This study investigated the association of hypertension with cognitive impairment and determined whether better adherence to plant-based diet(PBD)patterns may modify the association.We analyzed 4485 elderly individual...This study investigated the association of hypertension with cognitive impairment and determined whether better adherence to plant-based diet(PBD)patterns may modify the association.We analyzed 4485 elderly individuals with normal cognition at baseline from the Chinese Longitudinal Healthy Longevity Survey(2011−2018).Cognitive function was assessed by the Mini-mental State Examination(MMSE),and cognitive impairment was defined as an MMSE score below 18 points.Diet patterns were assessed using the overall plant-based diet index(PDI),healthful plant-based diet index(hPDI),and unhealthful plant-based diet index(uPDI)derived from a simplified food frequency questionnaire(FFQ).Blood pressure was measured through physical examination.Cox proportional hazard regression and restricted cubic spline were performed.Participants with hypertension had an increased risk of cognitive impairment compared with normal group.The associations between hypertension and cognitive impairment were more pronounced among participants with lower PDI than those with higher PDI,among participants with lower hPDI than those with higher hPDI,and among participants with higher uPDI than those with lower uPDI.A healthful PBD pattern may attenuate hypertension-induced cognitive impairment,while an unhealthful PBD pattern may exacerbate hypertensioninduced cognitive impairment in elderly.Adherence to healthful PBD pattern could be used to prevent or mitigate adverse neurological effects in the hypertensive population.展开更多
[Objectives]To study the reference value of thyroid function in healthy women of childbearing age during different pregnancies(early,middle and late pregnancy)in Jingzhou City.[Methods]362 healthy women of childbearin...[Objectives]To study the reference value of thyroid function in healthy women of childbearing age during different pregnancies(early,middle and late pregnancy)in Jingzhou City.[Methods]362 healthy women of childbearing age during different pregnancies(early,middle and late pregnancy)were selected as the study group,and 360 non-pregnant women were selected as the control group.Serum thyroid hormone levels in the two groups were detected,and the reference value was expressed as the median(M)and 95%confidence interval(CI).On this basis,the chart of changing trend of thyroid hormone in the early,middle and late pregnancy were plotted.[Results]Compared with the control group,FT3,TT4,TT3,FT4and TSH in the early,middle and late pregnancy were significantly different in the study group(P<0.05).In the study group,there were significant differences in the early,middle and late pregnancy(P<0.05).[Conclusions]This trend chart has certain reference value in the screening,diagnosis and treatment of thyroid diseases in healthy women of childbearing age during different pregnancies(early,middle and late pregnancy)in Jingzhou City of Hubei Province.展开更多
[Objectives]To observe the effects of Wuwei Xiaodu Decoction on uterine energy metabolism and serum inflammatory factors in the acute pelvic inflammatory disease(APID)model.[Methods]75 Wistar rats(females)were randoml...[Objectives]To observe the effects of Wuwei Xiaodu Decoction on uterine energy metabolism and serum inflammatory factors in the acute pelvic inflammatory disease(APID)model.[Methods]75 Wistar rats(females)were randomly divided into control group,model group and Wuwei Xiaodu Decoction low,medium and high dose groups(n=15).Except for the control group,the rat APID model was established by right uterine inoculation.On the fifth day after inoculation,the low,medium and high dose groups of Wuwei Xiaodu Decoction were administered at 4,8 and 16 g/kg,and the control group and model group received normal saline.Rats were killed 12 h after nondose administration,blood was collected from the abdominal aorta and measured by ELISA for serum interleukin-6(interleukin-6,IL-6),IL-8,and C-reactive proteins(CRP);the right uterus of rats was tested for high-energy phosphate adenosine phosphate(AMP),adenosine diphosphate(ADP),adenosine triphosphate(ATP)and total adenine nucleotides(TAN)level to evaluate the uterine energy metabolism.[Results]AMP,ADP,ATP and TAN were significantly higher in the Wuwei Xiaodu Decoction of low,medium and high dose than the model group,while the serum IL-6,IL-8 and CRP were significantly lower than the model group,and the difference between the low,medium and high doses(P<0.05).[Conclusions]The Wuwei Xiaodu Decoction can dose-dependent promote uterine energy metabolism and inhibit inflammatory response in APID model rats.展开更多
Jike 33 is a new disease-resistant high-yield multi-ear wheat variety with strong gluten bred by Anhui New Century Agricultural Co.,Ltd. in 2001 with Yannong 19 as the female parent and the self-selected Jike 19( vari...Jike 33 is a new disease-resistant high-yield multi-ear wheat variety with strong gluten bred by Anhui New Century Agricultural Co.,Ltd. in 2001 with Yannong 19 as the female parent and the self-selected Jike 19( variant of Lumai 14) as the male parent. In 2011-2012,the variety participated in the semi-winter wheat regional test in Huaibei area of Anhui Province,and exhibited a yield of 519. 5 kg/667 m^2,which was 7. 83% higher than that of Wanmai 50 as the CK. In the semi-winter wheat regional test in Huaibei area of Anhui Province in 2012-2013,it showed an average yield of 522. 1 kg/667 m^2,which was 14. 5% higher than that of Wanmai 50 as the CK. and in 2013-2014,the variety participated in the semi-winter wheat production test in Anhui Province,and showed an average yield of 589. 30 kg/667 m2,which was 7. 30% higher than that of Wanmai 52 as the CK. Jike 33 was approved by the Anhui Crop Variety Approval Committee in July,2015.展开更多
To investigate the shock response of cyclotetramethylene tetranitramine(HMX)single crystals at elevated temperatures(below the phase transition point),plate impact experiments at elevated temperatures were designed an...To investigate the shock response of cyclotetramethylene tetranitramine(HMX)single crystals at elevated temperatures(below the phase transition point),plate impact experiments at elevated temperatures were designed and conducted.The HMX/window interface particle velocities at temperatures of 300 K,373 K,and 423 K were measured by the velocity interferometry system for any reflector(VISAR)technique.To further analyze the related mesoscale deformation mechanisms,a nonlinear thermoelastic-viscoplastic model was developed,which considers thermal activation and phonon drag dislocation slip mechanisms.The proposed model could well reproduce the measured thermal hardening behavior of Hugoniot elastic limit(HEL)of HMX single crystals.At elevated temperatures,the reduced dislocation mobility was observed,which stems from both phonon scattering and radiative damping effects.Comparatively speaking,radiative damping contributes less than phonon scattering to thermal hardening behavior.The calibrated model was further used to predict shock response of HMX single crystals with different thicknesses at different initial temperatures.Both the stress relaxation and elastic precursor decrease with thickness are mainly due to the rapid dislocation generation.These insights shed light on the interplay between dislocation motion and dislocation generation in thermal hardening behavior,stress relaxation,and elastic precursor decay,which serves to reveal the mesoscale deformation mechanisms at elevated temperatures.展开更多
