Accretionary complex study provides important knowledge on the subduction and the geodynamic processes of the oceanic plate,which represents the ancient ocean basin extinction location.Nevertheless,there exist many di...Accretionary complex study provides important knowledge on the subduction and the geodynamic processes of the oceanic plate,which represents the ancient ocean basin extinction location.Nevertheless,there exist many disputes on the age,material source,and tectonic attribute of the Lancang Group,located in Southwest Yunnan,China.In this paper,the LA-ICP-MS detrital zircon U‒Pb chronology of nine metamorphic rocks in the Lancang Group was carried out.The U‒Pb ages of the three detrital zircons mainly range from 590-550 Ma,980-910 Ma,and 1150-1490 Ma,with the youngest detrital zircons having a peak age of about 560 Ma.The U‒Pb ages of the six detrital zircons mainly range from 440-460 Ma and 980-910 Ma,and the youngest detrital zircon has a peak age of about 445 Ma.In the Lancang Group,metamorphic acidic volcanic rocks,basic volcanic rocks,intermediate-acid intrusive rocks,and high-pressure metamorphic rocks are exposed in the form of tectonic lens in schist,rendering typical melange structural characteristics of“block+matrix”.Considering regional deformation and chronology,material composition characteristics,and the previous data,this study thinks the Lancang Group may be an early Paleozoic tectonic accretionary complex formed by the eastward subduction of the Changning-Menglian Proto-Tethys Ocean,which provides an important constraint for the Tethys evolution.展开更多
Broom-shaped structures are widely seen in transtensional basins, including those discovered in many sags of the Bohai Bay Basin. Broom-shaped transtensional structural zones are generally petroliferous and thus impor...Broom-shaped structures are widely seen in transtensional basins, including those discovered in many sags of the Bohai Bay Basin. Broom-shaped transtensional structural zones are generally petroliferous and thus important targets for hydrocarbon exploration. This study analyzed the evolution and genetic mechanisms of the broom-shaped transtensional structures in the Gaoqing area of the Dongying Sag using the 3D seismic flattening technique and a physical simulation experiment. Furthermore, the control effects of the broom-shaped transtensional structures on hydrocarbon accumulation and distribution were discussed. The research results are as follows. The Gaoqing area is of a broom-shaped transtensional structure in planar view, composed of several arc-shaped secondary faults intersecting with high-level main fault in the same direction. On the seismic section, it appears as a typical semi-flower-like structure. In the early stage (that is, during the deposition of the Kongdian Formation to the lower submember of the 4th member of the Shahejie Formation, Es4(L)), single-fault pattern consisting of single or multiple faults in alignment was developed under extensional stress. While with the change of structural stress (that is, during the deposition of the Es4(U) to the Es2(L)), more secondary faults were formed, and came in a pattern of broom-shaped structure together with the major fault. In the late stage (that is, during the deposition of the Es1 to the Guantao Formation), the en echelon fault pattern was formed, as the major fault broke into multiple secondary faults. The divergent end of the broom-shaped transtensional structure has many secondary faults developed, the fault planes are gentle, and small-scale fan deltas are the predominant type of deposits. The hydrocarbon tends to laterally migrate far away and accumulate mianly in structural and lithologic-structural traps. On the other hand, in the convergent end, the fault planes are relatively steep, resulting in small-scale subaqueous fans or large-scale deltas deposited along the major fault, with hydrocarbon accumulating minaly in structural-lithologic traps proximal to the provenances.展开更多
Deep carbonate rocks are important targets for oil and gas exploration in China. In recent years, significant oil/gas discoveries have been made in the deep carbonate sequences in the Tarim, Sichuan, Ordos, and Bohai ...Deep carbonate rocks are important targets for oil and gas exploration in China. In recent years, significant oil/gas discoveries have been made in the deep carbonate sequences in the Tarim, Sichuan, Ordos, and Bohai Bay basins. Despite significant oil/gas discoveries, large-scale exploration has not been conducted in the Gucheng area in the Tarim Basin. To break the bottleneck restricting the petroleum exploration in the Gucheng area, this study analyzed the factors controlling the formation of carbonate reservoirs of the Yingshan Formation in the Gucheng area in detail based on the basic geological conditions of the study area and the data from cores, thin sections, well logging, testing, and 3-D seismic survey. The inner shallow-ramp in the Gucheng area acts as the main sedimentary facies zone for the development of high-quality reservoirs. The grainstones formed in the high-energy environment of the inner shallow-ramp laid the foundation for subsequent reservoir development in the study area. The dolomitized shoal grainstones in the inner shallow-ramp have well-developed intercrystalline pores and intercrystalline dissolved pores due to later dolomitization, thus serving as high-quality reservoirs. Strike-slip faults are crucial to reservoir reformation and determine whether high production can be achieved in oil and gas exploitation in the study area. Moreover, later reformation by hydrothermal solutions also plays a constructive role in reservoir formation.展开更多
BACKGROUND Since the start of the 21st century,prostate cancer with lung metastasis(PCLM)has accumulated significant scientific research output.However,a systematic knowledge framework for PCLM is still lacking.AIM To...BACKGROUND Since the start of the 21st century,prostate cancer with lung metastasis(PCLM)has accumulated significant scientific research output.However,a systematic knowledge framework for PCLM is still lacking.AIM To reconstruct the global knowledge system in the field of PCLM,sort out hot research directions,and provide reference for the clinical and mechanism research of PCLM.METHODS We retrieved 280 high-quality papers from the Web of Science Core Collection and conducted a bibliometric analysis of keywords,publication volume,and citation frequency.Additionally,we selected differentially expressed genes from global high-throughput datasets and performed enrichment analysis and proteinprotein interaction analysis to further summarize and explore the mechanisms of PCLM.RESULTS PCLM has received extensive attention over the past 22 years,but there is an uneven spatial distribution in PCLM research.In the clinical aspect,the treatment of PCLM is mainly based on chemotherapy and immunotherapy,while diagnosis relies on methods such as prostate-specific membrane antigen positron emission tomography/computed tomography.In the basic research aspect,the focus is on cell adhesion molecules and signal transducer and activator of transcription 3,among others.Traditional treatments,such as chemotherapy,remain the mainstay of PCLM treatment,while novel approaches such as immunotherapy have limited effectiveness in PCLM.This study reveals for the first time that pathways related to coronavirus disease 2019,cytokinecytokine receptor interaction,and ribosome are closely associated with PCLM.CONCLUSION Future research should focus on exploring and enhancing mechanisms such as cytokine-cytokine receptor interaction and ribosome and improve existing mechanisms like cadherin binding and cell adhesion molecules.展开更多
