BACKGROUND Non-steroid anti-inflammatory drugs(NSAIDs)have played a crucial role in the treatment of osteoarthritis,especially in the early stages.However,the cardiovascular risk and adverse gastrointestinal reactions...BACKGROUND Non-steroid anti-inflammatory drugs(NSAIDs)have played a crucial role in the treatment of osteoarthritis,especially in the early stages.However,the cardiovascular risk and adverse gastrointestinal reactions of oral NSAIDs in elderly people cannot be underestimated.Intra-articular injection of NSAIDs may be a new attempt for early knee osteoarthritis treatment.Parecoxib may be a suitable drug for intra-articular injection.AIM To observe the clinical efficacy of the intra-articular injection of parecoxib for early knee osteoarthritis.METHODS Early knee osteoarthritis patients(n=110)were retrospectively analyzed.These patients were divided into three groups:Basic treatment+oral glucosamine(group A,n=37),oral celecoxib+basic treatment+oral glucosamine(group B,n=37),and intra-articular injection of parecoxib+basic treatment+oral glucosamine(group C,n=36).Intra-articular injection of parecoxib was performed once every 2 wk at a dose of 40 mg each time,for three times total.The three groups were compared in terms of visual analogue scale(VAS)scores,Hospital for Special Surgery(HSS)scores and patient satisfaction before and after treatment.The levels of inflammatory cytokines in the synovial fluid were detected in the three groups before and after treatment.RESULTS All patients were followed up for an average of 15.5±2.7 mo.The clinical efficacy was estimated by VAS and HSS scores at 12 mo after treatment.Inflammatory cytokine levels in the synovial fluid were evaluated at 3 mo after treatment.VAS and HSS scores were significantly improved in each group compared with before(P<0.001).There were significant differences among the three groups in VAS and HSS scores(P<0.001).The clinical efficacy of group C was superior to that of groups A and B(P<0.001),while group B outperformed group A in this respect(P<0.001).The patient satisfaction was the highest in group C(P<0.001).After treatment,the levels of tumor necrosis factorα(TNF-α)and interleukin(IL)-6 in the synovial fluid decreased in each group compared with before(P<0.001),while the levels of IL-10 increased(P<0.001).The three groups differed significantly in the levels of TNF-a,IL-6 and IL-10 in the synovial fluid after treatment(P<0.001).CONCLUSION For patients with early knee osteoarthritis,intra-articular injection of parecoxib could effectively improve clinical symptoms.This method may be a reliable alternative for early knee osteoarthritis.展开更多
Porous Si_(3)N_(4) ceramics were prepared by aqueous gelcasting using Si_(3)N_(4) poly-hollow microspheres(PHMs)as pore-forming agent.The effects of solid loading of Si_(3)N_(4) slurry and Si_(3)N_(4) PHM content on t...Porous Si_(3)N_(4) ceramics were prepared by aqueous gelcasting using Si_(3)N_(4) poly-hollow microspheres(PHMs)as pore-forming agent.The effects of solid loading of Si_(3)N_(4) slurry and Si_(3)N_(4) PHM content on the properties of porous Si_(3)N_(4) ceramics were investigated.Onlyβ-Si_(3)N_(4) phase is observed in porous Si_(3)N_(4) ceramics,and Si_(3)N_(4) PHMs distribute uniformly both in Si_(3)N_(4) green samples and porous Si_(3)N_(4) ceramics.Results show that solid loading of Si_(3)N_(4) slurry and Si_(3)N_(4) PHM content could considerably influence the properties of porous Si_(3)N_(4) ceramics.With the increase of solid loading of Si_(3)N_(4) slurry(decrease of Si_(3)N_(4) PHM content),the distributing state of Si_(3)N_(4) PHMs changes from contacting with each other to just embedding in the matrix,thus their porosity decreases,while their shrinkage,flexural strength,and fracture toughness increase.展开更多