Objective:Myeloma bone disease(MBD)is the most common complication of multiple myeloma(MM).Our previous study showed that the serum levels of C3/C4 in MM patients were significantly positively correlated with the seve...Objective:Myeloma bone disease(MBD)is the most common complication of multiple myeloma(MM).Our previous study showed that the serum levels of C3/C4 in MM patients were significantly positively correlated with the severity of bone disease.However,the mechanism of C3 a/C4 a in osteoclasts MM patients remains unclear.Methods:The formation and function of osteoclasts were analyzed after adding C3 a/C4 a in vitro.RNA-seq analysis was used to screen the potential pathways affecting osteoclasts,and the results were verified by Western blot,q RT-PCR,and pathway inhibitors.Results:The osteoclast area per view induced by 1μg/m L(mean±SD:50.828±12.984%)and 10μg/m L(53.663±12.685%)of C3 a was significantly increased compared to the control group(0μg/m L)(34.635±8.916%)(P<0.001 and P<0.001,respectively).The relative m RNA expressions of genes,OSCAR/TRAP/RANKL/cathepsin K,induced by 1μg/m L(median:5.041,3.726,1.638,and 4.752,respectively)and 10μg/m L(median:5.140,3.702,2.250,and 5.172,respectively)of C3 a was significantly increased compared to the control group(median:3.137,2.004,0.573,and 2.257,respectively)(1μg/m L P=0.001,P=0.003,P<0.001,and P=0.008,respectively;10μg/m L:P<0.001,P=0.019,P<0.001,and P=0.002,respectively).The absorption areas of the osteoclast resorption pits per view induced by 1μg/m L(mean±SD:51.464±11.983%)and 10μg/m L(50.219±12.067%)of C3 a was also significantly increased(33.845±8.331%)(P<0.001 and P<0.001,respectively)compared to the control.There was no difference between the C4 a and control groups.RNA-seq analysis showed that C3 a promoted the proliferation of osteoclasts using the phosphoinositide 3-kinase(PI3 K)signaling pathway.The relative expressions of PIK3 CA/phosphoinositide dependent kinase-1(PDK1)/serum and glucocorticoid inducible protein kinases(SGK3)genes and PI3 K/PDK1/p-SGK3 protein in the C3 a group were significantly higher than in the control group.The activation role of C3 a in osteoclasts of MM patients was reduced by the SGK inhibitor(EMD638683).Conclusions:C3 a activated osteoclasts by regulating the PI3 K/PDK1/SGK3 pathways in MM patients,which was reduced using a SGK inhibitor.Overall,our results identified potential therapeutic targets and strategies for MBD patients。展开更多
Currently, little work has been devoted to the mediators and tools for multi-role production interactions in the mass individualization environment. This paper proposes a kind of hardware-software-integrated mediators...Currently, little work has been devoted to the mediators and tools for multi-role production interactions in the mass individualization environment. This paper proposes a kind of hardware-software-integrated mediators called social sensors （S2ensors） to facilitate the production interactions among customers, manufacturers, and other stakeholders in the social manufacturing systems （SMS）. The concept, classification, operational logics, and for- malization of S2ensors are clarified. S2ensors collect sub- jective data from physical sensors and objective data from sensory input in mobile Apps, merge them into meaningful information for decision-making, and finally feed the decisions back for reaction and execution. Then, an S2en- sors-Cloud platform is discussed to integrate different S2- ensors to work for SMSs in an autonomous way. A demonstrative case is studied by developing a prototype system and the results show that S2ensors and S2ensors- Cloud platform can assist multi-role stakeholders interact and collaborate for the production tasks. It reveals the mediator-enabled mechanisms and methods for production interactions among stakeholders in SMS.展开更多
Under industry 4.0, internet of things(IoT), especially radio frequency identification(RFID) technology, has been widely applied in manufacturing environment. This technology can bring convenience to production contro...Under industry 4.0, internet of things(IoT), especially radio frequency identification(RFID) technology, has been widely applied in manufacturing environment. This technology can bring convenience to production control and production transparency. Meanwhile, it generates increasing production data that are sometimes discrete, uncorrelated, and hard-to-use. Thus,an efficient analysis method is needed to utilize the invaluable data. This work provides an RFID-based production data analysis method for production control in Io T-enabled smart job-shops.The physical configuration and operation logic of Io T-enabled smart job-shop production are firstly described. Based on that,an RFID-based production data model is built to formalize and correlate the heterogeneous production data. Then, an eventdriven RFID-based production data analysis method is proposed to construct the RFID events and judge the process command execution. Furthermore, a near big data approach is used to excavate hidden information and knowledge from the historical production data. A demonstrative case is studied to verify the feasibility of the proposed model and methods. It is expected that our work will provide a different insight into the RFIDbased production data analysis.展开更多
Objective To investigate the expression of the preferentially expressed antigen of melanoma （PRAME） gene in acute leukemia and its clinical significance. Methods The level of expressed PRAME mRNA in bone marrow mono...Objective To investigate the expression of the preferentially expressed antigen of melanoma （PRAME） gene in acute leukemia and its clinical significance. Methods The level of expressed PRAME mRNA in bone marrow mononuclear cells from 34 patients with acute leukemia （AL） and in 12 bone marrow samples from healthy volunteers was measured via RT-PCR. Correlation analyses between PRAME gene expression and the clinical characteristics （gender, age, white blood count, immunophenotype of leukemia, percentage of blast cells, and karyotype） of the patients were performed. Results The PRAME gene was expressed in 38.2% of all 34 patients, in 40.7% of the patients with acute myelogenous leukemia （AML, n=27）, and in 28.6% of the patients with acute lymphoblastic leukemia （ALL, n=7）, but was not expressed in the healthy volunteers. The difference in the expression levels between AML and ALL patients was statistically significant. The rate of gene expression was 80% in M~, 33.3% in M2, and 28.6% in M~. Gene expression was also found to be correlated with CDl5 and CD33 expression and abnormal karyotype, but not with age, gender; white blood count or percentage of blast cells. Conclusions The PRAME gene is highly expressed in acute leukemia and could be a useful marker to monitor minimal residual disease. This gene is also a candidate target for the immunotherapy of acute leukemia.展开更多
