The title complex has been synthesized by 4-methylbenzoic acid and 2,2?-bipyridine (bipy) in the mixed solvent of water and methanol. It crystallizes in the triclinic system, space group P1 with a = 0.7047(3), b = 1.1...The title complex has been synthesized by 4-methylbenzoic acid and 2,2?-bipyridine (bipy) in the mixed solvent of water and methanol. It crystallizes in the triclinic system, space group P1 with a = 0.7047(3), b = 1.1217(5), c = 1.6718(7) nm, α = 103.826(7), β = 90.772(6), γ = 104.195(6)o, C26H25CuN2O5.50, Mr = 517.02, V = 1.2404(9) nm3, Dc = 1.384 g/cm3, Z = 2, F(000) = 536, μ(MoKα) = 0.921 mm-1, R = 0.0782 and wR = 0.2172. Structural analysis shows that the copper atom is coordinated with three oxygen atoms from two 4-methylbenzoic acids and one water molecule together with two nitrogen atoms from 2,2?-bipyridine, giving a distorted square-pyramid coordination geometry. The cyclic voltametric behavior of the complex has also been described.展开更多
The 1,5-disubstituted thiocarbohydrazide ligands were prepared by the condensation of thiocarbohydrazide with salicylaldehyde and 5-methylsalicylaldehyde, respectively. The butyltin complexes,[(5-R-2-hydroxy)ArCH=NNH]...The 1,5-disubstituted thiocarbohydrazide ligands were prepared by the condensation of thiocarbohydrazide with salicylaldehyde and 5-methylsalicylaldehyde, respectively. The butyltin complexes,[(5-R-2-hydroxy)ArCH=NNH]2 CS(n-BuSnCl)2, R = H(T1);R = Me(T2), based on the1,5-disubstituted thiocarbohydrazide were obtained by microwave-assisted solvothermal reaction of n-butyltintrichloride precursor with the ligands in methanol environments, which have been structurally characterized by elemental analysis, IR and(1 H, 13 C) NMR spectra. The crystals belong to monoclinic system, space groups C2/c(T1) and Pc(T2), respectively. The Sn atom is six-coordinated with distorted octahedral geometry by O, N and S atoms from ligand, C atom of butyl and two Cl atoms. In the crystal, complex T1 forms three-dimensional supramolecular assembly mediated by noncovalent interactions such as C–H···Cl and π-stacking interactions.Similarly, T2 forms an interesting two-dimensional supramolecular structure by noncovalent interactions(e.g. C–H×××Cl and N–H×××Cl) of one-dimensional band-like chain. These ligands and its butyltin complexes have growth effect on the target plants, such as Portulaca oleracea L.,Amaranthus spinosus L., Cassia tora L., Brassica campestris L. ssp. chinensis var. utilis Tsen et Lee and Amaranthus tricolor L. The ligand L1 has a good inhibitory effect on the growth of Cassia tora L., and complex T2 has selective inhibition on the growth of Portulaca oleracea L. and Amaranthus tricolor L., which can be used as a candidate compound for Cassia tora L., Portulaca oleracea L.and Amaranthus tricolor L. herbicide.展开更多
A one-dimensional chain cobalt(II) coordination polymer with 2,4,6-trimethyl- benzoic acid, 4,4-bipyridine and cobalt perchlorate anhydrous has been synthesized and charac- terized in the mixture solvent of water and ...A one-dimensional chain cobalt(II) coordination polymer with 2,4,6-trimethyl- benzoic acid, 4,4-bipyridine and cobalt perchlorate anhydrous has been synthesized and charac- terized in the mixture solvent of water and alcohol. Crystal data for this complex: monoclinic, space group C2/c, a = 2.3805(8), b = 1.1464(4), c = 1.5807(5) nm, γ = 128.435(4)o, V = 3.3791(18) nm3, Dc = 1.246 g/cm3, Z = 4, F(000) = 1340, final GooF = 1.009, R = 0.0504 and wR = 0.1287. Structural analysis shows that the cobalt ion is coordinated with two nitrogen atoms of one 4,4- bipyridine molecule and four oxygen atoms from two 2,4,6-trimethylbenzoic acid molecules and two alcohol molecules, giving a distorted octahedral coordination geometry. The result of TG analysis indicates that the title complex is stable till 200 ℃.展开更多
