The Solar Close Observations and Proximity Experiments(SCOPE)mission,which has been proposed by the Yunnan Observatories,Chinese Academy of Sciences,aiming to operate at a distance of 5 to 10 solar radii from the Sun,...The Solar Close Observations and Proximity Experiments(SCOPE)mission,which has been proposed by the Yunnan Observatories,Chinese Academy of Sciences,aiming to operate at a distance of 5 to 10 solar radii from the Sun,plans to complete the in situ detection of the solar eruption process and observation of the magnetic field structure response.The solar flux received by the satellite ranges from 103 to 106 Wm-2,which poses challenges for thermal management of the solar arrays.In this work,the solar array cooling system of the Parker Solar Probe is discussed,the developments of the fluid loop technique are reviewed,and a research plan for a next-generation solar array cooling system is proposed.This paper provides a valuable reference for novel thermal control systems in spacecraft for solar observation.展开更多
In this paper,the mission and the thermal environment of the Solar Close Observations and Proximity Experiments(SCOPE)spacecraft are analyzed,and an advanced thermal management system(ATMS)is designed for it.The relat...In this paper,the mission and the thermal environment of the Solar Close Observations and Proximity Experiments(SCOPE)spacecraft are analyzed,and an advanced thermal management system(ATMS)is designed for it.The relationship and functions of the integrated database,the intelligent thermal control system and the efficient liquid cooling system in the ATMS are elaborated upon.For the complex thermal field regulation system and extreme space thermal environment,a modular simulation and thermal field planning method are proposed,and the feasibility of the planning algorithm is verified by numerical simulation.A solar array liquid cooling system is developed,and the system simulation results indicate that the temperatures of the solar arrays meet the requirements as the spacecraft flies by perihelion and aphelion.The advanced thermal management study supports the development of the SCOPE program and provides a reference for the thermal management in other deep-space exploration programs.展开更多
We attempt to model magnetic reconnection during the two-ribbon flare in a gravitationally stratified solar atmosphere with the Lundquist number of S=10~6 using 2 D simulations.We found that the tearing mode instabili...We attempt to model magnetic reconnection during the two-ribbon flare in a gravitationally stratified solar atmosphere with the Lundquist number of S=10~6 using 2 D simulations.We found that the tearing mode instability leads to inhomogeneous turbulence inside the reconnecting current sheet(CS)and invokes the fast phase of reconnection.Fast reconnection brings an extra dissipation of magnetic field which enhances the reconnection rate in an apparent way.The energy spectrum in the CS shows a power law pattern and the dynamics of plasmoids govern the associated spectral index.We noticed that the energy dissipation occurs at a scale l_(ko)of 100-200 km,and the associated CS thickness ranges from 1500 to 2500 km,which follows the Taylor scale l_(T)=l_(ko)S_(1/6).The termination shock(TS)appears in the turbulent region above flare loops,which is an important contributor to heating flare loops.Substantial magnetic energy is converted into both kinetic and thermal energies via TS,and the cumulative heating rate is greater than the rate of the kinetic energy transfer.In addition,the turbulence is somehow amplified by TS,in which the amplitude is related to the local geometry of the TS.展开更多
BACKGROUND Transplant renal artery stenosis is a relatively frequent vascular complication after transplantation.However,extra-renal pseudo-aneurysms(EPSAs)are rare after transplantation;they can be life-threatening a...BACKGROUND Transplant renal artery stenosis is a relatively frequent vascular complication after transplantation.However,extra-renal pseudo-aneurysms(EPSAs)are rare after transplantation;they can be life-threatening and usually need open surgical repair.We discuss the diagnosis and spontaneous healing of an asymptomatic renal allograft EPSA caused by renal artery anastomotic stenosis,which was diagnosed in a timely manner and managed by conservative treatments.CASE SUMMARY We present a 37-year-old male patient diagnosed with a renal allograft EPSA caused by renal artery anastomotic stenosis due to multiple atherosclerotic plaques with ultrasonographic examination 6 mo post transplantation.The stenosis rate of 90%and the EPSA were verified by computed tomography angiography.The diagnosis was further confirmed with digital subtraction angiography.Percutaneous transluminal angiography was conducted,and a metallic stent was successfully implanted at the stenosed site of the main renal artery trunk.No further intervention for the EPSA was undertaken due to the difficulty of stenting and the risk of bleeding;regular ultrasonographic follow-ups were recommended.The stenosis was significantly relieved immediately after stent implantation and the EPSA was healed spontaneously by completely filling with hypo-echoic thrombosis 8 mo after stenting.CONCLUSION Ultrasonography combined with a high-frequency linear probe can detect vascular complications post renal transplantation at an early stage and improve prognosis.展开更多
High speed and high efficiency synchronized electric motors are favored in the automotive industry and turbo machinery industry worldwide because of the demands placed on efficiency. Herein an electric motor thermal c...High speed and high efficiency synchronized electric motors are favored in the automotive industry and turbo machinery industry worldwide because of the demands placed on efficiency. Herein an electric motor thermal control system using cooling air which enters from the drive end of the motor and exits from the non-drive end of the motor as the rotor experiences dissipates heat is addressed using CFD. Analyses using CFD can help to find the appropriate mass flow rate and windage losses while satisfying temperature requirements on the motor. Here, the air flow through a small annular gap is fed at 620 L/min (0.011 kg/sec) as the rotor spins at 100,000 rpm (10,472 rad/sec) and the rotor dissipates 200 W. The CFD results are compared with experimental results. Based upon the CFD findings, a novel heat transfer correlation suitable for large axial Reynolds number, large Taylor number, small annular gap Taylor-Couette flows subject to axial cross-flow is proposed herein.展开更多
