Spatial heterogeneity or“patchiness”of plankton distributions in the ocean has always been an attractive and challenging scientific issue to oceanographers.We focused on the accumulation and dynamic mechanism of the...Spatial heterogeneity or“patchiness”of plankton distributions in the ocean has always been an attractive and challenging scientific issue to oceanographers.We focused on the accumulation and dynamic mechanism of the Acetes chinensis in the Lianyungang nearshore licensed fishing area.The Lagrangian frame approaches including the Lagrangian coherent structures theory,Lagrangian residual current,and Lagrangian particle-tracking model were applied to find the transport pathways and aggregation characteristics of Acetes chinensis.There exist some material transport pathways for Acetes chinensis passing through the licensed fishing area,and Acetes chinensis is easy to accumulate in the licensed fishing area.The main mechanism forming this distribution pattern is the local circulation induced by the nonlinear interaction of topography and tidal flow.Both the Lagrangian coherent structure analysis and the particle trajectory tracking indicate that Acetes chinensis in the licensed fishing area come from the nearshore estuary.This work contributed to the adjustment of licensed fishing area and the efficient utilization of fishery resources.展开更多
Naringin exists in a wide range of Chinese herbal medicine and has proven to possess several pharmacological properties.In this study,PC12,HepG2 cells,and female Drosophila melanogaster were used to investigate the an...Naringin exists in a wide range of Chinese herbal medicine and has proven to possess several pharmacological properties.In this study,PC12,HepG2 cells,and female Drosophila melanogaster were used to investigate the antioxidative and anti-aging effects of naringin and explore the underlying mechanisms.The results showed that naringin inhibited H_(2)O_(2)-induced decline in cell viability and decreased,the content of reactive oxygen species in cells.Meanwhile,naringin prolonged the lifespan of flies,enhanced the abilities of climbing and the resistance to stress,improved the activities of antioxidant enzymes,and decreased malondialdehyde content.Naringin also improved intestinal barrier dysfunction and reduced abnormal proliferation of intestinal stem cells.Moreover,naringin down-regulated the mRNA expressions of inr,chico,pi 3k,and akt-1,and up-regulated the mRNA expressions of dilp2,dilp3,dilp5,and foxo,thereby activating autophagy-related genes and increasing the number of lysosomes.Furthermore,the mutant stocks assays and computer molecular simulation results further indicated that naringin delayed aging by inhibiting the insulin signaling(IIS)pathway and activating the autophagy pathway,which was consistent with the result of network pharmacological predictions.展开更多
Demand of highly efficient earth-abundant transition metal-based electrocatalysts to replace noble metal materials for boosting oxygen evolution reaction(OER)is rapidly growing.Herein,an electrochemically exfoliated g...Demand of highly efficient earth-abundant transition metal-based electrocatalysts to replace noble metal materials for boosting oxygen evolution reaction(OER)is rapidly growing.Herein,an electrochemically exfoliated graphite(EG)foil supported bimetallic selenide encased in N-doped carbon(EG/(Co,Ni)Se2-NC)hybrid is developed and synthesized by a vapor-phase hydrothermal strategy and subsequent selenization process.The as-prepared EG/(Co,Ni)Se2-NC hybrid exhibits a core-shell structure where the particle diameter of(Co,Ni)Se2 core is about 70 nm and the thickness of N-doped carbon shell is approximately 5 nm.Benefitting from the synergistic effects between the combination of highly active Co species and improved electron transfer from Ni species,and N-doped carbon,the EG/(Co,Ni)Se2-NC hybrid shows remarkable electrocatalytic activity toward OER with a comparatively low overpotential of 258 mV at an current density of 10 mA cm?2 and a small Tafel slope of 73.3 mV dec?1.The excellent OER catalysis performance of EG/(Co,Ni)Se2-NC hybrid is much better than that of commercial Ir/C(343 mV at 10 mA cm?2 and 98.1 mV dec?1),and even almost the best among all previously reported binary CoNi selenide-based OER electrocatalysts.Furthermore,in situ electrochemical Raman spectroscopy combined with ex situ X-ray photoelectron spectroscopy analysis indicates that the superb OER catalysis activity can be attributed to the highly active Co-OOH species and modified electron transfer process from Ni element.展开更多