Phytochemical investigation of the aerial parts of the monotypic plant,Musella lasiocarpa,led to the isolation of four rare bicyclic diarylheptanoids,musellarins B-E(2-5),two new phenylphenalenones,2-methoxy-9-(3′,4...Phytochemical investigation of the aerial parts of the monotypic plant,Musella lasiocarpa,led to the isolation of four rare bicyclic diarylheptanoids,musellarins B-E(2-5),two new phenylphenalenones,2-methoxy-9-(3′,4′-dihydroxyphenyl)-1H-phenalen-1-one(9),2-methoxy-9-(3′-methoxy-4′-hydroxyphenyl)-1H-phenalen-1-one(10),a new acenaphtylene derivative,trans-(1S,2S)-3-(4′-methoxyphenyl)-acenaphthene-1,2-diol(13),and two new sucrose esters,1,2′,3′,4′,6′-O-pentaacetyl-3-O-trans-p-coumaroylsucrose(16),1,2′,3′,4′,6′-O-pentaacetyl-3-O-cis-p-coumaroylsucrose(17),together with nine known compounds.In addition,(4E,6E)-1-(3′,4′-dihydroxyphenyl)-7-(4′′-hydroxyphenyl)-hepta-4,6-dien-3-one(15)was isolated for the first time from a natural source.The structures of new compounds were elucidated by analysis of their spectroscopic data.Compounds 2,6,8-10,12,and 14 were cytotoxic toward several of the human tumor cell lines(HL-60,SMMC-7721,A-549,MCF-7,and SW480).Of these,the new compound 9 was the most potent one,with IC50 values of 5.8,10.3,6.3,3.3,and 2.3μM,respectively.展开更多
Objective:To investigate the effect of Fuhe decoction on the behavior and levels of monoamine neurotransmitters in different brain regions in a depression rat model induced by chronic unpredictable mild stimulation(CU...Objective:To investigate the effect of Fuhe decoction on the behavior and levels of monoamine neurotransmitters in different brain regions in a depression rat model induced by chronic unpredictable mild stimulation(CUMS)combined with social isolation.Methods:Fifty male SD rats were randomly divided into a blank group,model group,fluoxetine group,Chaiqinwendan decoction group,and Fuhe decoction group.Chronic unpredictable mild stimulation combined with a social isolation method was used to replicate the depression rat model.After 42 days of administration,a tail suspension test and high-performance liquid electrochemical detection(HPLC-ECD)were used to detect the behavioral changes and changes in the content of monoamine neurotransmitters norepinephrine(NE),dopamine(DA),5-hydroxytrytamine(5-HT),and metabolites in different brain regions of rats in each group before and after treatment.Results:Compared with the model group,the epinephrine(E)content in the Fuhe decoction group was highly significantly increased(P<.01).Compared with the model group,the 5-HT content of the prefrontal cortex in rats in the Fuhe decoction group was highly significantly increased(P<.01).Furthermore,compared with the model group,the 5-HT content in the hippocampus of rats in the Fuhe decoction group was significantly increased(P<.05).Conclusion:Fuhe decoction can improve the depression-like behaviors of model rats,and its antidepressant effect may be related to the increase in 5-HT content in the prefrontal cortex and hippocampus of rats.展开更多
Objective:This paper aims to study the correlativity between the number of pulmonary tuberculosis (PTB) cases and seasonal meteorological factors in Beijing.Methods:Based on theory of Human-Environmental Inter Relatio...Objective:This paper aims to study the correlativity between the number of pulmonary tuberculosis (PTB) cases and seasonal meteorological factors in Beijing.Methods:Based on theory of Human-Environmental Inter Relation in Huangdi's Internal Classics,we adopted monthly cases of PTB in Beijing from 2004 to 2011,and established a Seasonal Autoregressive Integrated Moving Average (SARIMA) model.Using the cross-correlation function (CCF),we then analyzed the correlation between meteorological factors and number of infected patients.The related meteorological factors were subsequently integrated,to establish a Seasonal Autoregressive Integrated Moving Average with explanatory variables (SARIMAX) model,which was used to estimate and verify the number of PTB cases in 2012.Results:In this study,a SARIMA(0,1,1) (0,1,1)12 model was established;CCF analysis was used to reveal the correlativity between PTB and precipitation with 1 lag,relative humidity with 1 lag.Then,integrated with relative humidity with 1 lag (β =2.405,95% confidence interval:0.433-4.377),the SARIMAX prediction model was proved to be an accurate approach for predicting local situations of PTB occurrence.Conclusions:The occurrence of PTB is correlated with seasonal meteorological factors.Combining these factors,an exact prediction model can be established,to estimate of the number of PTB infected patients.展开更多
Objective:To analyze the impact of meteorological factors on the incidence of influenza based on the Yunqi theory in Beijing area,and to establish an effective forecast modelMethods:Monthly data on the incidence of in...Objective:To analyze the impact of meteorological factors on the incidence of influenza based on the Yunqi theory in Beijing area,and to establish an effective forecast modelMethods:Monthly data on the incidence of influenza from 1970 to 2004 and daily data on the meteorological factors (including daily averages of temperature,wind speed,relative humidity,vapor pressure,and daily total precipitation) from 1966 to 2004 were collected and processed under the traditional Chinese medicine (TCM) theory of six qi.A back-propagation artificial neural network was then performed to analyze the data.Results:The highest incidence of influenza occurs in the sixth qi (the period of December and January),which is characterized by dryness and coldness.Altogether six models were successfully established.Climatic data used were of the same year,one year prior,two years prior,and three years prior to the influenza data respectively.The last two models involve climatic data of the previous three years plus the current year and of the past four years plus the current year.Finally,we determined the fifth model has the highest forecast accuracy (49%).Conclusions:Meteorological factors can exert an influence on the incidence of influenza,which corresponds to TCM theory that 'the pestilence occurred three years after the abnormal climatic changes'.This study may generate interest among the public health community and other TCM theories can be applied so that public health measures can be taken to prevent and control influenza,particularly during the winter months.展开更多
