期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson’s disease
1
作者 Huaibin Cai Guoxiang Liu +1 位作者 Lixin Sun jinhui ding 《Translational Neurodegeneration》 SCIE CAS 2014年第1期212-218,共7页
A preferential dysfunction/loss of dopaminergic(DA)neurons in the substantia nigra pars compacta(SNpc)accounts for the main motor symptoms of Parkinson’s disease(PD),the most common degenerative movement disorder.How... A preferential dysfunction/loss of dopaminergic(DA)neurons in the substantia nigra pars compacta(SNpc)accounts for the main motor symptoms of Parkinson’s disease(PD),the most common degenerative movement disorder.However,the neuronal loss is not stochastic,but rather displays regionally selectivity,indicating the existence of different DA subpopulations in the SNpc.To identify the underlying molecular determinants is thereby instrumental in understanding the pathophysiological mechanisms of PD-related neuron dysfunction/loss and offering new therapeutic targets.Recently,we have demonstrated that aldehyde dehydrogenase 1(ALDH1A1)is one such molecular determinant that defines and protects an SNpc DA neuron subpopulation preferentially affected in PD.In this review,we provide further analysis and discussion on the roles of ALDH1A1 in the function and survival of SNpc DA neurons in both rodent and human brains.We also explore the feasibility of ALDH1A1 as a potential biomarker and therapeutic target for PD. 展开更多
关键词 Parkinson’s disease Substantia nigra pars compacta Dopaminergic neuron Aldehyde dehydrogenase 1 α-synuclein NEURODEGENERATION Aging
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部