Research on the ecological effect of microronamentations on the scale surface in reptiles has been carried out over the past few decades.It is found that the microornamentation pattern in reptiles is related to their ...Research on the ecological effect of microronamentations on the scale surface in reptiles has been carried out over the past few decades.It is found that the microornamentation pattern in reptiles is related to their habitats.This study examined the wettability on scale surface,as well as the differences in microornamentation on ventral scales from the mid-body region in three snake species,Hypsiscopus plumbea(aquatic),Oocatochus rufodorsata(semi-aquatic) and Elaphe carinata(terricolous).Moreover,the scale specimens were metallized and analyzed using scanning electron microscopy.Our results showed that there are microornamentations on the ventral scale surfaces of the tested species,which showed interspecific differences.To be specific,the aquatic snake shows the narrow,fine and regular denticulations which are connected to reduce friction and dirt shedding.By contrast,the terrestrial snake acquired the wider and shorter denticulation which would render more friction during locomotion but it shows greater water resistance to improve the capacity of dirt shedding and compensate for the disadvantage of short and wide denticulations.Additionally,the denticulation characteristics of the semi-aquatic snake fell in between those of aquatic and terrestrial snakes.Therefore,it is deduced in this study that the ventral scale microornamentations in snakes contribute to ecological adaptation to their preferential microhabitats.展开更多
Alfalfa (Medicago sativa L.) is the most widely cultivated perennial leguminous forage crop woldwide.Micro RNA156 (miR156) precursor genes from dicotyledonous species are reportedly useful for improving alfalfa plant ...Alfalfa (Medicago sativa L.) is the most widely cultivated perennial leguminous forage crop woldwide.Micro RNA156 (miR156) precursor genes from dicotyledonous species are reportedly useful for improving alfalfa plant architecture and abiotic stress resistance.However,there has been no report on whether a miR156 precursor gene from a monocotyledonous species functions in alfalfa.We introduced two tandem precursor genes of miR156,rice Osa-MIR156b and Osa-MIR156c (Osa-MIR156bc),into alfalfa.The expression of miR156 in the transgenic (TG) alfalfa was significantly elevated.Compared to wild-type plants,the TG plants overexpressing miR156 had more branches and leaves and showed improved salt and drought tolerance.Overexpression of miR156 slightly reduced plant height,but the biomass yield of TG plants grown in flowerpots was still increased.Forage quality of TG plants was markedly improved by reduction of acid detergent lignin (ADL) content and increase in crude protein content.The expression of the putative miR156 target genes Ms SPL6,Ms SPL12,and Ms SPL13 in TG plants was repressed by miR156overexpression,and that of all tested Ms SPLs would be sharply increased under drought or salt stress.RNA sequencing revealed that overexpression of miR156 affected the expression of genes associated with abiotic stress resistance and plant development in multiple pathways.This first report of overexpression of monocot miR156 precursors in alfalfa sheds light on the function of mi RNA156 precursors from the monocot species rice that could be used for genetic improvement of the dicot forage crop alfalfa.展开更多
With the tide of economic globalization and the practice of“One Belt and One Road”Initiative,Sino-foreign cooperation has gradually become one of the effective ways to improve the quality of higher education.This pa...With the tide of economic globalization and the practice of“One Belt and One Road”Initiative,Sino-foreign cooperation has gradually become one of the effective ways to improve the quality of higher education.This paper based on the statistics and analysis of the data released by the Ministry of Education’s foreign-related supervision information platform,combining with the actual investigation and research on the situation of Sino-foreign cooperation of higher education in municipal universities of Wuhan,has found that the Sino-foreign cooperation programs commonly have problems of non-standardized enrollment of students,insufficient quality of teachers and teaching qualities,and lack of core competitiveness.Therefore,it is essential to upgrade the level of foreign cooperative institutions and the standards of students’recruitment,optimize the curriculum,pay attention to the public welfare of education,improve the teaching model,improve the level of teachers,so as to truly realize the original intention of Sino-foreign cooperation in municipal universities of Wuhan.展开更多