The triphenyltin complex with salicylidene-2-aminophenol(C_(31)H_(24)NO_2Sn,1)has been synthesized and characterized by elemental analysis,IR spectroscopy,thermogravimetric analysis,and X-ray single-crystal diffractio...The triphenyltin complex with salicylidene-2-aminophenol(C_(31)H_(24)NO_2Sn,1)has been synthesized and characterized by elemental analysis,IR spectroscopy,thermogravimetric analysis,and X-ray single-crystal diffraction.The complex crystallizes in monoclinic system,P2_1/c space group with a=1.09515(8),b=1.17739(8),c=2.29075(14)nm,β=117.070(4)°,V=2.6302(3)nm^3,Z=4,D_c=1.417 g/cm^3,?=0.999 mm^(–1),F(000)=1123,R=0.0472 and w R=0.1169.X-ray single-crystal diffraction showed that 1 demonstrates a one-dimensional chain structure.The quantum chemical calculation of 1 has been investigated.Complex 1 emits fluorescence at 558 nm and exhibits certain inhibitory activity against NCI-H460,A549 and MCF-7.展开更多
Di(o-cyanobenzyl)tin bis(quinoline-2-carboxylate) was synthesized by the reaction of tri(o-cyanobenzyl)tin chloride with quinoline-2-carboxylic acid. The molecular structure of the compound was characterized by elemen...Di(o-cyanobenzyl)tin bis(quinoline-2-carboxylate) was synthesized by the reaction of tri(o-cyanobenzyl)tin chloride with quinoline-2-carboxylic acid. The molecular structure of the compound was characterized by elemental analysis, IR, 1H NMR and X-ray diffraction. Crystal data for the compound: triclinic, space group P1, a = 0.80734(7), b = 1.00681(9), c = 1.04811(9) nm, α = 81.7570(10), β = 7.7240(10), γ = 81.2850(10)°, V = 0.77581(12) nm3, Z = 1, Dc = 1.488 g/cm3, μ(MoKα) = 0.870 mm-1 and F(000) = 350. The final R = 0.0204 and wR = 0.0530 for 2677 observed reflections with I >2σ(I), and R = 0.0208 and wR = 0.0532 for all reflections. The molecular structure adopts a distorted octahedral geometry around the Sn atom. The title compound molecules are connected via hydrogen bonding interactions to form a 3D network structure. Quantum chemistry calculation study on the title compound has been performed by means of G98W package at the Lanl2dz basis set. The stability of the compound, orbital energies and some frontier molecular orbital composition characteristics have also been investigated.展开更多
Two 2-oxo-3-phenylpropionic acid arylformylhydrazone dibenzyltin(IV)complexes{[C4H3O(O)C=N-N=C(PhCH2)COO](C6H5CH2)2Sn(CH3OH)}2(Ⅰ)and{[t-Bu-C6H4(O)C=N-N=C(PhCH2)COO](C6H5CH2)2Sn(CH3OH)}2(Ⅱ)have been synthesized and c...Two 2-oxo-3-phenylpropionic acid arylformylhydrazone dibenzyltin(IV)complexes{[C4H3O(O)C=N-N=C(PhCH2)COO](C6H5CH2)2Sn(CH3OH)}2(Ⅰ)and{[t-Bu-C6H4(O)C=N-N=C(PhCH2)COO](C6H5CH2)2Sn(CH3OH)}2(Ⅱ)have been synthesized and characterized by IR,1H,13C and 119Sn NMR spectra,HRMS,and elemental,thermal stability and single-crystal X-ray diffraction analyses.Complex I crystallizes in the triclinic system,space group P1 with a=9.0392(9),b=10.249(1),c=15.5762(15)?,α=98.605(1)°,β=103.765(1)°,γ=104.056(1)°,Z=2,V=1326.3(2)?3,Dc=1.511 Mg·m^–3,m(MoKa)=1.005 mm–1,F(000)=612,R=0.0206 and wR=0.0524.Complex Ⅱ belongs to triclinic system,space group P1,a=11.4643(3),b=11.8885(3),c=13.0362(4)?,α=73.800(1)°,β=71.679(1)°,γ=79.006(1)°,Z=2,V=1609.34(8)?3,Dc=1.381 Mg·m^–3,m(MoKa)=0.833 mm–1,F(000)=688,R=0.0244 and wR=0.0244.In vitro antitumor activities of both complexes were evaluated by MTT against three human cancer cell lines(NCI-H460,HepG2 and MCF7)and human cell lines(HL7702).Both complexes exhibit better antitumor activity.Furthermore,the interaction between both complexes and calf thymus DNA was studied with EB fluorescent probe.展开更多