The poplar and willow weevil,Crypto rhynchus lapathi L.,a major universally destructive wood-boring insect has become one of the important quarantine pests that is extremely destructive to forestry development and nee...The poplar and willow weevil,Crypto rhynchus lapathi L.,a major universally destructive wood-boring insect has become one of the important quarantine pests that is extremely destructive to forestry development and needs to be controlled.Entomopathogenic fungi(EPF) are considered safe and friendly for humans and the environment and play important roles in controlling insect pest populations.In this study,the screening of entomopathogenic fungi for control of C.lapathi is reported through the evaluation of virulence of four fungal Beauveria bassiana(CFCC81428,CFCC83116,CFCC83486,CFCC87297)strains,one B.brongniartii(CFCC83487) strain and one Metarhizium anisopliae(CFCC88953) strain.The virulence of the different strains was appraised by correct mortality rate,cumulative mortality rate,median lethal concentration(LC_(50)) and median lethal time(LT_(50)).B.bassiana strains CFCC81428 and CFCC83116 were the most virulent among the six strains with a mortality up to 100%,and the LT_(50) were 2.7 and 3.1 days.Five conidia concentrations of three strains(CFCC81428,CFCC83116 and CFCC87298) that caused high virulence was screened for dose-relationship.Their effect on controlling C.lapathi larvae were also determined under field condition by brushing conidia suspensions on C.lapathi larvae infested in a poplar trunk.The cumulative rate in the field was lower than those obtained from the laboratory,but the order of the virulence of different strains did not change.Mortality in all three strains occurred at their highest concentration(1.0 × 10^(8) conidia mL^(-1)).Under field conditions,the CFCC81428 strain was the most effective,causing mortalities of 80.3% and 75.2%in two plots in Beipiao and Lindian counties,respectively,followed by CFCC83116(69.1%,66.6%) and CFCC87298(60.7%,59.3%).Based on our results,the B.bassiana strain CFCC81428 has the potential as a biological insecticide to control C.lapathi larvae.展开更多
Purpose: To investigate the efficacy of a new algorithm to increase the volume of tissue ablation via gradual ramp-up of power using an internally cooled electrode for ablating hepatomas 3 cm or less. Materials and Me...Purpose: To investigate the efficacy of a new algorithm to increase the volume of tissue ablation via gradual ramp-up of power using an internally cooled electrode for ablating hepatomas 3 cm or less. Materials and Methods: 44 patients with 62 hepatomas were treated from March 4, 2004 to May 24, 2009. Ablation with a gradual ramp-up of power was performed using a single needle with an internally cooled electrode. Evaluation for tumor response was performed with 4-phase CT at 24 hours and 3 months. All immediate and follow-up complications were recorded. Results: Complete tumor ablation was achieved in 86%. The ablation volumes were 16 cm3 +/- 12 cm3 for tumors 3 +/- 12 cm3 for tumors 2 - 3 cm. Out of 68 total ablation sessions, there were 2 major complications (pleural effusions) requiring intervention (thoracentesis). Conclusion: Compared with existing techniques using a constant full-power setting, ablation of small hepatomas using an algorithm of gradual ramp-up of power provides comparable rate of complete tumor ablation, adequate ablation volumes, and a low rate of complications that require treatment.展开更多
The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor progression.However,the precise molecular mechanisms governing the nuclear import of YAP are not ...The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor progression.However,the precise molecular mechanisms governing the nuclear import of YAP are not fully understood.In this study,we have uncovered a crucial role of SOX9 in the activation of YAP.SOX9 promotes the nuclear translocation of YAP by direct interaction.Importantly,we have identified that the binding between Asp-125 of SOX9 and Arg-124 of YAP is essential for SOX9-YAP interaction and subsequent nuclear entry of YAP.Additionally,we have discovered a novel asymmetrical dimethylation of YAP at Arg-124(YAP-R124me2a)catalyzed by PRMT1.YAP-R124me2a enhances the interaction between YAP and SOX9 and is associated with poor prognosis in multiple cancers.Furthermore,we disrupted the interaction between SOX9 and YAP using a competitive peptide,S-A1,which mimics anα-helix of SOX9 containing Asp-125.S-A1 significantly inhibits YAP nuclear translocation and effectively suppresses tumor growth.This study provides the first evidence of SOX9 as a pivotal regulator driving YAP nuclear translocation and presents a potential therapeutic strategy for YAP-driven human cancers by targeting SOX9-YAP interaction.展开更多
Asia stands out as a priority for urgent biodiversity conservation due to its large protected areas(PAs)and threatened species.Since the 21st century,both the highlands and lowlands of Asia have been experiencing the ...Asia stands out as a priority for urgent biodiversity conservation due to its large protected areas(PAs)and threatened species.Since the 21st century,both the highlands and lowlands of Asia have been experiencing the dramatic human expansion.However,the threat degree of human expansion to biodiversity is poorly understood.Here,the threat degree of human expansion to biodiversity over 2000 to 2020 in Asia at the continental(Asia),national(48 Asian countries),and hotspot(6,502 Asian terrestrial PAs established before 2000)scales is investigated by integrating multiple large-scale data.The results show that human expansion poses widespread threat to biodiversity in Asia,especially in Southeast Asia,with Malaysia,Cambodia,and Vietnam having the largest threat degrees(~1.5 to 1.7 times of the Asian average level).Human expansion in highlands induces higher threats to biodiversity than that in lowlands in one-third Asian countries(most Southeast Asian countries).The regions with threats to biodiversity are present in~75%terrestrial PAs(including 4,866 PAs in 26 countries),and human expansion in PAs triggers higher threat degrees to biodiversity than that in non-PAs.Our findings provide novel insight for the Sustainable Development Goal 15(SDG-15 Life on Land)and suggest that human expansion in Southeast Asian countries and PAs might hinder the realization of SDG-15.To reduce the threat degree,Asian developing countries should accelerate economic transformation,and the developed countries in the world should reduce the demands for commodity trade in Southeast Asian countries(i.e.,trade leading to the loss of wildlife habitats)to alleviate human expansion,especially in PAs and highlands.展开更多
Zinc oxide,a wide band-gap semiconductor,has shown extensive potential applications in high-efficiency semiconductor photoelectronic devices,semiconductor photocatalysis,and diluted magnetic semiconductors.Due to the ...Zinc oxide,a wide band-gap semiconductor,has shown extensive potential applications in high-efficiency semiconductor photoelectronic devices,semiconductor photocatalysis,and diluted magnetic semiconductors.Due to the undisputed lattice integrity,ZnO single crystals are essential for the fabrication of high-quality ZnO-based photoelectronic devices,and also believed to be ideal research subjects for understanding the underlying mechanisms of semiconductor photocatalysis and diluted magnetic semiconductors.This review,which is organized in two main parts,introduces the recent progress in growth,basic characterization,and device development of ZnO single crystals,and some related works in our group.The first part begins from the growth of ZnO single crystal,and summarizes the fundamental and applied investigations based on ZnO single crystals.These works are composed of the fabrication of homoepitaxial ZnO-based photoelectronic devices,the research on the photocatalysis mechanism,and dilute magnetic mechanism.The second part describes the fabrication of highly thermostable n-type ZnO with high mobility and high electron concentration through intentional doping.More importantly,in this part,a conceptual approach for fabricating highly thermostable p-type ZnO materials with high mobility through an integrated three-step treatment is proposed on the basis of the preliminary research.展开更多
