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Transplantation of human induced pluripotent stem cell derived keratinocytes accelerates deep second-degree burn wound healing 被引量:1
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作者 li-Jun Wu Wei lin +5 位作者 Jian-Jiang liu Wei-Xin Chen Wen-Jun He Yuan Shi Xiao liu ke li 《World Journal of Stem Cells》 SCIE 2023年第7期713-733,共21页
BACKGROUND Current evidence shows that human induced pluripotent stem cells(hiPSCs)can effectively differentiate into keratinocytes(KCs),but its effect on skin burn healing has not been reported.AIM To observe the eff... BACKGROUND Current evidence shows that human induced pluripotent stem cells(hiPSCs)can effectively differentiate into keratinocytes(KCs),but its effect on skin burn healing has not been reported.AIM To observe the effects of hiPSCs-derived KCs transplantation on skin burn healing in mice and to preliminarily reveal the underlying mechanisms.METHODS An analysis of differentially expressed genes in burn wounds based on GEO datasets GSE140926,and GSE27186 was established.A differentiation medium containing retinoic acid and bone morphogenetic protein 4 was applied to induce hiPSCs to differentiate into KCs.The expression of KCs marker proteins was detected using immunofluorescence staining.A model of a C57BL/6 mouse with deep cutaneous second-degree burn was created,and then phosphate buffered saline(PBS),hiPSCs-KCs,or hiPSCs-KCs with knockdown of COL7A1 were injected around the wound surface.The wound healing,re-epithelialization,engraftment of hiPSCs-KCs into wounds,proinflammatory factor level,and the NF-κB pathway proteins were assessed by hematoxylin-eosin staining,carboxifluorescein diacetate succinimidyl ester(CFSE)fluorescence staining,enzyme linked immunosorbent assay,and Western blotting on days 3,7,and 14 after the injection,respectively.Moreover,the effects of COL7A1 knockdown on the proliferation and migration of hiPSCs-KCs were confirmed by immunohistochemistry,EdU,Transwell,and damage repair assays.RESULTS HiPSCs-KCs could express the hallmark proteins of KCs.COL7A1 was down-regulated in burn wound tissues and highly expressed in hiPSCs-KCs.Transplantation of hiPSCs-KCs into mice with burn wounds resulted in a significant decrease in wound area,an increase in wound re-epithelialization,a decrease in proinflammatory factors content,and an inhibition of NF-κB pathway activation compared to the PBS group.The in vitro assay showed that COL7A1 knockdown could rescue the inhibition of hiPSCs-KCs proliferation and migration,providing further evidence that COL7A1 speeds up burn wound healing by limiting cell proliferation and migration.CONCLUSION In deep,second-degree burn wounds,COL7A1 can promote KC proliferation and migration while also suppressing the inflammatory response. 展开更多
关键词 Induced pluripotent stem cell KERATINOCYTES Cell transplantation Burn wound healing COL7A1
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Bone marrow-derived mesenchymal stem cell-derived exosomeloaded miR-129-5p targets high-mobility group box 1 attenuates neurological-impairment after diabetic cerebral hemorrhage 被引量:1
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作者 Yue-Ying Wang ke li +5 位作者 Jia-Jun Wang Wei Hua Qi liu Yu-Lan Sun Ji-Ping Qi Yue-Jia Song 《World Journal of Diabetes》 SCIE 2024年第9期1979-2001,共23页
BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of diabetes.The role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patie... BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of diabetes.The role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patients with diabetes are unknown.In this study,we investigated the regulation of BMSC-exo on hyperglycemia-induced neuroinflammation.AIM To study the mechanism of BMSC-exo on nerve function damage after diabetes complicated with cerebral hemorrhage.METHODS BMSC-exo were isolated from mouse BMSC media.This was followed by transfection with microRNA-129-5p(miR-129-5p).BMSC-exo or miR-129-5poverexpressing