Two novel bis(2-hydroxy-5-R-benzylidene)carbohydrazide dibutyltin complexes(R:Cl(T1),Me(T2))with hexanuclear and triangular frame structures were obtained by microwave-assisted solvothermal reaction of dibutyltin oxid...Two novel bis(2-hydroxy-5-R-benzylidene)carbohydrazide dibutyltin complexes(R:Cl(T1),Me(T2))with hexanuclear and triangular frame structures were obtained by microwave-assisted solvothermal reaction of dibutyltin oxide precursor with the ligands in methanol environments,However,their structures are characterized by elemental analysis,IR,(1H,13C)NMR spectra,and the molecular structures of T1 and T2 were confirmed by X-ray diffraction.The crystal of T1 belongs to triclinic system,space group P1,and T2 is of monoclinic system,space group C2/c.Five-coordinated distorted triangular bipyramids and six-coordinated distorted octahedral configurations were formed by the coordination of oxygen and nitrogen atoms of ligands with two dibutyltins,respectively,and trimer hexanuclear dibutyltin complexes were constructed by the cross-coordination of enol imines.The two complexes exhibit fluorescence emission in DMF solvents and DMF-water mixtures.When the volume fraction of water content is between 0 and 10%(V/V),the aggregation fluorescence enhancement effect is good,and fluorescence quenching occurs when the water content is more than 10%(V/V).The T1 can inhibit the growth of target plants,such as Portulaca oleracea,Cassia tora L.,Brassica campestris L.ssp.chinensis var.utilis Tsen et Lee and Amaranthus tricolor L.The T2 can selectively inhibit the growth of Portulaca oleracea L.,Amaranthus spinosus L.and Amaranthus tricolor L.It can be used as a candidate herbicide for Portulaca oleracea L.,Amaranthus spinosus L.and Amaranthus tricolor L.展开更多
Two dibenzyltin compounds,{[C6H5O(O)C=N-N=C(Ph)COO](m-Cl-C6H4CH2)2-Sn(CH3OH)}2(1)and{[p-Me-C6H4O(O)C=N-N=C(Ph)COO](m-Cl-C6H4CH2)2Sn(CH3OH)}2(2),have been synthesized by microwave“one pot”reaction with benzoylhydrazi...Two dibenzyltin compounds,{[C6H5O(O)C=N-N=C(Ph)COO](m-Cl-C6H4CH2)2-Sn(CH3OH)}2(1)and{[p-Me-C6H4O(O)C=N-N=C(Ph)COO](m-Cl-C6H4CH2)2Sn(CH3OH)}2(2),have been synthesized by microwave“one pot”reaction with benzoylhydrazine(or p-methyl benzhydrazine),phenylglyoxylic acid and di-m-chlorobenzyltin dichloride.Compound 2 contains two crystals 2a and 2b.The compounds have been characterized with IR,elemental analysis,1H,13C and 119Sn NMR spectra,H RMS.Three crystals are all binuclear molecules with a Sn2O2 four-membered ring plane,and each Sn atom center is seven-coordinated with[SnO4C2N]to form a distorted pentagonal bipyramidal configuration.In vitro antitumor activities of all compounds and carboplatin were evaluated by MTT against three human cancer cells such as NCI-H460(lung cancer cells),HepG2(liver cancer cells)and MCF7(breast cancer cells),and compound 2 exhibited better antitumor activity.展开更多
