Objective: Few studies have evaluated the benefits of colorectal cancer(CRC) screening integrating both non-genetic and genetic risk factors. Here, we aimed to integrate an existing non-genetic risk model(QCancer-10) ...Objective: Few studies have evaluated the benefits of colorectal cancer(CRC) screening integrating both non-genetic and genetic risk factors. Here, we aimed to integrate an existing non-genetic risk model(QCancer-10) and a 139-variant polygenic risk score to evaluate the effectiveness of screening on CRC incidence and mortality.Methods: We applied the integrated model to calculate 10-year CRC risk for 430,908 participants in the UK Biobank, and divided the participants into low-, intermediate-, and high-risk groups. We calculated the screening-associated hazard ratios(HRs) and absolute risk reductions(ARRs) for CRC incidence and mortality according to risk stratification.Results: During a median follow-up of 11.03 years and 12.60 years, we observed 5,158 CRC cases and 1,487 CRC deaths, respectively. CRC incidence and mortality were significantly lower among screened than non-screened participants in both the intermediateand high-risk groups [incidence: HR: 0.87, 95% confidence interval(CI): 0.81±0.94;0.81, 0.73±0.90;mortality: 0.75, 0.64±0.87;0.70, 0.58±0.85], which composed approximately 60% of the study population. The ARRs(95% CI) were 0.17(0.11±0.24) and 0.43(0.24±0.61), respectively, for CRC incidence, and 0.08(0.05±0.11) and 0.24(0.15±0.33), respectively, for mortality. Screening did not significantly reduce the relative or absolute risk of CRC incidence and mortality in the low-risk group. Further analysis revealed that screening was most effective for men and individuals with distal CRC among the intermediate to high-risk groups.Conclusions: After integrating both genetic and non-genetic factors, our findings provided priority evidence of risk-stratified CRC screening and valuable insights for the rational allocation of health resources.展开更多
The composite pile consisting of core-pile and surrounding cement-enhanced soil is a promising pile foundation in recent years.However,how and to what extent the cement-enhanced soil influences the ultimate lateral re...The composite pile consisting of core-pile and surrounding cement-enhanced soil is a promising pile foundation in recent years.However,how and to what extent the cement-enhanced soil influences the ultimate lateral resistance has not been fully investigated.In this paper,the ultimate lateral resistance of the composite pile was studied by finite element limit analysis(FELA)and theoretical upper-bound analysis.The results of FELA and theoretical analysis revealed three failure modes of laterally loaded composite piles.The effects of the enhanced soil thickness,strength,and pile-enhanced soil interface characteristics on the ultimate lateral resistance were studied.The results show that increasing the enhanced soil thickness leads to a significant improvement on ultimate lateral resistance factor(N P),and there is a critical thickness beyond which the thickness no longer affects the N P.Increasing the enhanced soil strength induced 6.2%-232.6%increase of N P.However,no noticeable impact was detected when the enhanced soil strength was eight times higher than that of the natural soil.The maximum increment of N P is only 30.5%caused by the increase of interface adhesion factor(a).An empirical model was developed to calculate the N P of the composite pile,and the results show excellent agreement with the analytical results.展开更多
In the developmental dilemma of artificial intelligence(AI)-assisted judicial decision-making,the technical architecture of AI determines its inherent lack of transparency and interpretability,which is challenging to ...In the developmental dilemma of artificial intelligence(AI)-assisted judicial decision-making,the technical architecture of AI determines its inherent lack of transparency and interpretability,which is challenging to fundamentally improve.This can be considered a true challenge in the realm of AI-assisted judicial decision-making.By examining the court’s acceptance,integration,and trade-offs of AI technology embedded in the judicial field,the exploration of potential conflicts,interactions,and even mutual shaping between the two will not only reshape their conceptual connotations and intellectual boundaries but also strengthen the cognition and re-interpretation of the basic principles and core values of the judicial trial system.展开更多
Given the rapid changes in social structure(urbanization),economic structure(industrialization),and demographic structure(population aging)in China,cancer has become a major public health problem1.Extensive evidence h...Given the rapid changes in social structure(urbanization),economic structure(industrialization),and demographic structure(population aging)in China,cancer has become a major public health problem1.Extensive evidence has indicated that screening can decrease cancer mortality,particularly among high-risk groups,and several representative national and regional cancer screening programs have been launched in China to cope with the increasing burden of cancer.展开更多
This study investigates the modulation of initial wind field structure on the relationship between the size and intensity of a simulated vortex.A series of idealized experiments are conducted by varying the radius of ...This study investigates the modulation of initial wind field structure on the relationship between the size and intensity of a simulated vortex.A series of idealized experiments are conducted by varying the radius of maximum wind(RMW)and shape parameter of the initial vortices.The size–intensity relationship is quantified by the linear regression coefficient of the azimuthally-averaged gale-force wind radius against the maximum wind during the development stage,reflecting the degree of size expansion at the same intensity increment.The regression coefficient increases with increased RMW and decreased,with the RMW being the primary constraint.The effect of lowering on the elevation of the regression coefficient gradually stands out when the initial RMW is large.Enlarging the RMW leads to a secondary circulation with a horizontally elongated structure,which retards the intensification while promoting size expansion,thus substantially enhancing size expansion as the vortex intensifies.Broadening the wind field outside the RMW by reducing results in abounding convection in the outer region,which promotes size expansion.Based on the axisymmetric tangential wind tendency and Sawyer–Eliassen equations,when the RMW is large,the active convection in the outer region can weaken the radial inflow induced by the eyewall heating in the inner region,thus retarding the intensification by reducing the radial imports of vorticity near the RMW.展开更多
The development of allometric biomass models is important process in biomass estimation because the reliability of forest biomass and carbon estimations largely depends on the accuracy and precision of such models.Nat...The development of allometric biomass models is important process in biomass estimation because the reliability of forest biomass and carbon estimations largely depends on the accuracy and precision of such models.National Forest Inventories(NFI)are detailed assessments of forest resources at national and regional levels that provide valuable data for forest biomass estimation.However,the lack of biomass allometric equations for each tree species in the NFI currently hampers the estimation of national-scale forest biomass.The main objective of this study was to develop allometric biomass regression equations for each tree species in the NFI of China based on limited biomass observations.These equations optimally grouped NFI and biomass observation species according to their phylogenetic relationships.Significant phylogenetic signals demonstrated phylogenetic conservation of the crown-to-stem biomass ratio.Based on phylogenetic relationships,we grouped and matched NFI and biomass observation species into 22 categories.Allometric biomass regression models were developed for each of these 22 species categories,and the models performed successfully(R^(2)=0.97,root mean square error(RMSE)=12.9t·ha^(–1),relative RMSE=11.5%).Furthermore,we found that phylogeny-based models performed more effectively than wood density-based models.The results suggest that grouping species based on their phylogenetic relationships is a reliable approach for the development and selection of accurate allometric equations.展开更多