The conservation law for first-order coherence and mutual correlation of a bipartite qubit state was firstly proposed by Svozil′?k et al.,and their theories laid the foundation for the study of coherence migration un...The conservation law for first-order coherence and mutual correlation of a bipartite qubit state was firstly proposed by Svozil′?k et al.,and their theories laid the foundation for the study of coherence migration under unitary transformations.In this paper,we generalize the framework of first-order coherence and mutual correlation to an arbitrary(m■n)-dimensional bipartite composite state by introducing an extended Bloch decomposition form of the state.We also generalize two kinds of unitary operators in high-dimensional systems,which can bring about coherence migration and help to obtain the maximum or minimum first-order coherence.Meanwhile,the coherence migration in open quantum systems is investigated.We take depolarizing channels as examples and establish that the reduced first-order coherence of the principal system over time is completely transformed into mutual correlation of the(2■4)-dimensional system-environment bipartite composite state.It is expected that our results may provide a valuable idea or method for controlling the quantum resource such as coherence and quantum correlations.展开更多
Synthesis of N6-cyclopropy1-2.6-diamino-9 β-D-arabinofuranosyl-purine has beenaccomplished by treatment silylated 2-amino-6-chloro-purine 4 with 2.3.5-tri-O-benzyl- β-Darabinofuranosyl chloride 3 in the presence of ...Synthesis of N6-cyclopropy1-2.6-diamino-9 β-D-arabinofuranosyl-purine has beenaccomplished by treatment silylated 2-amino-6-chloro-purine 4 with 2.3.5-tri-O-benzyl- β-Darabinofuranosyl chloride 3 in the presence of molecular sieves. followed by reaction withcyclopropylamine and debenzyl reaction to give the β-anomeric nucleoside. The structures ofall products were confirmed by UV. ’H-NMR and elemental analysis.展开更多
Two undescribed Tricholoma triterpenoids,namely tricholopardins C(1)and D(2),were isolated from the wild mushroom Tricholoma pardinum.Their structures with absolute configurations were elucidated by spectroscopic meth...Two undescribed Tricholoma triterpenoids,namely tricholopardins C(1)and D(2),were isolated from the wild mushroom Tricholoma pardinum.Their structures with absolute configurations were elucidated by spectroscopic methods,as well as the single crystal X-ray diffraction.Compounds 1 and 2 were further obtained by chemical conversions from the known analogues.Compound 1 showed significant cytotoxicity to MCF-7 and Hela cell lines with IC_(50)values of 4.7μM and 9.7μM,respectively.Its mechanism of inducing MCF-7 cell apoptosis was studied briefly.展开更多
Kiwi,a fruit from plants of the genus Actinidia,is one of the famous fruits with thousand years of edible history.In the past twenty years,a great deal of research has been done on the chemical constituents of the Act...Kiwi,a fruit from plants of the genus Actinidia,is one of the famous fruits with thousand years of edible history.In the past twenty years,a great deal of research has been done on the chemical constituents of the Actinidia species.A large number of secondary metabolites including triterpenoids,flavonoids,phenols,etc.have been identified from differents parts of Actinidia plants,which exhibited significant in vitro and in vivo pharmacological activities including anticancer,anti-inflammatory,neuroprotective,anti-oxidative,anti-bacterial,and anti-diabetic activities.In order to fully understand the chemical compo-nents and biological activities of Actinidia plants,and to improve their further research,development and utilization,this review summarizes the compounds extracted from different parts of Actinidia plants since 1959 to 2020,classifies the types of constituents,reports on the pharmacological activities of relative compounds and medicinal potentials.展开更多
A small focused library which comprised of L-AA lactone derivatives was built with a facile method.This reported method was optimized by modifying the acidity of the solvent.As a result,12 L-AA lactones were synthesiz...A small focused library which comprised of L-AA lactone derivatives was built with a facile method.This reported method was optimized by modifying the acidity of the solvent.As a result,12 L-AA lactones were synthesized.Among these lactones,lactones 8–12 were new compounds.The cytotoxicity of these synthetic compounds were investigated.展开更多
Objective:To evaluate whether the traditional Chinese medicine(TCM)theory of five circuits and six qi(FCSQ)is beneficial in terms of improving clinical effectiveness.Methods:Randomized controlled trials(RCTs)evaluatin...Objective:To evaluate whether the traditional Chinese medicine(TCM)theory of five circuits and six qi(FCSQ)is beneficial in terms of improving clinical effectiveness.Methods:Randomized controlled trials(RCTs)evaluating the clinical value of FCSQ theory were reviewed.Multiple databases(China Network Knowledge Infrastructure,Chinese Scienti fic Journals Database,Wanfang Data,SinoMed,Cochrane Library,PubMed,and Embase)weresystematically searched from inception to June 12,2018.Two authors independently extracted the data and performed a methodological quality assessment of the RCTs.RevMan 5.3 software was used for the data analysis.The effect sizes for the primary outcome measures were expressed as relative risks or mean differences with 95%confidence intervals.Results:A total of 13 RCTs were selected,involving 12 types of diseases and 4695 patients.The methodological quality of the RCTs was generally low.Five studies compared the effectiveness of TCM treatments guided by FCSQ theory with conventional TCM therapies,and the remaining eight studies compared the effectiveness of TCM treatments guided by FCSQ theory with biomedical treatments.All of the RCTs reported that the effectiveness of the treatment intervention was better than that of the intervention in the control group.Conclusion:Because of many methodological problems in existing clinical studies,it remains impossible to definitively conclude that FCSQ theory can improve clinical effectiveness.It is difficult to unify the clinical application of FCSQ theory.The feasibility and repeatability of FCSQas an intervention should be given more attention in future clinical research.Future work should also follow international norms for clinical research implementation and reporting to provide high-quality evidence for evaluating the clinical value of FCSQ theory.展开更多