Ru with Pt-like hydrogen bond strength,knockdown cost(~1/3 of Pt),and eximious stability is a competitive replacement for Pt-based catalysts towards the hydrogen evolution reaction(HER)in water splitting.The design of...Ru with Pt-like hydrogen bond strength,knockdown cost(~1/3 of Pt),and eximious stability is a competitive replacement for Pt-based catalysts towards the hydrogen evolution reaction(HER)in water splitting.The design of Ru-based catalysts via interface construction,crystal phase control,and specific light element doping to realize the impressive promotion of limited activity and stability remains challenging.Herein,we report the fabrication of Pd@RuP core-shell nanorods(NRs)via an epitaxial growth method,where ultrathin RuP shells extend the face-centered cubic(fcc)crystal structure and(111)plane of the Pd NRs core.Density functio nal theory results confirm that the core-s hell interface engineering and P doping synergistically accelerate electron transfer and moderate the d-band center to generate a suitable affinity for H*,thus optimizing HER kinetics.Compared with Pd@Ru NRs and Pt/C,the Pd@RuP NRs exhibit preferable electrocatalytic stability and superior activity with a low overpotential of 18 mV at 10 mA cm-2in the alkaline HER process.Furthermore,the integrated Pd@RuP//RuO2-based electrolyzer also displays a low operation potential of 1.42 V to acquire 10 mA cm-2,demonstrating great potential for practical water electrolysis.Our work presents an efficient avenue to design Ru-based electrocatalysts via epitaxial growth for extraordinary HER performance.展开更多
Following our previous work,we studied the partial eruption of a large-scale horse-shoe-like filament that had beenobserved in a decaying active region on the solar disk for more than 4.5 days.The filament became acti...Following our previous work,we studied the partial eruption of a large-scale horse-shoe-like filament that had beenobserved in a decaying active region on the solar disk for more than 4.5 days.The filament became active after itwas broken into two pieces,P1 and P2 seen in Hα,by magnetic reconnection between the magnetic field around itand that of a newly emerging active region nearby.P1 eventually erupted 13 hr after the breaking and escaped fromthe Sun,developing to a fast coronal mass ejection,and P2 stayed.But the mass in P1 falling down to P2 in theeruption suggests that the global magnetic fields over P1 and P2 were still connected to each other prior to theeruption.The reconnection process breaking the filament occurred outside the filament,and P1 and P2 were locatedalmost at the same altitude,so the fashion of the filament partial eruption studied here differs from that of the“double-decker model”and that of reconnection inside the filament.Analyzing the decay indices of thebackground fields above P1 and P2,n_(1)and n_(2),showed that the altitude where n_(1)exceeds the critical value of n_(c)=1.5 for the loss of equilibrium or the torus instability is lower than that where n_(2)>nc,and that n_(1)>n_(2) alwaysholds at all altitudes.Combining this fact with that the eruption occurred 13 hr after filament was broken byreconnection,we conclude that the eruption of P1 was triggered by the loss of equilibrium or the torus instability inthe configuration,and magnetic reconnection breaking the filament helped weaken the confinement of thebackground field on P1,allowing P1 to erupt.Detailed features of the eruption and the corresponding physicalscenario were also discussed.展开更多
Background:Wear particles-induced osteolysis is a major long-term complication after total joint arthroplasty.Up to now,there is no effective treatment for wear particles-induced osteolysis except for the revision sur...Background:Wear particles-induced osteolysis is a major long-term complication after total joint arthroplasty.Up to now,there is no effective treatment for wear particles-induced osteolysis except for the revision surgery,which is a heavy psychological and economic burden to patients.A metabolite of gut microbiota,short chain fatty acids(SCFAs),has been reported to be beneficial for many chronic inflammatory diseases.This study aimed to investigate the therapeutic effect of SCFAs on osteolysis.Methods:A model of inflammatory osteolysis was established by applying CoCrMo alloy particles to mouse calvarium.After two weeks of intervention,the anti-inflammatory effects of SCFAs on wear particle-induced osteolysis were evaluated by micro-CT analysis and immunohistochemistry staining.In vitro study,lipopolysaccharide(LPS)primed bone marrow-derived macrophages(BMDMs)and Tohoku hospital pediatrics-1(THP-1)macrophages were stimulated with CoCrMo particles to activate inflammasome in the presence of acetate(C2),propionate(C3),and butyrate(C4).Western blotting,enzyme-linked immunosorbent assay,and immunofluorescence were used to detect the activation of NLRP3 inflammasome.The effects of SCFAs on osteoclasts were evaluate by qRT-PCR,Western blotting,immunofluorescence,and tartrate-resistant acid phosphatase(TRAP)staining.Additionally,histone deacetylase(HDAC)inhibitors,agonists of GPR41,GPR43,and GPR109A were applied to confirm the underlying mechanism of SCFAs on the inflammasome activation of macrophages and osteoclastogenesis.Results:C3 and C4 but not C2 could alleviate wear particles-induced osteolysis with fewer bone erosion pits(P<0.001),higher level of bone volume to tissue volume(BV/TV,P<0.001),bone mineral density(BMD,P<0.001),and a lower total porosity(P<0.001).C3 and C4 prevented CoCrMo alloy particles-induced ASC speck formation and nucleationinduced oligomerization,suppressing the cleavage of caspase-1(P<0.05)and IL-1β(P<0.05)stimulated by CoCrMo alloy particles.C3 and C4 also inhibited the generation of gasdermin D-N-terminal fragment(GSDMD-NT)to regulate pyroptosis.Besides,C3 and C4 have a negative impact on osteoclast differentiation(P<0.05)and its function(P<0.05),affecting the podosome arrangement and morphologically normal podosome belts formation.Conclusions:Our work showed that C3 and C4 are qualified candidates for the treatment of wear particle-induced osteolysis.展开更多