Tri(o-bromobenzyl)tin diethyldithiocarbamate(1) and tri(m-fluorobenzyl)tin pyrrolidine dithiocarbamate(2) have been synthesized and characterized by elemental analysis, IR spectroscopy, NMR(~1 H, ^(13)C and ^(119)Sn),...Tri(o-bromobenzyl)tin diethyldithiocarbamate(1) and tri(m-fluorobenzyl)tin pyrrolidine dithiocarbamate(2) have been synthesized and characterized by elemental analysis, IR spectroscopy, NMR(~1 H, ^(13)C and ^(119)Sn), thermogravimetric analysis and single-crystal X-ray diffraction. The two complexes crystallize in the triclinic system space group P1. For complex 1, a = 0.9770(1), b = 1.1011(1), c = 1.4583(1) nm, α = 78.431(1)°, β = 86.307(1)°, γ = 69.712(1)°, V = 1.4417(2) nm^3, Z = 2, Dc = 1.790 g/cm^3, m(Mo Kα) = 52.04 cm–1, F(000) = 756, R = 0.0434 and wR = 0.0593. For complex 2, a = 0.7055(1), b = 1.3349(3), c = 1.3782(3) nm, α = 89.216(2)°, β = 82.044(2)°, γ = 84.637(2)°, V = 1.2799(5) nm^3, Z = 2, Dc = 1.537 g/cm^3, m(Mo Kα) = 11.98 cm^(–1), F(000) = 596, R = 0.0313 and wR = 0.0333. The two complexes represent mononuclear structures with five-coordinated [SnC3S2] cores forming a distorted trigonal bipyramid. The quantum chemical calculations of 1 and 2 have been investigated. The antitumor activity shows that 1 and 2 have higher activities than cisplatinum against Colo205, HepG2, MCF-7, Hela and H460 cell line in vitro.展开更多
Diorganotin 2-(2-(4-methoxybenzoyl)hydrazono)-3-phenylpropanoic carboxylate complexes Ⅰ{[p-CH3 O-C6 H4 O(O)C=N-N=C(Ph CH2)COO](n-Bu)2 Sn(CH3 OH)}2 and Ⅱ {[p-CH3 O-C6 H4 O(O)C=NN=C(Ph CH2)COO](Ph CH2)2 Sn(CH3 OH)}2 h...Diorganotin 2-(2-(4-methoxybenzoyl)hydrazono)-3-phenylpropanoic carboxylate complexes Ⅰ{[p-CH3 O-C6 H4 O(O)C=N-N=C(Ph CH2)COO](n-Bu)2 Sn(CH3 OH)}2 and Ⅱ {[p-CH3 O-C6 H4 O(O)C=NN=C(Ph CH2)COO](Ph CH2)2 Sn(CH3 OH)}2 have been synthesized. The complexes have been characterized by IR, 1 H, 13 C and 119 Sn NMR spectra, HRMS, elemental analysis, thermal stability analysis and the crystal structures have been determined by X-ray diffraction. The crystal of complex I belongs to triclinic system, space group P1 with a = 10.437(2), b = 11.576(3), c = 13.085(3) ?, α = 66.272(2)°, β = 86.920(3)°, γ = 73.367(3)°, Z = 2, V = 1383.3(5) ?3, Dc = 1.381 Mg·m-3, m(Mo Kα) = 0.959 mm-1, F(000) = 592, R = 0.0233 and w R = 0.0644. The crystal of complex Ⅱ is of triclinic system, space group P1 with a = 10.446(1), b = 11.720(1), c = 13.063(2) ?, α = 84.190(1)°, β = 71.610(1)°, γ = 72.624(1)°, Z = 1, V = 1448.3(3) ?3, Dc = 1.475 Mg·m-3, m(Mo Kα) = 0.925 mm-1, F(000) = 656, R = 0.0169 and w R = 0.0432. In vitro antitumor activities of both complexes were evaluated by MTT against three human cancer cell lines(NCI-H460, Hep G2 and MCF7), and two complexes exhibited good antitumor activity. The interaction between complex Ⅰ and calf thymus DNA were studied by UV-vis and fluorescence spectroscopy, the interaction of complex Ⅰ with calf thymus DNA were intercalation.展开更多
基金Project supported by the Foundation of Education Committee of Hunan Province (05C001), Science and Technology Bureau Foundation of Hengyang (2005Cg10-23) and the Research Award Fund for Outstanding Young Teachers of Hengyang Normal University (No. 2003C16)
文摘The title complex has been synthesized by 4-methylbenzoic acid and 2,2?-bipyridine (bipy) in the mixed solvent of water and methanol. It crystallizes in the triclinic system, space group P1 with a = 0.7047(3), b = 1.1217(5), c = 1.6718(7) nm, α = 103.826(7), β = 90.772(6), γ = 104.195(6)o, C26H25CuN2O5.50, Mr = 517.02, V = 1.2404(9) nm3, Dc = 1.384 g/cm3, Z = 2, F(000) = 536, μ(MoKα) = 0.921 mm-1, R = 0.0782 and wR = 0.2172. Structural analysis shows that the copper atom is coordinated with three oxygen atoms from two 4-methylbenzoic acids and one water molecule together with two nitrogen atoms from 2,2?-bipyridine, giving a distorted square-pyramid coordination geometry. The cyclic voltametric behavior of the complex has also been described.