Breast cancer is the most common malignant tumor in Chinese women.Early screening is the best way to improve the rates of early diagnosis and survival of breast cancer patients.The peak onset age for breast cancer in ...Breast cancer is the most common malignant tumor in Chinese women.Early screening is the best way to improve the rates of early diagnosis and survival of breast cancer patients.The peak onset age for breast cancer in Chinese women is considerably younger than those in European and American women.It is imperative to develop breast cancer screening guideline that is suitable for Chinese women.By summarizing the current evidence on breast cancer screening in Chinese women,and referring to the latest guidelines and consensus on breast cancer screening in Europe,the United States,and East Asia,the China Anti-Cancer Association and National Clinical Research Center for Cancer(Tianjin Medical University Cancer Institute and Hospital)have formulated population-based guideline for breast cancer screening in Chinese women.The guideline provides recommendations on breast cancer screening for Chinese women at average or high risk of breast cancer according to the following three aspects:age of screening,screening methods,and screening interval.This article provides more detailed information to support the recommendations in this guideline and to provide more direction for current breast cancer screening practices in China.展开更多
Objective: European lung cancer screening studies using computed tomography(CT) have shown that a management protocol based on measuring lung nodule volume and volume doubling time(VDT) is more specific for early lung...Objective: European lung cancer screening studies using computed tomography(CT) have shown that a management protocol based on measuring lung nodule volume and volume doubling time(VDT) is more specific for early lung cancer detection than a diameter-based protocol. However, whether this also applies to a Chinese population is unclear. The aim of this study is to compare the diagnostic performance of a volume-based protocol with a diameter-based protocol for lung cancer detection and optimize the nodule management criteria for a Chinese population.Methods: This study has a population-based, prospective cohort design and includes 4000 participants from the Hexi district of Tianjin, China. Participants will undergo low-dose chest CT at baseline and after 1 year. Initially, detected lung nodules will be evaluated for diameter and managed according to a routine diameter-based protocol(Clinical Practice Guideline in Oncology for Lung Cancer Screening, Version 2.2018). Subsequently, lung nodules will be evaluated for volume and management will be simulated according to a volume-based protocol and VDT(a European lung nodule management protocol). Participants will be followed up for 4 years to evaluate lung cancer incidence and mortality. The primary outcome is the diagnostic performance of the European volume-based protocol compared to diameter-based management regarding lung nodules detected using low-dose CT.Results: The diagnostic performance of volume-and diameter-based management for lung nodules in a Chinese population will be estimated and compared.Conclusions: Through the study, we expect to improve the management of lung nodules and early detection of lung cancer in Chinese populations.展开更多
Low-density lipoprotein receptor-related protein 1(LRP1,also known as CD91),a multifunctional endocytic and cell signaling receptor,is widely expressed on the surface of multiple cell types such as hepatocytes,fibrobl...Low-density lipoprotein receptor-related protein 1(LRP1,also known as CD91),a multifunctional endocytic and cell signaling receptor,is widely expressed on the surface of multiple cell types such as hepatocytes,fibroblasts,neurons,astrocytes,macrophages,smooth muscle cells,and malignant cells.Emerging in vitro and in vivo evidence demonstrates that LRP1 is critically involved in many processes that drive tumorigenesis and tumor progression.For example,LRP1 not only promotes tumor cell migration and invasion by regulating matrix metalloproteinase(MMP)-2and MMP-9 expression and functions but also inhibits cell apoptosis by regulating the insulin receptor,the serine/threonine protein kinase signaling pathway,and the expression of Caspase-3.LRPI-mediated phosphorylation of the extracellular signal-regulated kinase pathway and c-jun N-terminal kinase are also involved in tumor cell proliferation and invasion.In addition,LRP1 has been shown to be down-regulated by microRNA-205 and methylation of LRP1CpG islands.Furthermore,a novel fusion gene,LRP1-SNRNP25,promotes osteosarcoma cell invasion and migration.Only by understanding the mechanisms of these effects can we develop novel diagnostic and therapeutic strategies for cancers mediated by LRP1.展开更多
Biobanks bridge the gap between basic and translational research.Traditional cancer biobanks typically contain normal and tumor tissues,and matched blood.However,biospecimens in traditional biobanks are usually nonren...Biobanks bridge the gap between basic and translational research.Traditional cancer biobanks typically contain normal and tumor tissues,and matched blood.However,biospecimens in traditional biobanks are usually nonrenewable.In recent years,increased interest has focused on establishing living biobanks,including organoid biobanks,for the collection and storage of viable and functional tissues for long periods of time.The organoid model is based on a 3D in vitro cell culture system,is highly similar to primary tissues and organs in vivo,and can recapitulate the phenotypic and genetic characteristics of target organs.Publications on cancer organoids have recently increased,and many types of cancer organoids have been used for modeling cancer processes,as well as for drug discovery and screening.On the basis of the current research status,more exploration of cancer organoids through technical advancements is required to improve reproducibility and scalability.Moreover,given the natural characteristics of organoids,greater attention must be paid to ethical considerations.Here,we summarize recent advances in cancer organoid biobanking research,encompassing rectal,gastric,pancreatic,breast,and glioblastoma cancers.Living cancer biobanks that contain cancerous tissues and matched organoids with different genetic backgrounds,subtypes,and individualized characteristics will eventually contribute to the understanding of cancer and ultimately facilitate the development of innovative treatments.展开更多
Two different initialization schemes for tropical cyclone(TC)prediction in numerical models are evaluated based on a case study of Typhoon Lekima(2019).The first is a dynamical initialization(DI)scheme where the axisy...Two different initialization schemes for tropical cyclone(TC)prediction in numerical models are evaluated based on a case study of Typhoon Lekima(2019).The first is a dynamical initialization(DI)scheme where the axisymmetric TC vortex in the initial conditions is spun up through the 6-h cycle runs before the initial forecast time.The second scheme is a bogussing scheme where the analysis TC vortex is replaced by a synthetic Rankine vortex.Results show that although both initialization schemes can help improve the simulated rapid intensification(RI)of Lekima,the simulation employing the DI scheme(DIS)reproduces better the RI onset and intensification rate than that employing the bogussing scheme(BOG).Further analyses show the cycle runs of DI help establish a realistic TC structure with stronger secondary circulation than those in the control run and BOG,leading to fast vortex spinup and contraction of the radius of maximum wind(RMW).The resultant strong inner-core primary circulation favors precession of the midlevel vortex under the moderate vertical wind shear(VWS)and thus helps vortex alignment,contributing to an earlier RI onset.Afterwards,the decreased vertical shear and the stronger convection inside the RMW support the persistent RI of Lekima in DIS.In contrast,the reduced VWS is not well captured and the inner-core convection is weaker and resides farther away from the TC center in BOG,leading to slower intensification.The results imply that the DI effectively improves the prediction of the inner-core process,which is crucial to the RI forecast.展开更多