As in recent years the deepening reform and opening-up and the accelerated economic development of Hubei region as well as the vigorously advocate of the government for innovation and enterpreneurship,small and medium...As in recent years the deepening reform and opening-up and the accelerated economic development of Hubei region as well as the vigorously advocate of the government for innovation and enterpreneurship,small and medium-sized manufacturing enterprises have already becoming a nucleus of pushing the rapid economic development in Hubei.This paper explores the whole development status of the Hubei Manufacturing Enterprises in SME Board through the analysis of eight aspects of the 186 Hubei Manufacturing Enterprises in SME Board Regularly Operated and Annual Report Disclosure in 2017,which finds out that currently Hubei Manufacturing Enterprises in SME Board concentrate to the developed region,the overall education background of the employees is low and most of the enterprises are private enterprises with labor-intensive economy,the financial situation reflects the characteristics of industry differences.Enterprises should accelerate upgrading and transformation,enhancing the market competitive ability,at the same time the government should carefully study,formulating encouraging and supporting policies suitable for different enterprises and industries,strengthening supervision and management of SME board market in order to attract more outstanding small and medium-sized manufacturing enterprises,accelerating the development of manufacturing industry in Hubei.展开更多
The Shuangwang gold deposit, located in the Fengxian-Taibai fore-arc basin in the western Qinling Orogen of Central China, has yielded over 70 tons of gold. It is an orogenic gold deposit occurring in an NW-trending b...The Shuangwang gold deposit, located in the Fengxian-Taibai fore-arc basin in the western Qinling Orogen of Central China, has yielded over 70 tons of gold. It is an orogenic gold deposit occurring in an NW-trending breccia belt. Most of the ores are hydrothermal breccia type containing fragments of adjacent strata cemented by ankerite and pyrite. Pyrite is the most abundant metallic mineral and the major gold-bearing mineral in the ores. A total of 58 pyrite samples from main ore bodies of the Shuangwang gold deposit have been analysed for 44 trace elements by HR-ICP-MS. Sb, Ba, Cu, Pb, Zn, Bi, Mo, Co are selected as indicator elements to investigate the potential usefulness of trace elements in pyrite as an indicator in gold exploration. The results show that the supra-ore halo elements Sb and Ba, which may have been more active than other near-ore halo elements and sub-ore halo elements, are best to characterize the shape of ore bodies. Five target areas are pointed out for deep ore exploration based on a comprehensive study of supra-ore, near-ore and sub-ore halos. This study provides evidence that trace elements in pyrite can be used to depict the deep extension of ore bodies and to vector towards undiscovered ore bodies.展开更多
Caries is considered to be the most prevalent non-communicable disease in humans, mainly deriving from acidogenic bacterial biofilm and resulting in the demineralization and decomposition of hard dental tissue. Herein...Caries is considered to be the most prevalent non-communicable disease in humans, mainly deriving from acidogenic bacterial biofilm and resulting in the demineralization and decomposition of hard dental tissue. Herein, a composite responsive foam brace loaded with magnesium organic framework (MPC) is designed for caries prevention and tooth remineralization. MPC can intelligently release organic antibacterial molecules (gallic acid) and mineralized ions (Mg2+, Ca2+ and PO43 ) under acidic conditions (pH < 5.5) of biofilm infection, regulating pH and killing bacteria. Additionally, due to the excellent photothermal conversion efficiency, MPC can further enhance the destruction of bacterial biofilm by inhibiting virulence genes and destroying bacterial adhesion under near-infrared light irradiation (808 nm). More importantly, MPC can not only reverse the cariogenic environment at both pH and microbial levels, but also promote self-healing of demineralized teeth in terms of both the micro-structure and mechanical properties.展开更多
Large-scale electric vehicle(EV)deployment powered by renewable electricity has the potential to drastically change the environmental impacts of road transportation.The transportation sector is a major contributor to ...Large-scale electric vehicle(EV)deployment powered by renewable electricity has the potential to drastically change the environmental impacts of road transportation.The transportation sector is a major contributor to global greenhouse gas(GHG)emissions[1,2],air pollution,and related health impacts[3].Renewable-powered EVs substantially decrease fossil fuel consumption and are a pivotal technology to reduce transportation’s climate burden while also substantially improving air quality and public health.However.展开更多