基金Supported by the Innovation Platform Open Foundation for Colleges and Universities of Hunan Province(No.16k011)
文摘The 1,5-disubstituted thiocarbohydrazide ligands were prepared by the condensation of thiocarbohydrazide with salicylaldehyde and 5-methylsalicylaldehyde, respectively. The butyltin complexes,[(5-R-2-hydroxy)ArCH=NNH]2 CS(n-BuSnCl)2, R = H(T1);R = Me(T2), based on the1,5-disubstituted thiocarbohydrazide were obtained by microwave-assisted solvothermal reaction of n-butyltintrichloride precursor with the ligands in methanol environments, which have been structurally characterized by elemental analysis, IR and(1 H, 13 C) NMR spectra. The crystals belong to monoclinic system, space groups C2/c(T1) and Pc(T2), respectively. The Sn atom is six-coordinated with distorted octahedral geometry by O, N and S atoms from ligand, C atom of butyl and two Cl atoms. In the crystal, complex T1 forms three-dimensional supramolecular assembly mediated by noncovalent interactions such as C–H···Cl and π-stacking interactions.Similarly, T2 forms an interesting two-dimensional supramolecular structure by noncovalent interactions(e.g. C–H×××Cl and N–H×××Cl) of one-dimensional band-like chain. These ligands and its butyltin complexes have growth effect on the target plants, such as Portulaca oleracea L.,Amaranthus spinosus L., Cassia tora L., Brassica campestris L. ssp. chinensis var. utilis Tsen et Lee and Amaranthus tricolor L. The ligand L1 has a good inhibitory effect on the growth of Cassia tora L., and complex T2 has selective inhibition on the growth of Portulaca oleracea L. and Amaranthus tricolor L., which can be used as a candidate compound for Cassia tora L., Portulaca oleracea L.and Amaranthus tricolor L. herbicide.
基金Project supported by the Natural Science Foundation of Hunan Province (No. 05JJ30016), Foundation of Education Committee of Hunan Province (05C001), Foundation of Hengyang Sci. & Tech. Bureau (2005Cg10-23) and Fund for Distinguished Young Cadreman of Hengyang Normal University(2006)
文摘A one-dimensional chain cobalt(II) coordination polymer with 2,4,6-trimethyl- benzoic acid, 4,4-bipyridine and cobalt perchlorate anhydrous has been synthesized and charac- terized in the mixture solvent of water and alcohol. Crystal data for this complex: monoclinic, space group C2/c, a = 2.3805(8), b = 1.1464(4), c = 1.5807(5) nm, γ = 128.435(4)o, V = 3.3791(18) nm3, Dc = 1.246 g/cm3, Z = 4, F(000) = 1340, final GooF = 1.009, R = 0.0504 and wR = 0.1287. Structural analysis shows that the cobalt ion is coordinated with two nitrogen atoms of one 4,4- bipyridine molecule and four oxygen atoms from two 2,4,6-trimethylbenzoic acid molecules and two alcohol molecules, giving a distorted octahedral coordination geometry. The result of TG analysis indicates that the title complex is stable till 200 ℃.