Objective: To study the correlation of the change of hypoxia-induced factor-1α (HIF-1α) in oral squamous cell carcinoma lesion with lymph node metastasis and malignant biological molecule expression. Methods: The pa...Objective: To study the correlation of the change of hypoxia-induced factor-1α (HIF-1α) in oral squamous cell carcinoma lesion with lymph node metastasis and malignant biological molecule expression. Methods: The patients with oral squamous cell carcinoma who underwent surgical resection in the First Hospital of Yulin between March 2012 and December 2017 were selected as the research subjects, and right amount of oral squamous cell carcinoma lesion and lesion adjacent to carcinoma were collected after surgical resection to determine the mRNA expression of HIF-1α, proliferation genes and invasion genes as well as the contents of angiogenesis molecules. Results: HIF-1α, PCNA, CDK4, CDK6, Slug, β-catenin and MMP9 mRNA expression as well as VEGF, Ang-2, bFGF and COX-2 contents in oral squamous cell carcinoma lesions were significantly higher than those in adjacent lesions whereas PDCD5, Smac, E-cadherin and RECK mRNA expression were significantly lower than those in adjacent lesions;Pearson correlation analysis showed that HIF-1α mRNA expression in oral squamous cell carcinoma lesions was positively correlated with PCNA, CDK4, CDK6, Slug, β-catenin and MMP9 mRNA expression as well as VEGF, Ang-2, bFGF and COX-2 contents, and negatively correlated with PDCD5, Smac, E-cadherin and RECK mRNA expression. Conclusion: Highly expressed HIF-1α in oral squamous cell carcinoma can promote the proliferation and invasion of cancer cells as well as the angiogenesis in the lesion.展开更多
The adsorption method has the advantages of low cost,high efficiency,and environmental friendliness in treating fluorinated wastewater,and the adsorbent material is the key.This study combines the inherent anion-excha...The adsorption method has the advantages of low cost,high efficiency,and environmental friendliness in treating fluorinated wastewater,and the adsorbent material is the key.This study combines the inherent anion-exchange adsorption properties of layered double hydroxides(LDHs).Self-supported porous adsorbent materials loaded with AFm and AFt were prepared from a composite cementitious system consisting of calcium aluminate cement(CAC)and flue gas desulfurization gypsum(FGDG)by chemical foaming technique.The mineral composition of the adsorbent material was characterized by X-ray diffraction(XRD)and Scanning electron microscopy(SEM).Through the static adsorption experiment,the adsorption effect of the mineral composition of the adsorbent on fluoride ions was deeply analyzed,and the adsorption mechanism was revealed.XRD and SEM showed that the main hydration phases of the composite cementitious system consisting of CAC and FGDG are AFm,AFt,AH_(3),and CaSO_(4)·2H_(2)O.FGDG accelerates the hydration process of CAC and inhibits the transformation of AFt to AFm.The AFt content increased,and the AFm content decreased or even disappeared as the amount of FGDG increased.Static adsorption experiment results showed that AFm and AFt in adsorbent materials could significantly enhance the adsorption of fluoride ions.The adsorption of F^(−)in aqueous solution by PAG tends more towards monolayer adsorption with a theoretical maximum capacity of 108.70 mg/g and is similar to the measured value of 112.77 mg/g.展开更多
Citral is a monoterpene aldehyde,which is the main chemical component of essential oils from Litsea cubeba and Cymbopogon citratus,as well as one of the most important representatives of open-chain monoterpene compoun...Citral is a monoterpene aldehyde,which is the main chemical component of essential oils from Litsea cubeba and Cymbopogon citratus,as well as one of the most important representatives of open-chain monoterpene compounds.The lemon flavor released by citral is very strong,and thus,it is widely used in essence,spices,manufacturing of various foods and beauty and other industries.It has antibacterial,anti-inflammatory,antioxidant,anti-tumor,insecticidal and other biological activity.This paper reviewed citral in Lauraceae plants and its biological activity,in order to provide reference for the development and utilization of citral in Lauraceae plants and its diversified applications.展开更多
The Asmari Formation in the G oilfield on the Iran-Iraq border is a fractured-porous multi-lithology mixed reservoir, for which fracture is an important factor affecting oil productivity and water cut. The characteriz...The Asmari Formation in the G oilfield on the Iran-Iraq border is a fractured-porous multi-lithology mixed reservoir, for which fracture is an important factor affecting oil productivity and water cut. The characterization and modeling of fractures in the carbonate reservoir of G oilfield are challenging due to weak conventional well log responses of fractures and a lack of specific logs, such as image logs. This study proposes an integrated approach for characterizing and modeling fractures in the carbonate reservoir. The features, formation mechanism, influencing factors, and prediction methods of fractures in the Asmari Formation carbonate reservoirs of G oilfield were studied using core observation, thin section, image log, cross-dipole acoustic log (CDAL), geomechanics numerical simulation (GNS), and production data. According to CDAL-based fracture density interpretation, GNS-based fracture intensity prediction between wells, and DFN-based rock fracture properties modeling, the quantitative fracture characterization for G oilfield was realized. This research shows that the fractures in the Asamri Formation are mainly medium-to high-angle shear fractures. The substantial compression stress during the Miocene played a major role in the formation of the prominent fractures and determined their trend in the region, with primary trends of NNW-SSE and NNE-SSW. The fracture distribution has regularity, and the fractures in zone A dolomites are more highly developed than that in zone B limestones vertically. Horizontally, fractures intensity is mainly controlled by faults and structural location. The results of this study may benefit the optimization of well design during field development. From 2019 to 2021, three horizontal wells pilot tests were deployed in the fractures belt in zone A, and these fractures prominently increased the permeability of tight dolomite reservoirs. The initial production of the wells is four to five times the average production of other wells in the area, showing a good development effect. Meanwhile, the updated numerical simulation validates that the history match accuracy of water cut based on the dual-porosity model is significantly improved, proving the fracture evaluation and prediction results to be relatively reliable and applicable.展开更多
基金supported by the Second Comprehensive Scientific Investigation and Research Program on the Qinghai-Tibet Plateau(2019QZKK0702)the China Geological Survey Program(DD20221715,DD20190053).
