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Dissolution behavior,thermodynamic and kinetic analysis of malonamide by experimental measurement and molecular simulation
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作者 Peng Yang Shengzhe Jia +4 位作者 Yan wang Zongqiu Li Songgu Wu jingkang wang Junbo Gong 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2023年第1期260-269,共10页
In this study,the solid structure,dissolution behavior,thermodynamic properties and nucleation kinetics of malonamide were explored.Firstly,the Hirshfeld surface analysis and molecular electrostatic potential surface ... In this study,the solid structure,dissolution behavior,thermodynamic properties and nucleation kinetics of malonamide were explored.Firstly,the Hirshfeld surface analysis and molecular electrostatic potential surface were plotted to reveal the percentage contribution of various intermolecular contacts and location of the strongest hydrogen bond.Next,the solubility of malonamide in 12 solvents was determined by dynamic method at temperatures from 278.15 K to 318.15 K.Four thermodynamic models were applied to analyze solubility results.In addition,the thermodynamic properties were calculated to further analyze and discuss the dissolution behavior of malonamide.Moreover,the physicochemical properties of solvents were explored to express the solvent effects.The results illustrate“like dissolves like”,“mass transfer”and“solvent–solute interaction”rules play the synergistic effects on the dissolution process.The molecular dynamic simulation,including radial distribution function analysis and solvent free energy,was used to further explain the dissolution behavior.At last,the nucleation rate and effective interfacial energy in methanol solvent was measured and calculated to reveal the nucleation behaviour. 展开更多
关键词 MALONAMIDE SOLUBILITY Thermodynamic properties Molecular simulation Nucleation rate
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Recent Developments in the Crystallization Process: Toward the Pharmaceutical Industry 被引量:16
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作者 Zhenguo Gao Sohrab Rohani +1 位作者 Junbo Gong jingkang wang 《Engineering》 SCIE EI 2017年第3期343-353,共11页
Crystallization is one of the oldest separation and purification unit operations, and has recently contributed to significant improvements in producing higher-value products with specific properties and in building ef... Crystallization is one of the oldest separation and purification unit operations, and has recently contributed to significant improvements in producing higher-value products with specific properties and in building efficient manufacturing processes. In this paper, we review recent developments in crystal engineering and crystallization process design and control in the pharmaceutical industry. We systematically summarize recent methods for understanding and developing new types of crystals such as co-crystals, polymorphs, and solvates, and include several milestones such as the launch of the first co-crystal drug, Entresto (No- vartis), and the continuous manufacture of Orkambi (Vertex). Conventional batch and continuous processes, which are becoming increasingly mature, are being coupled with various control strategies and the recently developed crystallizers are thus adapting to the needs of the pharmaceutical industry. The development of crystallization process design and control has led to the appearance of several new and innovative crystal- lizer geometries for continuous operation and improved performance. This paper also reviews major recent orogress in the area of process analytical technology. 展开更多
关键词 CRYSTALLIZATION Crystal engineering POLYMORPHISM Crystallization process design and control Crystal size distribution
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Phase equilibria for the pseudo-ternary system(NaCl+Na2SO4+H2O)of coal gasification wastewater at T=(268.15 to 373.15)K 被引量:8
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作者 Haijiao Lu jingkang wang +5 位作者 Jun Yu Yuefeng Wu Ting wang Ying Bao Dou Ma Hongxun Hao 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2017年第7期955-962,共8页
