Curcumin is a hydrophobic polyphenol compound exhibiting a wide range of biological activities such as anti-inflammatory, anti-bacterial, anti-fungal, anti-carcinogenic, anti-human immunodeficiency virus, and antimicr...Curcumin is a hydrophobic polyphenol compound exhibiting a wide range of biological activities such as anti-inflammatory, anti-bacterial, anti-fungal, anti-carcinogenic, anti-human immunodeficiency virus, and antimicrobial activity. In this employed to produce the work, a swirl mixer was micronized curcumin with polyvinylpyrrolidone （PVP） by the supercritical antisolvent process to improve the bioavailability of curcumin. The effects of operating parameters such as curcumin/PVP ratio, feed concentration, temperature, pressure, and CO2 flow rate were investigated. The characterization and solubility of particles were determined by using scanning electron microscopy, Fourier Transform Infrared spectroscopy, and ultra-violet-visible spectroscopy. The result shows that the optimal condition for the production of curcumin/PVP particles is at curcumin/PVP ratio of 1：30, feed concentration of 5 mg·mL^-1, temperature of 40 ℃, pressure of 15 MPa, and CO2 flow rate of 15 mL·min^-1. Moreover, the dissolution of curcumin/PVP particles is faster than that of raw curcumin.展开更多
文摘Curcumin is a hydrophobic polyphenol compound exhibiting a wide range of biological activities such as anti-inflammatory, anti-bacterial, anti-fungal, anti-carcinogenic, anti-human immunodeficiency virus, and antimicrobial activity. In this employed to produce the work, a swirl mixer was micronized curcumin with polyvinylpyrrolidone （PVP） by the supercritical antisolvent process to improve the bioavailability of curcumin. The effects of operating parameters such as curcumin/PVP ratio, feed concentration, temperature, pressure, and CO2 flow rate were investigated. The characterization and solubility of particles were determined by using scanning electron microscopy, Fourier Transform Infrared spectroscopy, and ultra-violet-visible spectroscopy. The result shows that the optimal condition for the production of curcumin/PVP particles is at curcumin/PVP ratio of 1：30, feed concentration of 5 mg·mL^-1, temperature of 40 ℃, pressure of 15 MPa, and CO2 flow rate of 15 mL·min^-1. Moreover, the dissolution of curcumin/PVP particles is faster than that of raw curcumin.