文摘Accretionary complex study provides important knowledge on the subduction and the geodynamic processes of the oceanic plate,which represents the ancient ocean basin extinction location.Nevertheless,there exist many disputes on the age,material source,and tectonic attribute of the Lancang Group,located in Southwest Yunnan,China.In this paper,the LA-ICP-MS detrital zircon U‒Pb chronology of nine metamorphic rocks in the Lancang Group was carried out.The U‒Pb ages of the three detrital zircons mainly range from 590-550 Ma,980-910 Ma,and 1150-1490 Ma,with the youngest detrital zircons having a peak age of about 560 Ma.The U‒Pb ages of the six detrital zircons mainly range from 440-460 Ma and 980-910 Ma,and the youngest detrital zircon has a peak age of about 445 Ma.In the Lancang Group,metamorphic acidic volcanic rocks,basic volcanic rocks,intermediate-acid intrusive rocks,and high-pressure metamorphic rocks are exposed in the form of tectonic lens in schist,rendering typical melange structural characteristics of“block+matrix”.Considering regional deformation and chronology,material composition characteristics,and the previous data,this study thinks the Lancang Group may be an early Paleozoic tectonic accretionary complex formed by the eastward subduction of the Changning-Menglian Proto-Tethys Ocean,which provides an important constraint for the Tethys evolution.
文摘Broom-shaped structures are widely seen in transtensional basins, including those discovered in many sags of the Bohai Bay Basin. Broom-shaped transtensional structural zones are generally petroliferous and thus important targets for hydrocarbon exploration. This study analyzed the evolution and genetic mechanisms of the broom-shaped transtensional structures in the Gaoqing area of the Dongying Sag using the 3D seismic flattening technique and a physical simulation experiment. Furthermore, the control effects of the broom-shaped transtensional structures on hydrocarbon accumulation and distribution were discussed. The research results are as follows. The Gaoqing area is of a broom-shaped transtensional structure in planar view, composed of several arc-shaped secondary faults intersecting with high-level main fault in the same direction. On the seismic section, it appears as a typical semi-flower-like structure. In the early stage (that is, during the deposition of the Kongdian Formation to the lower submember of the 4th member of the Shahejie Formation, Es4(L)), single-fault pattern consisting of single or multiple faults in alignment was developed under extensional stress. While with the change of structural stress (that is, during the deposition of the Es4(U) to the Es2(L)), more secondary faults were formed, and came in a pattern of broom-shaped structure together with the major fault. In the late stage (that is, during the deposition of the Es1 to the Guantao Formation), the en echelon fault pattern was formed, as the major fault broke into multiple secondary faults. The divergent end of the broom-shaped transtensional structure has many secondary faults developed, the fault planes are gentle, and small-scale fan deltas are the predominant type of deposits. The hydrocarbon tends to laterally migrate far away and accumulate mianly in structural and lithologic-structural traps. On the other hand, in the convergent end, the fault planes are relatively steep, resulting in small-scale subaqueous fans or large-scale deltas deposited along the major fault, with hydrocarbon accumulating minaly in structural-lithologic traps proximal to the provenances.
文摘Deep carbonate rocks are important targets for oil and gas exploration in China. In recent years, significant oil/gas discoveries have been made in the deep carbonate sequences in the Tarim, Sichuan, Ordos, and Bohai Bay basins. Despite significant oil/gas discoveries, large-scale exploration has not been conducted in the Gucheng area in the Tarim Basin. To break the bottleneck restricting the petroleum exploration in the Gucheng area, this study analyzed the factors controlling the formation of carbonate reservoirs of the Yingshan Formation in the Gucheng area in detail based on the basic geological conditions of the study area and the data from cores, thin sections, well logging, testing, and 3-D seismic survey. The inner shallow-ramp in the Gucheng area acts as the main sedimentary facies zone for the development of high-quality reservoirs. The grainstones formed in the high-energy environment of the inner shallow-ramp laid the foundation for subsequent reservoir development in the study area. The dolomitized shoal grainstones in the inner shallow-ramp have well-developed intercrystalline pores and intercrystalline dissolved pores due to later dolomitization, thus serving as high-quality reservoirs. Strike-slip faults are crucial to reservoir reformation and determine whether high production can be achieved in oil and gas exploitation in the study area. Moreover, later reformation by hydrothermal solutions also plays a constructive role in reservoir formation.
