BACKGROUND With the rapid development of haploidentical hematopoietic stem cell transplantation(haplo-HSCT),primary poor graft function(PGF)has become a lifethreatening complication.Effective therapies for PGF are inc...BACKGROUND With the rapid development of haploidentical hematopoietic stem cell transplantation(haplo-HSCT),primary poor graft function(PGF)has become a lifethreatening complication.Effective therapies for PGF are inconclusive.New Chinese patent medicine Pai-Neng-Da(PND)Capsule exerts dual effect in promoting hematopoiesis recovery and regulating immunity.Still,the application of PND capsule in hematopoietic stem cell transplantation,especially in the haplo-HSCT setting,has not yet been reported.AIM To evaluate the role of PND capsule in acute leukemia patients with haplo-HSCT.METHODS We retrospectively collected data of acute leukemia patients who underwent haplo-HSCT at the Affiliated People’s Hospital of Ningbo University between April 1,2015 and June 30,2020.Twenty-nine consecutive patients received oral PND capsule from the sixth day to the first month after haplo-HSCT were included in the PND group.In addition,31 patients who did not receive PND capsule during haplo-HSCT were included in the non-PND group.Subsequently,we compared the therapeutic efficacy according to the western medical evaluation indexes and Chinese medical symptom scores,and the survival between the PND group and the non-PND group,using the chi-square test,Fisher’s exact test,and the Kaplan-Meier method.RESULTS The duration of platelet engraftment was shorter in the PND group than in the non-PND group(P=0.039).The PND group received a lower frequency of red blood cells and platelet transfusions than the non-PND group(P=0.033 and P=0.035,respectively).In addition,PND capsule marginally reduced the rate of PGF(P=0.027)and relapse(P=0.043).After 33(range,4-106)months of follow-up,the 3-year relapse-free survival(P=0.046)and progression-free survival(P=0.049)were improved in the PND group than in the non-PND group.Also,the therapeutic efficacy of the PND group according to Chinese medical symptom scores was significantly better than that of the non-PND group(P=0.022).Moreover,the adverse events caused by PND capsule were mild.Nevertheless,there were no significant differences in the duration of neutrophil engraftment,the risk of infection within 100 days after haplo-HSCT,the acute graft-versus-host disease,or the 3-year overall survival between the two groups.CONCLUSION PND capsule could promote hematopoiesis reconstitution,improve the therapeutic efficacy of Chinese medical symptom scores,present anti-tumor effectiveness,and prolong the survival of acute leukemia patients with haplo-HSCT.展开更多
We propose a robust method for detecting features on triangular meshes by combining normal tensor voting with neighbor supporting. Our method contains two stages: feature detection and feature refinement. First, the n...We propose a robust method for detecting features on triangular meshes by combining normal tensor voting with neighbor supporting. Our method contains two stages: feature detection and feature refinement. First, the normal tensor voting method is modified to detect the initial features, which may include some pseudo features. Then, at the feature refinement stage, a novel salient measure deriving from the idea of neighbor supporting is developed. Benefiting from the integrated reliable salient measure feature, pseudo features can be effectively discriminated from the initially detected features and removed. Compared to previous methods based on the differential geometric property, the main advantage of our method is that it can detect both sharp and weak features. Numerical experiments show that our algorithm is robust, effective, and can produce more accurate results. We also discuss how detected features are incorporated into applications, such as feature-preserving mesh denoising and hole-filling, and present visually appealing results by integrating feature information.展开更多
In this work,a fourth-order numerical scheme in space and two second-order numerical schemes in both time and space are proposed for the derivative nonlinear Schrodinger equation.We verify the mass conservation for th...In this work,a fourth-order numerical scheme in space and two second-order numerical schemes in both time and space are proposed for the derivative nonlinear Schrodinger equation.We verify the mass conservation for the two-level implicit scheme.The influence on the soliton solution by adding a small random perturbation to the initial condition is discussed.The numerical experiments are given to test the accuracy order for different schemes,respectively.We also test the conservative property of mass and Hamiltonian for these schemes from the numerical point of view.展开更多
A smelting multiple recrystallization strategy and its effects on the morphology,composition,and defects of CsPbBrI_(2)film were investigated.An optimal number(n=2)of recrystallization cycles improved the crystallinit...A smelting multiple recrystallization strategy and its effects on the morphology,composition,and defects of CsPbBrI_(2)film were investigated.An optimal number(n=2)of recrystallization cycles improved the crystallinity and phase purity,minimized the grain boundaries,and optimized the crystal structure,yielding a high-quality perovskite film with significantly reduced defects density.The corresponding photovoltaic devices exhibited a champion efficiency of 16.02%under AM 1.5 G illumination and presented an even higher indoor efficiency of 33.50%under an LED(2956 K,P_(in):334.41𝜇W/cm^(2)).This recrystallization method offers a promising strategy for developing high-performance indoor and outdoor photovoltaics.Direct recrystallization in the cells was also explored to achieve enhanced stability and longer lifetime in humid conditions.展开更多
基金Supported by The Zhejiang Provincial Science and Technology Program of Traditional Chinese Medicine,No.2017ZA129 and No.2018ZA112.