基金Supported by the Open Fund Project of Key Laboratory of Functional Organometallic Materials of Hengyang Normal University(15K017,14K014,13K105)Natural Science Foundation of Hunan Province(No.13JJ3112)+3 种基金Scientific&Technological Projects of Hunan Province(No.2014NK3086)Aid programs for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Provincethe Key Discipline of Hunan ProvinceProject funding for research and innovation experiment of university students in Hunan Province
文摘The triphenyltin complex with salicylidene-2-aminophenol(C_(31)H_(24)NO_2Sn,1)has been synthesized and characterized by elemental analysis,IR spectroscopy,thermogravimetric analysis,and X-ray single-crystal diffraction.The complex crystallizes in monoclinic system,P2_1/c space group with a=1.09515(8),b=1.17739(8),c=2.29075(14)nm,β=117.070(4)°,V=2.6302(3)nm^3,Z=4,D_c=1.417 g/cm^3,?=0.999 mm^(–1),F(000)=1123,R=0.0472 and w R=0.1169.X-ray single-crystal diffraction showed that 1 demonstrates a one-dimensional chain structure.The quantum chemical calculation of 1 has been investigated.Complex 1 emits fluorescence at 558 nm and exhibits certain inhibitory activity against NCI-H460,A549 and MCF-7.
基金Supported by the Key Foundation of Educational Department of Hunan Province (06A009)the Construct Program of the Key Discipline in Hunan Province and Hengyang Bureau of Science & Technology (06kj17)
文摘Di(o-cyanobenzyl)tin bis(quinoline-2-carboxylate) was synthesized by the reaction of tri(o-cyanobenzyl)tin chloride with quinoline-2-carboxylic acid. The molecular structure of the compound was characterized by elemental analysis, IR, 1H NMR and X-ray diffraction. Crystal data for the compound: triclinic, space group P1, a = 0.80734(7), b = 1.00681(9), c = 1.04811(9) nm, α = 81.7570(10), β = 7.7240(10), γ = 81.2850(10)°, V = 0.77581(12) nm3, Z = 1, Dc = 1.488 g/cm3, μ(MoKα) = 0.870 mm-1 and F(000) = 350. The final R = 0.0204 and wR = 0.0530 for 2677 observed reflections with I >2σ(I), and R = 0.0208 and wR = 0.0532 for all reflections. The molecular structure adopts a distorted octahedral geometry around the Sn atom. The title compound molecules are connected via hydrogen bonding interactions to form a 3D network structure. Quantum chemistry calculation study on the title compound has been performed by means of G98W package at the Lanl2dz basis set. The stability of the compound, orbital energies and some frontier molecular orbital composition characteristics have also been investigated.
基金Supported by Hunan Provincial College Student Research Study and Innovative Experiment Project(No.cx1813)Natural Science Foundation of Hunan Province(No.2017JJ3003)+1 种基金Hengyang Normal University Discipline Group Construction Project(No.18XKQ01)Foundation of Key Laboratory of Functional Metal-organic Compounds of Hunan Province(No.MO18K01)
文摘Two 2-oxo-3-phenylpropionic acid arylformylhydrazone dibenzyltin(IV)complexes{[C4H3O(O)C=N-N=C(PhCH2)COO](C6H5CH2)2Sn(CH3OH)}2(Ⅰ)and{[t-Bu-C6H4(O)C=N-N=C(PhCH2)COO](C6H5CH2)2Sn(CH3OH)}2(Ⅱ)have been synthesized and characterized by IR,1H,13C and 119Sn NMR spectra,HRMS,and elemental,thermal stability and single-crystal X-ray diffraction analyses.Complex I crystallizes in the triclinic system,space group P1 with a=9.0392(9),b=10.249(1),c=15.5762(15)?,α=98.605(1)°,β=103.765(1)°,γ=104.056(1)°,Z=2,V=1326.3(2)?3,Dc=1.511 Mg·m^–3,m(MoKa)=1.005 mm–1,F(000)=612,R=0.0206 and wR=0.0524.Complex Ⅱ belongs to triclinic system,space group P1,a=11.4643(3),b=11.8885(3),c=13.0362(4)?,α=73.800(1)°,β=71.679(1)°,γ=79.006(1)°,Z=2,V=1609.34(8)?3,Dc=1.381 Mg·m^–3,m(MoKa)=0.833 mm–1,F(000)=688,R=0.0244 and wR=0.0244.In vitro antitumor activities of both complexes were evaluated by MTT against three human cancer cell lines(NCI-H460,HepG2 and MCF7)and human cell lines(HL7702).Both complexes exhibit better antitumor activity.Furthermore,the interaction between both complexes and calf thymus DNA was studied with EB fluorescent probe.