文摘BACKGROUND Since the start of the 21st century,prostate cancer with lung metastasis(PCLM)has accumulated significant scientific research output.However,a systematic knowledge framework for PCLM is still lacking.AIM To reconstruct the global knowledge system in the field of PCLM,sort out hot research directions,and provide reference for the clinical and mechanism research of PCLM.METHODS We retrieved 280 high-quality papers from the Web of Science Core Collection and conducted a bibliometric analysis of keywords,publication volume,and citation frequency.Additionally,we selected differentially expressed genes from global high-throughput datasets and performed enrichment analysis and proteinprotein interaction analysis to further summarize and explore the mechanisms of PCLM.RESULTS PCLM has received extensive attention over the past 22 years,but there is an uneven spatial distribution in PCLM research.In the clinical aspect,the treatment of PCLM is mainly based on chemotherapy and immunotherapy,while diagnosis relies on methods such as prostate-specific membrane antigen positron emission tomography/computed tomography.In the basic research aspect,the focus is on cell adhesion molecules and signal transducer and activator of transcription 3,among others.Traditional treatments,such as chemotherapy,remain the mainstay of PCLM treatment,while novel approaches such as immunotherapy have limited effectiveness in PCLM.This study reveals for the first time that pathways related to coronavirus disease 2019,cytokinecytokine receptor interaction,and ribosome are closely associated with PCLM.CONCLUSION Future research should focus on exploring and enhancing mechanisms such as cytokine-cytokine receptor interaction and ribosome and improve existing mechanisms like cadherin binding and cell adhesion molecules.
基金This work was financially supported by the National Basic Research Program of China(973 Program No.2009CB522303 and No.2011CB915503)the NSFC(No.U0932602)+1 种基金the National Natural Science Foundation of China(No.90813004)the State Key Laboratory of Phytochemistry and Plant Resources in West China(No.P2010-ZZ05).
文摘Phytochemical investigation of the aerial parts of the monotypic plant,Musella lasiocarpa,led to the isolation of four rare bicyclic diarylheptanoids,musellarins B-E(2-5),two new phenylphenalenones,2-methoxy-9-(3′,4′-dihydroxyphenyl)-1H-phenalen-1-one(9),2-methoxy-9-(3′-methoxy-4′-hydroxyphenyl)-1H-phenalen-1-one(10),a new acenaphtylene derivative,trans-(1S,2S)-3-(4′-methoxyphenyl)-acenaphthene-1,2-diol(13),and two new sucrose esters,1,2′,3′,4′,6′-O-pentaacetyl-3-O-trans-p-coumaroylsucrose(16),1,2′,3′,4′,6′-O-pentaacetyl-3-O-cis-p-coumaroylsucrose(17),together with nine known compounds.In addition,(4E,6E)-1-(3′,4′-dihydroxyphenyl)-7-(4′′-hydroxyphenyl)-hepta-4,6-dien-3-one(15)was isolated for the first time from a natural source.The structures of new compounds were elucidated by analysis of their spectroscopic data.Compounds 2,6,8-10,12,and 14 were cytotoxic toward several of the human tumor cell lines(HL-60,SMMC-7721,A-549,MCF-7,and SW480).Of these,the new compound 9 was the most potent one,with IC50 values of 5.8,10.3,6.3,3.3,and 2.3μM,respectively.
基金the Foundation of new teachers of Beijing University of Traditional Chinese Medicine(2019-JYB-XJSJJ-001)。
文摘Objective:To investigate the effect of Fuhe decoction on the behavior and levels of monoamine neurotransmitters in different brain regions in a depression rat model induced by chronic unpredictable mild stimulation(CUMS)combined with social isolation.Methods:Fifty male SD rats were randomly divided into a blank group,model group,fluoxetine group,Chaiqinwendan decoction group,and Fuhe decoction group.Chronic unpredictable mild stimulation combined with a social isolation method was used to replicate the depression rat model.After 42 days of administration,a tail suspension test and high-performance liquid electrochemical detection(HPLC-ECD)were used to detect the behavioral changes and changes in the content of monoamine neurotransmitters norepinephrine(NE),dopamine(DA),5-hydroxytrytamine(5-HT),and metabolites in different brain regions of rats in each group before and after treatment.Results:Compared with the model group,the epinephrine(E)content in the Fuhe decoction group was highly significantly increased(P<.01).Compared with the model group,the 5-HT content of the prefrontal cortex in rats in the Fuhe decoction group was highly significantly increased(P<.01).Furthermore,compared with the model group,the 5-HT content in the hippocampus of rats in the Fuhe decoction group was significantly increased(P<.05).Conclusion:Fuhe decoction can improve the depression-like behaviors of model rats,and its antidepressant effect may be related to the increase in 5-HT content in the prefrontal cortex and hippocampus of rats.
基金This study was supported by the Natural Science Foundation of China(81574098).
文摘Objective:This paper aims to study the correlativity between the number of pulmonary tuberculosis (PTB) cases and seasonal meteorological factors in Beijing.Methods:Based on theory of Human-Environmental Inter Relation in Huangdi's Internal Classics,we adopted monthly cases of PTB in Beijing from 2004 to 2011,and established a Seasonal Autoregressive Integrated Moving Average (SARIMA) model.Using the cross-correlation function (CCF),we then analyzed the correlation between meteorological factors and number of infected patients.The related meteorological factors were subsequently integrated,to establish a Seasonal Autoregressive Integrated Moving Average with explanatory variables (SARIMAX) model,which was used to estimate and verify the number of PTB cases in 2012.Results:In this study,a SARIMA(0,1,1) (0,1,1)12 model was established;CCF analysis was used to reveal the correlativity between PTB and precipitation with 1 lag,relative humidity with 1 lag.Then,integrated with relative humidity with 1 lag (β =2.405,95% confidence interval:0.433-4.377),the SARIMAX prediction model was proved to be an accurate approach for predicting local situations of PTB occurrence.Conclusions:The occurrence of PTB is correlated with seasonal meteorological factors.Combining these factors,an exact prediction model can be established,to estimate of the number of PTB infected patients.
基金This work was granted by the National Natural Science Foundation of China(81072896 and 81704198).