Background The ongoing Coronavirus disease of 2019(COVID-19)pandemic has hit Brazil hard in period of different dominant variants.Different COIVD-19 variants have swept through the region,resulting that the total numb...Background The ongoing Coronavirus disease of 2019(COVID-19)pandemic has hit Brazil hard in period of different dominant variants.Different COIVD-19 variants have swept through the region,resulting that the total number of cases in Brazil is the third highest in the world.This study is aimed at investigating the regional heterogeneity of in-hospital mortality of COVID-19 in Brazil and the effects of vaccination and social inequality.Methods We fitted a multivariate mixed-effects Cox model to a national database of inpatient data in Brazil who were admitted for COVID-19 from February 27,2020 to March 15,2022.The in-hospital mortality risks of vaccinated and unvaccinated patients were compared,with adjustment for age,state,ethnicity,education and comorbidities.And the effects of variables to in-hospital mortality were also compared.Stratified analysis was conducted across different age groups and vaccine types.Results By fitting the multivariate mixed-effects Cox model,we concluded that age was the most important risk factor for death.With regards to educational level,illiterate patients(hazard ratio:1.63,95%CI:1.56–1.70)had a higher risk than those with a university or college degree.Some common comorbidities were more dangerous for hospitalized patients,such as liver disease(HR:1.46,95%CI:1.34–1.59)and immunosuppression(HR:1.32,95%CI:1.26–1.40).In addition,the states involving Sergipe(HR:1.75,95%CI:1.46–2.11),Roraima(HR:1.65,95%CI:1.43–1.92),Maranhão(HR:1.57,95%CI:1.38–1.79),Acre(HR:1.44,95%CI:1.12–1.86),and Rondônia(HR:1.26,95%CI:1.10–1.44)in the north and the northeast region tended to have higher hazard ratios than other area.In terms of vaccine protection,vaccination did not significantly reduce mortality among hospitalized patients.Sinovac and AstraZeneca offered different protection in different regions,and no vaccine provided high protection in all regions.Conclusion The study revealed the regional heterogeneity of in-hospital mortality of Covid-19 in Brazil and the effects of vaccination and social inequality.We found that ethnic concentrations were consistent with higher proportion of death cases relative to population size.White Brazilians had more frequent international travel opportunities.As race revealed the intersection of social connections,we speculated that uneven interactions with residential communities partially contribute to the spread of the epidemic.Additionally,the vaccine showed different protection in different regions.In the northern and northeastern regions,AstraZeneca was much more protective than Sinovac,while Sinovac was more protective for hospitalized patients with varying numbers of comorbidities in the Central-west,Southeast and South regions.展开更多
A gold nanoparticle-based label-free colorimetric assay was developed to detect the shrimp allergenic protein tropomyosin(TM),an important biomarker responsible for severe clinical reactivity to shellfish.In a gold na...A gold nanoparticle-based label-free colorimetric assay was developed to detect the shrimp allergenic protein tropomyosin(TM),an important biomarker responsible for severe clinical reactivity to shellfish.In a gold nanoparticles(AuNPs)-tropomyosin-binding aptamer(TMBA)complex,the aptamer adsorbs onto the surface of AuNPs and dissociates in the presence of TM.In addition,AuNPs tend to aggregate in the presence of ionic salt,revealing a color change(i.e.,wine-red to purple/blue)with a shift in the maximum absorption peak from 520 nm.In the presence of specific binding TM,the aptamer folds into a tertiary structure where it more efficiently stabilizes AuNPs toward the salt-induced aggregation with a hypsochromic shift in the absorption spectra compared to the stabilized AuNPs by aptamer alone.Based on the aggregation and sensitive spectral transformation principle,the AuNPs-based colorimetric aptasensor was successfully applied to detect TM with a range of 10-200 nmol/L and a low detection limit of 40 nmol/L in water samples.The reliability,selectivity,and sensitivity of the aptasensor was then tested with food samples spiked with TM.The observed detection limit was as low as 70 nmol/L in shrimp,90 nmol/L in tofu,and 80 nmol/L in eggs,respectively.We anticipate the proposed AuNPs-based colorimetric aptasensor assay possesses a high potential for the easy and efficient visual colorimetric detection of TM.展开更多
基金the National Natural Science Foundation of China(No.31802297)。
文摘Spatial heterogeneity or“patchiness”of plankton distributions in the ocean has always been an attractive and challenging scientific issue to oceanographers.We focused on the accumulation and dynamic mechanism of the Acetes chinensis in the Lianyungang nearshore licensed fishing area.The Lagrangian frame approaches including the Lagrangian coherent structures theory,Lagrangian residual current,and Lagrangian particle-tracking model were applied to find the transport pathways and aggregation characteristics of Acetes chinensis.There exist some material transport pathways for Acetes chinensis passing through the licensed fishing area,and Acetes chinensis is easy to accumulate in the licensed fishing area.The main mechanism forming this distribution pattern is the local circulation induced by the nonlinear interaction of topography and tidal flow.Both the Lagrangian coherent structure analysis and the particle trajectory tracking indicate that Acetes chinensis in the licensed fishing area come from the nearshore estuary.This work contributed to the adjustment of licensed fishing area and the efficient utilization of fishery resources.