Profiled monolayer cBN wheel was induction brazed for grinding of titanium dovetail slot in this study.Aimed at acquiring a uniform temperature distribution along the profiled surface and reducing the thermal deformat...Profiled monolayer cBN wheel was induction brazed for grinding of titanium dovetail slot in this study.Aimed at acquiring a uniform temperature distribution along the profiled surface and reducing the thermal deformation of the brazed wheel,a finite element model was established to investigate the temperature uniformity during induction brazing.A suitable induction coil and the related working parameters were designed and chosen based on the simulation results.Ag-Cu-Ti alloy and cBN grains were applied in the induction brazing experiment.The results showed geometric deformation of the brazed wheel was no more than 0.01 mm and chemical reaction layer were found on the brazed joint interface.Further validation tests were carried out by grinding of Ti-6 Al-4 V alloy.Compared to the electroplated wheel,the brazed wheel showed better performance such as low specific grinding energy and good ground quality in grinding of Ti-6 Al-4 V alloy.Abrasion wear was found to be the main failure mode for the induction brazed wheel,while adhesion and grains pull-out were the main failure mode for the electroplated wheel.展开更多
High chromium （9-12% Cr） steels with excellent heat resistance and CrMoV steels with good toughness were potential candidates for combined rotor for steam turbine operated over 620℃. Two welding techniques were use...High chromium （9-12% Cr） steels with excellent heat resistance and CrMoV steels with good toughness were potential candidates for combined rotor for steam turbine operated over 620℃. Two welding techniques were used to fabricate 9% Cr and CrMoV dissimilar welded joint. The results show that the carbon migration only appears in the specimen using narrow gap submerged arc welding （NG-SAW） technique, yet it can be effectively prevented by adding tungsten inert gas （TlG） overlaying process before the NG-SAW. The carbon migration occurred in NG-SAW resulting from the sharp transition of the strong carbide-forming element Cr between the weld （-2.7 wt%） and the base metal （- 9 wt%）. On the contrary, the application of TIG overlaying layers can promote the diffusion of Cr element, and therefore result in its much smaller concentration gradient. That is to say, a gentle transition zone of Cr element can be created among the SAW weld, TIG overlaying layers and the base metal, which effectively prevents the carbon migration and therefore produces a decreased carbon concentration adjacent to the fusion line.展开更多
The morphology and distribution of residual austenite in the welded zone of 9% Cr/CrMoV dissimilar welded joint were observed by color metallographic method. Moreover, the details of the distribution, shape, length, l...The morphology and distribution of residual austenite in the welded zone of 9% Cr/CrMoV dissimilar welded joint were observed by color metallographic method. Moreover, the details of the distribution, shape, length, length-to-width ratio, and the content of residual austenite in each welding layer were systematically characterized using Image-Pro Plus image analysis software. Different from the techniques such as X-ray diffraction, vibrating sample magnetometer, and electron backscatter diffraction that only involve the content of residual austenite, color metallographic method can offer much more details of the residual austenite, including the location, shape, size, and content, helping evaluate the overall characteristics of the residual austenite produced in the weld. It is interesting that a large amount of block-like and film-like residual austenite was found in the root of each welding layer, while rare at the top. The area fraction of residual austenite located in this zone was approximately 7.5% compared with only 0.5% at the top. In addition, the average area, length, and length-to-width ratio of dispersed residual austenite were quantitatively evaluated to be （4.7 ± 0.6）μm2, （5.1 ±0.6） μm, and （1.1 ± 0.1） μm, respectively. This variety of residual austenite was resulted from the tempering effect by latter welding layer on the previous one and different cooling rates in these two regions during the welding process.展开更多
In recent years,feature engineering-based machine learning models have made significant progress in auto insurance fraud detection.However,most models or systems focused only on structural data and did not utilize mul...In recent years,feature engineering-based machine learning models have made significant progress in auto insurance fraud detection.However,most models or systems focused only on structural data and did not utilize multi-modal data to improve fraud detection efficiency.To solve this problem,we adapt both natural language processing and computer vision techniques to our knowledge-based algorithm and construct an Auto Insurance Multi-modal Learning(AIML)framework.We then apply AIML to detect fraud behavior in auto insurance cases with data from real scenarios and conduct experiments to examine the improvement in model performance with multi-modal data compared to baseline model with structural data only.A selfdesigned Semi-Auto Feature Engineer(SAFE)algorithm to process auto insurance data and a visual data processing framework are embedded within AIML.Results show that AIML substantially improves the model performance in detecting fraud behavior compared to models that only use structural data.展开更多
The cultivated area of jujube in Xinjiang has increased rapidly in recent years.While the jujube harvest by hand has the shortage of high labor intensity,low efficiency and high labor cost,in addition,the harvesting m...The cultivated area of jujube in Xinjiang has increased rapidly in recent years.While the jujube harvest by hand has the shortage of high labor intensity,low efficiency and high labor cost,in addition,the harvesting machinery applying to dwarf and dense planting mode of jujubes is unavailable in Xinjiang.The 4ZZ-4A2 based on the full-hydraulic self-propelled jujube harvester was designed to solve the above problems.The harvester was mainly composed of a frame,a vibrating device,a jujube collecting and conveying device,an air separation device,a steering system,a hydraulic system and a jujube suction device and was capable of completing vibration,collection,conveying,cleaning and sundries removal work of jujubes through one step.The jujubes dropped on the ground were picked up at the same time.The AMESim simulation software was adopted to perform simulation analysis on the overall hydraulic system.The results showed that the speed of the vibrating motor was stable at about 650 r/min(the corresponding vibration frequency is 10.83 Hz)with the torque of 80 N·m,the speed of the conveyor motor was stable at 77 r/min with the torque of 77 N·m;the speed of the fan motor was stable at 54 r/min with the torque of 53.6 N·m;the speed of the walking motor fluctuated around 100 r/min with the torque of about 1000 N·m;the hydraulic steering system responded rapidly and could satisfy the actual working requirements of the jujube harvester.The jujube garden test results showed that the harvester could reach to the optimum harvesting effect when running at the speed of 0.5 m/s.Under such speed,the ground jujube picking rate was 45.1%,the tree jujube harvesting rate was 93.2%,the loss rate was 2.9%,and the damage rate was 0.9%.This study can provide theoretical basis and technical support for the jujube harvester.展开更多
基金supported by the National Key R&D Program of China(2018YFC2000400)the National Natural Sciences Foundation of China(72061137004)+1 种基金the National Institute on Aging of National Institutes of Health(P01AG031719)Duke/DukeNUS(grant RECA(Pilot)/2019/0051 to Y.Z.).