BMSC-exo were intravitreally injected into a diabetes mouse model with ICH for in vivo analyses and were cocultured with high glucoseaffected BV2 cells for in vitro analyses.The dual luciferase test and RNA immunoprecipitation test verified the targeted binding relationship between miR-129-5p and high-mobility group box 1(HMGB1).Quantitative polymerase chain reaction,western blotting,and enzyme-linked immunosorbent assay were conducted to assess the levels of some inflammation factors,such as HMGB1,interleukin 6,interleukin 1β,toll-like receptor 4,and tumor necrosis factorα.Brain water content,neural function deficit score,and Evans blue were used to measure the neural function of mice.RESULTS Our findings indicated that BMSC-exo can promote neuroinflammation and functional recovery.MicroRNA chip analysis of BMSC-exo identified miR-129-5p as the specific microRNA with a protective role in neuroinflammation.Overexpression of miR-129-5p in BMSC-exo reduced the inflammatory response and neurological impairment in comorbid diabetes and ICH cases.Furthermore,we found that miR-129-5p had a targeted binding relationship with HMGB1 mRNA.CONCLUSION We demonstrated that BMSC-exo can reduce the inflammatory response after ICH with diabetes,thereby improving the neurological function of the brain. 展开更多
关键词 Bone marrow mesenchymal stem cells Exosome Diabetic cerebral hemorrhage Neuroinflammation MicroRNA-129-5p High mobility group box 1
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Effect of substrate temperature and oxygen plasma treatment on the properties of magnetron-sputtered CdS for solar cell applications
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作者 Runxuan Zang Haolin Wang +9 位作者 Xiaoqi Peng ke li Yuehao Gu Yizhe Dong Zhihao Yan Zhiyuan Cai Huihui Gao Shuwei Sheng Rongfeng Tang Tao Chen 《中国科学技术大学学报》 CAS CSCD 北大核心 2024年第6期22-33,I0010,共13页
Cadmium sulfide(CdS)is an n-type semiconductor with excellent electrical conductivity that is widely used as an electron transport material(ETM)in solar cells.At present,numerous methods for preparing CdS thin films h... Cadmium sulfide(CdS)is an n-type semiconductor with excellent electrical conductivity that is widely used as an electron transport material(ETM)in solar cells.At present,numerous methods for preparing CdS thin films have emerged,among which magnetron sputtering(MS)is one of the most commonly used vacuum techniques.For this type of technique,the substrate temperature is one of the key deposition parameters that affects the interfacial properties between the target film and substrate,determining the specific growth habits of the films.Herein,the effect of substrate temperature on the microstructure and electrical properties of magnetron-sputtered CdS(MS-CdS)films was studied and applied for the first time in hydrothermally deposited antimony selenosulfide(Sb_(2)(S,Se)_(3))solar cells.Adjusting the substrate temperature not only results in the design of the flat and dense film with enhanced crystallinity but also leads to the formation of an energy level arrangement with a Sb_(2)(S,Se)_(3)layer that is more favorable for electron transfer.In addition,we developed an oxygen plasma treatment for CdS,reducing the parasitic absorption of the device and resulting in an increase in the short-circuit current density of the solar cell.This study demonstrates the feasibility of MS-CdS in the fabrication of hydrothermal Sb_(2)(S,Se)_(3)solar cells and provides interface optimization strategies to improve device performance. 展开更多
关键词 magnetron sputtering CDS substrate heating plasma treatment Sb_(2)(S Se)_(3) thin film solar cell
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Hierarchical Optimization Method for Federated Learning with Feature Alignment and Decision Fusion
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作者 ke li Xiaofeng Wang Hu Wang 《Computers, Materials & Continua》 SCIE EI 2024年第10期1391-1407,共17页