The host structure of polymers significantly influences ion transport and interfacial stability of electrolytes,dictating battery cycle life and safety for solid-state lithium metal batteries.Despite promising propert...The host structure of polymers significantly influences ion transport and interfacial stability of electrolytes,dictating battery cycle life and safety for solid-state lithium metal batteries.Despite promising properties of ethylene oxide-based electrolytes,their typical clamp-like coordination geometry leads to crowd solvation sheath and overly strong interactions between Li^(+)and electrolytes,rendering difficult dissociation of Li+and unfavorable solid electrolyte interface(SEI).Herein,we explore weakly solvating characteristics of polyacetal electrolytes owing to their alternately changing intervals between–O–coordinating sites in the main chain.Such structural asymmetry leads to unique distorted helical solvation sheath,and can effectively reduce Li^(+)-electrolyte binding and tune Li^(+)desolvation kinetics in the insitu formed polymer electrolytes,yielding anion-derived SEI and dendrite-free Li electrodeposition.Combining with photoinitiated cationic ring-opening polymerization,polyacetal electrolytes can be instantly formed within 5 min at the surface of electrode,with high segmental chain motion and well adapted interfaces.Such in-situ polyacetal electrolytes enabled more than 1300-h of stable lithium electrodeposition and prolonged cyclability over 200 cycles in solid-state batteries at ambient temperatures,demonstrating the vital role of molecular structure in changing solvating behavior and Li deposition stability for high-performance electrolytes.展开更多
KVPO_(4)F(KVPF)has been extensively investigated as the potential cathode material for potassium-ion batteries(PIBs)owing to its high theoretical capacity,superior operating voltage,and three-dimensional Kt conduction...KVPO_(4)F(KVPF)has been extensively investigated as the potential cathode material for potassium-ion batteries(PIBs)owing to its high theoretical capacity,superior operating voltage,and three-dimensional Kt conduction pathway.Nevertheless,the electrochemical behavior of KVPF is limited by the inherent poor electronic conductivity of the phosphate framework and unstable electrode/electrolyte interface.To address the above issues,this work proposes an infiltration-calcination method to confine the in-situ grown KVPF into the mesoporous carbon CMK-3(denoted KVPF@CMK-3).The assembled KVPF@CMK-3 nanocomposite features three-dimensional interconnected carbon channels,which not only offer abundant active sites and significantly accelerate K t/electron transport,but also prevent the growth of KVPF nanoparticle agglomerates,hence stabilizing the structure of the material.Additionally,V–F–C bonds are created at the interface of KVPF and CMK-3,which reduce the loss of F and stabilize the electrode interface.Thus,when tested as a cathode material for PIBs,the KVPF@CMK-3 nanocomposite delivers superior reversible capacitiy(103.2 mAh g^(-1) at 0.2 C),outstanding rate performance(90.1 mAh g^(-1) at 20 C),and steady cycling performance(92.2 mAh g^(-1) at 10 C and with the retention of 88.2%after 500 cycles).Moreover,its potassium storage mechanism is further examined by ex-situ XRD and ex-situ XPS techniques.The above synthetic strategy demonstrates the potential of KVPF@CMK-3 to be applied as the cathode for PIBs.展开更多
Dear Editor,Multiple experiments have established TNF-α-induced protein 3 (A20/TNFAIP3) as a critical regulator associated with rheumatoid arthritis(RA)[1,2].The lack of TNF-α-induced protein 3 (A20) promotes the NO...Dear Editor,Multiple experiments have established TNF-α-induced protein 3 (A20/TNFAIP3) as a critical regulator associated with rheumatoid arthritis(RA)[1,2].The lack of TNF-α-induced protein 3 (A20) promotes the NOD-like receptor protein 3 (NLRP3) inflammasome and induces spontaneous arthritis,while increase of A20 reduces the secretion of IL-1β and favors immunological tolerance[3,4]. Hence, we investigate the feasibility of recombinant adeno-associated virus 6 (rAAV6)-mediated A20 gene therapy in a collageninduced arthritis (CIA) model.展开更多
An Ellerman Bomb(EB)is a kind of small scale reconnection event,which is ubiquitously formed in the upper photosphere or the lower chromosphere.The low temperature(<10,000 K)and high density(~1019–1022)plasma ther...An Ellerman Bomb(EB)is a kind of small scale reconnection event,which is ubiquitously formed in the upper photosphere or the lower chromosphere.The low temperature(<10,000 K)and high density(~1019–1022)plasma there makes the magnetic reconnection process strongly influenced by partially ionized effects and radiative cooling.This work studies the highβmagnetic reconnection near the solar temperature minimum region based on high-resolution 2.5D magnetohydrodynamics simulations.The time-dependent ionization degree of hydrogen and helium are included to realize more realistic diffusivities,viscosity and radiative cooling in simulations.Numerical results show that the reconnection rate is smaller than 0.01 and decreases with time during the early quasi-steady stage,then sharply increases to a value above 0.05 in the later stage as the plasmoid instability takes place.Both the large value ofηen(magnetic diffusion caused by the electron-neutral collision)and the plasmoid instability contribute to the fast magnetic reconnection in the EB-like event.The interactions and coalescence of plasmoids strongly enhance the local compression heating effect,which becomes the dominant mechanism for heating in EBs after plasmoid instability appears.However,the Joule heating contributed byηen can play a major role to heat plasmas when the magnetic reconnection in EBs is during the quasi-steady stage with smaller temperature increases.The results also show that the radiative cooling effect suppresses the temperature increase to a reasonable range,and increases the reconnection rate and generation of thermal energy.展开更多