文摘This study investigated the association of hypertension with cognitive impairment and determined whether better adherence to plant-based diet(PBD)patterns may modify the association.We analyzed 4485 elderly individuals with normal cognition at baseline from the Chinese Longitudinal Healthy Longevity Survey(2011−2018).Cognitive function was assessed by the Mini-mental State Examination(MMSE),and cognitive impairment was defined as an MMSE score below 18 points.Diet patterns were assessed using the overall plant-based diet index(PDI),healthful plant-based diet index(hPDI),and unhealthful plant-based diet index(uPDI)derived from a simplified food frequency questionnaire(FFQ).Blood pressure was measured through physical examination.Cox proportional hazard regression and restricted cubic spline were performed.Participants with hypertension had an increased risk of cognitive impairment compared with normal group.The associations between hypertension and cognitive impairment were more pronounced among participants with lower PDI than those with higher PDI,among participants with lower hPDI than those with higher hPDI,and among participants with higher uPDI than those with lower uPDI.A healthful PBD pattern may attenuate hypertension-induced cognitive impairment,while an unhealthful PBD pattern may exacerbate hypertensioninduced cognitive impairment in elderly.Adherence to healthful PBD pattern could be used to prevent or mitigate adverse neurological effects in the hypertensive population.
文摘[Objectives]To study the reference value of thyroid function in healthy women of childbearing age during different pregnancies(early,middle and late pregnancy)in Jingzhou City.[Methods]362 healthy women of childbearing age during different pregnancies(early,middle and late pregnancy)were selected as the study group,and 360 non-pregnant women were selected as the control group.Serum thyroid hormone levels in the two groups were detected,and the reference value was expressed as the median(M)and 95%confidence interval(CI).On this basis,the chart of changing trend of thyroid hormone in the early,middle and late pregnancy were plotted.[Results]Compared with the control group,FT3,TT4,TT3,FT4and TSH in the early,middle and late pregnancy were significantly different in the study group(P<0.05).In the study group,there were significant differences in the early,middle and late pregnancy(P<0.05).[Conclusions]This trend chart has certain reference value in the screening,diagnosis and treatment of thyroid diseases in healthy women of childbearing age during different pregnancies(early,middle and late pregnancy)in Jingzhou City of Hubei Province.
文摘[Objectives]To observe the effects of Wuwei Xiaodu Decoction on uterine energy metabolism and serum inflammatory factors in the acute pelvic inflammatory disease(APID)model.[Methods]75 Wistar rats(females)were randomly divided into control group,model group and Wuwei Xiaodu Decoction low,medium and high dose groups(n=15).Except for the control group,the rat APID model was established by right uterine inoculation.On the fifth day after inoculation,the low,medium and high dose groups of Wuwei Xiaodu Decoction were administered at 4,8 and 16 g/kg,and the control group and model group received normal saline.Rats were killed 12 h after nondose administration,blood was collected from the abdominal aorta and measured by ELISA for serum interleukin-6(interleukin-6,IL-6),IL-8,and C-reactive proteins(CRP);the right uterus of rats was tested for high-energy phosphate adenosine phosphate(AMP),adenosine diphosphate(ADP),adenosine triphosphate(ATP)and total adenine nucleotides(TAN)level to evaluate the uterine energy metabolism.[Results]AMP,ADP,ATP and TAN were significantly higher in the Wuwei Xiaodu Decoction of low,medium and high dose than the model group,while the serum IL-6,IL-8 and CRP were significantly lower than the model group,and the difference between the low,medium and high doses(P<0.05).[Conclusions]The Wuwei Xiaodu Decoction can dose-dependent promote uterine energy metabolism and inhibit inflammatory response in APID model rats.
基金Supported by Fuyang Municipal Government--Fuyang Normal University Horizontal Cooperation Project(XDHX2016014)2018 Anhui Provincial Key Research and Development Plan(1804h07020146)2017 Postgraduate Innovation Research Project of Fuyang Normal University(2017CXJH01)
文摘Jike 33 is a new disease-resistant high-yield multi-ear wheat variety with strong gluten bred by Anhui New Century Agricultural Co.,Ltd. in 2001 with Yannong 19 as the female parent and the self-selected Jike 19( variant of Lumai 14) as the male parent. In 2011-2012,the variety participated in the semi-winter wheat regional test in Huaibei area of Anhui Province,and exhibited a yield of 519. 5 kg/667 m^2,which was 7. 83% higher than that of Wanmai 50 as the CK. In the semi-winter wheat regional test in Huaibei area of Anhui Province in 2012-2013,it showed an average yield of 522. 1 kg/667 m^2,which was 14. 5% higher than that of Wanmai 50 as the CK. and in 2013-2014,the variety participated in the semi-winter wheat production test in Anhui Province,and showed an average yield of 589. 30 kg/667 m2,which was 7. 30% higher than that of Wanmai 52 as the CK. Jike 33 was approved by the Anhui Crop Variety Approval Committee in July,2015.
基金supported by the National Natural Science Foundation of China(No.12172051,No.11802024)Beijing Institute of Technology Research Fund Program for Young Scholars(WXJ2019).
文摘To investigate the shock response of cyclotetramethylene tetranitramine(HMX)single crystals at elevated temperatures(below the phase transition point),plate impact experiments at elevated temperatures were designed and conducted.The HMX/window interface particle velocities at temperatures of 300 K,373 K,and 423 K were measured by the velocity interferometry system for any reflector(VISAR)technique.To further analyze the related mesoscale deformation mechanisms,a nonlinear thermoelastic-viscoplastic model was developed,which considers thermal activation and phonon drag dislocation slip mechanisms.The proposed model could well reproduce the measured thermal hardening behavior of Hugoniot elastic limit(HEL)of HMX single crystals.At elevated temperatures,the reduced dislocation mobility was observed,which stems from both phonon scattering and radiative damping effects.Comparatively speaking,radiative damping contributes less than phonon scattering to thermal hardening behavior.The calibrated model was further used to predict shock response of HMX single crystals with different thicknesses at different initial temperatures.Both the stress relaxation and elastic precursor decrease with thickness are mainly due to the rapid dislocation generation.These insights shed light on the interplay between dislocation motion and dislocation generation in thermal hardening behavior,stress relaxation,and elastic precursor decay,which serves to reveal the mesoscale deformation mechanisms at elevated temperatures.