In the realm of data privacy protection,federated learning aims to collaboratively train a global model.However,heterogeneous data between clients presents challenges,often resulting in slow convergence and inadequate... In the realm of data privacy protection,federated learning aims to collaboratively train a global model.However,heterogeneous data between clients presents challenges,often resulting in slow convergence and inadequate accuracy of the global model.Utilizing shared feature representations alongside customized classifiers for individual clients emerges as a promising personalized solution.Nonetheless,previous research has frequently neglected the integration of global knowledge into local representation learning and the synergy between global and local classifiers,thereby limiting model performance.To tackle these issues,this study proposes a hierarchical optimization method for federated learning with feature alignment and the fusion of classification decisions(FedFCD).FedFCD regularizes the relationship between global and local feature representations to achieve alignment and incorporates decision information from the global classifier,facilitating the late fusion of decision outputs from both global and local classifiers.Additionally,FedFCD employs a hierarchical optimization strategy to flexibly optimize model parameters.Through experiments on the Fashion-MNIST,CIFAR-10 and CIFAR-100 datasets,we demonstrate the effectiveness and superiority of FedFCD.For instance,on the CIFAR-100 dataset,FedFCD exhibited a significant improvement in average test accuracy by 6.83%compared to four outstanding personalized federated learning approaches.Furthermore,extended experiments confirm the robustness of FedFCD across various hyperparameter values. 展开更多
关键词 Federated learning data heterogeneity feature alignment decision fusion hierarchical optimization
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Fast X-ray imaging beamline at SSRF
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作者 ke li Hong-Lan Xie +5 位作者 Ya-Nan Fu Fei-Xiang Wang Guo-Hao Du Jian-Feng ji Biao Deng Ti-Qiao Xiao 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第9期68-81,共14页
The fast X-ray imaging beamline(BL16U2)at Shanghai Synchrotron Radiation Facility(SSRF)is a new beamline that provides X-ray micro-imaging capabilities across a wide range of time scales,spanning from 100 ps toμs and... The fast X-ray imaging beamline(BL16U2)at Shanghai Synchrotron Radiation Facility(SSRF)is a new beamline that provides X-ray micro-imaging capabilities across a wide range of time scales,spanning from 100 ps toμs and ms.This beamline has been specifically designed to facilitate the investigation of a wide range of rapid phenomena,such as the deformation and failure of materials subjected to intense dynamic loads.In addition,it enables the study of high-pressure and high-speed fuel spray processes in automotive engines.The light source of this beamline is a cryogenic permanent magnet undulator(CPMU)that is cooled by liquid nitrogen.This CPMU can generate X-ray photons within an energy range of 8.7-30 keV.The beamline offers two modes of operation:monochromatic beam mode with a liquid nitrogen-cooled double-crystal monochromator(DCM)and pink beam mode with the first crystal of the DCM out of the beam path.Four X-ray imaging methods were implemented in BL16U2:single-pulse ultrafast X-ray imaging,microsecond-resolved X-ray dynamic imaging,millisecond-resolved X-ray dynamic micro-CT,and high-resolution quantitative micro-CT.Furthermore,BL16U2 is equipped with various in situ impact loading systems,such as a split Hopkinson bar system,light gas gun,and fuel spray chamber.Following the completion of the final commissioning in 2021 and subsequent trial operations in 2022,the beamline has been officially available to users from 2023. 展开更多
关键词 Multiple time-scale X ray imaging Single-pulse X ray imaging Dynamic 2D imaging Dynamic micro-CT
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Mechanism of floral scent production in Osmanthus fragrans and the production and regulation of its key floral constituents,β-ionone and linalool 被引量:18