基金supported by the open project of the Key Laboratory of Environmental Pollution Monitoring and Disease Control,Ministry of Education,Guizhou Medical University,China (GMU-2022-HJZ-06)。
文摘Naringin exists in a wide range of Chinese herbal medicine and has proven to possess several pharmacological properties.In this study,PC12,HepG2 cells,and female Drosophila melanogaster were used to investigate the antioxidative and anti-aging effects of naringin and explore the underlying mechanisms.The results showed that naringin inhibited H_(2)O_(2)-induced decline in cell viability and decreased,the content of reactive oxygen species in cells.Meanwhile,naringin prolonged the lifespan of flies,enhanced the abilities of climbing and the resistance to stress,improved the activities of antioxidant enzymes,and decreased malondialdehyde content.Naringin also improved intestinal barrier dysfunction and reduced abnormal proliferation of intestinal stem cells.Moreover,naringin down-regulated the mRNA expressions of inr,chico,pi 3k,and akt-1,and up-regulated the mRNA expressions of dilp2,dilp3,dilp5,and foxo,thereby activating autophagy-related genes and increasing the number of lysosomes.Furthermore,the mutant stocks assays and computer molecular simulation results further indicated that naringin delayed aging by inhibiting the insulin signaling(IIS)pathway and activating the autophagy pathway,which was consistent with the result of network pharmacological predictions.
基金Y.Hou expresses appreciation of the assistance of the NSFC 51702284 and 21878270Zhejiang Provincial Natural Science Foundation of China(LR19B060002)the Startup Foundation for Hundred-Talent Program of Zhejiang University(112100-193820101/001/022).
文摘Demand of highly efficient earth-abundant transition metal-based electrocatalysts to replace noble metal materials for boosting oxygen evolution reaction(OER)is rapidly growing.Herein,an electrochemically exfoliated graphite(EG)foil supported bimetallic selenide encased in N-doped carbon(EG/(Co,Ni)Se2-NC)hybrid is developed and synthesized by a vapor-phase hydrothermal strategy and subsequent selenization process.The as-prepared EG/(Co,Ni)Se2-NC hybrid exhibits a core-shell structure where the particle diameter of(Co,Ni)Se2 core is about 70 nm and the thickness of N-doped carbon shell is approximately 5 nm.Benefitting from the synergistic effects between the combination of highly active Co species and improved electron transfer from Ni species,and N-doped carbon,the EG/(Co,Ni)Se2-NC hybrid shows remarkable electrocatalytic activity toward OER with a comparatively low overpotential of 258 mV at an current density of 10 mA cm?2 and a small Tafel slope of 73.3 mV dec?1.The excellent OER catalysis performance of EG/(Co,Ni)Se2-NC hybrid is much better than that of commercial Ir/C(343 mV at 10 mA cm?2 and 98.1 mV dec?1),and even almost the best among all previously reported binary CoNi selenide-based OER electrocatalysts.Furthermore,in situ electrochemical Raman spectroscopy combined with ex situ X-ray photoelectron spectroscopy analysis indicates that the superb OER catalysis activity can be attributed to the highly active Co-OOH species and modified electron transfer process from Ni element.