The pseudo-ternary system(Na Cl + Na_2SO_4+ H_2O) of coal gasification wastewater was studied at T =(268.15 to 373.15) K. The solubility and density of the equilibrium liquid phase were determined by the isothermal so... The pseudo-ternary system(Na Cl + Na_2SO_4+ H_2O) of coal gasification wastewater was studied at T =(268.15 to 373.15) K. The solubility and density of the equilibrium liquid phase were determined by the isothermal solution saturation method. The equilibrium solids were also investigated by the Schreinemaker's method of wet residues and X-ray powder diffraction(XRD). According to the experimental data, the phase diagrams were determined. It was found that there was no significant solubility difference on the Na Cl-rich side between the ternary system(Na Cl + Na_2SO_4+ H_2O) in coal gasification wastewater and in pure water. However, the solubility on the Na_2SO_4-rich side of coal gasification wastewater was apparently higher than that of pure water. The increase in the solubility of Na_2SO_4 was most likely caused by the effects of other impurities apart from Na Cl and Na_2SO_4 in coal gasification wastewater. The measured data and phase equilibrium diagrams can provide fundamental basis for salt recovery in coal gasification wastewater. 展开更多
关键词 Pseudo-ternary system Phase equilibria THERMODYNAMICS Waste water Recovery
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Progress of Pharmaceutical Continuous Crystallization 被引量:7
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作者 Dejiang Zhang Shijie Xu +2 位作者 Shichao Du jingkang wang Junbo Gong 《Engineering》 SCIE EI 2017年第3期354-364,共11页
Crystallization is an important unit operation in the pharmaceutical industry. At present, most pharmaceutical crystallization processes are performed in batches. However, due to product variability from batch to batc... Crystallization is an important unit operation in the pharmaceutical industry. At present, most pharmaceutical crystallization processes are performed in batches. However, due to product variability from batch to batch and to the low productivity of batch crystallization, continuous crystallization is gaining increasing attention. In the past few years, progress has been made to allow the products of continuous crystallization to meet different requirements. This review summarizes the progress in pharmaceutical continuous crystallization from a product engineering perspective. The advantages and disadvantages of different types of continuous crystallization are compared, with the main difference between the two main types of crystallizers being their difference in residence time distribution. Approaches that use continuous crystallization to meet different quality requirements are summarized. Continuous crystallization has advantages in terms of size and morphology control. However, it also has the problem of a process yield that may be lower than that of a batch process, especially in the production of chirality crystals. Finally, different control strategies are compared. 展开更多
关键词 Continuous crystallization PHARMACEUTICAL MSMPR Tubular crystallizer Control strategy
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Relationship between hyperlipidemia and the gut microbiome of rats, characterized using high-throughput sequencing 被引量:4
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作者 Yaqi Li Quantao Ma +7 位作者 jingkang wang Pengfei Li Long Cheng Yongcheng An Yuhui Duan Hongyu Dai Ting wang Baosheng Zhao 《Journal of Traditional Chinese Medical Sciences》 2020年第2期154-161,共8页
Objective:To determine the effects of a high-fat diet(HFD)on the gut microbiome in rats,to explore the relationship between the intestinal flora and blood lipid profile.Methods:SpragueeDawley rats were fed an HFD for ... Objective:To determine the effects of a high-fat diet(HFD)on the gut microbiome in rats,to explore the relationship between the intestinal flora and blood lipid profile.Methods:SpragueeDawley rats were fed an HFD for four weeks to induce hyperlipidemia,then 16S rRNA sequencing was used to compare the intestinal flora between hyperlipidemic and control diet-fed rats.Results:The microbiome of rats fed an HFD for four weeks differed from that of control diet-fed rats.Bacterial species that were less abundant were most affected by HFD feeding,among which were many pathogenic species,which became significantly more abundant.Eighteen genera were present in significantly different numbers in hyperlipidemic and control rats,more than half of which have been linked to infection and inflammation,or energy intake and obesity.The results indicated a type of stress response of the flora to a high-fat environment.In addition,the age of the rats tended to influence the gut microbial composition.Conclusion:These findings suggest that HFD may induce hyperlipidemia by affecting the gut microbial composition.Changes in the abundance of pro-inflammatory and pathogenic bacteria,and those that influence energy intake and obesity,may be important mediators of this. 展开更多
关键词 HYPERLIPIDEMIA Gut microbiota 16S rRNA sequencing High-fat diet