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作者 Yuanji Han Hongyun Wang +5 位作者 Xiaodan Wang ke li Meifang Dong Yong li Qian Zhu Fude Shang 《Horticulture Research》 SCIE 2019年第1期432-443,共12页
Sweet osmanthus(Osmanthus fragrans Lour.)is among the top ten most well-known flowers in China and is recognized as both an aromatic plant and ornamental flower.Here,manual sectioning,scanning electron microscopy,and ... Sweet osmanthus(Osmanthus fragrans Lour.)is among the top ten most well-known flowers in China and is recognized as both an aromatic plant and ornamental flower.Here,manual sectioning,scanning electron microscopy,and transmission electron microscopy of sweet osmanthus petals revealed that large amounts of lipids are present inside the petal cells and on the cell surfaces.However,no secretory structures were observed.Instead,the petal cells protrude slightly outward,and the surfaces of the cells are adorned with highly regular brush-shaped hairs.The surfaces of the‘Yingui’petals possessed mostly curled and more numerous hairs,whereas the‘Dangui’petals possessed fewer brush-shaped and more sparsely arranged hairs.In addition,many granular substances were attached to the brush-shaped hairs,and the granules were denser on the hairs of the‘Yingui’petals compared to the hairs on the‘Dangui’petals.Furthermore,35 aromatic components in the‘Yingui’petals and 30 aromatic components in the‘Dangui’petals were detected via GC-MS.The main aromatic component of the‘Yingui’petals wasβ-ionone,whereas that of the‘Dangui’petals was linalool and its oxides.Transcriptome sequencing and qRT-PCR indicated that the highβ-ionone content in the‘Yingui’petals was due to the overexpression of CCD1 and CCD4 and that the high linalool content in the‘Dangui’petals was due to the overexpression of MECS,HDR,IDI1,and LIS1,which function upstream of the linalool synthetic pathway.In particular,the expression levels of CCD4 and LIS1 were upregulated by 5.5-and 5.1-fold in the‘Yingui’and‘Dangui’petals,respectively.One transcription factor(ERF61)was cloned and named,and the expression pattern of ERF61 in sweet osmanthus petals was found to be generally consistent with that of CCD4.Tobacco transformation experiments,yeast one-hybrid experiments,and electrophoretic mobility shift assays indicated that ERF61 binds to the CCD4 promoter and stimulates CCD4 expression,thereby regulating the synthesis ofβ-ionone in sweet osmanthus petals. 展开更多
关键词 SHAPED FLOWERS ATTACHED
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Calibrating the linearity between grayscale and element content for X-ray KES imaging of alloys 被引量:3
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作者 Xiao-Lu Ju Biao Deng +7 位作者 ke li Fu-Cheng Yu Hai-Peng Zhang Ming-Wei Xu Guo-Hao Du Hong-Lan Xie Bin li Ti-Qiao Xiao 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2022年第1期1-12,共12页
Doped elements in alloys significantly impact their performance.Conventional methods usually sputter the surface material of the sample,or their performance is limited to the surface of alloys owing to their poor pene... Doped elements in alloys significantly impact their performance.Conventional methods usually sputter the surface material of the sample,or their performance is limited to the surface of alloys owing to their poor penetration ability.The X-ray K-edge subtraction(KES)method exhibits great potential for the nondestructive in situ detection of element contents in alloys.However,the signal of doped elements usually deteriorates because of the strong absorption of the principal component and scattering of crystal grains.This in turn prevents the extensive application of X-ray KES imaging to alloys.In this study,methods were developed to calibrate the linearity between the grayscale of the KES image and element content.The methods were aimed at the sensitive analysis of elements in alloys.Furthermore,experiments with phantoms and alloys demonstrated that,after elaborate calibration,X-ray KES imaging is capable of nondestructive and sensitive analysis of doped elements in alloys. 展开更多
