Multiple myeloma is an incurable disease in many patients;therefore, maintaining good quality of life (QOL) for the duration of the long-term treatment is important. Taste dysfunction is reported to occur in 30 to 70%...Multiple myeloma is an incurable disease in many patients;therefore, maintaining good quality of life (QOL) for the duration of the long-term treatment is important. Taste dysfunction is reported to occur in 30 to 70%of patients receiving cancer chemotherapy (1)This adverse event affects the appetite of patients;consequently, QOL of patients decreases.展开更多
As one of the possible technologies to improve the oral absorption of poorly water-soluble drugs, supersaturable formulation, which enables to dissolve the drug to the higher concentration than their equilibrium solub...As one of the possible technologies to improve the oral absorption of poorly water-soluble drugs, supersaturable formulation, which enables to dissolve the drug to the higher concentration than their equilibrium solubility, is now attracting the attention (1)This include salt-formation, soliddispersion, co-crystallization or the use of amorphous form.Since supersaturation is a thermodynamically metastable state,supersaturated solution has a high potential to precipitate. Some pharmaceutical excipients.展开更多
文摘Multiple myeloma is an incurable disease in many patients;therefore, maintaining good quality of life (QOL) for the duration of the long-term treatment is important. Taste dysfunction is reported to occur in 30 to 70%of patients receiving cancer chemotherapy (1)This adverse event affects the appetite of patients;consequently, QOL of patients decreases.
文摘As one of the possible technologies to improve the oral absorption of poorly water-soluble drugs, supersaturable formulation, which enables to dissolve the drug to the higher concentration than their equilibrium solubility, is now attracting the attention (1)This include salt-formation, soliddispersion, co-crystallization or the use of amorphous form.Since supersaturation is a thermodynamically metastable state,supersaturated solution has a high potential to precipitate. Some pharmaceutical excipients.
