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A kinetic model for horizontal transfer and bacterial antibiotic resistance 被引量:1
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作者 Damian A. Knopoff juan m. sanchez sanso 《International Journal of Biomathematics》 2017年第4期131-151,共21页
This paper presents a mathematical model for bacterial growth, mutations, horizontal transfer and development of antibiotic resistance. The model is based on the so-called kinetic theory for active particles that is a... This paper presents a mathematical model for bacterial growth, mutations, horizontal transfer and development of antibiotic resistance. The model is based on the so-called kinetic theory for active particles that is able to capture the main complexity features of the system. Bacterial and immune cells are viewed as active particles whose microscopic state is described by a scalar variable. Particles interact among them and the temporal evolution of the system is described by a generalized distribution function over the microscopic state. The model is derived and tested in a couple of case studies in order to confirm its ability to describe one of the most fundamental problems of modern medicine, namely bacterial resistance to antibiotics. 展开更多
关键词 Kinetic theory active particles antibiotic resistance horizontal gene transfer
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