Interaction of acoustic waves and microbubbles occurs in numerous biomedical applications including ultrasound imaging,drug delivery,lithotripsy treatment,and cell manipulation,wherein the acoustically driven microbub...Interaction of acoustic waves and microbubbles occurs in numerous biomedical applications including ultrasound imaging,drug delivery,lithotripsy treatment,and cell manipulation,wherein the acoustically driven microbub-blcs routincly act as active microscale oscillators or actuators.In contrast,microbubbles were utilized here as passive reccivers to detect broadband ultrasound waves in aqueous environments.The microbubble was photo-thermally generated on a microstructured optical fiber(MOF)tip,forming a flexible Fabry-Perot cavity whose gas-water interface was sensitive to ultrasound waves.The MOF severed as both a low-loss waveguide and a compact light condenser,allowing high-efficiency generation and stabilization of ultrasmall microbubbles.Integrated with all-fiber interferometry,a 10 um diameter microbubble exhibited a low noise-cquivalcnt pressur elevei of^3.4 mPa/Hz^1/2 and a broad bandwidth of^0.8 MHz,capable of detecting weak ultrasounds emittedfrom red blood cells irradiated by pulsed laser light.With advantages of high sensitivity,compact size,and low cost,the microbubble-based ultrasound sensor has great potential in biomedical imaging and sensing applications.展开更多
基金Guangzhou Scicnce and Technology Plan Project(201904020032)The Local Innowative and Research leams Project of Guangdong Pearl River Talents Program(2019BT02X105)+3 种基金National Natural Science Foundation of China(61705082,U1701268)Natural Science Foundation of Guangdong Province(2017A030313361,2018030310587)Fundlamental Research Funds for the Central Universiies(21617304)Province High-Level Talents Introduction Plan(2017GCO10420).
文摘Interaction of acoustic waves and microbubbles occurs in numerous biomedical applications including ultrasound imaging,drug delivery,lithotripsy treatment,and cell manipulation,wherein the acoustically driven microbub-blcs routincly act as active microscale oscillators or actuators.In contrast,microbubbles were utilized here as passive reccivers to detect broadband ultrasound waves in aqueous environments.The microbubble was photo-thermally generated on a microstructured optical fiber(MOF)tip,forming a flexible Fabry-Perot cavity whose gas-water interface was sensitive to ultrasound waves.The MOF severed as both a low-loss waveguide and a compact light condenser,allowing high-efficiency generation and stabilization of ultrasmall microbubbles.Integrated with all-fiber interferometry,a 10 um diameter microbubble exhibited a low noise-cquivalcnt pressur elevei of^3.4 mPa/Hz^1/2 and a broad bandwidth of^0.8 MHz,capable of detecting weak ultrasounds emittedfrom red blood cells irradiated by pulsed laser light.With advantages of high sensitivity,compact size,and low cost,the microbubble-based ultrasound sensor has great potential in biomedical imaging and sensing applications.