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Research progress on preparation and purification of fluorine-containing chemicals in lithium-ion batteries 被引量:2
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作者 Xiaobin Liu Zhenguo Gao +2 位作者 Jingcai Cheng Junbo Gong jingkang wang 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2022年第1期73-84,共12页
With the development of digital products,electric vehicles and energy storage technology,electronic chemicals play an increasingly prominent role in the field of new energy such as lithium-ion batteries.Electronic che... With the development of digital products,electric vehicles and energy storage technology,electronic chemicals play an increasingly prominent role in the field of new energy such as lithium-ion batteries.Electronic chemicals have attracted extensive attention in various fields.Characteristics of high-end electronic chemicals are high purity and low impurity content,which requires a very strict separation and purification process.At present,crystallization is a key technology for their separation and purification of electronic chemicals.In this work,the representative fluorine-containing compounds in cathode and anode materials,separator and electrolyte of lithium-ion batteries are introduced.The latest technologies for the preparation and purification of four kinds of fluorine-containing battery chemicals by crystallization technology are reviewed.In addition,the research prospects and suggestions are put forward for the separation of fluorine-containing battery chemicals. 展开更多
关键词 Battery chemicals Lithium-ion batteries CRYSTALLIZATION Fluorine-containing chemicals
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Gelation Mechanism of Erythromycin Ethylsuccinate During Crystallization 被引量:1
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作者 Xiandong Su Zhenguo Gao +6 位作者 Ying Bao Miao Guan Sohrab Rohani Qiuxiang Yin Hongxun Hao Chuang Xie jingkang wang 《Transactions of Tianjin University》 EI CAS 2019年第2期110-117,共8页
In this paper, the gelation mechanism of erythromycin ethylsuccinate(EES) during crystallization is investigated for the first time. The generated semisolid gel-like phase exhibited a 3D fibrillar network morphology a... In this paper, the gelation mechanism of erythromycin ethylsuccinate(EES) during crystallization is investigated for the first time. The generated semisolid gel-like phase exhibited a 3D fibrillar network morphology and the typical rheological properties of gels. The fibers inside the gel-like phase were confirmed to be new types of EES solvates using powder X-ray diffraction, thermogravimetric analysis/differential scanning calorimetry, and gas chromatography. The gelation and crystallization regions in EES-1-propanol solid–liquid phase diagram were determined. Analyses of solvent parameters showed that moderate solvent polarity may promote EES gelation. Fourier transform infrared spectra, nuclear magnetic resonance spectra, and scanning electron microscopy analyses indicated that through intermolecular hydrogen bonds, EES and solvent molecules assembled into fibers via crystallographic mismatch branching growth. The fibers intertwined into a 3D network microstructure and formed a gel-like phase, completely immobilizing the solution. 展开更多
关键词 GELATION SOLVATE CRYSTALLIZATION Phase DIAGRAM MOLECULAR SELF-ASSEMBLY
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Characterization and structure analysis of the heterosolvate of erythromycin thiocyanate
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作者 Yuanjie Li Qiuxiang Yin +5 位作者 Meijing Zhang Ying Bao Baohong Hou jingkang wang Jiting Huang Ling Zhou 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2022年第4期268-274,共7页
Erythromycin thiocyanate is widely used for the production of other macrolide antibiotics. In this work, a novel heterosolvate of this pharmaceutical compound has been obtained and characterized for the first time, wh... Erythromycin thiocyanate is widely used for the production of other macrolide antibiotics. In this work, a novel heterosolvate of this pharmaceutical compound has been obtained and characterized for the first time, which was transformed from the dihydrate form in the acetone solvent through evaporation crystallization. Thermal behavior together with compositional analysis revealed that both water and acetone molecules participated in the formation of the crystal lattice which is rarely reported before. The general chemical name of the heterosolvate may be defined as erythromycin thiocyanate sesquihydrate hemiacetonate. Furthermore, studies on solid-state spectral analysis provided strong evidence of intermolecular hydrogen bonds in heterosolvate crystals. According to the crystal structure determined by single crystal X-ray diffraction, the formation mechanism of the heterosolvate is proposed in which strong multihydrogen bondings between water and solute molecules form the layer structure. While acetone molecules form single-hydrogen bonds with solutes and reside in channels between layers. This well explains why acetone solvent is easy to escape from the crystal structure during desolvation. 展开更多