文摘Objective:To analyze the impact of meteorological factors on the incidence of influenza based on the Yunqi theory in Beijing area,and to establish an effective forecast modelMethods:Monthly data on the incidence of influenza from 1970 to 2004 and daily data on the meteorological factors (including daily averages of temperature,wind speed,relative humidity,vapor pressure,and daily total precipitation) from 1966 to 2004 were collected and processed under the traditional Chinese medicine (TCM) theory of six qi.A back-propagation artificial neural network was then performed to analyze the data.Results:The highest incidence of influenza occurs in the sixth qi (the period of December and January),which is characterized by dryness and coldness.Altogether six models were successfully established.Climatic data used were of the same year,one year prior,two years prior,and three years prior to the influenza data respectively.The last two models involve climatic data of the previous three years plus the current year and of the past four years plus the current year.Finally,we determined the fifth model has the highest forecast accuracy (49%).Conclusions:Meteorological factors can exert an influence on the incidence of influenza,which corresponds to TCM theory that 'the pestilence occurred three years after the abnormal climatic changes'.This study may generate interest among the public health community and other TCM theories can be applied so that public health measures can be taken to prevent and control influenza,particularly during the winter months.
基金supported by the National Natural Science Foundation of China(Grant No.11605028)Anhui Provincial Natural Science Foundation,China(Grant Nos.2108085MA18 and 2008085QA47)+2 种基金the Natural Science Research Project of Education Department of Anhui Province of China(Grant Nos.KJ2020A0527,KJ2021ZD0071 and KJ2021A0678)the Key Program of Excellent Youth Talent Project of the Education Department of Anhui Province of China(Grant No.gxyqZD2019042)the Research Center for Quantum Information Technology of Fuyang Normal University(Grant No.kytd201706)。
文摘The conservation law for first-order coherence and mutual correlation of a bipartite qubit state was firstly proposed by Svozil′?k et al.,and their theories laid the foundation for the study of coherence migration under unitary transformations.In this paper,we generalize the framework of first-order coherence and mutual correlation to an arbitrary(m■n)-dimensional bipartite composite state by introducing an extended Bloch decomposition form of the state.We also generalize two kinds of unitary operators in high-dimensional systems,which can bring about coherence migration and help to obtain the maximum or minimum first-order coherence.Meanwhile,the coherence migration in open quantum systems is investigated.We take depolarizing channels as examples and establish that the reduced first-order coherence of the principal system over time is completely transformed into mutual correlation of the(2■4)-dimensional system-environment bipartite composite state.It is expected that our results may provide a valuable idea or method for controlling the quantum resource such as coherence and quantum correlations.
文摘Synthesis of N6-cyclopropy1-2.6-diamino-9 β-D-arabinofuranosyl-purine has beenaccomplished by treatment silylated 2-amino-6-chloro-purine 4 with 2.3.5-tri-O-benzyl- β-Darabinofuranosyl chloride 3 in the presence of molecular sieves. followed by reaction withcyclopropylamine and debenzyl reaction to give the β-anomeric nucleoside. The structures ofall products were confirmed by UV. ’H-NMR and elemental analysis.
基金This work was financially supported by the National Natural Science Foundation of China(81872762)the Hubei Provincial Natural Science Foundation of China(2019CFB387).
文摘Two undescribed Tricholoma triterpenoids,namely tricholopardins C(1)and D(2),were isolated from the wild mushroom Tricholoma pardinum.Their structures with absolute configurations were elucidated by spectroscopic methods,as well as the single crystal X-ray diffraction.Compounds 1 and 2 were further obtained by chemical conversions from the known analogues.Compound 1 showed significant cytotoxicity to MCF-7 and Hela cell lines with IC_(50)values of 4.7μM and 9.7μM,respectively.Its mechanism of inducing MCF-7 cell apoptosis was studied briefly.
基金the National Natural Science Foundation of China(22177139)the Scientific Research Program of Hubei Provincial Department of Education,China(D20183001).
文摘Kiwi,a fruit from plants of the genus Actinidia,is one of the famous fruits with thousand years of edible history.In the past twenty years,a great deal of research has been done on the chemical constituents of the Actinidia species.A large number of secondary metabolites including triterpenoids,flavonoids,phenols,etc.have been identified from differents parts of Actinidia plants,which exhibited significant in vitro and in vivo pharmacological activities including anticancer,anti-inflammatory,neuroprotective,anti-oxidative,anti-bacterial,and anti-diabetic activities.In order to fully understand the chemical compo-nents and biological activities of Actinidia plants,and to improve their further research,development and utilization,this review summarizes the compounds extracted from different parts of Actinidia plants since 1959 to 2020,classifies the types of constituents,reports on the pharmacological activities of relative compounds and medicinal potentials.
基金This work was financially supported by the National Natural Science Foundation of China(No.U0932602)the National Basic Research Program of China(973 Program No.2011CB915503).
文摘A small focused library which comprised of L-AA lactone derivatives was built with a facile method.This reported method was optimized by modifying the acidity of the solvent.As a result,12 L-AA lactones were synthesized.Among these lactones,lactones 8–12 were new compounds.The cytotoxicity of these synthetic compounds were investigated.
基金supported by the National Natural Science Foundation of China(81503678).
文摘Objective:To evaluate whether the traditional Chinese medicine(TCM)theory of five circuits and six qi(FCSQ)is beneficial in terms of improving clinical effectiveness.Methods:Randomized controlled trials(RCTs)evaluating the clinical value of FCSQ theory were reviewed.Multiple databases(China Network Knowledge Infrastructure,Chinese Scienti fic Journals Database,Wanfang Data,SinoMed,Cochrane Library,PubMed,and Embase)weresystematically searched from inception to June 12,2018.Two authors independently extracted the data and performed a methodological quality assessment of the RCTs.RevMan 5.3 software was used for the data analysis.The effect sizes for the primary outcome measures were expressed as relative risks or mean differences with 95%confidence intervals.Results:A total of 13 RCTs were selected,involving 12 types of diseases and 4695 patients.The methodological quality of the RCTs was generally low.Five studies compared the effectiveness of TCM treatments guided by FCSQ theory with conventional TCM therapies,and the remaining eight studies compared the effectiveness of TCM treatments guided by FCSQ theory with biomedical treatments.All of the RCTs reported that the effectiveness of the treatment intervention was better than that of the intervention in the control group.Conclusion:Because of many methodological problems in existing clinical studies,it remains impossible to definitively conclude that FCSQ theory can improve clinical effectiveness.It is difficult to unify the clinical application of FCSQ theory.The feasibility and repeatability of FCSQas an intervention should be given more attention in future clinical research.Future work should also follow international norms for clinical research implementation and reporting to provide high-quality evidence for evaluating the clinical value of FCSQ theory.