The era of information technology has dawned on the construction industry,and Building Information Modeling(BIM)is one of the necessary engineering skills for those engaged in civil engineering professions at present ...The era of information technology has dawned on the construction industry,and Building Information Modeling(BIM)is one of the necessary engineering skills for those engaged in civil engineering professions at present and those who will engage in these professions in the future.Therefore,top universities have begun exploring ways to increase BIM-related teaching content in the curriculum system.In this paper,we discuss the integration of BIM in an in-depth manner with regard to the four course modules offered by cost engineering majors(professional foundation course,professional core course,industry-oriented course,and professional practical course)and analyze the construction of BIM curriculum ideology and politics system,the setting of teaching objectives,and the key points of curriculum ideology and politics.展开更多
We focus on the goal of undergraduate talent training,consider the course features of Road Engineering Construction Technology and Organization,analyze the problems existing in the practical teaching of the course,use...We focus on the goal of undergraduate talent training,consider the course features of Road Engineering Construction Technology and Organization,analyze the problems existing in the practical teaching of the course,use the advantages of BIM+virtual simulation technology,design a scientific and reasonable practical teaching content of Road Engineering Construction Technology and Organization,and address the contrast between the strong practical aspect of the traditional Road Engineering Construction Technology and Organization course and the lack of practical instruments in hope to improve students’learning autonomy,enhance the quality of practical teaching,achieve the training objectives of the course,and nurture applied technical talents.展开更多
The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar community.The scientific objectives are to study the relationships between the solar magnetic fie...The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar community.The scientific objectives are to study the relationships between the solar magnetic field,solar flares and coronal mass ejections(CMEs).Three payloads are deployed:the Full-disk vector Magneto Graph(FMG),the Lyman-αSolar Telescope(LST)and the Hard X-ray Imager(HXI).ASO-S will perform the first simultaneous observations of the photospheric vector magnetic field,non-thermal imaging of solar flares,and the initiation and early propagation of CMEs on a single platform.ASO-S is scheduled to be launched into a 720 km Sun-synchronous orbit in 2022.This paper presents an overview of the mission till the end of Phase-B and the beginning of Phase-C.展开更多
Andrias davidianus,i.e.Chinese giant salamander(CGS),is one of the largest and oldest amphibians existing in the world and is also one of the valuable biological resources of China.Wild CGS has been threatened with ex...Andrias davidianus,i.e.Chinese giant salamander(CGS),is one of the largest and oldest amphibians existing in the world and is also one of the valuable biological resources of China.Wild CGS has been threatened with extinction in the past decades due to over capturing,deterioration of natural environment,the slow breeding and growth of the wild species in nature.However,in the past twenty years,with the breakthrough and progress of artificial breeding technology by artificial insemination,the number of artificially cultivated CGS has increased rapidly.Artificially cultivated CGS can either be released to the CGS living environment to increase the population in nature or legally applied in food and medicinal industry as a feedstock due to the unique nutritional and medicinal values of CGS as recorded historically.In this review,the nutritional components,bioactive components and medicinal activities of the artificially cultivated CGS will be summarized.The mucus,skin,meat and bone of CGS contain many different bioactive substances thereby having various medicinal activities including anti-aging,anti-fatigue,anti-tumor,therapy of burn and anti-infection and other physiological functions.This paper will further discuss the potential applications of the artificially cultivated CGS in healthcare industry and prospects of future technological development.展开更多
The impregnation behavior of molten 2LiF–BeF_2(FLiBe) salt into a graphite matrix of fuel elements for a solid fuel thorium molten salt reactor(TMSR-SF) at pressures varying from 0.4 to 1.0 MPa was studied by mercury...The impregnation behavior of molten 2LiF–BeF_2(FLiBe) salt into a graphite matrix of fuel elements for a solid fuel thorium molten salt reactor(TMSR-SF) at pressures varying from 0.4 to 1.0 MPa was studied by mercury intrusion, molten salt impregnation, X-ray diffraction, and scanning electron microscopy techniques.It was found that the entrance pore diameter of the graphite matrix is less than 1.0 μm and the contact angle is about 135°. The threshold impregnation pressure was found to be around 0.6 MPa experimentally, consistent with the predicted value of 0.57 MPa by the Washburn equation. With the increase of pressure from 0.6 to 1.0 MPa, the average weight gain of the matrix increased from 3.05 to 10.48%,corresponding to an impregnation volume increase from 2.74 to 9.40%. The diffraction patterns of FLiBe are found in matrices with high impregnation pressures(0.8 MPa and1.0 MPa). The FLiBe with sizes varying from tens of nanometers to a micrometer mainly occupies the open pores in the graphite matrix. The graphite matrix could inhibit the impregnation of the molten salt in the TMSR-SF with a maximum operation pressure of less than 0.5 MPa.展开更多
Superconducting quantum interference device(SQUID),with the advantages of ultra⁃high sensitivity,low noise,broad frequency bandwidth,and excellent low⁃frequency response,is widely used in several geophysical methods,s...Superconducting quantum interference device(SQUID),with the advantages of ultra⁃high sensitivity,low noise,broad frequency bandwidth,and excellent low⁃frequency response,is widely used in several geophysical methods,such as vector magnetic survey,electromagnetic method,gravity and gravity gradient measurement.In this paper,the latest technological progress of SQUID and SQUID⁃based geophysical precision measurement technology are described.In addition,the advantages,characteristics,and existing problems of each measurement technology are analyzed.Combined with the requirements of current geophysical technology,the future application prospect is discussed and development suggestions are given.展开更多
基金This work has been supported by National Key R&D Program of China No.2022YFF0503804.
