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Efficacy of recombinant human epidermal growth factor plus sodium hyaluronate eye drops in diabetic dry eye post-cataract surgery
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作者 jun-ling li Jin Zhao +2 位作者 Zhen-Feng Guo Chang Xiao Xuan liu 《World Journal of Diabetes》 SCIE 2024年第6期1234-1241,共8页
BACKGROUND Dry eye syndrome(DES)after diabetic cataract surgery can seriously affect the patient’s quality of life.Therefore,effective alleviation of symptoms in patients with this disease has important clinical sign... BACKGROUND Dry eye syndrome(DES)after diabetic cataract surgery can seriously affect the patient’s quality of life.Therefore,effective alleviation of symptoms in patients with this disease has important clinical significance.AIM To explore the clinical effect of recombinant human epidermal growth factor(rhEGF)plus sodium hyaluronate(SH)eye drops on DES after cataract surgery in patients with diabetes.METHODS We retrospectively evaluated 82 patients with diabetes who experienced DES after cataract surgery at Tianjin Beichen Hospital,Affiliated Hospital of Nankai University between April 2021 and April 2023.They were classified into an observation group(42 cases,rhEGF+SH eye drops)and a control group(40 cases,SH eye drops alone),depending on the different treatment schemes.The therapeutic efficacy,dry eye symptom score,tear film breakup time(TFBUT),basic tear secretion score[assessed using Schirmer I test(SIt)],corneal fluorescein staining(FL)score,tear inflammatory markers,adverse reactions during treat-ment,and treatment satisfaction were compared between the two groups.RESULTS Therapeutic efficacy was higher in the observation group compared with the control group.Both groups showed improved TFBUT and dry eye,as well as improved SIt and FL scores after treatment,with a more pronounced improvement in the observation group.Although no marked differences in adverse reactions were observed between the two groups,treatment satisfaction was higher in the observation group.CONCLUSION rhEGF+SH eye drops rendered clinical benefits to patients by effectively ameliorating dry eye and visual impairment with favorable efficacy,fewer adverse reactions,and high safety levels.Thus,this treatment should be promoted in clinical practice. 展开更多
关键词 Recombinant human epidermal growth factor Sodium hyaluronate eye drops Diabetic patients Dry eye syndrome after cataract surgery Therapeutic efficacy
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Efficacy and safety of albumin-bound paclitaxel in treating recurrent advanced non-small-cell lung cancer 被引量:2
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作者 Pu-Yuan Xing jun-ling li +5 位作者 Yan Wang Xue-Zhi Hao Bin Wang lin Yang Yuan-Kai Shi Xiang-Ru Zhang 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2013年第2期200-205,共6页
Objective: To observe the efficacy and safety of albumin-bound paclitaxel (ABP) monotherapy in treating recurrent advanced non-small-cell lung cancer (NSCLC). Methods: We retrospectively analyzed the short-term ... Objective: To observe the efficacy and safety of albumin-bound paclitaxel (ABP) monotherapy in treating recurrent advanced non-small-cell lung cancer (NSCLC). Methods: We retrospectively analyzed the short-term efficacy and toxicities of ABP monotherapy in treating 21 patients who had previously undergone multiple cycles of therapy for their advanced NSCLC in our hospital since 2010. The treatment-related survival was also analyzed. Results: Of these 21 patients, the best overall response was partial response (PR) in 6 patients (28.6%), stable disease (SD) in I0 patients (47.6%), and progressive disease (PD) in 5 patients (23.8%). The overall response rate (ORR) was 28.6% and the disease control rate (DCR) (PR + SD) was 76.2%. The median progression-flee survival (PFS) was 4.0 months (95% CI, 5.0-7.0 months). The main grade 3/4 toxicities included neutropenia (11.1%), peripheral nerve toxicity (5.6%), muscle and joint aches (5.6%), and fatigue (5.6%). Conclusions: The ABP monotherapy can achieve good objective response in advanced NSCLC patients who have previously received multiple cycles of treatment and be well tolerated. 展开更多