Objective:To develop and evaluate the screening performance of a low-cost high-risk screening strategy for breast cancer in low resource areas.Methods:Based on the Multi-modality Independent Screening Trial,6 question...Objective:To develop and evaluate the screening performance of a low-cost high-risk screening strategy for breast cancer in low resource areas.Methods:Based on the Multi-modality Independent Screening Trial,6 questionnaire-based risk factors of breast cancer(age at menarche,age at menopause,age at first live birth,oral contraceptive,obesity,family history of breast cancer)were used to determine the women with high risk of breast cancer.The screening performance of clinical breast examination(CBE),breast ultrasonography(BUS),and mammography(MAM)were calculated and compared to determine the optimal screening method for these high risk women.Results:A total of 94 breast cancers were detected among 31,720 asymptomatic Chinese women aged 45–65 years.Due to significantly higher detection rates(DRs)and suitable coverage of the population,high risk women were defined as those with any of 6 risk factors.Among high risk women,the DR for BUS[3.09/1,000(33/10,694)]was similar to that for MAM[3.18/1,000(34/10,696)],while it was significantly higher than that for the CBE[1.73/1,000(19/10,959),P=0.002].Compared with MAM,BUS showed significantly higher specificity[98.64%(10,501/10,646)vs.98.06%(10,443/10,650),P=0.001],but no significant differences in sensitivity[68.75%(33/48)vs.73.91%(34/46)],positive prediction values[18.54%(33/178)vs.14.11%(34/241)],and negative prediction values[99.86%(10,501/10,516)vs.99.89%(10,443/10,455)].Further analyses showed no significant difference in the percentages of early stage breast cancer[53.57%(15/28)vs.50.00%(15/30)],lymph node involvement[22.73%(5/22)vs.28.00%(7/25)],and tumor size≥2 cm[37.04%(10/27)vs.29.03%(9/31)]between BUS and MAM.Subgroup analyses stratified by breast densities or age at enrollment showed similar results.Conclusions:The low-cost high-risk screening strategy based on 6 questionnaire-based risk factors was an easy-to-use method to identify women with high risk of breast cancer.Moreover,BUS and MAM had comparable screening performances among high risk women.展开更多
This study reexamines the correlation between the size and intensity of tropical cyclones(TCs) over the western North Pacific from the perspective of individual TCs, rather than the previous large-sample framework mix...This study reexamines the correlation between the size and intensity of tropical cyclones(TCs) over the western North Pacific from the perspective of individual TCs, rather than the previous large-sample framework mixing up all TC records.Statistics show that the positive size-intensity correlation based on individual TCs is relatively high. However, this correlation is obscured by mixing large samples. The weakened correlation based on all TC records is primarily due to the diversity in the size change relative to the same intensity change among TCs, which can be quantitatively measured by the linear regression coefficient(RC) of size against intensity. To further explore the factors that cause the variability in RCs that weakens the size-intensity correlation when considering all TC records, the TCs from 2001 to 2020 are classified into two groups according to their RC magnitudes, within which the high-RC TCs have a larger size expansion than the low-RC TCs given the same intensity change. Two key mechanisms responsible for the RC differences are proposed. First, the highRC TCs are generally located at higher latitudes than the low-RC TCs, resulting in higher planetary vorticity and thus higher planetary angular momentum import at low levels. Second, the high-RC TCs are susceptible to stronger environmental vertical wind shear, leading to more prolific outer convection than the low-RC TCs. The positive feedback between outer diabatic heating and boundary layer inflow favors the inward import of absolute angular momentum in the outer region, thereby contributing to a larger size expansion in the high-RC TCs.展开更多
Objective:Sarcomas are a group of rare malignancies with various subtypes.Patients with metastatic sarcoma who have failed traditional treatments can possibly achieve better prognoses from using novel therapies,includ...Objective:Sarcomas are a group of rare malignancies with various subtypes.Patients with metastatic sarcoma who have failed traditional treatments can possibly achieve better prognoses from using novel therapies,including anti-programmed death-1(PD-1)-based therapies.Methods:We retrospectively analyzed clinical data of 24 metastatic sarcoma patients from June 15,2016 to December 30,2019.These patients mainly received angiogenesis inhibitors combined with anti-PD-1 therapy after they became resistant to traditional treatments.Furthermore,8 patients underwent panel DNA and whole transcript sequencing.Results:Six patients received 2 cycles of anti-PD-1 therapy and were included in the safety evaluation only group.The median follow-up time was 5.77 months.The median progression-free survival was 7.59 months,the overall response rate was 16.7%and the disease control rate was 55.6%.Based on whole exome and transcript sequencing data,there was no association between TMB,TNB,MSI,HLA-LOH,and PD-L1 expressions and sarcoma types with clinical responses.Immunotherapy efficacy and bioinformatics analyses indicated higher intratumoral heterogeneity(ITH)in progressive disease(PD)patients and lower ITH in partial response(PR)and stable disease patients.A higher percentage of immune cell infiltration,especially monocytes,was observed in PR patients.Active stromal gene expression was increased in PD patients but decreased in PR patients.Enrichment analysis revealed that an increased TGF-βsignaling pathway was reversely correlated with anti-PD-1 efficacy,while a decreased inflammatory response signaling pathway was positively correlated with anti-PD-1 efficacy.Conclusions:Our study showed PD-1 inhibitors combined with anti-angiogenesis agents were effective and well-tolerated.ITH,monocyte ratio,stroma subtypes,and the status of immune-associated signaling pathways may be related with anti-PD-1 based therapy.展开更多
Objective:Large volume radiological text data have been accumulated since the incorporation of electronic health record(EHR)systems in clinical practice.We aimed to determine whether deep natural language processing a...Objective:Large volume radiological text data have been accumulated since the incorporation of electronic health record(EHR)systems in clinical practice.We aimed to determine whether deep natural language processing algorithms could aid radiologists in improving thyroid cancer diagnosis.Methods:Sonographic EHR data were obtained from the EHR database.Pathological reports were used as the gold standard for diagnosing thyroid cancer.We developed thyroid cancer diagnosis based on natural language processing(THCaDxNLP)to interpret unstructured sonographic text reports for thyroid cancer diagnosis.We used the area under the receiver operating characteristic curve(AUROC)as the primary metric to measure the performance of the THCaDxNLP.We compared the performance of thyroid ultrasound radiologists aided with THCaDxNLP vs.those without THCaDxNLP using 5 independent test sets.Results:We obtained a total number of 788,129 sonographic radiological reports.The number of thyroid sonographic data points was 132,277,18,400 of which were thyroid cancer patients.Among the 5 test sets,the numbers of patients per set were 439,186,82,343,and 171.THCaDxNLP achieved high performance in identifying thyroid cancer patients(the AUROC ranged from 0.857–0.932).Thyroid ultrasound radiologists aided with THCaDxNLP achieved significantly higher performances than those without THCaDxNLP in terms of accuracy(93.8%vs.87.2%;one-sided t-test,adjusted P=0.003),precision(92.5%vs.86.0%;P=0.018),and F1 metric(94.2%vs.86.4%;P=0.007).Conclusions:THCaDxNLP achieved a high AUROC for the identification of thyroid cancer,and improved the accuracy,sensitivity,and precision of thyroid ultrasound radiologists.This warrants further investigation of THCaDxNLP in prospective clinical trials.展开更多