基金National Natural Science Foundation of China,NO.81774274Project of Jiangsu Provincial Hospital of Traditional Chinese Medicine,NO.Y19058
文摘BACKGROUND Non-steroid anti-inflammatory drugs(NSAIDs)have played a crucial role in the treatment of osteoarthritis,especially in the early stages.However,the cardiovascular risk and adverse gastrointestinal reactions of oral NSAIDs in elderly people cannot be underestimated.Intra-articular injection of NSAIDs may be a new attempt for early knee osteoarthritis treatment.Parecoxib may be a suitable drug for intra-articular injection.AIM To observe the clinical efficacy of the intra-articular injection of parecoxib for early knee osteoarthritis.METHODS Early knee osteoarthritis patients(n=110)were retrospectively analyzed.These patients were divided into three groups:Basic treatment+oral glucosamine(group A,n=37),oral celecoxib+basic treatment+oral glucosamine(group B,n=37),and intra-articular injection of parecoxib+basic treatment+oral glucosamine(group C,n=36).Intra-articular injection of parecoxib was performed once every 2 wk at a dose of 40 mg each time,for three times total.The three groups were compared in terms of visual analogue scale(VAS)scores,Hospital for Special Surgery(HSS)scores and patient satisfaction before and after treatment.The levels of inflammatory cytokines in the synovial fluid were detected in the three groups before and after treatment.RESULTS All patients were followed up for an average of 15.5±2.7 mo.The clinical efficacy was estimated by VAS and HSS scores at 12 mo after treatment.Inflammatory cytokine levels in the synovial fluid were evaluated at 3 mo after treatment.VAS and HSS scores were significantly improved in each group compared with before(P<0.001).There were significant differences among the three groups in VAS and HSS scores(P<0.001).The clinical efficacy of group C was superior to that of groups A and B(P<0.001),while group B outperformed group A in this respect(P<0.001).The patient satisfaction was the highest in group C(P<0.001).After treatment,the levels of tumor necrosis factorα(TNF-α)and interleukin(IL)-6 in the synovial fluid decreased in each group compared with before(P<0.001),while the levels of IL-10 increased(P<0.001).The three groups differed significantly in the levels of TNF-a,IL-6 and IL-10 in the synovial fluid after treatment(P<0.001).CONCLUSION For patients with early knee osteoarthritis,intra-articular injection of parecoxib could effectively improve clinical symptoms.This method may be a reliable alternative for early knee osteoarthritis.
基金supported by China Postdoctoral Science Foundation(Nos.2013M530618 and 2015M572136)National Natural Science Foundation of China(Nos.51172120 and 51372093)+2 种基金Fundamental Research Funds for the Central Universities(HUST:2015J07)Open Fund of State Key Laboratory of New Ceramic and Fine Processing(Tsinghua University)(No.KF201518)the 02 Important and Special Project for the State Science and Technology(No.2013ZX2104-001-002).
文摘Porous Si_(3)N_(4) ceramics were prepared by aqueous gelcasting using Si_(3)N_(4) poly-hollow microspheres(PHMs)as pore-forming agent.The effects of solid loading of Si_(3)N_(4) slurry and Si_(3)N_(4) PHM content on the properties of porous Si_(3)N_(4) ceramics were investigated.Onlyβ-Si_(3)N_(4) phase is observed in porous Si_(3)N_(4) ceramics,and Si_(3)N_(4) PHMs distribute uniformly both in Si_(3)N_(4) green samples and porous Si_(3)N_(4) ceramics.Results show that solid loading of Si_(3)N_(4) slurry and Si_(3)N_(4) PHM content could considerably influence the properties of porous Si_(3)N_(4) ceramics.With the increase of solid loading of Si_(3)N_(4) slurry(decrease of Si_(3)N_(4) PHM content),the distributing state of Si_(3)N_(4) PHMs changes from contacting with each other to just embedding in the matrix,thus their porosity decreases,while their shrinkage,flexural strength,and fracture toughness increase.