关键词 Erythromycin thiocyanate Heterosolvate Structure analysis CRYSTALLIZATION Thermodynamic properties TRANSITION
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Author correction to‘Pharmacologically targeting molecular motor promotes mitochondrial fission for anti-cancer’[Acta Pharm Sin B 11(2021)1853–1866]
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作者 Yi Qian Meimei Zhao +7 位作者 Qinghua Han jingkang wang Lixi Liao Heng Yang Dan Liu Pengfei Tu Hong Liang Kewu Zeng 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2024年第5期2358-2358,共1页
The authors regret that the representative images of tumor tissue staining for the intraperitoneal injection of J13 in the left panel of Fig.5E and G(Page 1862)were incorrect due to an inadvertent mistake of copying a... The authors regret that the representative images of tumor tissue staining for the intraperitoneal injection of J13 in the left panel of Fig.5E and G(Page 1862)were incorrect due to an inadvertent mistake of copying and pasting in the process of assembling figures with Adobe Photoshop software.In our studies,at least three biological replicates were included in each treatment group and at least three images were taken for different fields of each sample.The corrected version of Fig.5E and G have been provided below,and the change did not affect the results and conclusions of this study.The original data of these figures have been provided to the Editorial Office,and the corresponding authors or the Editorial Office can be contacted for original data access. 展开更多
关键词 CORRECTION FIGURES assembling
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可用于柔性光波导的具有二维弯曲和手动扭转特性的有机晶体
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作者 陈奎 王静康 +7 位作者 单慧婷 范浩然 郝芸荟 穆凯代斯·太外库力 王娜 黄欣 王霆 郝红勋 《Science China Materials》 SCIE EI CAS CSCD 2023年第6期2418-2428,共11页
大部分有机晶体是脆性的,这极大地限制了其在柔性智能材料领域的应用.本文报道了两种具有多重柔性的有机晶体,其中一种表现出二维弹性,而另一种晶体可以沿不同晶面表现出塑性和弹性双重柔性.另外,通过获得两种晶体的脆性多晶型,从晶体... 大部分有机晶体是脆性的,这极大地限制了其在柔性智能材料领域的应用.本文报道了两种具有多重柔性的有机晶体,其中一种表现出二维弹性,而另一种晶体可以沿不同晶面表现出塑性和弹性双重柔性.另外,通过获得两种晶体的脆性多晶型,从晶体工程的角度建立了结构与性质之间的关系.这些柔性晶体都可以被手动扭转而不断裂,首次证明了手工扭转的晶体也可以通过一维塑性和弹性晶体制备.详细的晶体学分析、能量框架计算和和纳米压痕测试揭示了晶体的多重机械响应机理.这些特性除了与晶体中独特的分子排列相关外,还与分子间相互作用的强度和方向的差异密切相关.最后,探究了这些柔性晶体材料在光波导领域的应用. 展开更多
关键词 有机晶体 分子间相互作用 晶体材料 光波导 扭转特性 晶体工程 智能材料 多晶型
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Design spherical particles of potassium peroxymonosulfate compound salt with high stability and good powder properties via an agglomeration-dissolution mechanism
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作者 Shanshan Feng Changyou Yu +8 位作者 Shilin Guo Jinbo Ouyang Fei Yin Xiaodong Zhang Yongjian Zhang Mingyang Chen Dandan Han Junbo Gong jingkang wang 《Particuology》 SCIE EI CAS CSCD 2023年第9期157-169,共13页
With the outbreak of COVID-19,disinfection protection has become a necessary measure to prevent infection.As a new type of disinfectant,potassium peroxymonosulfate compound salt(PMS)has the advantages of good bacteric... With the outbreak of COVID-19,disinfection protection has become a necessary measure to prevent infection.As a new type of disinfectant,potassium peroxymonosulfate compound salt(PMS)has the advantages of good bactericidal effect,non-toxicity,high safety and stability.However,the current PMS products with irregular particle shapes lead to poor flowability,high hygroscopicity,poor stability of reactive oxygen species(ROS)and serious caking problems.In this work,an agglomeration-dissolution mechanism was designed to prepare spherical PMS particles with large size(>300μm)and high sphericity(up to 90%),effectively addressing the above problems.Shaping(dissolution and abrasion)is the key to improving sphericity,which is mainly controlled by the design of the heating mode,residence time and stirring rate.Compared with the irregular PMS particles,the large spherical particles present better flowability(angle of repose decreased by 35.80%,Carr's index decreased by 64.29%,Hausner's ratio decreased by 19.14%),lower hygroscopicity(decreased by 38.0%),lower caking ratio(decreased by 84.50%),and higher stability(the monthly loss of ROS was reduced by 61.68%).The agglomeration-dissolution mechanism demonstrates the crystallization,agglomeration,dissolution and abrasion process of inorganic salt crystals,providing an opportunity to prepare high-end inorganic crystal materials with high-quality morphologies. 展开更多