In this study,the relationship of tropical cyclone(TC)size change rate(SCR),within 24 hours,with size,intensity,and intensity change rate(ICR)are explored over the western North Pacific.TC size is defined as the azimu...In this study,the relationship of tropical cyclone(TC)size change rate(SCR),within 24 hours,with size,intensity,and intensity change rate(ICR)are explored over the western North Pacific.TC size is defined as the azimuthally averaged radius of gale-force wind of 17 m s−1(R17)based on the Multiplatform Tropical Cyclone Surface Winds Analysis data.The majority of SCRs are mainly distributed in the range from−20 to 80 km d−1.The correlation coefficients between SCR and size(SCR-R17),intensity,and ICR(SCR-ICR)are−0.43,−0.12,and 0.25,respectively.The sensitivity of the SCR-R17 and SCR-ICR relationships to size,intensity,and evolution stage are further examined.Results show that the SCR-R17 relationship is more sensitive to variations of size and evolution stage than that of intensity.The relationship of SCR-ICR is largely modulated by the evolution stage.The correlation coefficient of SCR-ICR can increase from 0.25 to 0.40 when only considering the lifetime stages concurrently before and after the lifetime maximum size(LMS)and lifetime maximum intensity.This demonstrates that ICR is a potential factor in predicting SCR during these evolution stages.Besides,the TC size expansion(shrinkage)is more likely to occur for TCs with smaller(larger)size and weaker(stronger)intensity.The complexity of size change during a TC's lifetime can be attributed to the fact that shrinkage or expansion could occur both before and after LMS.展开更多
Homogeneous, high concentrated ceramic suspensions wi th low viscosity are the key controlling factors for the production of ceramic c omponents through colloidal processing. A well-dispersed suspension can be obta in...Homogeneous, high concentrated ceramic suspensions wi th low viscosity are the key controlling factors for the production of ceramic c omponents through colloidal processing. A well-dispersed suspension can be obta ined by choosing suitable dispersant, solvent, particle size distribution etc. B esides these factors, the homogenizing procedure is also a key step. In this paper, reaction sialon suspensions were prepared using 3-wt% KD1 as dis persant in organic media composed of 60-vol% methyletheylketone and 40-vol% et hanol. Different homogenizing procedures have been used and compared, including planetary milling, low energy ball milling and ultrasonic disaggregation. The ef fects of different homogenizing routes and mixing times on the rheology and stab ility of suspensions, and on the microstructure of slip casting green bodies, ha ve been studied. The varying dispersion efficiencies observed could be attribute d to differences in deagglomeration degrees achieved and in adsorption amount of dispersant onto the surface of reaction sialon powders.展开更多
In recent years,the frequent adjustment of the government’s economic policies and the uncertainty of foreign economic situations have made the degree of uncertainty of China’s economic policies rise continuously.The...In recent years,the frequent adjustment of the government’s economic policies and the uncertainty of foreign economic situations have made the degree of uncertainty of China’s economic policies rise continuously.The increasing degree of policy uncertainty will inevitably affect the investment and financing decisions of micro enterprises.Then,how does economic policy uncertainty(EPU)affect mergers and acquisitions(M&A)behavior?What’s the mechanism?Based on the above questions,this paper uses the data of non-financial listed companies in the Shanghai and Shenzhen stock exchanges from 2008 to 2018 as a sample to explore the relationship between EPU and M&A.The study shows that rising EPU will promote corporate M&A behavior,and this effect is more significant in slow-growth companies.The relationship between EPU and M&A is affected by corporate governance,stock price volatility and financing constraints.Specifically,the company’s M&A size is more sensitive to EPU with higher level of corporate governance,higher level of stock price volatility,and lesser financing constraints.Further research shows that the rise of EPU will significantly promote the improvement of M&A performance in the short-term,but this effect does not exist in the long-term.Various robustness checks do not change the empirical results of this paper.展开更多
Herein,a modified metal-free acetylene black(MMF-AB)catalyst was synthesized by a simple solvothermal-calcination method and designed successfully to activate peroxodisulfate(PDS)for the degradation of sulfisoxazole(S...Herein,a modified metal-free acetylene black(MMF-AB)catalyst was synthesized by a simple solvothermal-calcination method and designed successfully to activate peroxodisulfate(PDS)for the degradation of sulfisoxazole(SIZ).Due to the doping of N,S and O metal-free elements,the modified catalyst showed excellent catalytic performance with 100%SIZ removal within 30 min.Pseudo first-order reaction rate constants(evaluating catalytic efficiencies and activity)of MMF-AB(kobs=0.105 min^(−1))was 3 times higher than pure-AB(k_(obs)=0.029 min^(−1)).Interestingly,it was demonstrated that the reaction sys-tem is based on the transfer of electrons from SIZ to PDS to realize an electron-transfer-based mechanism by the evidence of premixing,electron paramagnetic resonance(EPR)spectroscopy,salt-bridge experi-ments and electrochemical analyses.The introduction of recyclable filtration device solved the secondary pollution caused by the dispersion of the powdered catalyst in the treated water,which further proved the practicality and superiority of the MMF-AB catalyst.展开更多
基金supported by grants from the National Key Research and Development Program of China (Grant No. 2021YFC2500400)the National Natural Science Foundation of China (Grant No. 82172894)。
文摘Objective: Few studies have evaluated the benefits of colorectal cancer(CRC) screening integrating both non-genetic and genetic risk factors. Here, we aimed to integrate an existing non-genetic risk model(QCancer-10) and a 139-variant polygenic risk score to evaluate the effectiveness of screening on CRC incidence and mortality.Methods: We applied the integrated model to calculate 10-year CRC risk for 430,908 participants in the UK Biobank, and divided the participants into low-, intermediate-, and high-risk groups. We calculated the screening-associated hazard ratios(HRs) and absolute risk reductions(ARRs) for CRC incidence and mortality according to risk stratification.Results: During a median follow-up of 11.03 years and 12.60 years, we observed 5,158 CRC cases and 1,487 CRC deaths, respectively. CRC incidence and mortality were significantly lower among screened than non-screened participants in both the intermediateand high-risk groups [incidence: HR: 0.87, 95% confidence interval(CI): 0.81±0.94;0.81, 0.73±0.90;mortality: 0.75, 0.64±0.87;0.70, 0.58±0.85], which composed approximately 60% of the study population. The ARRs(95% CI) were 0.17(0.11±0.24) and 0.43(0.24±0.61), respectively, for CRC incidence, and 0.08(0.05±0.11) and 0.24(0.15±0.33), respectively, for mortality. Screening did not significantly reduce the relative or absolute risk of CRC incidence and mortality in the low-risk group. Further analysis revealed that screening was most effective for men and individuals with distal CRC among the intermediate to high-risk groups.Conclusions: After integrating both genetic and non-genetic factors, our findings provided priority evidence of risk-stratified CRC screening and valuable insights for the rational allocation of health resources.