基金Supported by the Innovation Platform Open Foundation for Colleges and Universities of Hunan Province(No.16k011)the Foundation of Key Laboratory of Functional Metal-organic Compounds of Hunan Province。
文摘Two novel bis(2-hydroxy-5-R-benzylidene)carbohydrazide dibutyltin complexes(R:Cl(T1),Me(T2))with hexanuclear and triangular frame structures were obtained by microwave-assisted solvothermal reaction of dibutyltin oxide precursor with the ligands in methanol environments,However,their structures are characterized by elemental analysis,IR,(1H,13C)NMR spectra,and the molecular structures of T1 and T2 were confirmed by X-ray diffraction.The crystal of T1 belongs to triclinic system,space group P1,and T2 is of monoclinic system,space group C2/c.Five-coordinated distorted triangular bipyramids and six-coordinated distorted octahedral configurations were formed by the coordination of oxygen and nitrogen atoms of ligands with two dibutyltins,respectively,and trimer hexanuclear dibutyltin complexes were constructed by the cross-coordination of enol imines.The two complexes exhibit fluorescence emission in DMF solvents and DMF-water mixtures.When the volume fraction of water content is between 0 and 10%(V/V),the aggregation fluorescence enhancement effect is good,and fluorescence quenching occurs when the water content is more than 10%(V/V).The T1 can inhibit the growth of target plants,such as Portulaca oleracea,Cassia tora L.,Brassica campestris L.ssp.chinensis var.utilis Tsen et Lee and Amaranthus tricolor L.The T2 can selectively inhibit the growth of Portulaca oleracea L.,Amaranthus spinosus L.and Amaranthus tricolor L.It can be used as a candidate herbicide for Portulaca oleracea L.,Amaranthus spinosus L.and Amaranthus tricolor L.
基金supported by the Hengyang Normal University College Students Innovation and Entrepreneurship Training Program(No.cxcy1944)Scientific Research Fund of Hunan Provincial Education Department of China(No.19C0279)+1 种基金Hengyang Normal University Industrial Supported Project(Nos.HXKJ201907,HXKJ201908,HXKJ201911,HXKJ201946,HXKJ201947)Foundation of Key Laboratory of Functional Organometallic Materials,University of Hunan Province(No.GN19K07)。
文摘Two dibenzyltin compounds,{[C6H5O(O)C=N-N=C(Ph)COO](m-Cl-C6H4CH2)2-Sn(CH3OH)}2(1)and{[p-Me-C6H4O(O)C=N-N=C(Ph)COO](m-Cl-C6H4CH2)2Sn(CH3OH)}2(2),have been synthesized by microwave“one pot”reaction with benzoylhydrazine(or p-methyl benzhydrazine),phenylglyoxylic acid and di-m-chlorobenzyltin dichloride.Compound 2 contains two crystals 2a and 2b.The compounds have been characterized with IR,elemental analysis,1H,13C and 119Sn NMR spectra,H RMS.Three crystals are all binuclear molecules with a Sn2O2 four-membered ring plane,and each Sn atom center is seven-coordinated with[SnO4C2N]to form a distorted pentagonal bipyramidal configuration.In vitro antitumor activities of all compounds and carboplatin were evaluated by MTT against three human cancer cells such as NCI-H460(lung cancer cells),HepG2(liver cancer cells)and MCF7(breast cancer cells),and compound 2 exhibited better antitumor activity.