关键词 Potassium peroxymonosulfate compound salt Spherical crystallization AGGLOMERATION Dissolution Disinfection protection
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Pharmacologically targeting molecular motor promotes mitochondrial fission for anti-cancer 被引量:4
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作者 Yi Qian Meimei Zhao +7 位作者 Qinghua Han jingkang wang Lixi Liao Heng Yang Dan Liu Pengfei Tu Hong Liang Kewu Zeng 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2021年第7期1853-1866,共14页
Mitochondrial shape rapidly changes by dynamic balance of fusion and fission to adjust to constantly changing energy demands of cancer cells.Mitochondrial dynamics balance is exactly regulated by molecular motor consi... Mitochondrial shape rapidly changes by dynamic balance of fusion and fission to adjust to constantly changing energy demands of cancer cells.Mitochondrial dynamics balance is exactly regulated by molecular motor consisted of myosin and actin cytoskeleton proteins.Thus,targeting myosin eactin molecular motor is considered as a promising strategy for anti-cancer.In this study,we performed a proof-of-concept study with a natural-derived small-molecule J13 to test the feasibility of anti-cancer therapeutics via pharmacologically targeting molecular motor.Here,we found J13 could directly target myosin-9(MYH9)eactin molecular motor to promote mitochondrial fission progression,and markedly inhibited cancer cells survival,proliferation and migration.Mechanism study revealed that J13 impaired MYH9 eactin interaction to inactivate molecular motor,and caused a cytoskeleton-dependent mitochondrial dynamics imbalance.Moreover,stable isotope labeling with amino acids in cell culture(SILAC)technology-coupled with pulldown analysis identified HSPA9 as a crucial adaptor protein connecting MYH9 eactin molecular motor to mitochondrial fission.Taken together,we reported the first natural small-molecule directly targeting MYH9 eactin molecular motor for anti-cancer translational research.Besides,our study also proved the conceptual practicability of pharmacologically disrupting mitochondrial fission/fusion dynamics in human cancer therapy. 展开更多
关键词 ANTI-CANCER Liver hepatocellular carcinoma Mitochondrial fission Small molecule Target identification Molecular motor MYH9 HSPA9
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Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous composites 被引量:3
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作者 Huining HE Junxiao YE +5 位作者 Jianyong SHENG Jianxin wang Yongzhuo HUANG Guanyi CHEN jingkang wang Victor C YANG 《Frontiers of Chemical Science and Engineering》 SCIE EI CAS CSCD 2013年第1期9-19,共11页
Oral insulin delivery has received the most attention in insulin formulations due to its high patient compliance and, more importantly, to its potential to mimic the physiologic insulin secretion seen in non-diabetic ... Oral insulin delivery has received the most attention in insulin formulations due to its high patient compliance and, more importantly, to its potential to mimic the physiologic insulin secretion seen in non-diabetic individuals. However, oral insulin delivery has two major limitations: the enzymatic barrier that leads to rapid insulin degradation, and the mucosal barrier that limits insulin's bioavailability. Several approaches have been actively pursued to circumvent the enzyme barrier, with some of them receiving promising results. Yet, thus far there has been no major success in overcoming the mucosal barrier, which is the main cause in undercutting insulin's oral bioavailability. In this review of our group's research, an innovative silica-based, mucoadhesive oral insulin formulation with encapsulated-insulin/cell penetrating peptide (CPP) to overcome both enzyme and mucosal barriers is discussed, and the preliminary and convincing results to confirm the plausibility of this oral insulin delivery system are reviewed. In vitro studies demonstrated that the CPPinsulin conjugates could facilitate cellular uptake of insulin while keeping insulin's biologic functions intact. It was also confirmed that low molecular weight protamine (LMWP) behaves like a CPP peptide, with a cell translocation potency equivalent to that of the widely studied TAT. The mucoadhesive properties of the produced silica-chitosan composites could be controlled by varying both the pH and composition; the composite consisting of chitosan (25wt-%) and silica (75 wt-%) exhibited the greatest mucoadhesion at gastric pH. Furthermore, drugrelease from the composite network could also be regulated by altering the chitosan content. Overall, the universal applicability of those technologies could lead to development of a generic platform for oral delivery of many other bioactive compounds, especially for peptide or protein drugs which inevitably encounter the poor bioavailability issues. 展开更多