基金The work was supported by the National Natural Science Foundation of China(Grant No.51978540).
文摘The composite pile consisting of core-pile and surrounding cement-enhanced soil is a promising pile foundation in recent years.However,how and to what extent the cement-enhanced soil influences the ultimate lateral resistance has not been fully investigated.In this paper,the ultimate lateral resistance of the composite pile was studied by finite element limit analysis(FELA)and theoretical upper-bound analysis.The results of FELA and theoretical analysis revealed three failure modes of laterally loaded composite piles.The effects of the enhanced soil thickness,strength,and pile-enhanced soil interface characteristics on the ultimate lateral resistance were studied.The results show that increasing the enhanced soil thickness leads to a significant improvement on ultimate lateral resistance factor(N P),and there is a critical thickness beyond which the thickness no longer affects the N P.Increasing the enhanced soil strength induced 6.2%-232.6%increase of N P.However,no noticeable impact was detected when the enhanced soil strength was eight times higher than that of the natural soil.The maximum increment of N P is only 30.5%caused by the increase of interface adhesion factor(a).An empirical model was developed to calculate the N P of the composite pile,and the results show excellent agreement with the analytical results.
文摘In the developmental dilemma of artificial intelligence(AI)-assisted judicial decision-making,the technical architecture of AI determines its inherent lack of transparency and interpretability,which is challenging to fundamentally improve.This can be considered a true challenge in the realm of AI-assisted judicial decision-making.By examining the court’s acceptance,integration,and trade-offs of AI technology embedded in the judicial field,the exploration of potential conflicts,interactions,and even mutual shaping between the two will not only reshape their conceptual connotations and intellectual boundaries but also strengthen the cognition and re-interpretation of the basic principles and core values of the judicial trial system.
基金supported by grants from the National Key Research and Development Program of China(Grant No.2021YFC2500400)the National Natural Science Foundation of China(Grant Nos.81974439&82204121)+2 种基金the Beijing-Tianjin-Hebei Basic Research Cooperation Special Project(20JCZXJC00090)the Tianjin Health Committee Foundation(Grant No.TJWJ2021MS008)the Tianjin Key Medical Discipline(Specialty)Construction Project(Grant No.TJYXZDXK-009A).
文摘Given the rapid changes in social structure(urbanization),economic structure(industrialization),and demographic structure(population aging)in China,cancer has become a major public health problem1.Extensive evidence has indicated that screening can decrease cancer mortality,particularly among high-risk groups,and several representative national and regional cancer screening programs have been launched in China to cope with the increasing burden of cancer.
基金This study is supported by the National Natural Science Foundation of China(Grant Nos.42175073 and 41975071).
文摘This study investigates the modulation of initial wind field structure on the relationship between the size and intensity of a simulated vortex.A series of idealized experiments are conducted by varying the radius of maximum wind(RMW)and shape parameter of the initial vortices.The size–intensity relationship is quantified by the linear regression coefficient of the azimuthally-averaged gale-force wind radius against the maximum wind during the development stage,reflecting the degree of size expansion at the same intensity increment.The regression coefficient increases with increased RMW and decreased,with the RMW being the primary constraint.The effect of lowering on the elevation of the regression coefficient gradually stands out when the initial RMW is large.Enlarging the RMW leads to a secondary circulation with a horizontally elongated structure,which retards the intensification while promoting size expansion,thus substantially enhancing size expansion as the vortex intensifies.Broadening the wind field outside the RMW by reducing results in abounding convection in the outer region,which promotes size expansion.Based on the axisymmetric tangential wind tendency and Sawyer–Eliassen equations,when the RMW is large,the active convection in the outer region can weaken the radial inflow induced by the eyewall heating in the inner region,thus retarding the intensification by reducing the radial imports of vorticity near the RMW.
基金This work was supported by the Science and Technology Innovation Program of Hunan Province(2022RC4027)the Joint Fund for Regional Innovation and Development of the National Natural Science Foundation of China(U22A20570).
文摘The development of allometric biomass models is important process in biomass estimation because the reliability of forest biomass and carbon estimations largely depends on the accuracy and precision of such models.National Forest Inventories(NFI)are detailed assessments of forest resources at national and regional levels that provide valuable data for forest biomass estimation.However,the lack of biomass allometric equations for each tree species in the NFI currently hampers the estimation of national-scale forest biomass.The main objective of this study was to develop allometric biomass regression equations for each tree species in the NFI of China based on limited biomass observations.These equations optimally grouped NFI and biomass observation species according to their phylogenetic relationships.Significant phylogenetic signals demonstrated phylogenetic conservation of the crown-to-stem biomass ratio.Based on phylogenetic relationships,we grouped and matched NFI and biomass observation species into 22 categories.Allometric biomass regression models were developed for each of these 22 species categories,and the models performed successfully(R^(2)=0.97,root mean square error(RMSE)=12.9t·ha^(–1),relative RMSE=11.5%).Furthermore,we found that phylogeny-based models performed more effectively than wood density-based models.The results suggest that grouping species based on their phylogenetic relationships is a reliable approach for the development and selection of accurate allometric equations.
