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From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world 被引量:52
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作者 Dimitrios Dimitroulis Christos Damaskos +12 位作者 Serena Valsami Spyridon Davakis Nikolaos Garmpis Eleftherios Spartalis Antonios Athanasiou Demetrios Moris Stratigoula Sakellariou Stylianos Kykalos Gerasimos Tsourouflis Anna Garmpi Ioanna Delladetsima konstantinos kontzoglou Gregory Kouraklis 《World Journal of Gastroenterology》 SCIE CAS 2017年第29期5282-5294,共13页
Hepatocellular carcinoma(HCC) is the most frequent primary liver malignancy and the third cause of cancer-related death in the Western Countries. The well-established causes of HCC are chronic liver infections such as... Hepatocellular carcinoma(HCC) is the most frequent primary liver malignancy and the third cause of cancer-related death in the Western Countries. The well-established causes of HCC are chronic liver infections such as hepatitis B virus or chronic hepatitis C virus, nonalcoholic fatty liver disease, consumption of aflatoxins and tobacco smocking. Clinical presentation varies widely; patients can be asymptomatic while symptomatology extends from right upper abdominal quadrant paint and weight loss to obstructive jaundice and lethargy. Imaging is the first key and one of the most important aspects at all stages of diagnosis, therapy and follow-up of patients with HCC. The Barcelona Clinic Liver Cancer Staging System remains the most widely classification system used for HCC management guidelines. Up until now, HCC remains a challenge to early diagnose, and treat effectively; treating management is focused on hepatic resection, orthotopic liver transplantation, ablative therapies, chemoembolization and systemic therapies with cytotocix drugs, and targeted agents. This review article describes the current evidence on epidemiology, symptomatology, diagnosis and treatment of hepatocellular carcinoma. 展开更多
关键词 HEPATOCELLULAR Cancer EPIDEMIOLOGY TREATMENT DIAGNOSIS STAGING Transplantation
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Walled-off pancreatic necrosis 被引量:5
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作者 Michael Stamatakos Charikleia Stefanaki +3 位作者 konstantinos kontzoglou Spyros Stergiopoulos Georgios Giannopoulos Michael Safioleas 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第14期1707-1712,共6页
Walled-off pancreatic necrosis (WOPN), formerly known as pancreatic abscess is a late complication of acute pancreatitis. It can be lethal, even though it is rare. This critical review provides an overview of the cont... Walled-off pancreatic necrosis (WOPN), formerly known as pancreatic abscess is a late complication of acute pancreatitis. It can be lethal, even though it is rare. This critical review provides an overview of the continually expanding knowledge about WOPN, by review of current data from references identified in Medline and PubMed, to September 2009, using key words, such as WOPN, infected pseudocyst, severe pancreatitis, pancreatic abscess, acute necrotizing pancreatitis (ANP), pancreas, inflammation and alcoholism. WOPN comprises a later and local complication of ANP, occurring more than 4 wk after the initial attack, usually following development of pseudocysts and other pancreatic fluid collections. The mortality rate associated with WOPN is generally less than that of infected pancreatic necrosis. Surgical intervention had been the mainstay of treatment for infected peripancreatic fluid collection and abscesses for decades. Increasingly, percutaneous catheter drainage and endoscopic retrograde cholangiopancreatography have been used, and encourag-ing results have recently been reported in the medical literature, rendering these techniques invaluable in the treatment of WOPN. Applying the recommended therapeutic strategy, which comprises early treatment with antibiotics combined with restricted surgical intervention, fewer patients with ANP undergo surgery and interventions are ideally performed later in the course of the disease, when necrosis has become well demarcated. 展开更多
关键词 Walled-off pancreatic necrosis Infected pseudocyst Severe pancreatitis Acute necrotizing pancreatitis PANCREAS Inflammation ALCOHOLISM
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Primary melanoma of the gallbladder: Does it exist? Report of a case and review of the literature 被引量:2
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作者 Michail Safioleas Emmanouil Agapitos +4 位作者 konstantinos kontzoglou Michail Stamatakos Panagiotis Safioleas George Mouzopoulos Alkiviadis Kostakis 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第26期4259-4261,共3页
With the occasion of a case of malignant melanoma of the gallbladder, which appeared to be primary, we have reviewed the literature and the result of this research was that primary melanoma of the gallbladder remains ... With the occasion of a case of malignant melanoma of the gallbladder, which appeared to be primary, we have reviewed the literature and the result of this research was that primary melanoma of the gallbladder remains a questionable medical entity. Only few cases of both primary and metastatic gallbladder melanoma have been reported so far, and the only agreement is that surgery is the mainstaytreatment. The role of adjuvant chemotherapy, hormonotherapy or immunotherapy for both primary and metastatic disease remains undefined. 展开更多
关键词 Neoplasms of the gallbladder GALLBLADDER Metastatic melanoma
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