关键词 INSULIN cell penetrating peptide mucoadhesive composites oral delivery
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Significance and strategies in developing delivery systems for bio-macromolecular drugs 被引量:2
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作者 Huining HE Qiuling LIANG +6 位作者 Meong Cheoi SHIN Kyuri LEE Junbo GONG Junxiao YE Quan LIU jingkang wang Victor YANG 《Frontiers of Chemical Science and Engineering》 SCIE EI CAS CSCD 2013年第4期496-507,共12页
Successful development of a new drug is prohibitively expensive, and is estimated to cost approxi- mately S100-500 million US dollars for a single clinical drug. Yet, a newly developed drug can only enjoy its patent p... Successful development of a new drug is prohibitively expensive, and is estimated to cost approxi- mately S100-500 million US dollars for a single clinical drug. Yet, a newly developed drug can only enjoy its patent protection for 18 years, meaning that after this protected time period, any company can manufacture this product and thus the profit generated by this drug entity would reduce dramatically. Most critically, once a drug is being synthesized, its physical, chemical, and biological attri- butes such as bioavailability and in vivo pharmacokinetics are all completely fixed and cannot be changed. In principal and practice, only the application of an appro- priately designed drug delivery system (DDS) is able to overcome such limitations, and yet the cost of developing a novel drug delivery system is less than 10% of that of developing a new drug. Because of these reasons, the new trend in pharmaceutical development has already begun to shift from the single direction of developing new drugs in the past to a combined mode of developing both new drugs and innovative drug delivery systems in this century. Hence, for developing countries with relatively limited financial resources, a smart strategic move would be to focus on the development of new DDS, which has a significantly higher benefit/risk ratio when comparing to the development of a new drug. Because of the unmatched reaction efficiency and a repetitive action mode, the therapeutic activity of a single bio-macromolecular drug (e.g., protein toxins, gene products, etc.) is equivalent to about 10^6- 10^8 of that from a conventional small molecule anti-cancer agent (e.g., doxorubicin). Hence, bio-macromolecular drugs have been recognized around the world as the future "drug-of-choice". Yet, among the 〉 10000 drugs that are currently available, only -150 of them belong to these bio- macromolecular drugs (an exceedingly low 1.2%), reflect- ing the difficulties of utilizing these agents in clinical practice. In general, the bottleneck limitations of these bio- macromolecular drugs are two-fold: (1) the absence of a preferential action of the drug on tumor cells as opposed to normal tissues, and (2) the lack of ability to cross the tumor cell membrane. In this review, we provide strategies of how to solve these problems simultaneously and collec- tively via the development of innovative drug delivery systems. Since worldwide progress on bio-macromolecular therapeutics still remains in the infant stage and thus open for an equal-ground competition, we wish that this review would echo the desire to industrialized countries such as China to set up its strategic plan on developing delivery systems for these bio-macromolecular drugs, thereby realizing their clinical potential. 展开更多
关键词 delivery systems bio-macromolecular drugs cell penetrating peptides
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Fast determination of tobramycin by reversed-phase ion-pair high performance liquid chromatography with a refractive index detector 被引量:1
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作者 Liang ZHU jingkang wang 《Frontiers of Chemical Science and Engineering》 SCIE EI CAS CSCD 2013年第3期322-328,共7页