文摘The Solar Close Observations and Proximity Experiments(SCOPE)mission,which has been proposed by the Yunnan Observatories,Chinese Academy of Sciences,aiming to operate at a distance of 5 to 10 solar radii from the Sun,plans to complete the in situ detection of the solar eruption process and observation of the magnetic field structure response.The solar flux received by the satellite ranges from 103 to 106 Wm-2,which poses challenges for thermal management of the solar arrays.In this work,the solar array cooling system of the Parker Solar Probe is discussed,the developments of the fluid loop technique are reviewed,and a research plan for a next-generation solar array cooling system is proposed.This paper provides a valuable reference for novel thermal control systems in spacecraft for solar observation.
文摘In this paper,the mission and the thermal environment of the Solar Close Observations and Proximity Experiments(SCOPE)spacecraft are analyzed,and an advanced thermal management system(ATMS)is designed for it.The relationship and functions of the integrated database,the intelligent thermal control system and the efficient liquid cooling system in the ATMS are elaborated upon.For the complex thermal field regulation system and extreme space thermal environment,a modular simulation and thermal field planning method are proposed,and the feasibility of the planning algorithm is verified by numerical simulation.A solar array liquid cooling system is developed,and the system simulation results indicate that the temperatures of the solar arrays meet the requirements as the spacecraft flies by perihelion and aphelion.The advanced thermal management study supports the development of the SCOPE program and provides a reference for the thermal management in other deep-space exploration programs.
基金the Strategic Priority Research Programme of Chinese Academy of Sciences(CAS)with grants XDA17040507 and QYZDJ-SSWSLH012the National Natural Science Foundation of China(NSFC,Grant Nos.12073073,1193300911973083 and U2031141)+2 种基金grants associated with the Yunling Scholar Project of Yunnan Provincethe Yunnan Province Scientist Workshop of Solar Physicsgrants 202101AT070018 and 2019FB005 associated with the Applied Basic Research of Yunnan Province。
文摘We attempt to model magnetic reconnection during the two-ribbon flare in a gravitationally stratified solar atmosphere with the Lundquist number of S=10~6 using 2 D simulations.We found that the tearing mode instability leads to inhomogeneous turbulence inside the reconnecting current sheet(CS)and invokes the fast phase of reconnection.Fast reconnection brings an extra dissipation of magnetic field which enhances the reconnection rate in an apparent way.The energy spectrum in the CS shows a power law pattern and the dynamics of plasmoids govern the associated spectral index.We noticed that the energy dissipation occurs at a scale l_(ko)of 100-200 km,and the associated CS thickness ranges from 1500 to 2500 km,which follows the Taylor scale l_(T)=l_(ko)S_(1/6).The termination shock(TS)appears in the turbulent region above flare loops,which is an important contributor to heating flare loops.Substantial magnetic energy is converted into both kinetic and thermal energies via TS,and the cumulative heating rate is greater than the rate of the kinetic energy transfer.In addition,the turbulence is somehow amplified by TS,in which the amplitude is related to the local geometry of the TS.
基金the Funding from Beijing Municipal Administration of Hospitals’Ascent Plan,No.DFL 20180102and the Capital's Funds for Health Improvement and Research,No.2020-4-20211.
文摘BACKGROUND Transplant renal artery stenosis is a relatively frequent vascular complication after transplantation.However,extra-renal pseudo-aneurysms(EPSAs)are rare after transplantation;they can be life-threatening and usually need open surgical repair.We discuss the diagnosis and spontaneous healing of an asymptomatic renal allograft EPSA caused by renal artery anastomotic stenosis,which was diagnosed in a timely manner and managed by conservative treatments.CASE SUMMARY We present a 37-year-old male patient diagnosed with a renal allograft EPSA caused by renal artery anastomotic stenosis due to multiple atherosclerotic plaques with ultrasonographic examination 6 mo post transplantation.The stenosis rate of 90%and the EPSA were verified by computed tomography angiography.The diagnosis was further confirmed with digital subtraction angiography.Percutaneous transluminal angiography was conducted,and a metallic stent was successfully implanted at the stenosed site of the main renal artery trunk.No further intervention for the EPSA was undertaken due to the difficulty of stenting and the risk of bleeding;regular ultrasonographic follow-ups were recommended.The stenosis was significantly relieved immediately after stent implantation and the EPSA was healed spontaneously by completely filling with hypo-echoic thrombosis 8 mo after stenting.CONCLUSION Ultrasonography combined with a high-frequency linear probe can detect vascular complications post renal transplantation at an early stage and improve prognosis.
文摘High speed and high efficiency synchronized electric motors are favored in the automotive industry and turbo machinery industry worldwide because of the demands placed on efficiency. Herein an electric motor thermal control system using cooling air which enters from the drive end of the motor and exits from the non-drive end of the motor as the rotor experiences dissipates heat is addressed using CFD. Analyses using CFD can help to find the appropriate mass flow rate and windage losses while satisfying temperature requirements on the motor. Here, the air flow through a small annular gap is fed at 620 L/min (0.011 kg/sec) as the rotor spins at 100,000 rpm (10,472 rad/sec) and the rotor dissipates 200 W. The CFD results are compared with experimental results. Based upon the CFD findings, a novel heat transfer correlation suitable for large axial Reynolds number, large Taylor number, small annular gap Taylor-Couette flows subject to axial cross-flow is proposed herein.
