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Recent advances in protein conformation sampling by combining machine learning with molecular simulation
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作者 唐一鸣 杨中元 +7 位作者 姚逸飞 周运 谈圆 王子超 潘瞳 熊瑞 孙俊力 韦广红 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第3期80-87,共8页
The rapid advancement and broad application of machine learning(ML)have driven a groundbreaking revolution in computational biology.One of the most cutting-edge and important applications of ML is its integration with... The rapid advancement and broad application of machine learning(ML)have driven a groundbreaking revolution in computational biology.One of the most cutting-edge and important applications of ML is its integration with molecular simulations to improve the sampling efficiency of the vast conformational space of large biomolecules.This review focuses on recent studies that utilize ML-based techniques in the exploration of protein conformational landscape.We first highlight the recent development of ML-aided enhanced sampling methods,including heuristic algorithms and neural networks that are designed to refine the selection of reaction coordinates for the construction of bias potential,or facilitate the exploration of the unsampled region of the energy landscape.Further,we review the development of autoencoder based methods that combine molecular simulations and deep learning to expand the search for protein conformations.Lastly,we discuss the cutting-edge methodologies for the one-shot generation of protein conformations with precise Boltzmann weights.Collectively,this review demonstrates the promising potential of machine learning in revolutionizing our insight into the complex conformational ensembles of proteins. 展开更多
关键词 machine learning molecular simulation protein conformational space enhanced sampling
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Thermal runaway propagation behavior of the Cell-to-Pack battery system 被引量:3
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作者 Huaibin Wang Qinzheng Wang +9 位作者 Zhenyang Zhao Changyong Jin Chengshan Xu Wensheng Huang Zhuchen Yuan Shuyu Wang Yang Li Yanhong Zhao junli sun Xuning Feng 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第9期162-172,共11页
Structurally compact battery packs significantly improve the driving range of electric vehicles.Technologies like Cell-to-Pack increase energy density by 15%-20%.However,the safety implications of multiple tightly-pac... Structurally compact battery packs significantly improve the driving range of electric vehicles.Technologies like Cell-to-Pack increase energy density by 15%-20%.However,the safety implications of multiple tightly-packed battery cells still require in-depth research.This paper studies thermal runaway propagation behavior in a Cell-to-Pack system and assesses propagation speed relative to other systems.The investigation includes temperature response,extent of battery damage,pack structure deformation,chemical analysis of debris,and other considerations.Results suggest three typical patterns for the thermal runaway propagation process:ordered,disordered,and synchronous.The synchronous propagation pattern displayed the most severe damage,indicating energy release is the largest under the synchronous pattern.This study identifies battery deformation patterns,chemical characteristics of debris,and other observed factors that can both be applied to identify the cause of thermal runaway during accident investigations and help promote safer designs of large battery packs used in large-scale electric energy storage systems. 展开更多
关键词 Energy storage Cell-to-Pack Lithium-ion battery Thermal runaway Battery safety
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Effects of NPY Gene on Total Number of Eggs at 300 Days of Age in Donglan Black-bone Chicken 被引量:1
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作者 Yuying LIAO junli sun +3 位作者 Xinwang WEN Yingfei HUANG Bing ZHANG Fengying WEI 《Agricultural Biotechnology》 CAS 2015年第4期23-24,28,共3页
In this study, PCR-RFLP technique was employed to detect the genetic polymorphism of NPY gene and analyze the effects of various genotypes on the total number of eggs at 300 days of age in 135 Donglan black-bone chick... In this study, PCR-RFLP technique was employed to detect the genetic polymorphism of NPY gene and analyze the effects of various genotypes on the total number of eggs at 300 days of age in 135 Donglan black-bone chicken. According to the results, there were three genotypes (AA, AB and BB) of NPYgene in Donglan black-bone chicken group. Different genotypes exhibited significant effects (P 〈 0. 05 ) on the total number of eggs at 300 days of age. The total number of eggs at 300 days of age of AA genotype was significantly higher than that of BB genotype (P 〈 0. 05). Therefore, the polymorphic site of NPY gene could be used as a candidate molecular marker that affects egg laying in Donglan black-bone chicken. 展开更多
关键词 Donglan black-bone chicken NPY gene Total number of eggs at 300 days of age
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Assessing indica-japonica differentiation of improved rice varieties using microsatellite markers 被引量:5
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作者 Yongwen Qi Hongliang Zhang +5 位作者 Dongling Zhang Meixing Wang junli sun Li Ding Fenghua Wang Zichao Li 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2009年第5期305-312,共8页
To assess the indica-japonica differentiation of improved rice varieties, a total of 512 modem varieties including 301 indica and 211 japonica accessions were analyzed using 36 microsatellites. The Fst coefficients ra... To assess the indica-japonica differentiation of improved rice varieties, a total of 512 modem varieties including 301 indica and 211 japonica accessions were analyzed using 36 microsatellites. The Fst coefficients ranged from 0.002 to 0.730 among the loci with an average of 0.315. Significant differentiation was detected at 94.4% of the loci studied (P 〈 0.05, pairwise Fst tests), indicating that there was a high level of indica-japonica differentiation within the improved varieties. At 18 loci, about 74%-98% of the alleles of indica and japonica accessions were distributed in two ranges of amplicon length. Linkage disequilibrium analysis showed that the distribution trends were significantly nonrandomly associated. Using the differentiation trends at the 18 loci, microsatellite index (MI) was proposed for discrimination of the two subspecies. When rice accessions with MI value greater than zero were classified as indica, and those with MI value smaller than zero were classified as japonica, about 96.1% of the accessions could be classified. This result agrees with the classification based on morphological-physiological characters, indicating that this method is feasible and effective. 展开更多
关键词 improved rice varieties indica-japonica differentiation microsatellite index (MI)
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