A simple and direct method without a deriva- tion step for routine analysis of tobramycin has been developed. This method used reversed-phase ion-pair high performance liquid chromatography (HPLC) with a refractive ... A simple and direct method without a deriva- tion step for routine analysis of tobramycin has been developed. This method used reversed-phase ion-pair high performance liquid chromatography (HPLC) with a refractive index (RI) detector and a C18 column which is stable at pH above 1.00. The presence of 4.50mg.mL ] trifluoroacetic acid (TFA) in the mobile phase improved the protonation of tobramycin and the formation of ionpairs, and thus reduced its hydrophility. This unique separation-detection combination showed good linearity with correlation coefficients 0.9996 in the concentration range of 0.25-2.50mg.mL 1. The quantitation limit and detection limit were determined to be 0.23 mg.mL ~ and 0.071 mg. mL ~, respectively. Tobramycin was recovered in 98.00%, 98.84% and 99.64% for tobramycin solutions at concentrations of 2.25 mg.mL^-1, 1.50mg.mL 1 and 0.75 mg.mL ', respectively. The relative standard deviations for six spiked samples ranged from 0.20% to 2.40%, indicating a good reproducibility of this method. 展开更多
关键词 TOBRAMYCIN AMINOGLYCOSIDE refractive index detector high-performance liquid chromatography ionpairing
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Molecular mechanism of crystal nucleation from solution 被引量:1
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作者 Xin Li jingkang wang +4 位作者 Ting wang Na wang Shuyi Zong Xin Huang Hongxun Hao 《Science China Chemistry》 SCIE EI CSCD 2021年第9期1460-1481,共22页
Nucleation from solution is fundamental to many natural and industrial processes.The understanding of molecular mechanism of nucleation from solution is conducive to predict crystal structure,control polymorph and des... Nucleation from solution is fundamental to many natural and industrial processes.The understanding of molecular mechanism of nucleation from solution is conducive to predict crystal structure,control polymorph and design desired crystal materials.In this review,the nucleation theories,including classical nucleation theory(CNT),nonclassical nucleation theory,as well as other new proposed theories,were reprised,and the molecular mechanism of these theories was compared.Then,the molecular process of nucleation,including the current study techniques,the effect of molecular self-assembly in solutions,desolvation process,as well as the properties of solvent and crystal structure on nucleation from solution were summarized.Furthermore,the relationship of molecular conformation in solution and in crystal,and the effect of solute molecular flexibility on nucleation were discussed.Finally,the current challenges and future scopes of crystal nucleation from solution were discussed. 展开更多
关键词 NUCLEATION molecular assembly molecular conformation POLYMORPHISM solution chemistry
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The solubility of cefquinome sulfate in pure and mixed solvents 被引量:1
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作者 Rongbao Qi jingkang wang +2 位作者 Junxiao Ye Hongxun Hao Ying Bao 《Frontiers of Chemical Science and Engineering》 SCIE EI CAS CSCD 2016年第2期245-254,共10页
Solid-liquid equilibrium data of cefquinome sulfate is important to develop industrial crystallization processes for cefquinome sulfate. The solubilities of cefquinome sulfate in five pure solvents (methanol, ethanol... Solid-liquid equilibrium data of cefquinome sulfate is important to develop industrial crystallization processes for cefquinome sulfate. The solubilities of cefquinome sulfate in five pure solvents (methanol, ethanol, ethylene glycol, acetic acid and water) from 277.15 to 305.15 K and in a binary acetone-water solvent from 278.15 to 293.15 K were measured at atmospheric pressure. The pure-solvent solubility data was correlated to the modified Apelblat and Van't Hoff equations whereas the mixed-solvent system data was correlated to the modified Apelblat, Van't Hoff, CNIBS/R-K and Jouy- ban-Acree models. It was found that the solubilities of cefquinome sulfate in all tested solvents decreased with the increasing of temperature. In addition, the thermodynamic properties of the dissolution processes, including standard Gibbs free energy, enthalpy and entropy changes, were calculated using the Van't Hoff equation. It was found that the dissolution of cefquinome sulfate is exothermic. 展开更多
关键词 cefquinome sulfate SOLUBILITY thermodynamic properties
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Mechanism and inhibition of trisodium phosphate particle caking: Effect of particle shape and solubility 被引量:1
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作者 Mingyang Chen Lanlan Lin +5 位作者 Yuqi Zhang Songgu Wu Ergang Liu Kun wang jingkang wang Junbo Gong 《Particuology》 SCIE EI CAS CSCD 2016年第4期115-121,共7页