基金financially supported by the National Natural Science Foundation of China(22232004,22279062 and 22202104)the Natural Science Foundation of Jiangsu Province(BK20220933)+2 种基金the Shuangchuang Doctor Plan of Jiangsu Province,Jiangsu Specially Appointed Professor Planthe supports from the National and Local Joint Engineering Research Center of Biomedical Functional Materialsa project sponsored by the Priority Academic Program Development of Jiangsu Higher Education Institutions。
文摘Ru with Pt-like hydrogen bond strength,knockdown cost(~1/3 of Pt),and eximious stability is a competitive replacement for Pt-based catalysts towards the hydrogen evolution reaction(HER)in water splitting.The design of Ru-based catalysts via interface construction,crystal phase control,and specific light element doping to realize the impressive promotion of limited activity and stability remains challenging.Herein,we report the fabrication of Pd@RuP core-shell nanorods(NRs)via an epitaxial growth method,where ultrathin RuP shells extend the face-centered cubic(fcc)crystal structure and(111)plane of the Pd NRs core.Density functio nal theory results confirm that the core-s hell interface engineering and P doping synergistically accelerate electron transfer and moderate the d-band center to generate a suitable affinity for H*,thus optimizing HER kinetics.Compared with Pd@Ru NRs and Pt/C,the Pd@RuP NRs exhibit preferable electrocatalytic stability and superior activity with a low overpotential of 18 mV at 10 mA cm-2in the alkaline HER process.Furthermore,the integrated Pd@RuP//RuO2-based electrolyzer also displays a low operation potential of 1.42 V to acquire 10 mA cm-2,demonstrating great potential for practical water electrolysis.Our work presents an efficient avenue to design Ru-based electrocatalysts via epitaxial growth for extraordinary HER performance.
基金supported by the National Key R&D Program of China No.2022YFF0503804the Strategic Priority Research Programme of the Chinese Academy of Sciences with grant XDA17040507+1 种基金the National Natural Science Foundation of China (NSFC) grant 11 933 009grants associated with the Yunling Scholar Project of Yunnan Province,the Yunnan Province Scientist Workshop of Solar Physics.
文摘Following our previous work,we studied the partial eruption of a large-scale horse-shoe-like filament that had beenobserved in a decaying active region on the solar disk for more than 4.5 days.The filament became active after itwas broken into two pieces,P1 and P2 seen in Hα,by magnetic reconnection between the magnetic field around itand that of a newly emerging active region nearby.P1 eventually erupted 13 hr after the breaking and escaped fromthe Sun,developing to a fast coronal mass ejection,and P2 stayed.But the mass in P1 falling down to P2 in theeruption suggests that the global magnetic fields over P1 and P2 were still connected to each other prior to theeruption.The reconnection process breaking the filament occurred outside the filament,and P1 and P2 were locatedalmost at the same altitude,so the fashion of the filament partial eruption studied here differs from that of the“double-decker model”and that of reconnection inside the filament.Analyzing the decay indices of thebackground fields above P1 and P2,n_(1)and n_(2),showed that the altitude where n_(1)exceeds the critical value of n_(c)=1.5 for the loss of equilibrium or the torus instability is lower than that where n_(2)>nc,and that n_(1)>n_(2) alwaysholds at all altitudes.Combining this fact with that the eruption occurred 13 hr after filament was broken byreconnection,we conclude that the eruption of P1 was triggered by the loss of equilibrium or the torus instability inthe configuration,and magnetic reconnection breaking the filament helped weaken the confinement of thebackground field on P1,allowing P1 to erupt.Detailed features of the eruption and the corresponding physicalscenario were also discussed.
基金supported by the National Natural Science Foundation of China(81871789,81802200,82172387)the Natural Science Foundation of Jiangsu Province(BK20180052)the Gusu Health Talents Program(GSWS2020023)。
文摘Background:Wear particles-induced osteolysis is a major long-term complication after total joint arthroplasty.Up to now,there is no effective treatment for wear particles-induced osteolysis except for the revision surgery,which is a heavy psychological and economic burden to patients.A metabolite of gut microbiota,short chain fatty acids(SCFAs),has been reported to be beneficial for many chronic inflammatory diseases.This study aimed to investigate the therapeutic effect of SCFAs on osteolysis.Methods:A model of inflammatory osteolysis was established by applying CoCrMo alloy particles to mouse calvarium.After two weeks of intervention,the anti-inflammatory effects of SCFAs on wear particle-induced osteolysis were evaluated by micro-CT analysis and immunohistochemistry staining.In vitro study,lipopolysaccharide(LPS)primed bone marrow-derived macrophages(BMDMs)and Tohoku hospital pediatrics-1(THP-1)macrophages were stimulated with CoCrMo particles to activate inflammasome in the presence of acetate(C2),propionate(C3),and butyrate(C4).Western blotting,enzyme-linked immunosorbent assay,and immunofluorescence were used to detect the activation of NLRP3 inflammasome.The effects of SCFAs on osteoclasts were evaluate by qRT-PCR,Western blotting,immunofluorescence,and tartrate-resistant acid phosphatase(TRAP)staining.Additionally,histone deacetylase(HDAC)inhibitors,agonists of GPR41,GPR43,and GPR109A were applied to confirm the underlying mechanism of SCFAs on the inflammasome activation of macrophages and osteoclastogenesis.Results:C3 and C4 but not C2 could alleviate wear particles-induced osteolysis with fewer bone erosion pits(P<0.001),higher level of bone volume to tissue volume(BV/TV,P<0.001),bone mineral density(BMD,P<0.001),and a lower total porosity(P<0.001).C3 and C4 prevented CoCrMo alloy particles-induced ASC speck formation and nucleationinduced oligomerization,suppressing the cleavage of caspase-1(P<0.05)and IL-1β(P<0.05)stimulated by CoCrMo alloy particles.C3 and C4 also inhibited the generation of gasdermin D-N-terminal fragment(GSDMD-NT)to regulate pyroptosis.Besides,C3 and C4 have a negative impact on osteoclast differentiation(P<0.05)and its function(P<0.05),affecting the podosome arrangement and morphologically normal podosome belts formation.Conclusions:Our work showed that C3 and C4 are qualified candidates for the treatment of wear particle-induced osteolysis.
