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Chemogenetic activation of G12 signaling enhances adipose tissue browning
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作者 Yuki Ono Ryo Ito +7 位作者 Kaito Arai Gurdeep Singh Tsuyoshi Saitoh Robert BRussell Francesco Raimondi Junken Aoki juro sakai Asuka Inoue 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2023年第9期3923-3926,共4页
Dear Editor,Beige adipocytes,which increase energy expenditure by dissipating energy as heat,have gained attention as a therapeutic target for combating obesity.1 Adipocytes express many types of G-protein-coupled rec... Dear Editor,Beige adipocytes,which increase energy expenditure by dissipating energy as heat,have gained attention as a therapeutic target for combating obesity.1 Adipocytes express many types of G-protein-coupled receptors(GPCRs),each of which has a unique preference for the Gs,Gi,Gq,and G12 subfamilies.While the function of Gs-coupledβ-adrenergic receptors in beige adipocyte induction is well established,2 little is known about the function of G12-coupled GPCRs beyond its suppressive roles in white adipocyte maturation.3 In this study,we generated transgenic mice conditionally expressing a G12-coupled designer GPCR using a Cre-loxP system and investigated the potential effects of G12 signaling on adipocyte biology. 展开更多
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