We investigated the influence of particle shape and solubility on the caking behavior of trisodium phosphate by considering the adhesion free energy and crystal bridge theory. Caking of trisodium phosphate during the ... We investigated the influence of particle shape and solubility on the caking behavior of trisodium phosphate by considering the adhesion free energy and crystal bridge theory. Caking of trisodium phosphate during the drying process under static conditions is a two-step process: adhesion followed by crystal bridge formation between particles. The adhesion free energy plays an important role in adhesion. Trisodium phosphate particles cannot adhere to each other and cake when the adhesion free energy is greater than a critical value, which varies with particle shape. Compared with granular particles, cylindrical particles have larger contact area between particles, which results in more crystal bridges forming and a higher caking ratio. Thus, the critical value is about 100 mJ/m^2 for cylindrical particles, but 60 mJ/m^2 for granular particles at 25 ℃. Concerning the solubility, when particles are similar shapes and soluble in the rinsing liquid, the caking ratio has a linear relationship with adhesion free energy. However, if the particles are insoluble in the rinsing liquid, caking can be completely prevented regardless of adhesion free energy because no crystal bridges form during the growth process. Hence, caking of trisodium phosphate particles could be inhibited by screening rinsing liquids, and optimizing the particle shape and size distribution. 展开更多
关键词 Caking Particle shape Solubility Adhesion free energy Crystal bridge Trisodium phosphate
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Permeability analysis and seepage process study on crystal layer in melt crystallization with fractal and porous media theory
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作者 Xiaobin JIANG Baohong HOU +1 位作者 Yongli wang jingkang wang 《Frontiers of Chemical Science and Engineering》 SCIE EI CSCD 2011年第4期435-441,共7页
In this paper a porous media seepage model was applied to analyze the permeability and study the seepage process of crystal pillar formed in the preparation of electronic grade phosphoric acid(EGPA).By inspecting the ... In this paper a porous media seepage model was applied to analyze the permeability and study the seepage process of crystal pillar formed in the preparation of electronic grade phosphoric acid(EGPA).By inspecting the seeping process,the structure parameter of crystal pillar could be obtained.Two basic ideal models(perfectly separated model and perfectly connected model)were presented and a characterized factorφwas introduced to modify the model.A good simulation result was obtained which met the experiment result well.The relationship betweenφand permeability were also discussed.The characterized factorφshowed potential application on optimizing process. 展开更多
关键词 melt crystallization porous media FRACTAL PERMEABILITY hyperpure material simulation
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FBRM and PVM investigations of the double feed semi-batch crystallization of 6-aminopenicillanic acid
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作者 Min SU Lin wang +1 位作者 Hua SUN jingkang wang 《Frontiers of Chemical Science and Engineering》 SCIE EI CSCD 2009年第3期282-288,共7页
6-Aminopenicillanic acid(6-APA)is a crucial pharmaceutical intermediate in the chemistry of semi-synthetic antibiotics.The focused beam reflectance measurement(FBRM)technology and particle vision measurement(PVM)techn... 6-Aminopenicillanic acid(6-APA)is a crucial pharmaceutical intermediate in the chemistry of semi-synthetic antibiotics.The focused beam reflectance measurement(FBRM)technology and particle vision measurement(PVM)technology were employed to the processes of online-monitoring of 6-APA crystallization behavior in a double-feeding semi-batch crystallizer.Experiments were carried out with four kinds of double-feeding policies and the results were compared with the traditional single-feeding.Records and analysis of FBRM indicated that the nucleation of double feeding policy was much higher than single policy,and chord length of 6-APA was almost determined and had little change after the nucleation peak.Ostwald ripening process had no significant effect on further growth of 6-APA crystal.PVM images showed that the crystal habit of 6-APA was continuously changed during the crystallization process.The development of(002)face in the final crystal for the five feeding policies were different. 展开更多
关键词 6-aminopenicillanic acid CRYSTALLIZATION double-feeding FBRM PVM crystal habit
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