基金financially supported by National Natural Science Foundation of China(52003231,22065037)Yunnan Fundamental Research Projects(202201AW070015)。
文摘The host structure of polymers significantly influences ion transport and interfacial stability of electrolytes,dictating battery cycle life and safety for solid-state lithium metal batteries.Despite promising properties of ethylene oxide-based electrolytes,their typical clamp-like coordination geometry leads to crowd solvation sheath and overly strong interactions between Li^(+)and electrolytes,rendering difficult dissociation of Li+and unfavorable solid electrolyte interface(SEI).Herein,we explore weakly solvating characteristics of polyacetal electrolytes owing to their alternately changing intervals between–O–coordinating sites in the main chain.Such structural asymmetry leads to unique distorted helical solvation sheath,and can effectively reduce Li^(+)-electrolyte binding and tune Li^(+)desolvation kinetics in the insitu formed polymer electrolytes,yielding anion-derived SEI and dendrite-free Li electrodeposition.Combining with photoinitiated cationic ring-opening polymerization,polyacetal electrolytes can be instantly formed within 5 min at the surface of electrode,with high segmental chain motion and well adapted interfaces.Such in-situ polyacetal electrolytes enabled more than 1300-h of stable lithium electrodeposition and prolonged cyclability over 200 cycles in solid-state batteries at ambient temperatures,demonstrating the vital role of molecular structure in changing solvating behavior and Li deposition stability for high-performance electrolytes.
基金This work was supported by the National Natural Science Foundation of China(22179063).
文摘KVPO_(4)F(KVPF)has been extensively investigated as the potential cathode material for potassium-ion batteries(PIBs)owing to its high theoretical capacity,superior operating voltage,and three-dimensional Kt conduction pathway.Nevertheless,the electrochemical behavior of KVPF is limited by the inherent poor electronic conductivity of the phosphate framework and unstable electrode/electrolyte interface.To address the above issues,this work proposes an infiltration-calcination method to confine the in-situ grown KVPF into the mesoporous carbon CMK-3(denoted KVPF@CMK-3).The assembled KVPF@CMK-3 nanocomposite features three-dimensional interconnected carbon channels,which not only offer abundant active sites and significantly accelerate K t/electron transport,but also prevent the growth of KVPF nanoparticle agglomerates,hence stabilizing the structure of the material.Additionally,V–F–C bonds are created at the interface of KVPF and CMK-3,which reduce the loss of F and stabilize the electrode interface.Thus,when tested as a cathode material for PIBs,the KVPF@CMK-3 nanocomposite delivers superior reversible capacitiy(103.2 mAh g^(-1) at 0.2 C),outstanding rate performance(90.1 mAh g^(-1) at 20 C),and steady cycling performance(92.2 mAh g^(-1) at 10 C and with the retention of 88.2%after 500 cycles).Moreover,its potassium storage mechanism is further examined by ex-situ XRD and ex-situ XPS techniques.The above synthetic strategy demonstrates the potential of KVPF@CMK-3 to be applied as the cathode for PIBs.
基金supported by the National Natural Science Foundation of China (81871789, 82172387)the Natural Science Foundation of Jiangsu Province (BK20180052)the Gusu Health Talents Program (GSWS2020023)。
文摘Dear Editor,Multiple experiments have established TNF-α-induced protein 3 (A20/TNFAIP3) as a critical regulator associated with rheumatoid arthritis(RA)[1,2].The lack of TNF-α-induced protein 3 (A20) promotes the NOD-like receptor protein 3 (NLRP3) inflammasome and induces spontaneous arthritis,while increase of A20 reduces the secretion of IL-1β and favors immunological tolerance[3,4]. Hence, we investigate the feasibility of recombinant adeno-associated virus 6 (rAAV6)-mediated A20 gene therapy in a collageninduced arthritis (CIA) model.
基金supported by the National Key R&D Program of China No.2022YFF0503800the National Natural Science Foundation of China(NSFC,Grant Nos.11973083 and 11933009)+6 种基金the Strategic Priority Research Program of CAS with grants XDA17040507the outstanding member of the Youth Innovation Promotion Association CAS(No.Y2021024)the Applied Basic Research of Yunnan Province in China Grant 2018FB009the Yunling Talent Project for the Youththe project of the Group for Innovation of Yunnan Province grant 2018HC023the Yunling Scholar Project of the Yunnan Province and the Yunnan Province Scientist Workshop of Solar PhysicsYunnan Key Laboratory of Solar Physics and Space Exploration(No.202205AG070009)。
文摘An Ellerman Bomb(EB)is a kind of small scale reconnection event,which is ubiquitously formed in the upper photosphere or the lower chromosphere.The low temperature(<10,000 K)and high density(~1019–1022)plasma there makes the magnetic reconnection process strongly influenced by partially ionized effects and radiative cooling.This work studies the highβmagnetic reconnection near the solar temperature minimum region based on high-resolution 2.5D magnetohydrodynamics simulations.The time-dependent ionization degree of hydrogen and helium are included to realize more realistic diffusivities,viscosity and radiative cooling in simulations.Numerical results show that the reconnection rate is smaller than 0.01 and decreases with time during the early quasi-steady stage,then sharply increases to a value above 0.05 in the later stage as the plasmoid instability takes place.Both the large value ofηen(magnetic diffusion caused by the electron-neutral collision)and the plasmoid instability contribute to the fast magnetic reconnection in the EB-like event.The interactions and coalescence of plasmoids strongly enhance the local compression heating effect,which becomes the dominant mechanism for heating in EBs after plasmoid instability appears.However,the Joule heating contributed byηen can play a major role to heat plasmas when the magnetic reconnection in EBs is during the quasi-steady stage with smaller temperature increases.The results also show that the radiative cooling effect suppresses the temperature increase to a reasonable range,and increases the reconnection rate and generation of thermal energy.
