Ultra-thick steep coal seam mining will inevitably lead to the increase of greater and violent ground subsidence and deformation.A subsidence control method by inversely-inclined slicing and upward mining is proposed ...Ultra-thick steep coal seam mining will inevitably lead to the increase of greater and violent ground subsidence and deformation.A subsidence control method by inversely-inclined slicing and upward mining is proposed in this paper.By this method,the sequence of collapse of overlying strata and the direction of propagation of strata movement are changed,the extent of roof-side deformation thereby is lessened,and boundary angle of roof-side subsidence is reduced by 5°-10°.The mechanism of this mining method for control of strata movement has been evidenced by numerical simulation and experiments with similarity materials.A subsidence prediction model based on the variation of mining influence propagation angle can be used to evaluate the surface movement and deformation of the mining method.The application of the method in No.3 Mine in Yaojie mining area has yielded the expected result.展开更多
Objective:To investigate the immunomodulatory activity of polysaccharides from the roots of Brassica rapa.Methods:The crude polysaccharide from roots of B.rapa(BRP)was extracted and purified to further investigate the...Objective:To investigate the immunomodulatory activity of polysaccharides from the roots of Brassica rapa.Methods:The crude polysaccharide from roots of B.rapa(BRP)was extracted and purified to further investigate the active fraction of BRT for inducing macrophage phagocytosis.Results:Effects on RAW264.7 cells demonstrated that BRP behaved better phagocytic capacity and had potent immunomodulatory activity,including increasing production of nitric oxide(NO),tumor necrosis factor a(TNFa)and upregulating mRNA levels of inducible NO synthase(iNOS)and TNFa.Furthermore,modulation of macrophage by BRP was indicated to be mediated via the activation of Akt and nuclear factor-kappa B(NF-κB).Conclusion:The beneficial effects of BRP could be used as an immunotherapeutic adjuvant in treatment of inflammatory diseases.展开更多
基金sponsored by the National Natural Science Foundation of China(Nos.51574242 and 5097412).
文摘Ultra-thick steep coal seam mining will inevitably lead to the increase of greater and violent ground subsidence and deformation.A subsidence control method by inversely-inclined slicing and upward mining is proposed in this paper.By this method,the sequence of collapse of overlying strata and the direction of propagation of strata movement are changed,the extent of roof-side deformation thereby is lessened,and boundary angle of roof-side subsidence is reduced by 5°-10°.The mechanism of this mining method for control of strata movement has been evidenced by numerical simulation and experiments with similarity materials.A subsidence prediction model based on the variation of mining influence propagation angle can be used to evaluate the surface movement and deformation of the mining method.The application of the method in No.3 Mine in Yaojie mining area has yielded the expected result.
基金supported by grants from the Natural Science Foundation of China (81760778)the Fundamental Research Funds for Public-interest Scientific Institution in Xinjiang Uygur Autonomous Region (KYGY2016169)CAMS Innovation Fund for Medical Sciences (2017-I2M-1-012)
文摘Objective:To investigate the immunomodulatory activity of polysaccharides from the roots of Brassica rapa.Methods:The crude polysaccharide from roots of B.rapa(BRP)was extracted and purified to further investigate the active fraction of BRT for inducing macrophage phagocytosis.Results:Effects on RAW264.7 cells demonstrated that BRP behaved better phagocytic capacity and had potent immunomodulatory activity,including increasing production of nitric oxide(NO),tumor necrosis factor a(TNFa)and upregulating mRNA levels of inducible NO synthase(iNOS)and TNFa.Furthermore,modulation of macrophage by BRP was indicated to be mediated via the activation of Akt and nuclear factor-kappa B(NF-κB).Conclusion:The beneficial effects of BRP could be used as an immunotherapeutic adjuvant in treatment of inflammatory diseases.