基金supported by grants from Natural Science Foundation of China(31200283 and 31770443)the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) of Jiangsu Higher Education Institutions。
文摘Research on the ecological effect of microronamentations on the scale surface in reptiles has been carried out over the past few decades.It is found that the microornamentation pattern in reptiles is related to their habitats.This study examined the wettability on scale surface,as well as the differences in microornamentation on ventral scales from the mid-body region in three snake species,Hypsiscopus plumbea(aquatic),Oocatochus rufodorsata(semi-aquatic) and Elaphe carinata(terricolous).Moreover,the scale specimens were metallized and analyzed using scanning electron microscopy.Our results showed that there are microornamentations on the ventral scale surfaces of the tested species,which showed interspecific differences.To be specific,the aquatic snake shows the narrow,fine and regular denticulations which are connected to reduce friction and dirt shedding.By contrast,the terrestrial snake acquired the wider and shorter denticulation which would render more friction during locomotion but it shows greater water resistance to improve the capacity of dirt shedding and compensate for the disadvantage of short and wide denticulations.Additionally,the denticulation characteristics of the semi-aquatic snake fell in between those of aquatic and terrestrial snakes.Therefore,it is deduced in this study that the ventral scale microornamentations in snakes contribute to ecological adaptation to their preferential microhabitats.
基金supported by the National Natural Science Foundation of China (31971755)the Beijing Municiple Natural Science Foundation (6192011) of China。
文摘Alfalfa (Medicago sativa L.) is the most widely cultivated perennial leguminous forage crop woldwide.Micro RNA156 (miR156) precursor genes from dicotyledonous species are reportedly useful for improving alfalfa plant architecture and abiotic stress resistance.However,there has been no report on whether a miR156 precursor gene from a monocotyledonous species functions in alfalfa.We introduced two tandem precursor genes of miR156,rice Osa-MIR156b and Osa-MIR156c (Osa-MIR156bc),into alfalfa.The expression of miR156 in the transgenic (TG) alfalfa was significantly elevated.Compared to wild-type plants,the TG plants overexpressing miR156 had more branches and leaves and showed improved salt and drought tolerance.Overexpression of miR156 slightly reduced plant height,but the biomass yield of TG plants grown in flowerpots was still increased.Forage quality of TG plants was markedly improved by reduction of acid detergent lignin (ADL) content and increase in crude protein content.The expression of the putative miR156 target genes Ms SPL6,Ms SPL12,and Ms SPL13 in TG plants was repressed by miR156overexpression,and that of all tested Ms SPLs would be sharply increased under drought or salt stress.RNA sequencing revealed that overexpression of miR156 affected the expression of genes associated with abiotic stress resistance and plant development in multiple pathways.This first report of overexpression of monocot miR156 precursors in alfalfa sheds light on the function of mi RNA156 precursors from the monocot species rice that could be used for genetic improvement of the dicot forage crop alfalfa.
文摘With the tide of economic globalization and the practice of“One Belt and One Road”Initiative,Sino-foreign cooperation has gradually become one of the effective ways to improve the quality of higher education.This paper based on the statistics and analysis of the data released by the Ministry of Education’s foreign-related supervision information platform,combining with the actual investigation and research on the situation of Sino-foreign cooperation of higher education in municipal universities of Wuhan,has found that the Sino-foreign cooperation programs commonly have problems of non-standardized enrollment of students,insufficient quality of teachers and teaching qualities,and lack of core competitiveness.Therefore,it is essential to upgrade the level of foreign cooperative institutions and the standards of students’recruitment,optimize the curriculum,pay attention to the public welfare of education,improve the teaching model,improve the level of teachers,so as to truly realize the original intention of Sino-foreign cooperation in municipal universities of Wuhan.
基金Subsidized Project of Management Science and Engineering of Key Disciplines in Hubei Province“The Research of the Development of the Hubei Manufacturing Enterprises in SME Board”(Project No.ZDXK2018YB12).