基金Supported by the Open Fund Project of Innovation Platform Hunan Province Higher Educational Institutions(18K089)the Fund for the Applied Key Discipline of Hunan Province+1 种基金the Support Plan for University Science and Technology Innovation Team of Hunan ProvinceAid programs for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province。
文摘Tri(o-bromobenzyl)tin diethyldithiocarbamate(1) and tri(m-fluorobenzyl)tin pyrrolidine dithiocarbamate(2) have been synthesized and characterized by elemental analysis, IR spectroscopy, NMR(~1 H, ^(13)C and ^(119)Sn), thermogravimetric analysis and single-crystal X-ray diffraction. The two complexes crystallize in the triclinic system space group P1. For complex 1, a = 0.9770(1), b = 1.1011(1), c = 1.4583(1) nm, α = 78.431(1)°, β = 86.307(1)°, γ = 69.712(1)°, V = 1.4417(2) nm^3, Z = 2, Dc = 1.790 g/cm^3, m(Mo Kα) = 52.04 cm–1, F(000) = 756, R = 0.0434 and wR = 0.0593. For complex 2, a = 0.7055(1), b = 1.3349(3), c = 1.3782(3) nm, α = 89.216(2)°, β = 82.044(2)°, γ = 84.637(2)°, V = 1.2799(5) nm^3, Z = 2, Dc = 1.537 g/cm^3, m(Mo Kα) = 11.98 cm^(–1), F(000) = 596, R = 0.0313 and wR = 0.0333. The two complexes represent mononuclear structures with five-coordinated [SnC3S2] cores forming a distorted trigonal bipyramid. The quantum chemical calculations of 1 and 2 have been investigated. The antitumor activity shows that 1 and 2 have higher activities than cisplatinum against Colo205, HepG2, MCF-7, Hela and H460 cell line in vitro.
基金Supported by Hengyang Normal University College Students Scientific and Technological Works Project (No. 167 and 168)Foundation of Key Laboratory of Functional Organometallic Materials,University of Hunan Province (No. GN19K07)+1 种基金Scientific Research Fund of Hunan Provincial Education Department of China (No. 19C0279)Hengyang Normal University Industrial Supported Project (Nos. HXKJ201908,HXKJ201911,HXKJ201946 and HXKJ201947)。
文摘Diorganotin 2-(2-(4-methoxybenzoyl)hydrazono)-3-phenylpropanoic carboxylate complexes Ⅰ{[p-CH3 O-C6 H4 O(O)C=N-N=C(Ph CH2)COO](n-Bu)2 Sn(CH3 OH)}2 and Ⅱ {[p-CH3 O-C6 H4 O(O)C=NN=C(Ph CH2)COO](Ph CH2)2 Sn(CH3 OH)}2 have been synthesized. The complexes have been characterized by IR, 1 H, 13 C and 119 Sn NMR spectra, HRMS, elemental analysis, thermal stability analysis and the crystal structures have been determined by X-ray diffraction. The crystal of complex I belongs to triclinic system, space group P1 with a = 10.437(2), b = 11.576(3), c = 13.085(3) ?, α = 66.272(2)°, β = 86.920(3)°, γ = 73.367(3)°, Z = 2, V = 1383.3(5) ?3, Dc = 1.381 Mg·m-3, m(Mo Kα) = 0.959 mm-1, F(000) = 592, R = 0.0233 and w R = 0.0644. The crystal of complex Ⅱ is of triclinic system, space group P1 with a = 10.446(1), b = 11.720(1), c = 13.063(2) ?, α = 84.190(1)°, β = 71.610(1)°, γ = 72.624(1)°, Z = 1, V = 1448.3(3) ?3, Dc = 1.475 Mg·m-3, m(Mo Kα) = 0.925 mm-1, F(000) = 656, R = 0.0169 and w R = 0.0432. In vitro antitumor activities of both complexes were evaluated by MTT against three human cancer cell lines(NCI-H460, Hep G2 and MCF7), and two complexes exhibited good antitumor activity. The interaction between complex Ⅰ and calf thymus DNA were studied by UV-vis and fluorescence spectroscopy, the interaction of complex Ⅰ with calf thymus DNA were intercalation.
