CdS受力刺激下形成压电电场强度和变形能力的差别.通过对球状CdS和不同长度的CdS纳米棒的比表面积测试分析得出,压电电势和表面活性位点间的平衡对最大化压电催化效率至关重要.压电化学测试结果表明,CdS纳米棒强的压电电势和显著的形变对压电催化氢气析出过程中载流子分离和迁移具有提升作用.在超声刺激下,CdS纳米棒比CdS球表现出大的电流响应和小的电化学阻值,这为CdS纳米棒高效的载流子分离和利用提供证据.由此可以推断,CdS纳米棒增强的压电催化活性归因于其大的压电系数和较强的机械能捕获能力,从而进一步诱导其在机械应力下产生更大的压电电势和更有效的载流子分离和运输,最终得到更好的压电催化性能.综上,本研究为清洁能源发展和利用以及先进压电材料发展提供参考. 展开更多
关键词 CDS 压电催化 产氢 一维纳米棒 电荷分离
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Two-dimensional ultrathin MoS2-modified black Ti^3+-TiO2 nanotubes for enhanced photocatalytic water splitting hydrogen production 被引量:7
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作者 Wei Ou Jiaqi Pan +7 位作者 Yanyan Liu Shi Li Hongli Li Weijie Zhao jingjing wang Changsheng Song Yingying Zheng Chaorong Li 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2020年第4期188-194,共7页
Two-dimensional (2D) ultrathin MoS2-modified black Ti^3+-TiO2 nanotubes were fabricated using an electrospinning-hydrothermal treatment-reduction method.Bare TiO2 nanotubes were fabricated via electrospinning.Then,2D ... Two-dimensional (2D) ultrathin MoS2-modified black Ti^3+-TiO2 nanotubes were fabricated using an electrospinning-hydrothermal treatment-reduction method.Bare TiO2 nanotubes were fabricated via electrospinning.Then,2D MoS2 lamellae were grown on the surface of the nanotubes and Ti^3+/Ov ions were introduced by reduction.The photocatalytic performance of the 2D MoS2/Ti^3+-TiO2 nanotubes was^15 times better than that of TiO2.The HER enhancement of the MoS2/Ti^3+-TiO2 nanotubes can be attributed to the Pt-like behavior of 2D MoS2 and the presence of Ti^3+-ions,which facilitated the quick diffusion of the photogenerated electrons to water,reducing the H2 activation barrier.The presence of Ov ions in the nanotubes and their hollow structure increased their solar utilization. 展开更多
关键词 2D MOS2 TiO2 NANOTUBES Ti^3+self-doping Photocatalytic hydrogen production
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Fasudil alleviates LPS-induced lung injury by restoring aquaporin 5 expression and inhibiting inflammation in lungs 被引量:3
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作者 jingjing wang Hui Kong +3 位作者 Jian Xu Yanli wang Hong wang Weiping Xie 《The Journal of Biomedical Research》 CAS CSCD 2019年第3期156-163,共8页
Fasudil, a selective rho kinase(ROCK) inhibitor, has been reported to play a beneficial role in systemic inflammation in acute lung injury, but its mechanism for ameliorating pulmonary edema and inflammation remains u... Fasudil, a selective rho kinase(ROCK) inhibitor, has been reported to play a beneficial role in systemic inflammation in acute lung injury, but its mechanism for ameliorating pulmonary edema and inflammation remains unclear. Using hematoxylin-and-eosin(H&E) staining, immunohistochemistry, enzyme-linked immunosorbent assay,quantitative real time PCR and Western blotting, we found that fasudil attenuated LPS-induced lung injury, decreased lung edema, and suppressed inflammatory responses including leukocyte infiltration and IL-6 production. Further,fasudil upregulated LPS-induced aquaporin 5 reduction and inhibited NF-κB activation in the lungs of mice. Our results suggest that fasudil could restore the expression of aquaporin 5 to eliminate LPS-induced lung edema and prevent LPS-induced pulmonary inflammation by blocking the inflammatory pathway. Collectively, blockade of the ROCK pathway by fasudil may be a potential strategy for the treatment of acute lung injury. 展开更多
关键词 acute LUNG injury AQUAPORIN 5 FASUDIL fliud transport NF-κB
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