关键词 X-ray KES imaging Grayscale calibration Element analysis for alloy Nondestructive imaging of elements
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临床护士感知社会支持和抗逆力在职业倦怠与抑郁间的链式中介效应 被引量:1
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作者 柯丽 徐兰兰 +2 位作者 李艳 李龙倜 贾佳 《护理学杂志》 CSCD 北大核心 2024年第15期56-60,共5页
目的探讨感知社会支持和抗逆力在临床护士职业倦怠对抑郁影响机制的多重中介作用,为开展干预以促进护士心理健康提供参考。方法基于资源保护理论,采用职业倦怠量表、感知社会支持量表、抗逆力量表和抑郁量表对1574名临床护士进行调查,... 目的探讨感知社会支持和抗逆力在临床护士职业倦怠对抑郁影响机制的多重中介作用,为开展干预以促进护士心理健康提供参考。方法基于资源保护理论,采用职业倦怠量表、感知社会支持量表、抗逆力量表和抑郁量表对1574名临床护士进行调查,构建并检验链式中介模型。结果护士职业倦怠得分为2.19(1.33,3.02)分,感知社会支持得分为71.00(59.00,80.00)分,抗逆力得分为30.00(22.00,34.00)分,抑郁得分为8.00(2.00,10.00)分;职业倦怠与感知社会支持及抗逆力呈负相关,与抑郁呈正相关,感知社会支持和抗逆力与抑郁呈负相关(均P<0.05)。职业倦怠对抑郁影响的总效应为0.441,感知社会支持和抗逆力在职业倦怠对抑郁的影响中起部分中介作用,中介效应分别占11.56%和14.74%,两者的链式中介效应占总效应的14.51%。结论临床护士职业倦怠和抑郁负性心理问题仍较为严重。感知社会支持和抗逆力在护士职业倦怠与抑郁间起链式中介作用。可通过提高护士群体的感知社会支持和抗逆力水平,以帮助其缓解职业倦怠对抑郁的影响,改善其心理健康。 展开更多
关键词 护士 感知社会支持 抗逆力 职业倦怠 抑郁 心理健康 资源保护理论 链式中介效应
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Long noncoding RNA Pvt1 promotes the proliferation and migration of Schwann cells by sponging microRNA-214 and targeting c-Jun following peripheral nerve injury 被引量:2
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作者 Bin Pan Di Guo +8 位作者 li Jing ke li Xin li Gen li Xiao Gao Zhi-Wen li Wei Zhao Hu Feng Meng-Han Cao 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第5期1147-1153,共7页
Research has shown that long-chain noncoding RNAs(lncRNAs) are involved in the regulation of a variety of biological processes, including peripheral nerve regeneration, in part by acting as competing endogenous RNAs. ... Research has shown that long-chain noncoding RNAs(lncRNAs) are involved in the regulation of a variety of biological processes, including peripheral nerve regeneration, in part by acting as competing endogenous RNAs. c-Jun plays a key role in the repair of peripheral nerve injury. However, the precise underlying mechanism of c-Jun remains unclear. In this study, we performed microarray and bioinformatics analysis of mouse crush-injured sciatic nerves and found that the lncRNA Pvt1 was overexpressed in Schwann cells after peripheral nerve injury. Mechanistic studies revealed that Pvt1 increased c-Jun expression through sponging miRNA-214. We overexpressed Pvt1 in Schwann cells cultured in vitro and found that the proliferation and migration of Schwann cells were enhanced, and overexpression of miRNA-214 counteracted the effects of Pvt1 overexpression on Schwann cell proliferation and migration. We conducted in vivo analyses and injected Schwann cells overexpressing Pvt1 into injured sciatic nerves of mice. Schwann cells overexpressing Pvt1 enhanced the regeneration of injured sciatic nerves following peripheral nerve injury and the locomotor function of mice was improved. Our findings reveal the role of lncRNAs in the repair of peripheral nerve injury and highlight lncRNA Pvt1 as a novel potential treatment target for peripheral nerve injury. 展开更多
关键词 cell migration ceRNA C-JUN lncRNA MICROARRAY miR-214 nerve regeneration peripheral nerve injury Pvt1 Schwann cells
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Vibration and Sound Radiation of Cylindrical Shell Covered with a Skin Made of Micro Floating Raft Arrays Excited by Turbulence 被引量:1
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作者 Dan Zhao Qiong Wu +5 位作者 Minyao Gan ke li Wenhong Ma Qun Wu liqiang Dong Shaogang liu 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第3期2041-2055,共15页