基金supported by National Key Technology Support Program (Grant No. 2015BAI12B15)
文摘Breast cancer is the most common malignant tumor in Chinese women.Early screening is the best way to improve the rates of early diagnosis and survival of breast cancer patients.The peak onset age for breast cancer in Chinese women is considerably younger than those in European and American women.It is imperative to develop breast cancer screening guideline that is suitable for Chinese women.By summarizing the current evidence on breast cancer screening in Chinese women,and referring to the latest guidelines and consensus on breast cancer screening in Europe,the United States,and East Asia,the China Anti-Cancer Association and National Clinical Research Center for Cancer(Tianjin Medical University Cancer Institute and Hospital)have formulated population-based guideline for breast cancer screening in Chinese women.The guideline provides recommendations on breast cancer screening for Chinese women at average or high risk of breast cancer according to the following three aspects:age of screening,screening methods,and screening interval.This article provides more detailed information to support the recommendations in this guideline and to provide more direction for current breast cancer screening practices in China.
基金a part of NELCIN-B3 project. The NELCIN-B3 project is funded by The Royal Netherlands Academy of Arts and Sciences (Grant No. PSA_SA_BD_01)Ministry of Science and Technology of the People’s Republic of China+1 种基金National Key R & D Program of China (Grant No. 2016YFE0103000)the financial support from China Scholarship Council (CSC file No. 201708340072)
文摘Objective: European lung cancer screening studies using computed tomography(CT) have shown that a management protocol based on measuring lung nodule volume and volume doubling time(VDT) is more specific for early lung cancer detection than a diameter-based protocol. However, whether this also applies to a Chinese population is unclear. The aim of this study is to compare the diagnostic performance of a volume-based protocol with a diameter-based protocol for lung cancer detection and optimize the nodule management criteria for a Chinese population.Methods: This study has a population-based, prospective cohort design and includes 4000 participants from the Hexi district of Tianjin, China. Participants will undergo low-dose chest CT at baseline and after 1 year. Initially, detected lung nodules will be evaluated for diameter and managed according to a routine diameter-based protocol(Clinical Practice Guideline in Oncology for Lung Cancer Screening, Version 2.2018). Subsequently, lung nodules will be evaluated for volume and management will be simulated according to a volume-based protocol and VDT(a European lung nodule management protocol). Participants will be followed up for 4 years to evaluate lung cancer incidence and mortality. The primary outcome is the diagnostic performance of the European volume-based protocol compared to diameter-based management regarding lung nodules detected using low-dose CT.Results: The diagnostic performance of volume-and diameter-based management for lung nodules in a Chinese population will be estimated and compared.Conclusions: Through the study, we expect to improve the management of lung nodules and early detection of lung cancer in Chinese populations.
基金the National Natural Science Foundation of China(81372872 to J.Yang,81402215 to X.Du,and 81320108022 to K.Chen)funds from the University Cancer Foundation via the Sister Institution Network Fund at the Tianjin Medical University Cancer Institute and Hospital,Fudan University Shanghai Cancer Center,and University of Texas MD Anderson Cancer Centersupported by the program for Innovative Research Team in University in China(IRT1076 to K.Chen)
文摘Low-density lipoprotein receptor-related protein 1(LRP1,also known as CD91),a multifunctional endocytic and cell signaling receptor,is widely expressed on the surface of multiple cell types such as hepatocytes,fibroblasts,neurons,astrocytes,macrophages,smooth muscle cells,and malignant cells.Emerging in vitro and in vivo evidence demonstrates that LRP1 is critically involved in many processes that drive tumorigenesis and tumor progression.For example,LRP1 not only promotes tumor cell migration and invasion by regulating matrix metalloproteinase(MMP)-2and MMP-9 expression and functions but also inhibits cell apoptosis by regulating the insulin receptor,the serine/threonine protein kinase signaling pathway,and the expression of Caspase-3.LRPI-mediated phosphorylation of the extracellular signal-regulated kinase pathway and c-jun N-terminal kinase are also involved in tumor cell proliferation and invasion.In addition,LRP1 has been shown to be down-regulated by microRNA-205 and methylation of LRP1CpG islands.Furthermore,a novel fusion gene,LRP1-SNRNP25,promotes osteosarcoma cell invasion and migration.Only by understanding the mechanisms of these effects can we develop novel diagnostic and therapeutic strategies for cancers mediated by LRP1.
基金supported by the Program for Changjiang Scholars and Innovative Research Team in University in China(Grant No.IRT_14R40)National Key Research and Development Program of China(Grant No.2021YFC2500400)+4 种基金National Science and Technology Major Project(Grant No.2017ZX10203207)National Human Genetic Resources Sharing Service Platform(Grant No.2005DKA21300)National Key Research and Development Program of ChinaNet Construction of Human Genetic Resource Bio-bank in North China(Grant No.2016YFC1201703)and National Key R&D Program of China(Grant No.2017YFC0908300).
文摘Biobanks bridge the gap between basic and translational research.Traditional cancer biobanks typically contain normal and tumor tissues,and matched blood.However,biospecimens in traditional biobanks are usually nonrenewable.In recent years,increased interest has focused on establishing living biobanks,including organoid biobanks,for the collection and storage of viable and functional tissues for long periods of time.The organoid model is based on a 3D in vitro cell culture system,is highly similar to primary tissues and organs in vivo,and can recapitulate the phenotypic and genetic characteristics of target organs.Publications on cancer organoids have recently increased,and many types of cancer organoids have been used for modeling cancer processes,as well as for drug discovery and screening.On the basis of the current research status,more exploration of cancer organoids through technical advancements is required to improve reproducibility and scalability.Moreover,given the natural characteristics of organoids,greater attention must be paid to ethical considerations.Here,we summarize recent advances in cancer organoid biobanking research,encompassing rectal,gastric,pancreatic,breast,and glioblastoma cancers.Living cancer biobanks that contain cancerous tissues and matched organoids with different genetic backgrounds,subtypes,and individualized characteristics will eventually contribute to the understanding of cancer and ultimately facilitate the development of innovative treatments.