文摘BACKGROUND With the rapid development of haploidentical hematopoietic stem cell transplantation(haplo-HSCT),primary poor graft function(PGF)has become a lifethreatening complication.Effective therapies for PGF are inconclusive.New Chinese patent medicine Pai-Neng-Da(PND)Capsule exerts dual effect in promoting hematopoiesis recovery and regulating immunity.Still,the application of PND capsule in hematopoietic stem cell transplantation,especially in the haplo-HSCT setting,has not yet been reported.AIM To evaluate the role of PND capsule in acute leukemia patients with haplo-HSCT.METHODS We retrospectively collected data of acute leukemia patients who underwent haplo-HSCT at the Affiliated People’s Hospital of Ningbo University between April 1,2015 and June 30,2020.Twenty-nine consecutive patients received oral PND capsule from the sixth day to the first month after haplo-HSCT were included in the PND group.In addition,31 patients who did not receive PND capsule during haplo-HSCT were included in the non-PND group.Subsequently,we compared the therapeutic efficacy according to the western medical evaluation indexes and Chinese medical symptom scores,and the survival between the PND group and the non-PND group,using the chi-square test,Fisher’s exact test,and the Kaplan-Meier method.RESULTS The duration of platelet engraftment was shorter in the PND group than in the non-PND group(P=0.039).The PND group received a lower frequency of red blood cells and platelet transfusions than the non-PND group(P=0.033 and P=0.035,respectively).In addition,PND capsule marginally reduced the rate of PGF(P=0.027)and relapse(P=0.043).After 33(range,4-106)months of follow-up,the 3-year relapse-free survival(P=0.046)and progression-free survival(P=0.049)were improved in the PND group than in the non-PND group.Also,the therapeutic efficacy of the PND group according to Chinese medical symptom scores was significantly better than that of the non-PND group(P=0.022).Moreover,the adverse events caused by PND capsule were mild.Nevertheless,there were no significant differences in the duration of neutrophil engraftment,the risk of infection within 100 days after haplo-HSCT,the acute graft-versus-host disease,or the 3-year overall survival between the two groups.CONCLUSION PND capsule could promote hematopoiesis reconstitution,improve the therapeutic efficacy of Chinese medical symptom scores,present anti-tumor effectiveness,and prolong the survival of acute leukemia patients with haplo-HSCT.
基金supported by the National Natural Science Foundation of China (Nos. U0935400, 60873181, and 61173102)the Fundamental Research Funds for the Central Universities, China(No. DUT11SX08)
文摘We propose a robust method for detecting features on triangular meshes by combining normal tensor voting with neighbor supporting. Our method contains two stages: feature detection and feature refinement. First, the normal tensor voting method is modified to detect the initial features, which may include some pseudo features. Then, at the feature refinement stage, a novel salient measure deriving from the idea of neighbor supporting is developed. Benefiting from the integrated reliable salient measure feature, pseudo features can be effectively discriminated from the initially detected features and removed. Compared to previous methods based on the differential geometric property, the main advantage of our method is that it can detect both sharp and weak features. Numerical experiments show that our algorithm is robust, effective, and can produce more accurate results. We also discuss how detected features are incorporated into applications, such as feature-preserving mesh denoising and hole-filling, and present visually appealing results by integrating feature information.
基金National Natural Science Foundation of China(No.11671044)Beijing Municipal Education Commission under Grant(No.PXM2016014224000028)the Science Challenge project(No.JCKY2016212A501).
文摘In this work,a fourth-order numerical scheme in space and two second-order numerical schemes in both time and space are proposed for the derivative nonlinear Schrodinger equation.We verify the mass conservation for the two-level implicit scheme.The influence on the soliton solution by adding a small random perturbation to the initial condition is discussed.The numerical experiments are given to test the accuracy order for different schemes,respectively.We also test the conservative property of mass and Hamiltonian for these schemes from the numerical point of view.
基金The authors acknowledge financial support from the National Natural Science Foundation of China(Nos.62075148,52073197)the Natural Science Foundation of Jiangsu Province(No.BK20201413).
文摘A smelting multiple recrystallization strategy and its effects on the morphology,composition,and defects of CsPbBrI_(2)film were investigated.An optimal number(n=2)of recrystallization cycles improved the crystallinity and phase purity,minimized the grain boundaries,and optimized the crystal structure,yielding a high-quality perovskite film with significantly reduced defects density.The corresponding photovoltaic devices exhibited a champion efficiency of 16.02%under AM 1.5 G illumination and presented an even higher indoor efficiency of 33.50%under an LED(2956 K,P_(in):334.41𝜇W/cm^(2)).This recrystallization method offers a promising strategy for developing high-performance indoor and outdoor photovoltaics.Direct recrystallization in the cells was also explored to achieve enhanced stability and longer lifetime in humid conditions.