To reduce the vibration and sound radiation of underwater cylindrical shells,a skin composed of micro floating raft arrays and a compliant wall is proposed in this paper.A vibroacoustic coupling model of a finite cyli... To reduce the vibration and sound radiation of underwater cylindrical shells,a skin composed of micro floating raft arrays and a compliant wall is proposed in this paper.A vibroacoustic coupling model of a finite cylindrical shell covered with this skin for the case of turbulence excitation is established based on the shell theories of Donnell.The model is solved with the modal superposition method to investigate the effects of the structural parameters of micro floating raft elements on the performance of reducing vibration and sound radiation of the cylindrical shell of this skin.The results indicate that increasing the stiffness ratio,damping ratio,mass ratio,or decreasing the interval betweenmicro floating raft elements can improve the vibration and sound radiation reduction performance of this skin over the frequency range 0∼2000 Hz.Moreover,the mean quadratic velocity level and sound radiation power level of the finite cylindrical shell with this skin can be reduced by 12.00 dB and 9.65 dB respectively compared to the finite cylindrical shell with homogeneous viscoelastic coating in the frequency range from0∼2000Hz,implying a favorable performance of this skin for reducing the vibration and sound radiation of cylindrical shells. 展开更多
关键词 Finite cylindrical shell vibration and sound radiation noise reduction turbulent pulsating pressure micro floating raft
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RFID电缆中间接头无线无源湿度监测
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作者 方春华 周国锐 +4 位作者 汪晋豪 柯力 陆杰炜 庄立 许瑶 《中国测试》 CAS 北大核心 2024年第2期46-53,共8页
针对电缆中间接头受潮导致的运行故障问题,提出一种基于13.56 MHz RFID技术的无源湿度监测方法。该文利用HFSS建立传感器模型,调整天线匝距使天线达到理想状态,并对天线进行谐振匹配;然后研究传感器天线在水中的传输效果及存在金属屏蔽... 针对电缆中间接头受潮导致的运行故障问题,提出一种基于13.56 MHz RFID技术的无源湿度监测方法。该文利用HFSS建立传感器模型,调整天线匝距使天线达到理想状态,并对天线进行谐振匹配;然后研究传感器天线在水中的传输效果及存在金属屏蔽层时金属对天线性能的影响;最后将所设计的传感器放置于中间接头内部进行性能测试。结果表明:天线匝距为0.6 mm时传感器性能最佳;在天线外部增加47μH电容可实现13.56 MHz谐振匹配;传感器天线在水中的传输效果良好;加装金属屏蔽层可解决路径上金属对传感器信号传输的抑制作用;实际测量距离可达到8.2 cm、相对湿度测量误差最大为0.48%,最大波动幅度仅为0.3%,传感器长期处于高湿度环境仍能准确测量。该方法可实现电缆中间接头内部湿度的直接、快速及无源测量,对防止电缆受潮具有一定的参考意义。 展开更多
关键词 中间接头 RFID 湿度监测 无线通信
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Computational biology in topical bioactive peptide discovery for cosmeceutical application:a concise review
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作者 Xu-Hui li Wen-Rou Su +7 位作者 Fei-Fei Wang ke li Jing-Yong Zhu Si-Yu Zhu Si-Ning Kang Cong-Fen He Jun-Xiang li Xiao lin 《Biomedical Engineering Communications》 2023年第3期7-15,共9页
Regenerative medicine and anti-aging research have made great strides at the molecular and cellular levels in dermatology and the medical aesthetic field,targeting potential treatments with skin therapeutic and interv... Regenerative medicine and anti-aging research have made great strides at the molecular and cellular levels in dermatology and the medical aesthetic field,targeting potential treatments with skin therapeutic and intervention pathways,which make it possible to develop effective skin regeneration and repair ingredients.With the rapid development of computational biology,bioinformatics as well as artificial intelligence(A.I.),the development of new ingredients for regenerative medicine has been greatly accelerated,and the success rate has been improved.Some application cases have appeared in topical skin regeneration and repair scenarios.This review will briefly introduce the application of bioactive peptides in skin repair and anti-aging as emerging ingredients in cosmeceutics and emphasize how A.I.based computational biology technology may accelerate the development of innovative peptide molecules and ultimately translate them into potential skin regenerative and anti-aging scenarios.Typically,two research routines have been summarized and current limitations as well as directions were discussed for border applications in future research. 展开更多
关键词 computational biology artificial intelligence COSMECEUTICAL bioactive peptide regenerative medicine
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Application Strategy of CBR Test in Highway Engineering
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作者 Yan liu lin Nan +3 位作者 Guangjun li Daqing Wu Shichang Chen ke li 《Journal of World Architecture》 2023年第3期32-37,共6页