关键词 Albumin-bound paclitaxel PACLITAXEL advanced non-small cell lung cancer CHEMOTHERAPY
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Performance of common imaging techniques vs serum biomarkers in assessing fibrosis in patients with chronic hepatitis B: A systematic review and meta-analysis 被引量:14
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作者 Xue-Ying Xu Wu-Sheng Wang +4 位作者 Qi-Meng Zhang jun-ling li Jin-Bin Sun Tian-Tian Qin Hong-Bo liu 《World Journal of Clinical Cases》 SCIE 2019年第15期2022-2037,共16页
BACKGROUND Noninvasive biomarkers have been developed to predict hepatitis B virus(HBV)related fibrosis owing to the significant limitations of liver biopsy.Both serum biomarkers and imaging techniques have shown prom... BACKGROUND Noninvasive biomarkers have been developed to predict hepatitis B virus(HBV)related fibrosis owing to the significant limitations of liver biopsy.Both serum biomarkers and imaging techniques have shown promising results and may improve the evaluation of liver fibrosis.However,most of the previous studies focused on the diagnostic effects of various imaging techniques on fibrosis in all chronic liver diseases.AIM To compare the performance of common imaging methods and serum biomarkers for prediction of significant fibrosis caused only by HBV infection.METHODS A systematic review was conducted on the records available in PubMed,EMBASE,and the Cochrane Library electronic databases until December 2018.We systematically assessed the effectiveness of two serum biomarkers and three imagine techniques in predicting significant fibrosis solely caused by HBV infection.The serum biomarkers included aspartate aminotransferase-to-platelet ratio index(APRI)and fibrosis index based on the 4 factors(FIB-4).The three imaging techniques included acoustic radiation force impulse(ARFI),FibroScan,and magnetic resonance elastography(MRE).Three parameters,the area under the summary receiver operating characteristic curve(AUSROC),the summary diagnostic odds ratio,and the summary sensitivity and specificity,were used to examine the accuracy of all tests for liver fibrosis.RESULTS Out of 2831 articles evaluated for eligibility,204 satisfied the predetermined inclusion criteria for this current meta-analysis.Eventually,our final data contained 81 studies.The AUSROCs of serum biomarkers of APRI and FIB-4 were both 0.75.For imaging techniques(ARFI,FibroScan,and MRE),the areas were 0.89,0.83,and 0.97,respectively.The heterogeneities of ARFI and FibroScan were statistically significant(I2>50%).The publication bias was not observed in any of the serum biomarkers or imaging methods.CONCLUSION These five methods have attained an acceptable level of diagnostic accuracy.Imaging techniques,MRE in particular,demonstrate significant advantages in accurately predicting HBV-related significant fibrosis,while serum biomarkers are admissible methods. 展开更多
关键词 HEPATITIS B VIRUS DIAGNOSTIC test Imaging technology LIVER FIBROSIS Metaanalysis
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Combination of symptoms, syndrome and disease: Treatment of refractory diabetic gastroparesis 被引量:13
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作者 jun-ling li Min li +5 位作者 Bing Pang Qiang Zhou Jia-Xing Tian Hong-Xing liu Xi-Yan Zhao Xiao-lin Tong 《World Journal of Gastroenterology》 SCIE CAS 2014年第26期8674-8680,共7页
AIM: To assess effect of combination of symptoms, syndrome and disease on treatment of diabetic gastroparesis with severe nausea and vomiting.
