The space noncooperative target maneuvering trajectory tracking is essential for the safety of the on-orbit spacecraft.For the noncooperative target,the maneuvering model is complex and changeable.Besides,the maneuver...The space noncooperative target maneuvering trajectory tracking is essential for the safety of the on-orbit spacecraft.For the noncooperative target,the maneuvering model is complex and changeable.Besides,the maneuvering dynamics model,the operation time,and the maneuvering frequency are previously unknown.It is difficult to achieve high-precision maneuvering trajectory tracking.In this paper,a novel real-time maneuvering trajectory tracking algorithm is developed,in which the maneuvering trajectory of the noncooperative target is discretized first,and then the differential algebra method is utilized to estimate the maneuvering parameter of the noncooperative target in the discretized time.Since the discretized period is very short,the maneuvering parameters of the target in the next discretized time are assumed to be the same as those in the previous discretized time,and the estimated maneuvering parameters are utilized to predict the target’s relative state in the next discretized time to achieve maneuvering trajectory tracking.Compared with the interactive multimodel method(IMM),the proposed method can estimate the maneuvering parameter of the noncooperative target in real time,which greatly reduces the tracking error caused by the mismatching of the target’s maneuvering model.In order to verify the effectiveness of the algorithm,a simulation of a noncooperative target’s maneuvering trajectory tracking is provided.The results demonstrated that the proposed method could track the noncooperative target maneuvering in real time,and the estimation accuracy was improved by about 93.07%compared with the IMM.展开更多
Background and aims:To investigate the safety and efficacy of direct-acting antiviral(DAA)regimens in a cohort of Chinese patients with chronic hepatitis C virus(HCV)infection.Methods:A total of 222 adult Chinese pati...Background and aims:To investigate the safety and efficacy of direct-acting antiviral(DAA)regimens in a cohort of Chinese patients with chronic hepatitis C virus(HCV)infection.Methods:A total of 222 adult Chinese patients were enrolled and treated via DAA regimens in accor-dance with HCV management guidelines.Treatment responses were evaluated 4 weeks after treatment,at the end of treatment(EOT)and 12 weeks post-treatment.Virological responses,biochemical re-sponses,model for end-stage liver disease(MELD)and Child-Pugh(CP)scores were recorded.Results:A total of 218 patients(98.2%)achieved sustained virological response 12 weeks post-treatment and 4 patients relapsed.The combined number of rapid virological responses for all six regimens was 170/222(76.6%),and 221/222(99.6%)had achieved virological responses by the end of treatment.In decompensated cirrhosis patients the baseline mean CP score was 6.8±1.3 and the mean MELD score was 10.1±3.3.Compared with the mean CP score at baseline,the mean score is significantly lower at the end of treatment(5.7±1.3)and 12 weeks post-treatment(5.6±1.0).Estimated glomerular filtration rates did not differ significantly from baseline during the treatment or 12 weeks post-treatment.The incidence of adverse events in patients with chronic hepatitis C and compensated cirrhosis was 42/172(24.4%),and in patients with decompensated cirrhosis it was 8/22(36.4%).The most frequently reported adverse events were elevated indirect bilirubin,fatigue and rash.There were no cases of serious adverse events,death or treatment discontinuation because of adverse events.Conclusion:DAA regimens were highly effective and well tolerated irrespective of HCV genotype,cirrhosis,liver or kidney transplantation,hepatocellular carcinoma,HCV/hepatitis B virus co-infection,or renal failure.展开更多
基金supported by Key Laboratory Fund for Aerospace Flight Dynamics Technology 20211205。
文摘The space noncooperative target maneuvering trajectory tracking is essential for the safety of the on-orbit spacecraft.For the noncooperative target,the maneuvering model is complex and changeable.Besides,the maneuvering dynamics model,the operation time,and the maneuvering frequency are previously unknown.It is difficult to achieve high-precision maneuvering trajectory tracking.In this paper,a novel real-time maneuvering trajectory tracking algorithm is developed,in which the maneuvering trajectory of the noncooperative target is discretized first,and then the differential algebra method is utilized to estimate the maneuvering parameter of the noncooperative target in the discretized time.Since the discretized period is very short,the maneuvering parameters of the target in the next discretized time are assumed to be the same as those in the previous discretized time,and the estimated maneuvering parameters are utilized to predict the target’s relative state in the next discretized time to achieve maneuvering trajectory tracking.Compared with the interactive multimodel method(IMM),the proposed method can estimate the maneuvering parameter of the noncooperative target in real time,which greatly reduces the tracking error caused by the mismatching of the target’s maneuvering model.In order to verify the effectiveness of the algorithm,a simulation of a noncooperative target’s maneuvering trajectory tracking is provided.The results demonstrated that the proposed method could track the noncooperative target maneuvering in real time,and the estimation accuracy was improved by about 93.07%compared with the IMM.
基金This work was supported by the Science and Technology Plan-ning Project of Guangdong Province Grant(2014B020212025).
文摘Background and aims:To investigate the safety and efficacy of direct-acting antiviral(DAA)regimens in a cohort of Chinese patients with chronic hepatitis C virus(HCV)infection.Methods:A total of 222 adult Chinese patients were enrolled and treated via DAA regimens in accor-dance with HCV management guidelines.Treatment responses were evaluated 4 weeks after treatment,at the end of treatment(EOT)and 12 weeks post-treatment.Virological responses,biochemical re-sponses,model for end-stage liver disease(MELD)and Child-Pugh(CP)scores were recorded.Results:A total of 218 patients(98.2%)achieved sustained virological response 12 weeks post-treatment and 4 patients relapsed.The combined number of rapid virological responses for all six regimens was 170/222(76.6%),and 221/222(99.6%)had achieved virological responses by the end of treatment.In decompensated cirrhosis patients the baseline mean CP score was 6.8±1.3 and the mean MELD score was 10.1±3.3.Compared with the mean CP score at baseline,the mean score is significantly lower at the end of treatment(5.7±1.3)and 12 weeks post-treatment(5.6±1.0).Estimated glomerular filtration rates did not differ significantly from baseline during the treatment or 12 weeks post-treatment.The incidence of adverse events in patients with chronic hepatitis C and compensated cirrhosis was 42/172(24.4%),and in patients with decompensated cirrhosis it was 8/22(36.4%).The most frequently reported adverse events were elevated indirect bilirubin,fatigue and rash.There were no cases of serious adverse events,death or treatment discontinuation because of adverse events.Conclusion:DAA regimens were highly effective and well tolerated irrespective of HCV genotype,cirrhosis,liver or kidney transplantation,hepatocellular carcinoma,HCV/hepatitis B virus co-infection,or renal failure.