California Bearing Ratio(CBR)test is highly professional and requires a high level of skills.In order to improve the accuracy of the test results,the relevant staff will not only need to understand the rules and proce... California Bearing Ratio(CBR)test is highly professional and requires a high level of skills.In order to improve the accuracy of the test results,the relevant staff will not only need to understand the rules and procedures involved in the test,they would also need to be meticulous in their work to avoid human errors,provide good data support for highway engineering,and improve the overall quality of the project.Therefore,this paper presents an analysis of the application of CBR test in highway engineering,which can provide reference for engineering and promote the development of the highway industry. 展开更多
关键词 Highway engineering CBR test detection technology Soil quality
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黄钾铁矾对硫脲浸金的影响及草酸盐的作用机理
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作者 李科 李骞 +4 位作者 姜涛 杨永斌 徐斌 许瑞 张雁 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2024年第1期322-335,共14页
研究生物氧化产生的黄钾铁矾对酸性硫脲浸金的影响,并探讨草酸添加剂的作用机制。结果表明,黄钾铁矾会增加硫脲的消耗和阻碍金的溶解。黄钾铁矾能显著提高硫脲的分解,阻碍金的溶解。黄钾铁矾造成不利影响的主要原因可能是酸性溶液中黄... 研究生物氧化产生的黄钾铁矾对酸性硫脲浸金的影响,并探讨草酸添加剂的作用机制。结果表明,黄钾铁矾会增加硫脲的消耗和阻碍金的溶解。黄钾铁矾能显著提高硫脲的分解,阻碍金的溶解。黄钾铁矾造成不利影响的主要原因可能是酸性溶液中黄钾铁矾释放的铁离子使溶液浆电位增加,从而加速硫脲的分解,并加剧硫脲分解产生的钝化物种对金表面的钝化作用。添加草酸盐可以有效削弱黄钾铁矾的不利影响,表现为明显降低硫脲的消耗和促进金的溶解。通过溶液电位、Zeta电位和XPS分析,揭示草酸的可能作用机理。草酸盐不仅可以通过与Fe^(3+)配位减弱Fe^(3+)与硫脲之间的相互作用,还可以通过无差别吸附和静电斥力阻止钝化产物在金表面包裹。 展开更多
关键词 生物黄钾铁矾 金浸出 硫脲消耗 草酸盐
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胸腔生物阻抗检测对人体植入电子设备安全性研究
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作者 贾静 柯丽 +1 位作者 杜强 任自艳 《电工技术学报》 EI CSCD 北大核心 2024年第22期6990-6997,共8页
全球范围内佩戴心脏植入电子设备的患者日益增加,采用生物电阻抗技术进行病理检测,可能会对心脏植入电子设备患者产生干扰。该文建立生物电阻抗交流激励系统及心脏起搏电极仿真模型,完成胸腔生物阻抗检测技术对心脏起搏器电磁干扰的安... 全球范围内佩戴心脏植入电子设备的患者日益增加,采用生物电阻抗技术进行病理检测,可能会对心脏植入电子设备患者产生干扰。该文建立生物电阻抗交流激励系统及心脏起搏电极仿真模型,完成胸腔生物阻抗检测技术对心脏起搏器电磁干扰的安全性研究。仿真研究表明,胸腔生物阻抗测量引起的电压干扰超过了ISO 14117标准中定义的最大阈值,且干扰水平随着生物阻抗激励信号的频率和电极位置的不同而变化,并且组织电特性也会对干扰水平产生影响。生物电阻抗技术可能会对心脏植入电子设备存在潜在干扰,不建议在该人群中使用胸腔阻抗法进行检测。 展开更多
关键词 心脏起搏器 胸腔电阻抗 感应电动势 设备干扰
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Oxygen‑Coordinated Single Mn Sites for Efficient Electrocatalytic Nitrate Reduction to Ammonia 被引量:2
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作者 Shengbo Zhang Yuankang Zha +8 位作者 Yixing Ye ke li Yue lin lirong Zheng Guozhong Wang Yunxia Zhang Huajie Yin Tongfei Shi Haimin Zhang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第1期147-159,共13页
Electrocatalytic nitrate reduction reaction has attracted increasing attention due to its goal of low carbon emission and environmental protection.Here,we report an efficient NitRR catalyst composed of single Mn sites... Electrocatalytic nitrate reduction reaction has attracted increasing attention due to its goal of low carbon emission and environmental protection.Here,we report an efficient NitRR catalyst composed of single Mn sites with atomically dispersed oxygen(O)coordination on bacterial cellulose-converted graphitic carbon(Mn-O-C).Evidence of the atomically dispersed Mn-(O-C_(2))_(4)moieties embedding in the exposed basal plane of carbon surface is confirmed by X-ray absorption spectroscopy.As a result,the as-synthesized Mn-O-C catalyst exhibits superior NitRR activity with an NH_(3)yield rate(RNH_(3))of 1476.9±62.6μg h^(−1)cm^(−2)at−0.7 V(vs.reversible hydrogen electrode,RHE)and a faradaic efficiency(FE)of 89.0±3.8%at−0.5 V(vs.RHE)under ambient conditions.Further,when evaluated with a practical flow cell,Mn-O-C shows a high RNH_(3)of 3706.7±552.0μg h^(−1)cm^(−2)at a current density of 100 mA cm−2,2.5 times of that in the H cell.The in situ FT-IR and Raman spectroscopic studies combined with theoretical calculations indicate that the Mn-(O-C_(2))_(4)sites not only effectively inhibit the competitive hydrogen evolution reaction,but also greatly promote the adsorption and activation of nitrate(NO_(3)^(−)),thus boosting both the FE and selectivity of NH_(3)over Mn-(O-C_(2))_(4)sites. 展开更多