基金supported by the National Natural Science Foundation of China(Grant Nos.81770110,81900131,and 82000219)the Anticancer Major Special Project of Tianjin(Grant No.12ZCDZSY18000)+4 种基金the Tianjin Municipal Natural Science Foundation(Grant Nos.18JCYBJC27200 and 18JCQNJC80400)the Tianjin Education Commission Research Project(Grant Nos.2018KJ043 and 2018KJ045)the Tianjin Health and Family Planning Commission(Grant No.15KG150)the Youth Incubation Fund of Tianjin Medical University General Hospital(Grant No.ZYYFY2019020)the Tianjin Science and Technology Planning Project(Grant No.20YFZCSY00060)。
文摘Objective:Myeloma bone disease(MBD)is the most common complication of multiple myeloma(MM).Our previous study showed that the serum levels of C3/C4 in MM patients were significantly positively correlated with the severity of bone disease.However,the mechanism of C3 a/C4 a in osteoclasts MM patients remains unclear.Methods:The formation and function of osteoclasts were analyzed after adding C3 a/C4 a in vitro.RNA-seq analysis was used to screen the potential pathways affecting osteoclasts,and the results were verified by Western blot,q RT-PCR,and pathway inhibitors.Results:The osteoclast area per view induced by 1μg/m L(mean±SD:50.828±12.984%)and 10μg/m L(53.663±12.685%)of C3 a was significantly increased compared to the control group(0μg/m L)(34.635±8.916%)(P<0.001 and P<0.001,respectively).The relative m RNA expressions of genes,OSCAR/TRAP/RANKL/cathepsin K,induced by 1μg/m L(median:5.041,3.726,1.638,and 4.752,respectively)and 10μg/m L(median:5.140,3.702,2.250,and 5.172,respectively)of C3 a was significantly increased compared to the control group(median:3.137,2.004,0.573,and 2.257,respectively)(1μg/m L P=0.001,P=0.003,P<0.001,and P=0.008,respectively;10μg/m L:P<0.001,P=0.019,P<0.001,and P=0.002,respectively).The absorption areas of the osteoclast resorption pits per view induced by 1μg/m L(mean±SD:51.464±11.983%)and 10μg/m L(50.219±12.067%)of C3 a was also significantly increased(33.845±8.331%)(P<0.001 and P<0.001,respectively)compared to the control.There was no difference between the C4 a and control groups.RNA-seq analysis showed that C3 a promoted the proliferation of osteoclasts using the phosphoinositide 3-kinase(PI3 K)signaling pathway.The relative expressions of PIK3 CA/phosphoinositide dependent kinase-1(PDK1)/serum and glucocorticoid inducible protein kinases(SGK3)genes and PI3 K/PDK1/p-SGK3 protein in the C3 a group were significantly higher than in the control group.The activation role of C3 a in osteoclasts of MM patients was reduced by the SGK inhibitor(EMD638683).Conclusions:C3 a activated osteoclasts by regulating the PI3 K/PDK1/SGK3 pathways in MM patients,which was reduced using a SGK inhibitor.Overall,our results identified potential therapeutic targets and strategies for MBD patients。
基金Supported by National Natural Science Foundation of China(Grant Nos.71571142,51275396)
文摘Currently, little work has been devoted to the mediators and tools for multi-role production interactions in the mass individualization environment. This paper proposes a kind of hardware-software-integrated mediators called social sensors （S2ensors） to facilitate the production interactions among customers, manufacturers, and other stakeholders in the social manufacturing systems （SMS）. The concept, classification, operational logics, and for- malization of S2ensors are clarified. S2ensors collect sub- jective data from physical sensors and objective data from sensory input in mobile Apps, merge them into meaningful information for decision-making, and finally feed the decisions back for reaction and execution. Then, an S2en- sors-Cloud platform is discussed to integrate different S2- ensors to work for SMSs in an autonomous way. A demonstrative case is studied by developing a prototype system and the results show that S2ensors and S2ensors- Cloud platform can assist multi-role stakeholders interact and collaborate for the production tasks. It reveals the mediator-enabled mechanisms and methods for production interactions among stakeholders in SMS.
基金supported by the National Natural Science Foundation of China(71571142,51275396)
文摘Under industry 4.0, internet of things(IoT), especially radio frequency identification(RFID) technology, has been widely applied in manufacturing environment. This technology can bring convenience to production control and production transparency. Meanwhile, it generates increasing production data that are sometimes discrete, uncorrelated, and hard-to-use. Thus,an efficient analysis method is needed to utilize the invaluable data. This work provides an RFID-based production data analysis method for production control in Io T-enabled smart job-shops.The physical configuration and operation logic of Io T-enabled smart job-shop production are firstly described. Based on that,an RFID-based production data model is built to formalize and correlate the heterogeneous production data. Then, an eventdriven RFID-based production data analysis method is proposed to construct the RFID events and judge the process command execution. Furthermore, a near big data approach is used to excavate hidden information and knowledge from the historical production data. A demonstrative case is studied to verify the feasibility of the proposed model and methods. It is expected that our work will provide a different insight into the RFIDbased production data analysis.
文摘Objective To investigate the expression of the preferentially expressed antigen of melanoma （PRAME） gene in acute leukemia and its clinical significance. Methods The level of expressed PRAME mRNA in bone marrow mononuclear cells from 34 patients with acute leukemia （AL） and in 12 bone marrow samples from healthy volunteers was measured via RT-PCR. Correlation analyses between PRAME gene expression and the clinical characteristics （gender, age, white blood count, immunophenotype of leukemia, percentage of blast cells, and karyotype） of the patients were performed. Results The PRAME gene was expressed in 38.2% of all 34 patients, in 40.7% of the patients with acute myelogenous leukemia （AML, n=27）, and in 28.6% of the patients with acute lymphoblastic leukemia （ALL, n=7）, but was not expressed in the healthy volunteers. The difference in the expression levels between AML and ALL patients was statistically significant. The rate of gene expression was 80% in M~, 33.3% in M2, and 28.6% in M~. Gene expression was also found to be correlated with CDl5 and CD33 expression and abnormal karyotype, but not with age, gender; white blood count or percentage of blast cells. Conclusions The PRAME gene is highly expressed in acute leukemia and could be a useful marker to monitor minimal residual disease. This gene is also a candidate target for the immunotherapy of acute leukemia.
基金The work was supported by the“Applied Technology Research and Development Project of Heilongjiang Province(GA20B401-2)”the Central University Basic Research Business Expenses Special Fund Project(2572018BA06).
文摘The poplar and willow weevil,Crypto rhynchus lapathi L.,a major universally destructive wood-boring insect has become one of the important quarantine pests that is extremely destructive to forestry development and needs to be controlled.Entomopathogenic fungi(EPF) are considered safe and friendly for humans and the environment and play important roles in controlling insect pest populations.In this study,the screening of entomopathogenic fungi for control of C.lapathi is reported through the evaluation of virulence of four fungal Beauveria bassiana(CFCC81428,CFCC83116,CFCC83486,CFCC87297)strains,one B.brongniartii(CFCC83487) strain and one Metarhizium anisopliae(CFCC88953) strain.The virulence of the different strains was appraised by correct mortality rate,cumulative mortality rate,median lethal concentration(LC_(50)) and median lethal time(LT_(50)).B.bassiana strains CFCC81428 and CFCC83116 were the most virulent among the six strains with a mortality up to 100%,and the LT_(50) were 2.7 and 3.1 days.Five conidia concentrations of three strains(CFCC81428,CFCC83116 and CFCC87298) that caused high virulence was screened for dose-relationship.Their effect on controlling C.lapathi larvae were also determined under field condition by brushing conidia suspensions on C.lapathi larvae infested in a poplar trunk.The cumulative rate in the field was lower than those obtained from the laboratory,but the order of the virulence of different strains did not change.Mortality in all three strains occurred at their highest concentration(1.0 × 10^(8) conidia mL^(-1)).Under field conditions,the CFCC81428 strain was the most effective,causing mortalities of 80.3% and 75.2%in two plots in Beipiao and Lindian counties,respectively,followed by CFCC83116(69.1%,66.6%) and CFCC87298(60.7%,59.3%).Based on our results,the B.bassiana strain CFCC81428 has the potential as a biological insecticide to control C.lapathi larvae.
