In this study,we present characteristics of post-sunset GHz scintillation occurrence and their correlations with ionospheric parameters derived from ionosonde observations in high solar activity years(2012−2013)of sol...In this study,we present characteristics of post-sunset GHz scintillation occurrence and their correlations with ionospheric parameters derived from ionosonde observations in high solar activity years(2012−2013)of solar cycle 24 at Sanya(18.3°N,109.6°E;dip lat.:12.8°N),China.The analyzed data include the F_(2)-layer’s critical frequency(foF_(2)),peak height(h_(m)F_(2)),and minimum virtual height(h’F),as well as the scale height around the F_(2)-layer peak(H_(m)),and virtual height(h’F_(5))and true height(hF_(5))measured at 5 MHz.We have investigated relationships between the equinoctial asymmetry of these scintillations and these ionospheric parameters.In addition,we calculate the growth rates of Rayleigh−Taylor instability on the basis of the ionosonde measurements and theoretical models,respectively.We find that the equinoctial asymmetry of scintillation onset time is associated with the scale length of the vertical electron density gradient(L),which has been shown to affect the growth of Rayleigh−Taylor instability at the bottom of the F-layer.The seasonal variations of foF_(2),H_(m)and scale length of vertical electron density gradient appear to cause the seasonal variations of scintillation occurrence;the equinoctial asymmetry of scintillation occurrence rate over low latitudes appears to be related to background electron density and vertical drifts in the F-layer around time of sunset.Further study is required to explain the observed correlational weakness in low latitudes between scintillation strength,represented by the daily maximum S4,and daily maximum values of foF_(2),h_(m)F_(2),h’F,H_(m),and also the drifts.展开更多
Gliomas are the most commonly occurring tumors of the central nervous system. Glioblastoma multiforme (GBM) is the most malignant and aggressive brain cancer in adults. Further understanding of the mechanisms underlyi...Gliomas are the most commonly occurring tumors of the central nervous system. Glioblastoma multiforme (GBM) is the most malignant and aggressive brain cancer in adults. Further understanding of the mechanisms underlying the aggressive nature of GBM is urgently needed. Here we identified homeobox B8(HOXB8), a member of the homeobox family, as a crucial contributor to the aggressiveness of GBM. Data mining of publicly accessible RNA sequence datasets and our patient cohorts confirmed a higher expression of HOXB8 in the tumor tissue of GBM patients, and a strong positive correlation between the expression level and pathological grading of tumors and a negative correlation between the expression level and the overall survival rate. We next showed that HOXB8 promotes the proliferation and migration of glioblastoma cells and is crucial for the activation of the PI3K/AKT pathway and expression of epithelial–mesenchymal transition-related genes, possibly through direct binding to the promoter of SAMD9 (Sterile Alpha Motif Domain-Containing Protein 9) and activating its transcription. Collectively, we identified HOXB8 as a critical contributor to the aggressiveness of GBM, which provides insights into a potential therapeutic target for GBM and opens new avenues for improving its treatment outcome.展开更多
The concept of Yang Qi in Traditional Chinese Medicine(TCM)has many similarities with mitochondria in modern medicine.Both are indispensable to human beings and closely related to life and death.This article discusses...The concept of Yang Qi in Traditional Chinese Medicine(TCM)has many similarities with mitochondria in modern medicine.Both are indispensable to human beings and closely related to life and death.This article discusses the similarities in various aspects between mitochondria and Yang Qi,including body temperature,aging,newborns,circadian rhythm,immunity,and meridian.It is well-known that Yang Qi is vital for human health.Interestingly,decreased mitochondrial function is thought to be key to the development of various diseases.Here,we further explain diseases induced by Yang Qi deficiency,such as cancer,chronic fatigue syndrome,sleep disorder,senile dementia,and metabolic diseases,from the perspective of mitochondrial function.We aim to establish similarities and connections between two important concepts,and hope our essay can stimulate further discussion and investigation on unifying important concepts in western medicine and alternative medicine,especially TCM,and provide unique holistic insights into understanding human health.展开更多
Erotic fiction produced during the 16th and the early 17th centuries used different strategies to create settings for subversive sexual desires. This article examines one of these strategies： Authors of Ming erotic s...Erotic fiction produced during the 16th and the early 17th centuries used different strategies to create settings for subversive sexual desires. This article examines one of these strategies： Authors of Ming erotic stories often associated the sexual expressions that challenged the existing social order with portrayals of the foreign. This article demonstrates that historical accounts and literary traditions informed the representations of the foreign in Ming erotic stories produced during the mid- and late Ming period through the examination ofRuyijun zhuan and ＂Jinhailing zongyu wangshen.＂ I argue that both narratives exoticized the erotic in order to exclude unsettling elements of sexual desire from China. However, due to their different views of sexual desire, they depicted the foreign differently. This paper concludes that the different strategies for appropriating sexual desire into foreign settings may be related to the historical contexts within which the two works of fiction were created.展开更多
基金supported by the Fundamental Research Funds for the Central Universities,South-Central MinZu University(Grant Number:CPT22019).