关键词 Diabetic gastroparesis Refractory nausea and vomiting Traditional Chinese medicine TREATMENT Gastroparesis Cardinal Symptom Index
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Treatment of refractory diabetic gastroparesis: Western medicine and traditional Chinese medicine therapies 被引量:10
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作者 Bing Pang Qiang Zhou +2 位作者 jun-ling li lin-Hua Zhao Xiao-lin Tong 《World Journal of Gastroenterology》 SCIE CAS 2014年第21期6504-6514,共11页
Refractory diabetic gastroparesis(DGP),a disorder that occurs in both type 1 and type 2 diabetics,is associated with severe symptoms,such as nausea and vomiting,and results in an economic burden on the health care sys... Refractory diabetic gastroparesis(DGP),a disorder that occurs in both type 1 and type 2 diabetics,is associated with severe symptoms,such as nausea and vomiting,and results in an economic burden on the health care system.In this article,the basic characteristics of refractory DGP are reviewed,followed by a discussion of therapeutic modalities,which encompasses the definitions and clinical manifestations,pathogenesis,diagnosis,and therapeutic efficacy evaluation of refractory DGP.The diagnostic standards assumed in this study are those set forth in the published literature due to the absence of recognized diagnosis criteria that have been assessed by an international organization.The therapeutic modalities for refractory DGP are as follows:drug therapy,nutritional support,gastricelectrical stimulation,pyloric botulinum toxin injection,endoscopic or surgical therapy,and traditional Chinese treatment.The therapeutic modalities may be used alone or in combination.The use of traditional Chinese treatments is prevalent in China.The effectiveness of these therapies appears to be supported by preliminary evidence and clinical experience,although the mechanisms that underlie these effects will require further research.The purpose of this article is to explore the potential of combined Western and traditional Chinese medicine treatment methods for improved patient outcomes in refractory DGP. 展开更多
关键词 Refractory diabetic gastroparesis NUTRITION Gastric electrical stimulation Botulinum toxin Traditional Chinese treatment Surgery
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Angiography reveals early hiding iris neovascularization after ischemic CRVO 被引量:4
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作者 Zhi-Qing li Xiao-Xu Zhou +2 位作者 Song lin jun-ling li Jian-Guo Wu 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2013年第2期253-254,共2页
Dear Sir, I am Dr. Zhi-Qing Li from Tianjin Medical University Eye Hospital, Tianjin City, China. I write to present a case with hiding iris neovascularization (INV) following central retinal vein occlusion (CRVO) can... Dear Sir, I am Dr. Zhi-Qing Li from Tianjin Medical University Eye Hospital, Tianjin City, China. I write to present a case with hiding iris neovascularization (INV) following central retinal vein occlusion (CRVO) can be detected early by iris angiography (IA) and neovascular glaucoma (NVG) was 展开更多
关键词 Angiography reveals early hiding iris neovascularization after ischemic CRVO INV IA NVG Figure
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Inhibition of Yuyihe Powder on Tumor Growth in Mice Models of Sarcoma 180
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作者 jun-ling li Shi-li Wang +3 位作者 Jin-xiang Han Hai Xu Xiao-bin Xu Jun-ying Xue 《Chinese Herbal Medicines》 CAS 2017年第2期183-187,共5页
Objective To explore the antitumor effect of Yuyihe Powder(Yu Yi He San,YYHS) and its antitumor mechanism.Methods After treatment,tumor weight,immune apparatus weight,the life span of transplanted animals,spleen lym... Objective To explore the antitumor effect of Yuyihe Powder(Yu Yi He San,YYHS) and its antitumor mechanism.Methods After treatment,tumor weight,immune apparatus weight,the life span of transplanted animals,spleen lymphocyte proliferation assays,and IL-2 concentration in mouse serum were recorded or detected.Results YYHS showed strong antitumor ability.Compared with control group,mid-dose YYHS(1.0g/kg) could inhibit the tumor growth,prolong the life span of S180-bearing mice to some extent,significantly increase the thymic and splenic indices of S180 mice,and strongly promote the secretion of IL-2 in blood;The inhibitory rate on tumor growth and life prolongation rate were 37.1%and 38.37%,respectively.Conclusion YYHS could not only significantly inhibit the growth of S180 cells,but also markedly prolong the survival time of S180 bearing mice.The mechanism of antitumor effect could obviously enhance immunologic function of the S180 bearing mice to inhibit the growth of S180 cells. 展开更多
关键词 antitumor effect mice model Sarcoma 180 traditional Chinese medicine recipe Yuyihe Powder
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