文摘Purpose: To investigate the efficacy of a new algorithm to increase the volume of tissue ablation via gradual ramp-up of power using an internally cooled electrode for ablating hepatomas 3 cm or less. Materials and Methods: 44 patients with 62 hepatomas were treated from March 4, 2004 to May 24, 2009. Ablation with a gradual ramp-up of power was performed using a single needle with an internally cooled electrode. Evaluation for tumor response was performed with 4-phase CT at 24 hours and 3 months. All immediate and follow-up complications were recorded. Results: Complete tumor ablation was achieved in 86%. The ablation volumes were 16 cm3 +/- 12 cm3 for tumors 3 +/- 12 cm3 for tumors 2 - 3 cm. Out of 68 total ablation sessions, there were 2 major complications (pleural effusions) requiring intervention (thoracentesis). Conclusion: Compared with existing techniques using a constant full-power setting, ablation of small hepatomas using an algorithm of gradual ramp-up of power provides comparable rate of complete tumor ablation, adequate ablation volumes, and a low rate of complications that require treatment.
基金supported by the National Natural Science Foundation of China(grant 82072641 to X.Z.,grant 82030021 to W.F.X.,grant 82070620 to H.Q.,grant 81802324 to C.H.D.,grant 81703415 to S.J.C.,grant 91853205 to C.L.,grant 81900514 to K.D.)National Key R&D Program of China(grant 2023YFC2507500 to W.F.X.)+4 种基金the Science and Technology Commission of Shanghai Municipality(grant 21ZR1474700 to S.J.C.)the Youth Innovation Promotion Association of CAS(grant 2022279 to S.J.C.)the High-level New R&D Institute(grant 2019B090904008 to C.L.)High-level Innovative Research Institute(grant 2021B0909050003 to C.L.)This work was also supported by the Ministry of Education Key Laboratory on Signaling Regulation and Targeting Therapy of Liver Cancer,and Shanghai Key Laboratory of Hepato-biliary Tumor Biology.
文摘The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor progression.However,the precise molecular mechanisms governing the nuclear import of YAP are not fully understood.In this study,we have uncovered a crucial role of SOX9 in the activation of YAP.SOX9 promotes the nuclear translocation of YAP by direct interaction.Importantly,we have identified that the binding between Asp-125 of SOX9 and Arg-124 of YAP is essential for SOX9-YAP interaction and subsequent nuclear entry of YAP.Additionally,we have discovered a novel asymmetrical dimethylation of YAP at Arg-124(YAP-R124me2a)catalyzed by PRMT1.YAP-R124me2a enhances the interaction between YAP and SOX9 and is associated with poor prognosis in multiple cancers.Furthermore,we disrupted the interaction between SOX9 and YAP using a competitive peptide,S-A1,which mimics anα-helix of SOX9 containing Asp-125.S-A1 significantly inhibits YAP nuclear translocation and effectively suppresses tumor growth.This study provides the first evidence of SOX9 as a pivotal regulator driving YAP nuclear translocation and presents a potential therapeutic strategy for YAP-driven human cancers by targeting SOX9-YAP interaction.
基金supported by National Natural Science Foundation of China(42201319)the Basic Research Project of Shenzhen Science and Technology Innovation Committee(JCYJ20180507182022554)+3 种基金the National Natural Science Foundation of China(71961137003,41890854,and 62102268)the Shenzhen Polytechnic Youth Innovation Project(6021310008K)the China Postdoctoral Science Foundation(2021M702231)the Basic and Applied Basic Research Funding Program of Guangdong Province of China(2019A1515110303).
文摘Asia stands out as a priority for urgent biodiversity conservation due to its large protected areas(PAs)and threatened species.Since the 21st century,both the highlands and lowlands of Asia have been experiencing the dramatic human expansion.However,the threat degree of human expansion to biodiversity is poorly understood.Here,the threat degree of human expansion to biodiversity over 2000 to 2020 in Asia at the continental(Asia),national(48 Asian countries),and hotspot(6,502 Asian terrestrial PAs established before 2000)scales is investigated by integrating multiple large-scale data.The results show that human expansion poses widespread threat to biodiversity in Asia,especially in Southeast Asia,with Malaysia,Cambodia,and Vietnam having the largest threat degrees(~1.5 to 1.7 times of the Asian average level).Human expansion in highlands induces higher threats to biodiversity than that in lowlands in one-third Asian countries(most Southeast Asian countries).The regions with threats to biodiversity are present in~75%terrestrial PAs(including 4,866 PAs in 26 countries),and human expansion in PAs triggers higher threat degrees to biodiversity than that in non-PAs.Our findings provide novel insight for the Sustainable Development Goal 15(SDG-15 Life on Land)and suggest that human expansion in Southeast Asian countries and PAs might hinder the realization of SDG-15.To reduce the threat degree,Asian developing countries should accelerate economic transformation,and the developed countries in the world should reduce the demands for commodity trade in Southeast Asian countries(i.e.,trade leading to the loss of wildlife habitats)to alleviate human expansion,especially in PAs and highlands.
基金supported by the National Natural Science Foundation of China(60736032,20971123,51002153,21007070,51102232,61106004 and 21103191)the National Basic Research Program of China(2007CB936703)+2 种基金the Knowledge Innovation Program of the Chinese Academy of Sciences(KJC2.YW.317,KJC2.YW.W01)the Fujian Natural Science Foundation of China(2005HZ1023,2006F3140,2007F3113,2007HZ0005-3,2010J01054,2010J06006,2010J05038 and 2012J05033)the China NationalFunds for Distinguished Young Scientists(50625205)
文摘Zinc oxide,a wide band-gap semiconductor,has shown extensive potential applications in high-efficiency semiconductor photoelectronic devices,semiconductor photocatalysis,and diluted magnetic semiconductors.Due to the undisputed lattice integrity,ZnO single crystals are essential for the fabrication of high-quality ZnO-based photoelectronic devices,and also believed to be ideal research subjects for understanding the underlying mechanisms of semiconductor photocatalysis and diluted magnetic semiconductors.This review,which is organized in two main parts,introduces the recent progress in growth,basic characterization,and device development of ZnO single crystals,and some related works in our group.The first part begins from the growth of ZnO single crystal,and summarizes the fundamental and applied investigations based on ZnO single crystals.These works are composed of the fabrication of homoepitaxial ZnO-based photoelectronic devices,the research on the photocatalysis mechanism,and dilute magnetic mechanism.The second part describes the fabrication of highly thermostable n-type ZnO with high mobility and high electron concentration through intentional doping.More importantly,in this part,a conceptual approach for fabricating highly thermostable p-type ZnO materials with high mobility through an integrated three-step treatment is proposed on the basis of the preliminary research.