文摘In this study,we present characteristics of post-sunset GHz scintillation occurrence and their correlations with ionospheric parameters derived from ionosonde observations in high solar activity years(2012−2013)of solar cycle 24 at Sanya(18.3°N,109.6°E;dip lat.:12.8°N),China.The analyzed data include the F_(2)-layer’s critical frequency(foF_(2)),peak height(h_(m)F_(2)),and minimum virtual height(h’F),as well as the scale height around the F_(2)-layer peak(H_(m)),and virtual height(h’F_(5))and true height(hF_(5))measured at 5 MHz.We have investigated relationships between the equinoctial asymmetry of these scintillations and these ionospheric parameters.In addition,we calculate the growth rates of Rayleigh−Taylor instability on the basis of the ionosonde measurements and theoretical models,respectively.We find that the equinoctial asymmetry of scintillation onset time is associated with the scale length of the vertical electron density gradient(L),which has been shown to affect the growth of Rayleigh−Taylor instability at the bottom of the F-layer.The seasonal variations of foF_(2),H_(m)and scale length of vertical electron density gradient appear to cause the seasonal variations of scintillation occurrence;the equinoctial asymmetry of scintillation occurrence rate over low latitudes appears to be related to background electron density and vertical drifts in the F-layer around time of sunset.Further study is required to explain the observed correlational weakness in low latitudes between scintillation strength,represented by the daily maximum S4,and daily maximum values of foF_(2),h_(m)F_(2),h’F,H_(m),and also the drifts.
基金the National Natural Science Foundation of China(31571298).
文摘Gliomas are the most commonly occurring tumors of the central nervous system. Glioblastoma multiforme (GBM) is the most malignant and aggressive brain cancer in adults. Further understanding of the mechanisms underlying the aggressive nature of GBM is urgently needed. Here we identified homeobox B8(HOXB8), a member of the homeobox family, as a crucial contributor to the aggressiveness of GBM. Data mining of publicly accessible RNA sequence datasets and our patient cohorts confirmed a higher expression of HOXB8 in the tumor tissue of GBM patients, and a strong positive correlation between the expression level and pathological grading of tumors and a negative correlation between the expression level and the overall survival rate. We next showed that HOXB8 promotes the proliferation and migration of glioblastoma cells and is crucial for the activation of the PI3K/AKT pathway and expression of epithelial–mesenchymal transition-related genes, possibly through direct binding to the promoter of SAMD9 (Sterile Alpha Motif Domain-Containing Protein 9) and activating its transcription. Collectively, we identified HOXB8 as a critical contributor to the aggressiveness of GBM, which provides insights into a potential therapeutic target for GBM and opens new avenues for improving its treatment outcome.
基金This work was partially supported by Shanghai Municipal Science and Technology Major Project(2017SHZDZX01)the 111 Project(B13016)to JW,and a grant for ENN science and technology development to ZLG.
文摘The concept of Yang Qi in Traditional Chinese Medicine(TCM)has many similarities with mitochondria in modern medicine.Both are indispensable to human beings and closely related to life and death.This article discusses the similarities in various aspects between mitochondria and Yang Qi,including body temperature,aging,newborns,circadian rhythm,immunity,and meridian.It is well-known that Yang Qi is vital for human health.Interestingly,decreased mitochondrial function is thought to be key to the development of various diseases.Here,we further explain diseases induced by Yang Qi deficiency,such as cancer,chronic fatigue syndrome,sleep disorder,senile dementia,and metabolic diseases,from the perspective of mitochondrial function.We aim to establish similarities and connections between two important concepts,and hope our essay can stimulate further discussion and investigation on unifying important concepts in western medicine and alternative medicine,especially TCM,and provide unique holistic insights into understanding human health.
文摘Erotic fiction produced during the 16th and the early 17th centuries used different strategies to create settings for subversive sexual desires. This article examines one of these strategies： Authors of Ming erotic stories often associated the sexual expressions that challenged the existing social order with portrayals of the foreign. This article demonstrates that historical accounts and literary traditions informed the representations of the foreign in Ming erotic stories produced during the mid- and late Ming period through the examination ofRuyijun zhuan and ＂Jinhailing zongyu wangshen.＂ I argue that both narratives exoticized the erotic in order to exclude unsettling elements of sexual desire from China. However, due to their different views of sexual desire, they depicted the foreign differently. This paper concludes that the different strategies for appropriating sexual desire into foreign settings may be related to the historical contexts within which the two works of fiction were created.