基金supported by the National Natural Science Foundation of China(Grant Nos.41775063 and 41975071)。
文摘Two different initialization schemes for tropical cyclone(TC)prediction in numerical models are evaluated based on a case study of Typhoon Lekima(2019).The first is a dynamical initialization(DI)scheme where the axisymmetric TC vortex in the initial conditions is spun up through the 6-h cycle runs before the initial forecast time.The second scheme is a bogussing scheme where the analysis TC vortex is replaced by a synthetic Rankine vortex.Results show that although both initialization schemes can help improve the simulated rapid intensification(RI)of Lekima,the simulation employing the DI scheme(DIS)reproduces better the RI onset and intensification rate than that employing the bogussing scheme(BOG).Further analyses show the cycle runs of DI help establish a realistic TC structure with stronger secondary circulation than those in the control run and BOG,leading to fast vortex spinup and contraction of the radius of maximum wind(RMW).The resultant strong inner-core primary circulation favors precession of the midlevel vortex under the moderate vertical wind shear(VWS)and thus helps vortex alignment,contributing to an earlier RI onset.Afterwards,the decreased vertical shear and the stronger convection inside the RMW support the persistent RI of Lekima in DIS.In contrast,the reduced VWS is not well captured and the inner-core convection is weaker and resides farther away from the TC center in BOG,leading to slower intensification.The results imply that the DI effectively improves the prediction of the inner-core process,which is crucial to the RI forecast.
基金supported by the Chinese National Key Research and Development Project(Grant No.2018YFC1315601)the National Natural Science Foundation of China(Grant No.81974488)the Tianjin Science and Technology Committee Foundation(Grant Nos.18JCQNJC80300 and 17JCYBJC25300).
文摘Objective:To develop and evaluate the screening performance of a low-cost high-risk screening strategy for breast cancer in low resource areas.Methods:Based on the Multi-modality Independent Screening Trial,6 questionnaire-based risk factors of breast cancer(age at menarche,age at menopause,age at first live birth,oral contraceptive,obesity,family history of breast cancer)were used to determine the women with high risk of breast cancer.The screening performance of clinical breast examination(CBE),breast ultrasonography(BUS),and mammography(MAM)were calculated and compared to determine the optimal screening method for these high risk women.Results:A total of 94 breast cancers were detected among 31,720 asymptomatic Chinese women aged 45–65 years.Due to significantly higher detection rates(DRs)and suitable coverage of the population,high risk women were defined as those with any of 6 risk factors.Among high risk women,the DR for BUS[3.09/1,000(33/10,694)]was similar to that for MAM[3.18/1,000(34/10,696)],while it was significantly higher than that for the CBE[1.73/1,000(19/10,959),P=0.002].Compared with MAM,BUS showed significantly higher specificity[98.64%(10,501/10,646)vs.98.06%(10,443/10,650),P=0.001],but no significant differences in sensitivity[68.75%(33/48)vs.73.91%(34/46)],positive prediction values[18.54%(33/178)vs.14.11%(34/241)],and negative prediction values[99.86%(10,501/10,516)vs.99.89%(10,443/10,455)].Further analyses showed no significant difference in the percentages of early stage breast cancer[53.57%(15/28)vs.50.00%(15/30)],lymph node involvement[22.73%(5/22)vs.28.00%(7/25)],and tumor size≥2 cm[37.04%(10/27)vs.29.03%(9/31)]between BUS and MAM.Subgroup analyses stratified by breast densities or age at enrollment showed similar results.Conclusions:The low-cost high-risk screening strategy based on 6 questionnaire-based risk factors was an easy-to-use method to identify women with high risk of breast cancer.Moreover,BUS and MAM had comparable screening performances among high risk women.
基金supported by the National Natural Science Foundation of China (Grant Nos. 41975071,42175073)the open project of the Shanghai Typhoon Institute,China Meteorological Administration (TFJJ202003)。
文摘This study reexamines the correlation between the size and intensity of tropical cyclones(TCs) over the western North Pacific from the perspective of individual TCs, rather than the previous large-sample framework mixing up all TC records.Statistics show that the positive size-intensity correlation based on individual TCs is relatively high. However, this correlation is obscured by mixing large samples. The weakened correlation based on all TC records is primarily due to the diversity in the size change relative to the same intensity change among TCs, which can be quantitatively measured by the linear regression coefficient(RC) of size against intensity. To further explore the factors that cause the variability in RCs that weakens the size-intensity correlation when considering all TC records, the TCs from 2001 to 2020 are classified into two groups according to their RC magnitudes, within which the high-RC TCs have a larger size expansion than the low-RC TCs given the same intensity change. Two key mechanisms responsible for the RC differences are proposed. First, the highRC TCs are generally located at higher latitudes than the low-RC TCs, resulting in higher planetary vorticity and thus higher planetary angular momentum import at low levels. Second, the high-RC TCs are susceptible to stronger environmental vertical wind shear, leading to more prolific outer convection than the low-RC TCs. The positive feedback between outer diabatic heating and boundary layer inflow favors the inward import of absolute angular momentum in the outer region, thereby contributing to a larger size expansion in the high-RC TCs.
文摘Objective:Sarcomas are a group of rare malignancies with various subtypes.Patients with metastatic sarcoma who have failed traditional treatments can possibly achieve better prognoses from using novel therapies,including anti-programmed death-1(PD-1)-based therapies.Methods:We retrospectively analyzed clinical data of 24 metastatic sarcoma patients from June 15,2016 to December 30,2019.These patients mainly received angiogenesis inhibitors combined with anti-PD-1 therapy after they became resistant to traditional treatments.Furthermore,8 patients underwent panel DNA and whole transcript sequencing.Results:Six patients received 2 cycles of anti-PD-1 therapy and were included in the safety evaluation only group.The median follow-up time was 5.77 months.The median progression-free survival was 7.59 months,the overall response rate was 16.7%and the disease control rate was 55.6%.Based on whole exome and transcript sequencing data,there was no association between TMB,TNB,MSI,HLA-LOH,and PD-L1 expressions and sarcoma types with clinical responses.Immunotherapy efficacy and bioinformatics analyses indicated higher intratumoral heterogeneity(ITH)in progressive disease(PD)patients and lower ITH in partial response(PR)and stable disease patients.A higher percentage of immune cell infiltration,especially monocytes,was observed in PR patients.Active stromal gene expression was increased in PD patients but decreased in PR patients.Enrichment analysis revealed that an increased TGF-βsignaling pathway was reversely correlated with anti-PD-1 efficacy,while a decreased inflammatory response signaling pathway was positively correlated with anti-PD-1 efficacy.Conclusions:Our study showed PD-1 inhibitors combined with anti-angiogenesis agents were effective and well-tolerated.ITH,monocyte ratio,stroma subtypes,and the status of immune-associated signaling pathways may be related with anti-PD-1 based therapy.