文摘Objective: To study the correlation of the change of hypoxia-induced factor-1α (HIF-1α) in oral squamous cell carcinoma lesion with lymph node metastasis and malignant biological molecule expression. Methods: The patients with oral squamous cell carcinoma who underwent surgical resection in the First Hospital of Yulin between March 2012 and December 2017 were selected as the research subjects, and right amount of oral squamous cell carcinoma lesion and lesion adjacent to carcinoma were collected after surgical resection to determine the mRNA expression of HIF-1α, proliferation genes and invasion genes as well as the contents of angiogenesis molecules. Results: HIF-1α, PCNA, CDK4, CDK6, Slug, β-catenin and MMP9 mRNA expression as well as VEGF, Ang-2, bFGF and COX-2 contents in oral squamous cell carcinoma lesions were significantly higher than those in adjacent lesions whereas PDCD5, Smac, E-cadherin and RECK mRNA expression were significantly lower than those in adjacent lesions;Pearson correlation analysis showed that HIF-1α mRNA expression in oral squamous cell carcinoma lesions was positively correlated with PCNA, CDK4, CDK6, Slug, β-catenin and MMP9 mRNA expression as well as VEGF, Ang-2, bFGF and COX-2 contents, and negatively correlated with PDCD5, Smac, E-cadherin and RECK mRNA expression. Conclusion: Highly expressed HIF-1α in oral squamous cell carcinoma can promote the proliferation and invasion of cancer cells as well as the angiogenesis in the lesion.
基金supported by the National Natural Science Foundation of China(No.52279138)supported by Scientific Research Project of Shanxi Province(2018SF-367).
文摘The adsorption method has the advantages of low cost,high efficiency,and environmental friendliness in treating fluorinated wastewater,and the adsorbent material is the key.This study combines the inherent anion-exchange adsorption properties of layered double hydroxides(LDHs).Self-supported porous adsorbent materials loaded with AFm and AFt were prepared from a composite cementitious system consisting of calcium aluminate cement(CAC)and flue gas desulfurization gypsum(FGDG)by chemical foaming technique.The mineral composition of the adsorbent material was characterized by X-ray diffraction(XRD)and Scanning electron microscopy(SEM).Through the static adsorption experiment,the adsorption effect of the mineral composition of the adsorbent on fluoride ions was deeply analyzed,and the adsorption mechanism was revealed.XRD and SEM showed that the main hydration phases of the composite cementitious system consisting of CAC and FGDG are AFm,AFt,AH_(3),and CaSO_(4)·2H_(2)O.FGDG accelerates the hydration process of CAC and inhibits the transformation of AFt to AFm.The AFt content increased,and the AFm content decreased or even disappeared as the amount of FGDG increased.Static adsorption experiment results showed that AFm and AFt in adsorbent materials could significantly enhance the adsorption of fluoride ions.The adsorption of F^(−)in aqueous solution by PAG tends more towards monolayer adsorption with a theoretical maximum capacity of 108.70 mg/g and is similar to the measured value of 112.77 mg/g.
基金Supported by Changsha Science and Technology Program (kh2101007).
文摘Citral is a monoterpene aldehyde,which is the main chemical component of essential oils from Litsea cubeba and Cymbopogon citratus,as well as one of the most important representatives of open-chain monoterpene compounds.The lemon flavor released by citral is very strong,and thus,it is widely used in essence,spices,manufacturing of various foods and beauty and other industries.It has antibacterial,anti-inflammatory,antioxidant,anti-tumor,insecticidal and other biological activity.This paper reviewed citral in Lauraceae plants and its biological activity,in order to provide reference for the development and utilization of citral in Lauraceae plants and its diversified applications.
基金supported by the National Science and Technology Major Project“Reservoir Characterization of Typical Thick Carbonate Reservoirs in the Middle East”(Grant No.2017ZX05032004-001).
文摘The Asmari Formation in the G oilfield on the Iran-Iraq border is a fractured-porous multi-lithology mixed reservoir, for which fracture is an important factor affecting oil productivity and water cut. The characterization and modeling of fractures in the carbonate reservoir of G oilfield are challenging due to weak conventional well log responses of fractures and a lack of specific logs, such as image logs. This study proposes an integrated approach for characterizing and modeling fractures in the carbonate reservoir. The features, formation mechanism, influencing factors, and prediction methods of fractures in the Asmari Formation carbonate reservoirs of G oilfield were studied using core observation, thin section, image log, cross-dipole acoustic log (CDAL), geomechanics numerical simulation (GNS), and production data. According to CDAL-based fracture density interpretation, GNS-based fracture intensity prediction between wells, and DFN-based rock fracture properties modeling, the quantitative fracture characterization for G oilfield was realized. This research shows that the fractures in the Asamri Formation are mainly medium-to high-angle shear fractures. The substantial compression stress during the Miocene played a major role in the formation of the prominent fractures and determined their trend in the region, with primary trends of NNW-SSE and NNE-SSW. The fracture distribution has regularity, and the fractures in zone A dolomites are more highly developed than that in zone B limestones vertically. Horizontally, fractures intensity is mainly controlled by faults and structural location. The results of this study may benefit the optimization of well design during field development. From 2019 to 2021, three horizontal wells pilot tests were deployed in the fractures belt in zone A, and these fractures prominently increased the permeability of tight dolomite reservoirs. The initial production of the wells is four to five times the average production of other wells in the area, showing a good development effect. Meanwhile, the updated numerical simulation validates that the history match accuracy of water cut based on the dual-porosity model is significantly improved, proving the fracture evaluation and prediction results to be relatively reliable and applicable.