关键词 Atomically dispersed Oxygen coordination Nitrate reduction reaction In situ spectroscopic studies Hydrogen evolution reaction
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基础护理学线上线下混合式“金课”思政教学设计与实践 被引量:1
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作者 徐兰兰 柯丽 +4 位作者 李艳 徐萍萍 曹琼雅 孙莉 王金娜 《护理学杂志》 CSCD 北大核心 2024年第7期77-80,共4页
在基础护理学课程中构建以课堂教学为主体,以线上平台自主学习和第二课堂社会实践为两翼的“一体两翼”式大思政育人模式,将政治认同、家国情怀、职业素养、科学精神、道德修养、法治素养、文化素养、南丁格尔精神8大核心思政元素与专... 在基础护理学课程中构建以课堂教学为主体,以线上平台自主学习和第二课堂社会实践为两翼的“一体两翼”式大思政育人模式,将政治认同、家国情怀、职业素养、科学精神、道德修养、法治素养、文化素养、南丁格尔精神8大核心思政元素与专业知识有机融合开展课程思政,取得了良好效果,实现了线上线下、课内课外、校内校外三维度协同育人。该课程被评为省级课程思政示范课程。 展开更多
关键词 基础护理学 线上线下混合式教学 金课 课程思政 一体两翼 教学方法 护理教育
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基于Kaczmarz算法的磁粒子成像快速重建算法研究
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作者 谌继超 柯丽 白石 《医疗卫生装备》 CAS 2024年第1期9-14,共6页
目的:为了解决磁粒子断层成像中系统矩阵方法成像时间长、计算复杂的问题,提出一种基于Kaczmarz算法的磁粒子成像快速重建算法。方法:首先,分析经典Kaczmarz算法及其变体算法的收敛速度,并计算在任意矩阵下的迭代次数和计算时间;其次,... 目的:为了解决磁粒子断层成像中系统矩阵方法成像时间长、计算复杂的问题,提出一种基于Kaczmarz算法的磁粒子成像快速重建算法。方法:首先,分析经典Kaczmarz算法及其变体算法的收敛速度,并计算在任意矩阵下的迭代次数和计算时间;其次,比较欧氏距离和余弦距离对系统数据的区分能力,并运用基于余弦距离的K-means算法来增强块Kaczmarz算法的运算能力,缩短系统矩阵重建时间并最终实现磁粒子成像快速重建。最后,通过计算机仿真实验验证提出的算法的有效性。结果:提出的算法大幅缩短了重建时间,提高了重建图像的空间分辨力和质量。结论:提出的算法可以实现磁粒子成像的快速重建,并且在处理含有噪声的数据时具备较强的重建能力。 展开更多
关键词 磁粒子成像 系统矩阵 Kaczmarz算法 块Kaczmarz算法 图像重建 余弦聚类
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基于CiteSpace的国内认知行为疗法相关文献可视化分析
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作者 谢松洪 柯丽 +1 位作者 冯寸 刘冰 《中国社会医学杂志》 2024年第4期440-444,共5页
目的分析认知行为疗法(congnitive behavioral therapy,CBT)领域研究热点及发展趋势,为后续深入研究提供参考。方法利用CiteSpace软件对中国知网(CNKI)收录的认知行为疗法相关文献从发文量、作者、机构、关键词等方面进行可视化分析。... 目的分析认知行为疗法(congnitive behavioral therapy,CBT)领域研究热点及发展趋势,为后续深入研究提供参考。方法利用CiteSpace软件对中国知网(CNKI)收录的认知行为疗法相关文献从发文量、作者、机构、关键词等方面进行可视化分析。结果共纳入文献529篇,年度发文量呈波动式增长,总体发文量不高,发文量最多的作者是李占江,发文量最多的机构是上海交通大学医学院附属精神卫生中心,国内研究热点主要集中在负性情绪、失眠和生命质量方面;睡眠质量、乳腺癌是近二十年的研究前沿。结论国内CBT研究处于发展阶段,研究话题聚焦于睡眠质量和乳腺癌,未来应加强作者与机构间合作,以推动CBT相关研究高质量发展。 展开更多
关键词 认知行为疗法 文献计量学 可视化分析 CiteSpace软件
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Phomaketals A and B,pentacyclic meroterpenoids from a eupC overexpressed mutant strain of Phoma sp.
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作者 Chuan li Yangyang Han +5 位作者 Yanan Zhai ke li Xingzhong liu Zhuan Zhang Cai Jia Yongsheng Che 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第7期350-354,共5页
Phomaketals A(1)and B(2),two tropolonic meroterpenoids with the unprecedented pentacyclic skeletons,were isolated from the solid-substrate fermentation cultures of a eupC overexpressed mutant strain of the fungus Phom... Phomaketals A(1)and B(2),two tropolonic meroterpenoids with the unprecedented pentacyclic skeletons,were isolated from the solid-substrate fermentation cultures of a eupC overexpressed mutant strain of the fungus Phoma sp.,together with a biogenetically related secondary metabolite pughiinin B(3),and the known one noreupenifeldin B(4).The structures of 1–3 were elucidated primarily by nuclear magnetic resonance(NMR)experiments.The absolute configurations of 1 and 2 were assigned by electronic circular dichroism calculations and the calculated NMR with DP4+analysis,while that of 3 was established by single-crystal X-ray diffraction analysis using Cu Kαradiation.Biogenetically,phomaketals A(1)and B(2)could be derived from the hypothetical tropolonic sesquiterpene intermediates neosetophomone B(6)and 9-R-neosetophomone B(6),respectively,via different reactions cascades.Compound 1 showed antiproliferative effect only against the SUPB15 cells,with an 50%inhibitory concentration(IC50)value of 4.85μmol/L,while the co-isolated known meroterpenoid 4 displayed potent effects against three tumor cell lines,SUPB15,EL4,and H9,showing IC50values of 0.36–27.08μmol/L. 展开更多
关键词 Phoma sp. Tropolonic sesquiterpenes Biosynthetic pathways Hetero-Diels–Alder CYTOTOXICITY
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