Late-stage peptide modification showcases a huge potential for the construction of peptide libraries,and the investigation of structure-activity relationships.Herein we report a dimethyl sulfoxide/visible light comedi...Late-stage peptide modification showcases a huge potential for the construction of peptide libraries,and the investigation of structure-activity relationships.Herein we report a dimethyl sulfoxide/visible light comediated chemoselective modification of tryptophan residue by forging the C-S structure using thiophenols irradiated with blue light-emitting diodes at room temperature.This method shows excellent chemoselectivity toward the C-2 position of the tryptophan residue and good compatibility with diverse thiophenol derivatives bearing various functional groups.Both protected oligopeptides and unmasked bioactive peptides smoothly underwent site-selective modification,furnishing the corresponding products.Above all,this study provides a new competent toolkit for late-stage peptide modification,labelling,and peptide-drug conjugation and provides a clue for protein bioconjugation.展开更多
Sea ice growth and consolidation play a significant role in heat and momentum exchange between the atmosphere and the ocean.However,few in situ observations of sea ice kinematics have been reported owing to difficulti...Sea ice growth and consolidation play a significant role in heat and momentum exchange between the atmosphere and the ocean.However,few in situ observations of sea ice kinematics have been reported owing to difficulties of deployment of buoys in the marginal ice zone(MIZ).To investigate the characteristics of sea ice kinematics from MIZ to packed ice zone(PIZ),eight drifting buoys designed by Taiyuan University of Technology were deployed in the open water at the ice edge of the Canadian Basin.Sea ice near the buoy constantly increased as the buoy drifted,and the kinematics of the buoy changed as the buoy was frozen into the ice.This process can be determined using sea ice concentration,sea skin temperature,and drift speed of buoy together.Sea ice concentration data showed that buoys entered the PIZ in mid-October as the ice grew and consolidated around the buoys,with high amplitude,high frequency buoy motions almost ceasing.Our results confirmed that good correlation coefficient in monthly scale between buoy drift and the wind only happened in the ice zone.The correlation coefficient between buoys and wind was below 0.3 while the buoys were in open water.As buoys entered the ice zone,the buoy speed was normally distributed at wind speeds above 6 m/s.The buoy drifted mainly to the right of the wind within 45°at wind speeds above 8 m/s.During further consolidation of the ice in MIZ,the direct forcing on the ice through winds will be lessened.The correlation coefficient value increased to 0.9 in November,and gradually decreased to 0.7 in April.展开更多
This paper is concerned with two aspects of the fractional Navier-Stokes equation. First, we establish the local L^(2)theory of the hypo-dissipative Navier-Stokes system. More precisely, the existence of local-in-time...This paper is concerned with two aspects of the fractional Navier-Stokes equation. First, we establish the local L^(2)theory of the hypo-dissipative Navier-Stokes system. More precisely, the existence of local-in-time as well as global-in-time local energy weak solutions to the hypo-dissipative Navier-Stokes system is proved.In particular, in order to construct a pressure with an explicit representation, some technical innovations are required due to the lack of known results on the local regularity of the non-local Stokes operator. Secondly, as an important application to the local L^(2)theory, we give a second construction of large self-similar solutions of the hypo-dissipative Navier-Stokes system along with the Leray-Schauder degree theory.展开更多
基金the CAMS Innovation Fund for Medical Sciences(CIFMS)(grant nos.2019-I2M-5-074,2021-I2M-1-026,2021-I2M-3-001,and 2022-I2M-2-002)the National Natural Science Foundation of China(grant nos.81773564,82173678 and 22307052)+2 种基金the Program for Chang-Jiang Scholars and Innovative Research Team in University(grant no.IRT_15R27)the fellowship of China Postdoctoral Science Foundation(grant no.2021M701533)the Gansu Science and Technology Program(grant nos.23JRRA1103,22JR5RA502,and 21JR7RA449).
文摘Late-stage peptide modification showcases a huge potential for the construction of peptide libraries,and the investigation of structure-activity relationships.Herein we report a dimethyl sulfoxide/visible light comediated chemoselective modification of tryptophan residue by forging the C-S structure using thiophenols irradiated with blue light-emitting diodes at room temperature.This method shows excellent chemoselectivity toward the C-2 position of the tryptophan residue and good compatibility with diverse thiophenol derivatives bearing various functional groups.Both protected oligopeptides and unmasked bioactive peptides smoothly underwent site-selective modification,furnishing the corresponding products.Above all,this study provides a new competent toolkit for late-stage peptide modification,labelling,and peptide-drug conjugation and provides a clue for protein bioconjugation.
基金The National Key Research and Development Program of China under contract No.2016YFC1402702the Basic Research Program of Shanxi Province under contract No.202103021224054.
文摘Sea ice growth and consolidation play a significant role in heat and momentum exchange between the atmosphere and the ocean.However,few in situ observations of sea ice kinematics have been reported owing to difficulties of deployment of buoys in the marginal ice zone(MIZ).To investigate the characteristics of sea ice kinematics from MIZ to packed ice zone(PIZ),eight drifting buoys designed by Taiyuan University of Technology were deployed in the open water at the ice edge of the Canadian Basin.Sea ice near the buoy constantly increased as the buoy drifted,and the kinematics of the buoy changed as the buoy was frozen into the ice.This process can be determined using sea ice concentration,sea skin temperature,and drift speed of buoy together.Sea ice concentration data showed that buoys entered the PIZ in mid-October as the ice grew and consolidated around the buoys,with high amplitude,high frequency buoy motions almost ceasing.Our results confirmed that good correlation coefficient in monthly scale between buoy drift and the wind only happened in the ice zone.The correlation coefficient between buoys and wind was below 0.3 while the buoys were in open water.As buoys entered the ice zone,the buoy speed was normally distributed at wind speeds above 6 m/s.The buoy drifted mainly to the right of the wind within 45°at wind speeds above 8 m/s.During further consolidation of the ice in MIZ,the direct forcing on the ice through winds will be lessened.The correlation coefficient value increased to 0.9 in November,and gradually decreased to 0.7 in April.
基金supported by National Natural Science Foundation of China(Grant Nos.11871087 and 11971148)。
文摘This paper is concerned with two aspects of the fractional Navier-Stokes equation. First, we establish the local L^(2)theory of the hypo-dissipative Navier-Stokes system. More precisely, the existence of local-in-time as well as global-in-time local energy weak solutions to the hypo-dissipative Navier-Stokes system is proved.In particular, in order to construct a pressure with an explicit representation, some technical innovations are required due to the lack of known results on the local regularity of the non-local Stokes operator. Secondly, as an important application to the local L^(2)theory, we give a second construction of large self-similar solutions of the hypo-dissipative Navier-Stokes system along with the Leray-Schauder degree theory.