基金This work was supported by the National Natural Science Foundation of China(Grant No.31801117 to Dr.X.Li and 82073287 to Dr.Zhang)the Program for Changjiang Scholars and Innovative Research Team in University in China(Grant No.IRT_14R40 to Dr.K.Chen)the Chinese National Key Research and Development Project(Grant No.2018YFC1315601).
文摘Objective:Large volume radiological text data have been accumulated since the incorporation of electronic health record(EHR)systems in clinical practice.We aimed to determine whether deep natural language processing algorithms could aid radiologists in improving thyroid cancer diagnosis.Methods:Sonographic EHR data were obtained from the EHR database.Pathological reports were used as the gold standard for diagnosing thyroid cancer.We developed thyroid cancer diagnosis based on natural language processing(THCaDxNLP)to interpret unstructured sonographic text reports for thyroid cancer diagnosis.We used the area under the receiver operating characteristic curve(AUROC)as the primary metric to measure the performance of the THCaDxNLP.We compared the performance of thyroid ultrasound radiologists aided with THCaDxNLP vs.those without THCaDxNLP using 5 independent test sets.Results:We obtained a total number of 788,129 sonographic radiological reports.The number of thyroid sonographic data points was 132,277,18,400 of which were thyroid cancer patients.Among the 5 test sets,the numbers of patients per set were 439,186,82,343,and 171.THCaDxNLP achieved high performance in identifying thyroid cancer patients(the AUROC ranged from 0.857–0.932).Thyroid ultrasound radiologists aided with THCaDxNLP achieved significantly higher performances than those without THCaDxNLP in terms of accuracy(93.8%vs.87.2%;one-sided t-test,adjusted P=0.003),precision(92.5%vs.86.0%;P=0.018),and F1 metric(94.2%vs.86.4%;P=0.007).Conclusions:THCaDxNLP achieved a high AUROC for the identification of thyroid cancer,and improved the accuracy,sensitivity,and precision of thyroid ultrasound radiologists.This warrants further investigation of THCaDxNLP in prospective clinical trials.
基金This study was supported by the National Natural Science Foundation of China[grant numbers 41975071 and 41775063].
文摘In this study,the relationship of tropical cyclone(TC)size change rate(SCR),within 24 hours,with size,intensity,and intensity change rate(ICR)are explored over the western North Pacific.TC size is defined as the azimuthally averaged radius of gale-force wind of 17 m s−1(R17)based on the Multiplatform Tropical Cyclone Surface Winds Analysis data.The majority of SCRs are mainly distributed in the range from−20 to 80 km d−1.The correlation coefficients between SCR and size(SCR-R17),intensity,and ICR(SCR-ICR)are−0.43,−0.12,and 0.25,respectively.The sensitivity of the SCR-R17 and SCR-ICR relationships to size,intensity,and evolution stage are further examined.Results show that the SCR-R17 relationship is more sensitive to variations of size and evolution stage than that of intensity.The relationship of SCR-ICR is largely modulated by the evolution stage.The correlation coefficient of SCR-ICR can increase from 0.25 to 0.40 when only considering the lifetime stages concurrently before and after the lifetime maximum size(LMS)and lifetime maximum intensity.This demonstrates that ICR is a potential factor in predicting SCR during these evolution stages.Besides,the TC size expansion(shrinkage)is more likely to occur for TCs with smaller(larger)size and weaker(stronger)intensity.The complexity of size change during a TC's lifetime can be attributed to the fact that shrinkage or expansion could occur both before and after LMS.
文摘Homogeneous, high concentrated ceramic suspensions wi th low viscosity are the key controlling factors for the production of ceramic c omponents through colloidal processing. A well-dispersed suspension can be obta ined by choosing suitable dispersant, solvent, particle size distribution etc. B esides these factors, the homogenizing procedure is also a key step. In this paper, reaction sialon suspensions were prepared using 3-wt% KD1 as dis persant in organic media composed of 60-vol% methyletheylketone and 40-vol% et hanol. Different homogenizing procedures have been used and compared, including planetary milling, low energy ball milling and ultrasonic disaggregation. The ef fects of different homogenizing routes and mixing times on the rheology and stab ility of suspensions, and on the microstructure of slip casting green bodies, ha ve been studied. The varying dispersion efficiencies observed could be attribute d to differences in deagglomeration degrees achieved and in adsorption amount of dispersant onto the surface of reaction sialon powders.
文摘In recent years,the frequent adjustment of the government’s economic policies and the uncertainty of foreign economic situations have made the degree of uncertainty of China’s economic policies rise continuously.The increasing degree of policy uncertainty will inevitably affect the investment and financing decisions of micro enterprises.Then,how does economic policy uncertainty(EPU)affect mergers and acquisitions(M&A)behavior?What’s the mechanism?Based on the above questions,this paper uses the data of non-financial listed companies in the Shanghai and Shenzhen stock exchanges from 2008 to 2018 as a sample to explore the relationship between EPU and M&A.The study shows that rising EPU will promote corporate M&A behavior,and this effect is more significant in slow-growth companies.The relationship between EPU and M&A is affected by corporate governance,stock price volatility and financing constraints.Specifically,the company’s M&A size is more sensitive to EPU with higher level of corporate governance,higher level of stock price volatility,and lesser financing constraints.Further research shows that the rise of EPU will significantly promote the improvement of M&A performance in the short-term,but this effect does not exist in the long-term.Various robustness checks do not change the empirical results of this paper.
基金financial support from Sichuan Program of Science and Technology (Nos.2023NSFSC0344,2023JDZH0010)the National Natural Science Foundation of China (No.52200105)+1 种基金the National Key Research and Development Program of China (No.2021YFA1202500)the Analytical&Testing Center of Sichuan University for EPR detection
文摘Herein,a modified metal-free acetylene black(MMF-AB)catalyst was synthesized by a simple solvothermal-calcination method and designed successfully to activate peroxodisulfate(PDS)for the degradation of sulfisoxazole(SIZ).Due to the doping of N,S and O metal-free elements,the modified catalyst showed excellent catalytic performance with 100%SIZ removal within 30 min.Pseudo first-order reaction rate constants(evaluating catalytic efficiencies and activity)of MMF-AB(kobs=0.105 min^(−1))was 3 times higher than pure-AB(k_(obs)=0.029 min^(−1)).Interestingly,it was demonstrated that the reaction sys-tem is based on the transfer of electrons from SIZ to PDS to realize an electron-transfer-based mechanism by the evidence of premixing,electron paramagnetic resonance(EPR)spectroscopy,salt-bridge experi-ments and electrochemical analyses.The introduction of recyclable filtration device solved the secondary pollution caused by the dispersion of the powdered catalyst in the treated water,which further proved the practicality and superiority of the MMF-AB catalyst.