文摘As in recent years the deepening reform and opening-up and the accelerated economic development of Hubei region as well as the vigorously advocate of the government for innovation and enterpreneurship,small and medium-sized manufacturing enterprises have already becoming a nucleus of pushing the rapid economic development in Hubei.This paper explores the whole development status of the Hubei Manufacturing Enterprises in SME Board through the analysis of eight aspects of the 186 Hubei Manufacturing Enterprises in SME Board Regularly Operated and Annual Report Disclosure in 2017,which finds out that currently Hubei Manufacturing Enterprises in SME Board concentrate to the developed region,the overall education background of the employees is low and most of the enterprises are private enterprises with labor-intensive economy,the financial situation reflects the characteristics of industry differences.Enterprises should accelerate upgrading and transformation,enhancing the market competitive ability,at the same time the government should carefully study,formulating encouraging and supporting policies suitable for different enterprises and industries,strengthening supervision and management of SME board market in order to attract more outstanding small and medium-sized manufacturing enterprises,accelerating the development of manufacturing industry in Hubei.
基金supported by the National Natural Science Foundation of China(Nos.41230311,41272106,41030423)the Special Program on Mineral Resources Survey from CGS(No.1212011220923)
文摘The Shuangwang gold deposit, located in the Fengxian-Taibai fore-arc basin in the western Qinling Orogen of Central China, has yielded over 70 tons of gold. It is an orogenic gold deposit occurring in an NW-trending breccia belt. Most of the ores are hydrothermal breccia type containing fragments of adjacent strata cemented by ankerite and pyrite. Pyrite is the most abundant metallic mineral and the major gold-bearing mineral in the ores. A total of 58 pyrite samples from main ore bodies of the Shuangwang gold deposit have been analysed for 44 trace elements by HR-ICP-MS. Sb, Ba, Cu, Pb, Zn, Bi, Mo, Co are selected as indicator elements to investigate the potential usefulness of trace elements in pyrite as an indicator in gold exploration. The results show that the supra-ore halo elements Sb and Ba, which may have been more active than other near-ore halo elements and sub-ore halo elements, are best to characterize the shape of ore bodies. Five target areas are pointed out for deep ore exploration based on a comprehensive study of supra-ore, near-ore and sub-ore halos. This study provides evidence that trace elements in pyrite can be used to depict the deep extension of ore bodies and to vector towards undiscovered ore bodies.
基金The project of Hebei Administration of Traditional Chinese Medicine (Grant No. 2020167)the project of the Second Hospital of Hebei Medical University (Grant No. 2HS202014)the Chinese Medicine Association (Grant No. CMEI2019KPYJ00142)
基金the National Natural Science Foundation of China(No.31860263 to Xiaolei WangNo.82160194 and No.81960492 to Lan Liao)+3 种基金Key Youth Project of Jiangxi Province(20202ACB216002 to Xiaolei Wang)Key Research and Development Program of Jiangxi Province(20212BBG73004 to Xiaolei Wang20212BBG73022 to Lan Liao)Natural Science Foundation of Jiangxi Province(No.20181ACB20022 to Lan Liao).
文摘Caries is considered to be the most prevalent non-communicable disease in humans, mainly deriving from acidogenic bacterial biofilm and resulting in the demineralization and decomposition of hard dental tissue. Herein, a composite responsive foam brace loaded with magnesium organic framework (MPC) is designed for caries prevention and tooth remineralization. MPC can intelligently release organic antibacterial molecules (gallic acid) and mineralized ions (Mg2+, Ca2+ and PO43 ) under acidic conditions (pH < 5.5) of biofilm infection, regulating pH and killing bacteria. Additionally, due to the excellent photothermal conversion efficiency, MPC can further enhance the destruction of bacterial biofilm by inhibiting virulence genes and destroying bacterial adhesion under near-infrared light irradiation (808 nm). More importantly, MPC can not only reverse the cariogenic environment at both pH and microbial levels, but also promote self-healing of demineralized teeth in terms of both the micro-structure and mechanical properties.
基金This study was funded by the National Natural Science Foundation of China(No.71974092).
文摘Large-scale electric vehicle(EV)deployment powered by renewable electricity has the potential to drastically change the environmental impacts of road transportation.The transportation sector is a major contributor to global greenhouse gas(GHG)emissions[1,2],air pollution,and related health impacts[3].Renewable-powered EVs substantially decrease fossil fuel consumption and are a pivotal technology to reduce transportation’s climate burden while also substantially improving air quality and public health.However.