文摘The era of information technology has dawned on the construction industry,and Building Information Modeling(BIM)is one of the necessary engineering skills for those engaged in civil engineering professions at present and those who will engage in these professions in the future.Therefore,top universities have begun exploring ways to increase BIM-related teaching content in the curriculum system.In this paper,we discuss the integration of BIM in an in-depth manner with regard to the four course modules offered by cost engineering majors(professional foundation course,professional core course,industry-oriented course,and professional practical course)and analyze the construction of BIM curriculum ideology and politics system,the setting of teaching objectives,and the key points of curriculum ideology and politics.
基金the Chongqing Engineering College Educational Teaching Reform Research Project“Practical Teaching Research of Road Engineering Construction Technology and Organization Course Based on BIM+Virtual Simulation Technology”(Project No.JY2021310).
文摘We focus on the goal of undergraduate talent training,consider the course features of Road Engineering Construction Technology and Organization,analyze the problems existing in the practical teaching of the course,use the advantages of BIM+virtual simulation technology,design a scientific and reasonable practical teaching content of Road Engineering Construction Technology and Organization,and address the contrast between the strong practical aspect of the traditional Road Engineering Construction Technology and Organization course and the lack of practical instruments in hope to improve students’learning autonomy,enhance the quality of practical teaching,achieve the training objectives of the course,and nurture applied technical talents.
基金supported by the Strategic Priority Research Program on Space Science, Chinese Academy of Sciences (Grant Nos. XDA15320100, XDA15320102, XDA15320103, XDA15320104, XDA15320300 and XDA15052200)supported by the National Natural Science Foundation of China (Grant Nos. 11427803, U1731241, U1631242 and 11820101002)
文摘The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar community.The scientific objectives are to study the relationships between the solar magnetic field,solar flares and coronal mass ejections(CMEs).Three payloads are deployed:the Full-disk vector Magneto Graph(FMG),the Lyman-αSolar Telescope(LST)and the Hard X-ray Imager(HXI).ASO-S will perform the first simultaneous observations of the photospheric vector magnetic field,non-thermal imaging of solar flares,and the initiation and early propagation of CMEs on a single platform.ASO-S is scheduled to be launched into a 720 km Sun-synchronous orbit in 2022.This paper presents an overview of the mission till the end of Phase-B and the beginning of Phase-C.
基金The authors would like to thank the National Key R&D Plan of China for providing support(NO:2016YFD0400203-4).
文摘Andrias davidianus,i.e.Chinese giant salamander(CGS),is one of the largest and oldest amphibians existing in the world and is also one of the valuable biological resources of China.Wild CGS has been threatened with extinction in the past decades due to over capturing,deterioration of natural environment,the slow breeding and growth of the wild species in nature.However,in the past twenty years,with the breakthrough and progress of artificial breeding technology by artificial insemination,the number of artificially cultivated CGS has increased rapidly.Artificially cultivated CGS can either be released to the CGS living environment to increase the population in nature or legally applied in food and medicinal industry as a feedstock due to the unique nutritional and medicinal values of CGS as recorded historically.In this review,the nutritional components,bioactive components and medicinal activities of the artificially cultivated CGS will be summarized.The mucus,skin,meat and bone of CGS contain many different bioactive substances thereby having various medicinal activities including anti-aging,anti-fatigue,anti-tumor,therapy of burn and anti-infection and other physiological functions.This paper will further discuss the potential applications of the artificially cultivated CGS in healthcare industry and prospects of future technological development.
基金supported by the Thorium Molten Salt Reactor Nuclear Energy System under the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA02030000)the Frontier Science Key Program of the Chinese Academy of Sciences(No.QYZDY-SSW-JSC016)the State Key Laboratory of Particle Detection and Electronics(No.SKLPDE-KF-201811)
文摘The impregnation behavior of molten 2LiF–BeF_2(FLiBe) salt into a graphite matrix of fuel elements for a solid fuel thorium molten salt reactor(TMSR-SF) at pressures varying from 0.4 to 1.0 MPa was studied by mercury intrusion, molten salt impregnation, X-ray diffraction, and scanning electron microscopy techniques.It was found that the entrance pore diameter of the graphite matrix is less than 1.0 μm and the contact angle is about 135°. The threshold impregnation pressure was found to be around 0.6 MPa experimentally, consistent with the predicted value of 0.57 MPa by the Washburn equation. With the increase of pressure from 0.6 to 1.0 MPa, the average weight gain of the matrix increased from 3.05 to 10.48%,corresponding to an impregnation volume increase from 2.74 to 9.40%. The diffraction patterns of FLiBe are found in matrices with high impregnation pressures(0.8 MPa and1.0 MPa). The FLiBe with sizes varying from tens of nanometers to a micrometer mainly occupies the open pores in the graphite matrix. The graphite matrix could inhibit the impregnation of the molten salt in the TMSR-SF with a maximum operation pressure of less than 0.5 MPa.
基金National Natural Science Foundation of China(Grant No.41704172)the National Key Research and Development Project(Grant No.2017YFC0602000)the National Key Research and Development Project(Grant No.2016YFC0303000).
文摘Superconducting quantum interference device(SQUID),with the advantages of ultra⁃high sensitivity,low noise,broad frequency bandwidth,and excellent low⁃frequency response,is widely used in several geophysical methods,such as vector magnetic survey,electromagnetic method,gravity and gravity gradient measurement.In this paper,the latest technological progress of SQUID and SQUID⁃based geophysical precision measurement technology are described.In addition,the advantages,characteristics,and existing problems of each measurement technology are analyzed.Combined with the requirements of current geophysical technology,the future application prospect is discussed and development suggestions are given.