基金the National Natural Science Foundation of China(Nos.51905234,51805231,51975264,51905275,51705463)。
文摘Profiled monolayer cBN wheel was induction brazed for grinding of titanium dovetail slot in this study.Aimed at acquiring a uniform temperature distribution along the profiled surface and reducing the thermal deformation of the brazed wheel,a finite element model was established to investigate the temperature uniformity during induction brazing.A suitable induction coil and the related working parameters were designed and chosen based on the simulation results.Ag-Cu-Ti alloy and cBN grains were applied in the induction brazing experiment.The results showed geometric deformation of the brazed wheel was no more than 0.01 mm and chemical reaction layer were found on the brazed joint interface.Further validation tests were carried out by grinding of Ti-6 Al-4 V alloy.Compared to the electroplated wheel,the brazed wheel showed better performance such as low specific grinding energy and good ground quality in grinding of Ti-6 Al-4 V alloy.Abrasion wear was found to be the main failure mode for the induction brazed wheel,while adhesion and grains pull-out were the main failure mode for the electroplated wheel.
文摘High chromium （9-12% Cr） steels with excellent heat resistance and CrMoV steels with good toughness were potential candidates for combined rotor for steam turbine operated over 620℃. Two welding techniques were used to fabricate 9% Cr and CrMoV dissimilar welded joint. The results show that the carbon migration only appears in the specimen using narrow gap submerged arc welding （NG-SAW） technique, yet it can be effectively prevented by adding tungsten inert gas （TlG） overlaying process before the NG-SAW. The carbon migration occurred in NG-SAW resulting from the sharp transition of the strong carbide-forming element Cr between the weld （-2.7 wt%） and the base metal （- 9 wt%）. On the contrary, the application of TIG overlaying layers can promote the diffusion of Cr element, and therefore result in its much smaller concentration gradient. That is to say, a gentle transition zone of Cr element can be created among the SAW weld, TIG overlaying layers and the base metal, which effectively prevents the carbon migration and therefore produces a decreased carbon concentration adjacent to the fusion line.
文摘The morphology and distribution of residual austenite in the welded zone of 9% Cr/CrMoV dissimilar welded joint were observed by color metallographic method. Moreover, the details of the distribution, shape, length, length-to-width ratio, and the content of residual austenite in each welding layer were systematically characterized using Image-Pro Plus image analysis software. Different from the techniques such as X-ray diffraction, vibrating sample magnetometer, and electron backscatter diffraction that only involve the content of residual austenite, color metallographic method can offer much more details of the residual austenite, including the location, shape, size, and content, helping evaluate the overall characteristics of the residual austenite produced in the weld. It is interesting that a large amount of block-like and film-like residual austenite was found in the root of each welding layer, while rare at the top. The area fraction of residual austenite located in this zone was approximately 7.5% compared with only 0.5% at the top. In addition, the average area, length, and length-to-width ratio of dispersed residual austenite were quantitatively evaluated to be （4.7 ± 0.6）μm2, （5.1 ±0.6） μm, and （1.1 ± 0.1） μm, respectively. This variety of residual austenite was resulted from the tempering effect by latter welding layer on the previous one and different cooling rates in these two regions during the welding process.
基金supported by"Research on intelligent Computing technology in Financial Risk Control and Anti-fraud",funding code 2020NFACO1,Zhejiang Lab,leaded by Dr.Chongning Na.
文摘In recent years,feature engineering-based machine learning models have made significant progress in auto insurance fraud detection.However,most models or systems focused only on structural data and did not utilize multi-modal data to improve fraud detection efficiency.To solve this problem,we adapt both natural language processing and computer vision techniques to our knowledge-based algorithm and construct an Auto Insurance Multi-modal Learning(AIML)framework.We then apply AIML to detect fraud behavior in auto insurance cases with data from real scenarios and conduct experiments to examine the improvement in model performance with multi-modal data compared to baseline model with structural data only.A selfdesigned Semi-Auto Feature Engineer(SAFE)algorithm to process auto insurance data and a visual data processing framework are embedded within AIML.Results show that AIML substantially improves the model performance in detecting fraud behavior compared to models that only use structural data.
基金Thanks the National Natural Science Foundation of China-Based on Self-excited Vibration and Force Compensation Theory Jujube Vibration Recovery Mechanism Research(51365049)National Key Research and Development Plan-Jujube Harvesting Technical Equipment and Development(2016YFD0701504)for supporting the project,and Xinjiang Production&Construction Corps major scientific research projects:The optimization and pilot test of self-propelled harvester of dwarf and close planting jujube(2013AA001-3).
文摘The cultivated area of jujube in Xinjiang has increased rapidly in recent years.While the jujube harvest by hand has the shortage of high labor intensity,low efficiency and high labor cost,in addition,the harvesting machinery applying to dwarf and dense planting mode of jujubes is unavailable in Xinjiang.The 4ZZ-4A2 based on the full-hydraulic self-propelled jujube harvester was designed to solve the above problems.The harvester was mainly composed of a frame,a vibrating device,a jujube collecting and conveying device,an air separation device,a steering system,a hydraulic system and a jujube suction device and was capable of completing vibration,collection,conveying,cleaning and sundries removal work of jujubes through one step.The jujubes dropped on the ground were picked up at the same time.The AMESim simulation software was adopted to perform simulation analysis on the overall hydraulic system.The results showed that the speed of the vibrating motor was stable at about 650 r/min(the corresponding vibration frequency is 10.83 Hz)with the torque of 80 N·m,the speed of the conveyor motor was stable at 77 r/min with the torque of 77 N·m;the speed of the fan motor was stable at 54 r/min with the torque of 53.6 N·m;the speed of the walking motor fluctuated around 100 r/min with the torque of about 1000 N·m;the hydraulic steering system responded rapidly and could satisfy the actual working requirements of the jujube harvester.The jujube garden test results showed that the harvester could reach to the optimum harvesting effect when running at the speed of 0.5 m/s.Under such speed,the ground jujube picking rate was 45.1%,the tree jujube harvesting rate was 93.2%,the loss rate was 2.9%,and the damage rate was 0.9%.This study can provide theoretical basis and technical support for the jujube harvester.