基金National Natural Science Foundation of China (Grant No. 82003953)China Postdoctoral Science Foundation (Grant No. 2019M662278)+2 种基金Science and Technology Project of Education Department of Jiangxi Province (Grant No. GJJ190688, GJJ201252)Po stdoctoral Science Foundation of Jiangxi Province (Grant No. 2019KY42)Key Scientific Research Foundation of Jiangxi University of Traditional Chinese Medicine (Grant No. 2004/538200010402)。
基金The work described in this paper was partially supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region,China(HKU C7123-20G).
文摘Background The ongoing Coronavirus disease of 2019(COVID-19)pandemic has hit Brazil hard in period of different dominant variants.Different COIVD-19 variants have swept through the region,resulting that the total number of cases in Brazil is the third highest in the world.This study is aimed at investigating the regional heterogeneity of in-hospital mortality of COVID-19 in Brazil and the effects of vaccination and social inequality.Methods We fitted a multivariate mixed-effects Cox model to a national database of inpatient data in Brazil who were admitted for COVID-19 from February 27,2020 to March 15,2022.The in-hospital mortality risks of vaccinated and unvaccinated patients were compared,with adjustment for age,state,ethnicity,education and comorbidities.And the effects of variables to in-hospital mortality were also compared.Stratified analysis was conducted across different age groups and vaccine types.Results By fitting the multivariate mixed-effects Cox model,we concluded that age was the most important risk factor for death.With regards to educational level,illiterate patients(hazard ratio:1.63,95%CI:1.56–1.70)had a higher risk than those with a university or college degree.Some common comorbidities were more dangerous for hospitalized patients,such as liver disease(HR:1.46,95%CI:1.34–1.59)and immunosuppression(HR:1.32,95%CI:1.26–1.40).In addition,the states involving Sergipe(HR:1.75,95%CI:1.46–2.11),Roraima(HR:1.65,95%CI:1.43–1.92),Maranhão(HR:1.57,95%CI:1.38–1.79),Acre(HR:1.44,95%CI:1.12–1.86),and Rondônia(HR:1.26,95%CI:1.10–1.44)in the north and the northeast region tended to have higher hazard ratios than other area.In terms of vaccine protection,vaccination did not significantly reduce mortality among hospitalized patients.Sinovac and AstraZeneca offered different protection in different regions,and no vaccine provided high protection in all regions.Conclusion The study revealed the regional heterogeneity of in-hospital mortality of Covid-19 in Brazil and the effects of vaccination and social inequality.We found that ethnic concentrations were consistent with higher proportion of death cases relative to population size.White Brazilians had more frequent international travel opportunities.As race revealed the intersection of social connections,we speculated that uneven interactions with residential communities partially contribute to the spread of the epidemic.Additionally,the vaccine showed different protection in different regions.In the northern and northeastern regions,AstraZeneca was much more protective than Sinovac,while Sinovac was more protective for hospitalized patients with varying numbers of comorbidities in the Central-west,Southeast and South regions.
基金This work was supported by National Natural Science Foundation of China(31771892).
文摘A gold nanoparticle-based label-free colorimetric assay was developed to detect the shrimp allergenic protein tropomyosin(TM),an important biomarker responsible for severe clinical reactivity to shellfish.In a gold nanoparticles(AuNPs)-tropomyosin-binding aptamer(TMBA)complex,the aptamer adsorbs onto the surface of AuNPs and dissociates in the presence of TM.In addition,AuNPs tend to aggregate in the presence of ionic salt,revealing a color change(i.e.,wine-red to purple/blue)with a shift in the maximum absorption peak from 520 nm.In the presence of specific binding TM,the aptamer folds into a tertiary structure where it more efficiently stabilizes AuNPs toward the salt-induced aggregation with a hypsochromic shift in the absorption spectra compared to the stabilized AuNPs by aptamer alone.Based on the aggregation and sensitive spectral transformation principle,the AuNPs-based colorimetric aptasensor was successfully applied to detect TM with a range of 10-200 nmol/L and a low detection limit of 40 nmol/L in water samples.The reliability,selectivity,and sensitivity of the aptasensor was then tested with food samples spiked with TM.The observed detection limit was as low as 70 nmol/L in shrimp,90 nmol/L in tofu,and 80 nmol/L in eggs,respectively.We anticipate the proposed AuNPs-based colorimetric aptasensor assay possesses a high potential for the easy and efficient visual colorimetric detection of TM.
