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Facile fabrication of quaternized chitosan-incorporated biomolecular patches for non-compressive haemostasis and wound healing
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作者 Zesheng Chen Yixuan Zhang +7 位作者 Kexin Feng Tao Hu Bohan Huang jinlan tang Junjie Ai Liang Guo Weikang Hu Zijian Wang 《Fundamental Research》 CAS CSCD 2024年第5期1243-1253,共11页
Cell-free wound dressings (WDs) with desirable effectiveness and safety have received much attention in the field of regenerative medicine. However, the weak linkages between bioactive polymers and the spatial structu... Cell-free wound dressings (WDs) with desirable effectiveness and safety have received much attention in the field of regenerative medicine. However, the weak linkages between bioactive polymers and the spatial structure of WDs frequently result in interventional treatment failure. Herein, we create a series of quaternized chitosan (QCS)-incorporated composite hydrogels (referred to as GHCH-n) by UV cross-linking and then convert them into microneedle patches (MNPs). QCS, which is positively charged and amphiphilic, is essential for broad-spectrum antibacterial and haemostatic activities. QCS is proven to be slightly toxic, so it is immobilized into the methacrylate gelatine (GelMA) molecular cage to minimize adverse effects. A polydimethylsiloxane micro-mould is used to shape the MNPs. MNPs can pierce tissue, seal off bleeding sites, and cling to wounds securely. Thus, MNPs can cooperate with GHCH-n hydrogels to halt bleeding and accelerate wound healing. This study recommends GHCH-10 MNPs as an advanced biomaterial. Several preclinical research models have thoroughly validated the application effect of GHCH-10 MNPs. This research also proposes a novel strategy for integrating the nature of bioactive polymers and the structure of composite biomaterials. This strategy is not only applicable to the fabrication of next-generation WDs but also shows great potential in expanding interdisciplinary domains. 展开更多
关键词 Quaternized chitosan PATCHES BIOCOMPATIBLE ANTIBACTERIAL Haemostatic Wound healing
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现代远程教育环境下学长助学模式的探索 被引量:5
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作者 唐锦兰 陈丽萍 《中国远程教育》 CSSCI 2021年第11期48-57,共10页
远程教育教与学时空分离的特征使得连接学校与学员的助学支持服务显得尤为重要。良好的助学支持服务是远程学习得以顺利进行的重要条件和保证,也是确保远程教育质量的关键。为缓解远程教育中师资力量不足的问题,落实立德树人任务,切实... 远程教育教与学时空分离的特征使得连接学校与学员的助学支持服务显得尤为重要。良好的助学支持服务是远程学习得以顺利进行的重要条件和保证,也是确保远程教育质量的关键。为缓解远程教育中师资力量不足的问题,落实立德树人任务,切实给每位学员提供帮助,研究者设计了学长助学模式。本研究介绍了学长助学模式的内容和运行机制,并通过对比学员作业提交率、保有率以及学员对学长助学的体验和反馈等数据,探讨了学长助学模式的有效性。研究结果表明,学长助学促进师生交互,提高学习效果,并在提高学员作业提交率和保有率方面发挥了一定积极作用。 展开更多
关键词 远程教育 在线教育 英语教育 助学支持 学长助学 助学体验 同伴支持 保有率
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