Background: We previously reported the effects of finasteride on scalp hair weight and count over a 2-year period in men with androgenetic alopecia (AGA). Objective: Our purpose was to evaluate the effects of finaster...Background: We previously reported the effects of finasteride on scalp hair weight and count over a 2-year period in men with androgenetic alopecia (AGA). Objective: Our purpose was to evaluate the effects of finasteride on hair weight and count over 4 years in men with AGA. Methods: Men with AGA were randomized to receive finasteride (1 mg/d) or placebo for 192weeks. Results of the second (weeks 96- 144) and third (weeks144- 192) extension periods are reported. Results: Finasteride increased hair weight at 144 and 192 weeks (week 192: finasteride,21.6% increase from baseline; placebo, 24.5% decrease from baseline; net increase in hair weight for finasteride vs placebo = 46.0% , P < .001). Hair count also increased with finasteride at 144 and 192 weeks (week 192: finasteride, 7.2% increase from baseline; placebo, 13.0% decrease from baseline;net increase in hair count for finasteride vs placebo = 20.3% , P< .05). Finasteride was generally well tolerated. Limitations:Because this study was extended from its original 48- week duration to nearly 4 years, the sample size available for analysis decreased with time. Conclusion: Long-term finasteride treatment led to sustained improvement in hair weight compared with placebo. Hair weight increased to a larger extent than hair count, implying that factors other than the number of hairs,such as increased growth rate (length) and thickness of hairs,contribute to the beneficial effects of finasteride in treated men.展开更多
文摘Background: We previously reported the effects of finasteride on scalp hair weight and count over a 2-year period in men with androgenetic alopecia (AGA). Objective: Our purpose was to evaluate the effects of finasteride on hair weight and count over 4 years in men with AGA. Methods: Men with AGA were randomized to receive finasteride (1 mg/d) or placebo for 192weeks. Results of the second (weeks 96- 144) and third (weeks144- 192) extension periods are reported. Results: Finasteride increased hair weight at 144 and 192 weeks (week 192: finasteride,21.6% increase from baseline; placebo, 24.5% decrease from baseline; net increase in hair weight for finasteride vs placebo = 46.0% , P < .001). Hair count also increased with finasteride at 144 and 192 weeks (week 192: finasteride, 7.2% increase from baseline; placebo, 13.0% decrease from baseline;net increase in hair count for finasteride vs placebo = 20.3% , P< .05). Finasteride was generally well tolerated. Limitations:Because this study was extended from its original 48- week duration to nearly 4 years, the sample size available for analysis decreased with time. Conclusion: Long-term finasteride treatment led to sustained improvement in hair weight compared with placebo. Hair weight increased to a larger extent than hair count, implying that factors other than the number of hairs,such as increased growth rate (length) and thickness of hairs,contribute to the beneficial effects of finasteride in treated men.
